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| 1 | Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin显示文摘Isolation rearing(IR) enhances aggressive behavior, and the central serotonin(5-hydroxytryptamine,5-HT) system has been linked to IR-induced aggression.However, whether the alteration of central serotonin is the cause or consequence of enhanced aggression is still unknown. In the present study, using mice deficient in central serotonin Tph2-/-and Lmx1 b-/-, we examined the association between central serotonin and aggression with or without social isolation. We demonstrated that central serotonergic neurons are critical for the enhanced aggression after IR. 5-HT depletion in wild-type mice increased aggression. On the other hand, application of 5-HT in Lmx1 b-/-mice inhibited the enhancement of aggression under social isolation conditions. Dopamine was downregulated in Lmx1 b-/-mice. Similar to 5-HT, L-DOPA decreased aggression in Lmx1 b-/-mice. Our results linkthe serotoninergic system directly to aggression and this may have clinical implications for aggression-related human conditions. | Yiqiong Liu Yunong Sun Xiaoyan Zhao Ji-Young Kim Lu Luo Qian Wang Xiaolu Meng Yonghui Li Nan Sui Zhou-Feng Chen Chuxiong Pan Liang Li Yan Zhang | 2019 | Neuroscience Bulletin2019，35，5： | 5 |
| 2 | Nanoengineered hydrogels as 3D biomimetic extracellular matrix with injectable and sustained delivery capability for cartilage regeneration显示文摘The regeneration of articular cartilage remains a great challenge due to the difficulty in effectively enhancing spontaneous healing.Recently,the combination of implanted stem cells,suitable biomaterials and bioactive molecules has attracted attention for tissue regeneration.In this study,a novel injectable nanocomposite was rationally designed as a sustained release platform for enhanced cartilage regeneration through integration of a chitosan-based hydrogel,articular cartilage stem cells(ACSCs)and mesoporous SiO_(2)nanoparticles loaded with anhydroicaritin(AHI).The biocompatible engineered nanocomposite acting as a novel 3D biomimetic extracellular matrix exhibited a remarkable sustained release effect due to the synergistic regulation of the organic hydrogel framework and mesopore channels of inorganic mSiO_(2)nanoparticles(mSiO_(2)NPs).Histological assessment and biomechanical tests showed that the nanocomposites exhibited superior performance in inducing ACSCs proliferation and differentiation in vitro and promoting extracellular matrix(ECM)production and cartilage regeneration in vivo.Such a novel multifunctional biocompatible platform was demonstrated to significantly enhance cartilage regeneration based on the sustained release of AHI,an efficient bioactive natural small molecule for ACSCs chondrogenesis,within the hybrid matrix of hydrogel and mSiO_(2)NPs.Hence,the injectable nanocomposite holds great promise for use as a 3D biomimetic extracellular matrix for tissue regeneration in clinical diagnostics. | Penglei Cui Panpan Pan Ling Qin Xinluan Wang Xiaodong Chen Yonghui Deng Xiaoling Zhang | 2023 | Bioactive Materials2023，，1： | 2 |
| 3 | Dynamics of local extreme rainfall of super Typhoon Soudelor (2015) in East China显示文摘The characteristics and dynamics associated with the distribution, intensity, and triggering factors of local severe precipitation in Zhejiang Province induced by Super Typhoon Soudelor(2015) were investigated using mesoscale surface observations, radar reflectivity, satellite nephograms, and the final(FNL) analyses of the Global Forecasting System(GFS) of the National Center for Environmental Prediction(NCEP). The rainfall processes during Soudelor's landfall and translation over East China could be separated into four stages based on rainfall characteristics such as distribution, intensity, and corresponding dynamics. The relatively less precipitation in the first stage resulted from interaction between the easterly wind to the north flank of this tropical cyclone(TC) and the coastal topography along the southeast of Zhejiang Province, China. With landfall of the TC in East China during the second stage, precipitation maxima occurred because of interaction between the TC's principal rainbands and the local topography from northeastern Fujian Province to southwestern Zhejiang Province. The distribution of precipitation presented significant asymmetric features in the third stage with maximal rainfall bands in the northeast quadrant of the TC when Soudelor's track turned from westward to northward as the TC decayed rapidly. Finally, during the northward to northeastward translation of the TC in the fourth stage, the interaction between a mid-latitude weather system and the northern part of the TC resulted in transfer of the maximum rainfall from the north of Zhejiang Province to the north of Jiangsu Province,which represented the end of rainfall in Zhejiang Province. Further quantitative calculations of the rainfall rate induced by the interaction between local topography and TC circulation(defined as 'orographic effects') in the context of a one-dimensional simplified model showed that orographic effects were the primary factor determining the intensity of precipitation in this case,and accounted for over 50% of the total precipitation. The asymmetric distribution of the TC's rainbands was closely related to the asymmetric distribution of moisture resulted from changes of the TC's structure, and led to asymmetric distribution of local intense precipitation induced by Soudelor. Based on analysis of this TC, it could be concluded that local severe rainfall in the coastal regions of East China is closely related to changes of TC structure and intensity, as well as the outer rainbands. In addition, precipitation intensity and duration will increase correspondingly because of the complex interactions between the TC and local topography, and the particular TC track along large-scale steering flow. The results of this study may be useful for the understanding, prediction, and warning of disasters induced by local extreme rainfall caused by TCs, especially for facilitating forecasting and warning of flooding and mudslides associated with torrential rain caused by interactions between landfalling TCs and coastal topography. | Jinsong PAN Daigao TENG Fuqing ZHANG Lingli ZHOU Ling LUO Yonghui WENG Yunji ZHANG | 2018 | Science China Earth Sciences2018，61，5： | 1 |
| 4 | Ultra-thin CoAl layered double hydroxide nanosheets for the construction of highly sensitive and selective QCM humidity sensor显示文摘To achieve real-time monitoring of humidity in various applications,we prepared facile and ultra-thin CoAl layered double hydroxide(CoAl LDH)nanosheets to engineer quartz crystal microbalances(QCM).The characteristics of CoAl LDH were investigated by transmission electron microscopy(TEM),X-ray diffraction(XRD),X-ray photoelectric spectroscopy(XPS),Brunauer–Emmett–Telle(BET),atomic force microscopy(AFM)and zeta potential.Due to their large specific surface area and abundant hydroxyl groups,CoAl LDH nanosheets exhibit good humidity sensing performance.In a range of 11.3%and 97.6%relative humidity(RH),the sensor behaved an ultrahigh sensitivity(127.8 Hz/%RH),fast response(9.1 s)and recovery time(3.1 s),low hysteresis(3.1%RH),good linearity(R^(2)=0.9993),stability and selectivity.Besides,the sensor can recover the initial response frequency after being wetted by deionized water,revealing superior self-recovery ability under high humidity.Based on in-situ Fourier transform infrared spectroscopy(FT-IR),the adsorption mechanism of CoAl LDH toward water molecules was explored.The QCM sensor can distinguish different respiratory states of people and wetting degree of fingers,as well as monitor the humidity in vegetable packaging,suggesting excellent properties and a promising application in humidity sensing. | Yongheng Zhu Xuhua Dong Jinsheng Cheng Lumin Wang Cheng Zhao Yonghui Deng Siqi Xie Yingjie Pan Yong Zhao Gengzhi Sun Tianjun Ni | 2023 | Chinese Chemical Letters2023，34，8： | 1 |
| 5 | A Wavelet Neural Networks License Recognition Algorithm and Its Application 显示文摘 | Yonghui Pan Rui Fan | 2012 | Journal of Computers2012，7，7： | 1 |
| 6 | Comprehensive map- ping of immunodominant and conserved serotype- and group-spe- cific B-cell epitopes of nonstructural protein 1 from dengue virus type l显示文摘 | Chen Yue Pan Yuxian Guo Yonghui | 2010 | Virology2010，398，2： | 1 |
| 7 | SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin显示文摘 | Huifeng Pi Shangcheng Xu Russel J Reiter Pan Guo Lei Zhang Yuming Li Min Li Zhenwang Cao Li Tian Jia Xie Ruiqi Zhang Mindi He Yonghui Lu Chuan Liu Weixia Duan Zhengping Yu Zhou Zhou | 2015 | Autophagy2015，，7： | 1 |
| 8 | RIRS versus mPCNL for single renal stone of 2–3 cm: clinical outcome and cost-effective analysis in Chinese medical setting显示文摘 | Jiahua Pan Qi Chen Wei Xue Yonghui Chen Lei Xia Haige Chen Yiran Huang | 2013 | Urolithiasis2013，，1： | 1 |
| 9 | Hydrothermal synthesis of hierarchical SnO_(2)nanomaterials for high-efficiency detection of pesticide residue显示文摘Acephate pesticide contamination in agricultural production has caused serious human health problems.Metal oxide semiconductor(MOS)gas sensor can be used as a portable and promising alternative tool for efficiently detection of acephate.In this study,hierarchical assembled SnO_(2)nanosphere,SnO_(2)hollow nanosphere and SnO_2 nanoflower were synthesized respectively as high efficiency sensing materials to build rapid and selective acephate pesticide residues sensors.The morphologies of different SnO_(2)3 D nanostructures were characterized by various material characterization technology.The sensitive performance test results of the 3 D SnO_(2)nanomaterials towards acephate show that hollow nanosphere SnO_(2)based sensor displayed preferable sensitivity,selectivity,and rapid response(9 s)properties toward acephate at the optimal working temperature(300℃).This SnO_(2)hollow nanosphere based gas sensor represents a useful tool for simple and highly effective monitoring of acephate pesticide residues in food and environment.According to the characterization results,particularly Brunauer-Emmett-Teller(BET)and Ultraviolet-Visible Spectroscopy(UV-vis),the obvious and fast response can be attributed to the mesoporous hollow nanosphere structure and appropriate band gap of SnO_2 hollow nanosphere. | Haijie Cai Xiaopeng Qiao Meilian Chen Dongsheng Feng Abdulaziz AAlghamdi Fahad A.Alharthi Yingjie Pan Yong Zhao Yongheng Zhu Yonghui Deng | 2021 | Chinese Chemical Letters2021，32，4： | 1 |
| 10 | A prospective study of the incidence and correlate factors of post-stroke depres- sion in China显示文摘 | Zhang Weina Pan Yonghui Yu Xiao | 2013 | PLOS ONE2013，8，11： | 1 |
| 11 | Eupalinolide B inhibits hepatic carcinoma by inducing ferroptosis and ROS-ER-JNK pathway显示文摘Primary hepatic carcinoma is a common malignant tumor.The classic molecular targeted drug sorafenib is costly and is only effective for some patients.Therefore,it is of great clinical significance to search for new molecular targeted drugs.Eupalinolide B(EB)from Eupatorium lindleyanum DC.is used to treat chronic tracheitis in clinical practice.However,the role of EB in hepatic carcinoma is unknown.In this study,we first measure the effect of EB on tumor growth in a xenograft model and PDX model.The cell proliferation and migration are also detected in human hepatocarcinoma cell lines(SMMC-7721 and HCCLM3).Then,we investigate cell cycle,cell apoptosis,cell necrosis,cell autophagy,and ferroptosis by flow cytometry,western blot analysis and electron microscopy.The results demonstrate that EB exerts anti-proliferative activity in hepatic carcinoma by blocking cell cycle arrest at S phase and inducing ferroptosis mediated by endoplasmic reticulum(ER)stress,as well as HO-1 activation.When HO-1 is inhibited,EB-induced cell death and ER protein expression are rescued.The migration-related mechanism consists of activation of the ROS-ER-JNK signaling pathway and is not connected to ferroptosis.In summary,we first discover that EB inhibits cell proliferation and migration in hepatic carcinoma,and thus EB is a promising anti-tumor compound that can be used for hepatic carcinoma. | Yonghui Zhang Haoyang Zhang Jinage Mu Meiyue Han Zhihao Cao Feng Dong Tingting Wang Lian Pan Wujing Luo Jiaxin Li Huan Liu Lishan Jin Wenxuan Ding Yong Wei Xuesong Deng Dan Liu Xiuzhen He Yi Pang Xiao Mu Zhongjun Wu Dilong Chen | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 1 |
| 12 | A fast on-demand preparation of injectable self-healing nanocomposite hydrogels for efficient osteoinduction显示文摘Injectable hydrogels have been considered as promising materials for bone regeneration,but their osteoinduction and mechanical performance are yet to be improved.In this study,a novel biocompatible injectable and self-healing nano hybrid hydrogel was on-demand prepared via a fast(within 30 s)and easy gelation approach by reversible Schiff base formed between-CH=O of oxidized sodium alginate(OSA)and-NH2 of glycol chitosan(GCS)mixed with calcium phosphate nanoparticles(CaP NPs).Its raw materials can be ready in large quantities by a simple synthesis process.The mechanical strength,degradation and swelling behavior of the hydrogel can be readily controlled by simply controlling the molar ratio of-CH=O and-NH2.This hydrogel exhibits pH responsiveness,good degradability and biocompatibility.The hydrogel used as the matrix for mesenchymal stem cells can significantly induce the proliferation,differentiation and osteoinduction in vitro.These results showed this novel hydrogel is an ideal candidate for applications in bone tissue regeneration and drug delivery. | Panpan Pan Xiao Chen Huaran Xing Yonghui Deng Jingdi Chen Fahad AAlharthi Abdulaziz AAlghamdi Jiacan Su | 2021 | Chinese Chemical Letters2021，32，7： | 0 |
| 13 | Coalbursts in China: Theory, practice and management显示文摘Coalburst is one of the most serious disasters that threaten the safe production of coal mines, and this disaster is particularly serious in China. This paper presents an overview of coalbursts in China since 1980s. From the 'stress and energy' and 'regional and local' perspectives, the achievements in the theory, practice and management of coalbursts in China are systematically summarized. A theoretical system of coalbursts has been formed to reveal the deformational behavior of coalbursts and explain the mechanism of coalbursts. The occurrence conditions of coalbursts are put forward and the critical stress is obtained. The stress index method for risk evaluation of coalbursts before mining is proposed, and the deformation localization prediction method of coalbursts is put forward. The relationship between energy release and absorption in the process of coalbursts is found, and the prevention and control methods of coalbursts, including the regional method, the local method and support, are presented. The safety evaluation index of coalburst prevention and control is put forward. The integrated prevention and control method for coal and gas outbursts is proposed. The prevention and control technology and equipment of coalbursts have also been developed. Amongst them, the distribution law of the critical stress in China coalburst mines is discovered. The technology and equipment for monitoring, prevention and control of coalbursts, as well as for integrated prevention and control of combined coalbursts and other disasters, have been developed. The energy-absorbing and coalburst-preventing support technology for roadways is invented, and key engineering parameters of coalburst prevention and control are pointed out. In China, coalburst prevention and control laws and standards have been developed. Technical standards for coalbursts are formulated, statute and regulations for coal mines are established, and regulatory documents are promoted. | Yishan Pan Yimin Song Hao Luo Yonghui Xiao | 2024 | Journal of Rock Mechanics and Geotechnical Engineering2024，16，1： | 0 |
| 14 | One-dimensional nanochains consisting of magnetic core and mesoporous aluminosilicate for use as efficient nanocatalysts显示文摘Magnetic assembly at the nanoscale level brings potential possibilities in obtaining novel delicate nanostructures with unique physical, photonic or electronic properties. Interface surfactant micelle-directed assembly strategy holds great promising in fabricating ordered mesoporous materials with multifunctionality and pore parameter tunability. Combing these, herein, one-dimensional (1D) nanochains with well-aligned silica-coated magnetic particles as core and mesoporous aluminosilicate as shell are rational fabricated for the first time through magnetic field induced interface coassembly in biliquid system followed by the incorporation of Al species via in-situ chemical modification and transformation strategy. The obtained magnetic mesoporous aluminosilicate nanochains (MMAS-NCs) possess well-defined core-shell-shell sandwich nanostructure, tunable perpendicular mesopore channels in the shell (2.7–7.6 nm), high surface area (359 m^(2)·g^(-1)), abundant acidic sites, and superparamagnetism with a magnetization saturation of 13.8 emu·g^(-1). Thanks to the unique properties, the MMAS-NCs exhibit excellent performance in acting as magnetically recyclable superior solid acid catalysts and nanostirrers with high conversion of over 96.8%, selectivity of 95.0% in the deprotection reaction of benzaldehyde dimethylacetal to benzaldehyde. Moreover, MMAS-NCs exhibit an interesting pore size effect on the catalytic activity, namely, in the pore size range of 2–8 nm, the catalysts with larger pores show significantly enhanced catalytic activity due to the balanced mass transport and density of surface active sites. | Tong Zhang Qin Yue Panpan Pan Yuan Ren Xuanyu Yang Xiaowei Cheng Fahad A.Alharthi Abdulaziz A.Alghamdi Yonghui Deng | 2021 | Nano Research2021，14，11： | 0 |
| 15 | Advances on pathogenesis of migraine in cold regions显示文摘Migraine is a common primary headache which seriously affects the quality of patients’life due to the high prevalence and disability rate.Recent years a large number of studies have found that temperature is directly bound to migraine and migraine patients in cold regions have higher prevalence,different manifestations and poor response to the conventional therapy.We propose in this review article a new concept of migraine in cold regions on the basis of geography and summarize the research advances on the pathogenesis of migraine in cold regions to provide conceptual basis for the clinical diagnosis and treatment of this disease entity. | Qihui Chen Yonghui Pan Dan Yao Yongchen Wang | 2022 | Frigid Zone Medicine2022，2，1： | 0 |
| 16 | Elucidating the excited-state dynamics behavior in near-infrared Bodipy dye and aggregates toward biophotonics显示文摘Photo-induced excited-state dynamics within organic materials fundamentally determine their photophysical properties for various applications,and thus understanding the primary excited-state dynamics behavior is of fundamental and practical significance.Until recently,the excited-state dynamics of organic materials towards biophotonics have been rarely studied,although numerous endeavors have been devoted to the design of organic materials for biophotonics.Herein,various spectroscopy technologies including femtosecond transient absorption(fs-TA)spectroscopy clearly reveal a totally different excited state dynamics behavior within Bodipy monomer(2B-BDP dye)and aggregates(2B-BDP NPs),indicating strongly morphology dependent character.2B-BDP dye undergoes an ultrafast conversion from S1 to intramolecular charge transfer(ICT)state for subsequent photoluminescence(PL)and nonradiative(NR)decay,while 2B-BDP NPs show an accelerated excited-state deactivation mainly through S1→S0 NR decay.The potential bioapplications based on the corresponding excited state dynamics behavior are discussed together with experimental results.Interestingly,the accelerated NR decay in 2B-BDP NPs does not yield a stronger photoacoustic(PA)signal than that in 2B-BDP dye,which violates the conventional wisdom that faster NR decay would benefit the photothermal effects for better photoacoustic imaging(PAI).These insightful and fundamental observations of the excited-state dynamics may contribute an alternative approach at the molecular level towards the future design of functional Bodipy-based organic molecules with desirable performances. | Xiaofei Miao Haojie Tao Wenbo Hu Yonghui Pan Quli Fan Wei Huang | 2020 | Science China Chemistry2020，63，8： | 0 |
| 17 | Bioinspired Closed-loop CPG-based Control of a Robotic Manta for Autonomous Swimming显示文摘Fish in nature exhibit a variety of swimming modes such as forward swimming,backward swimming,turning,pitching,etc.,enabling them to swim in complex scenes such as coral reefs.It is still difficult for a robotic fish to swim autonomously in a confined area as a real fish.Here,we develop an untethered robotic manta as an experimental platform,which consists of two flexible pectoral fins and a tail fin,with three infrared sensors installed on the front,left,and right sides of the head to sense the surrounding obstacles.To generate multiple swimming modes of the robotic manta and online switching of different modes,we design a closed-loop Central Pattern Generator(CPG)controller based on distance information and use a combination of phase difference and amplitude of the CPG model to achieve stable and rapid adjustment of yaw angle.To verify the autonomous swimming ability of the robotic manta in complex scenes,we design an experimental scenario with a concave obstacle.The experimental results show that the robotic manta can achieve forward swimming,backward swimming,in situ turning within the concave obstacle,and finally exit from the area safely while relying on the perception of external obstacles,which can provide insight into the autonomous exploration of complex scenes by the biomimetic robotic fish.Finally,the swimming ability of the robotic manta is verified by field tests. | Yiwei Hao Yonghui Cao Yingzhuo Cao Xiong Mo Qiaogao Huang Lei Gong Guang Pan Yong Cao | 2024 | Journal of Bionic Engineering2024，21，1： | 0 |
| 18 | Versatile core-shell magnetic fluorescent mesoporous microspheres for multilevel latent fingerprints magneto-optic information recognition显示文摘Latent fingerprints are extremely vital for personal identification and criminalinvestigation,and potential information recognition techniques have been widelyused in the fields of information and communication electronics.Although physicalpowder dusting methods have been frequently employed to develop latent fingerprintsand most of them are carried out by using single component powders ofmicron-sized fluorescent particles,magnetic powders,or metal particles,there isstill an enormous challenge in producing high-resolution image of latent fingerprintsat different backgrounds or substrates.Herein,a novel and effectivenanoimpregnation method is developed to synthesize bifunctional magnetic fluorescentmesoporous microspheres for latent fingerprints visualization by growthof mesoporous silica(mesoSiO_(2))on magical Fe_(3)O_(4) core and then deposition offluorescent YVO4:Eu^(3+)nanoparticles in the mesopores.The obtainedFe_(3)O_(4)@mesoSiO_(2)@YVO4:Eu^(3+)microspheres possess spatially isolated magneticcore and fluorescent shell which were insulated by mesoporous silica layer.Dueto their small particle size of submicrometer scale,high magnetization and lowmagnetic remanence as well as the combined magnetic and fluorescent properties,the microspheres show superior performance in visual latent fingerprint recognitionwith high contrast,high anti-interference,and sensitivity as well as goodretention on multifarious substrates regardless of surface permeability,roughness,refraction,colorfulness,and background fluorescence interference,and it makesthem ideal candidates for practical application in fingerprint visualization andeven magneto-optic information storage. | Bingjie Yu Shude Liu Wenhe Xie Panpan Pan Peng Zhou Yidong Zou Qin Yue Yonghui Deng | 2022 | InfoMat2022，4，5： | 0 |
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