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| 1 | A prospective, multicenter study of 1111 colorectal endoscopic submucosal dissections (with video)显示文摘 | Yutaka Saito Toshio Uraoka Yuichiro Yamaguchi Kinichi Hotta Naoto Sakamoto Hiroaki Ikematsu Masakatsu Fukuzawa Nozomu Kobayashi Junichirou Nasu Tomoki Michida Shigeaki Yoshida Hisatomo Ikehara Yosuke Otake Takeshi Nakajima Takahisa Matsuda Daizo Saito | 2010 | Gastrointestinal Endoscopy2010，，6： | 6 |
| 2 | 个旧市郊室内氡、钍射气浓度和地面γ辐射水平初步调查显示文摘目的调查个旧地区居室内氡(^222Rn)、钍射气(^220Rn)及其子体水平,明确钍射气的剂量贡献。方法考虑住宅类型和地理分布因素,从个旧市郊某村选取建筑结构有代表性的50户住宅的主卧室,采用氡-钍射气鉴别探测器测量氡、钍射气浓度,用沉积率装置测量钍射气子体浓度。其中14间居室采用连续性氡测量探测器和α谱氡、钍射气鉴别探测器测量氡、钍射气浓度,空气采样滤膜结合CR-39探测器测量钍射气衰变产物浓度,碘化钠闪烁计数器测量地表γ剂量率。结果50间居室的氡浓度为32~498Bq/m^3,平均136Bq/m^3;钍射气浓度为39~7908Bq/m^3,平均3297Bq/m^3;钍射气子体浓度为2.0~23.9Bq/m^3,平均10.2Bq/m^3。钍射气子体衰变产物致居民年平均有效剂量大于氡子体衰变产物的平均年有效剂量(2.9mSv vs 1.6mSv)。结论个旧市郊部分居室室内钍射气及其子体浓度高,钍射气子体的剂量贡献要高于氡子体的剂量贡献。在个旧开展氡致肺癌危险评价研究应当考虑钍射气子体的剂量贡献。 | 雷淑洁 Shinji TOKONAMI 孙全富 Tetsuo ISHIKAWA Yosuke KOBAYASHI 李小娟 闵向东 武国亮 Shinji YOSHINAGA 尚兵 | 2008 | 中国职业医学2008，35，3： | 6 |
| 3 | Prophylactic lateral pelvic lymph node dissection in stage Ⅳ low rectal cancer显示文摘AIM To assess the clinical significance of prophylactic lateral pelvic lymph node dissection (LPLND) in stage Ⅳ low rectal cancer.METHODS We selected 71 consecutive stage Ⅳ low rectal cancer patients who underwent primary tumor resection,and enrolled 50 of these 71 patients without clinical LPLN metastasis.The patients had distant metastasis such as liver,lung,peritoneum,and paraaortic LN.Clinical LPLN metastasis was defined as LN with a maximum diameter of 10 mm or more on preoperative pelvic computed tomography scan.All patients underwent primary tumor resection,27 patients underwent total mesorectal excision(TME) with LPLND(LPLND group),and 23 patients underwent only TME(TME group).Bilateral LPLND was performed simultaneously with primary tumor resection in LPLND group.R0 resection of both primary and metastatic sites was achieved in 20 of 50 patients.We evaluated possible prognostic factors for 5-year overall survival (OS),and compared 5-year cumulative local recurrence between the LPLND and TME groups.RESULTS For OS,univariate analyses revealed no significant benefit in the LPLND compared with the TME group (28.7% vs 17.0%,P = 0.523); multivariate analysis revealed that R0 resection was an independent prognostic factor.Regarding cumulative local recurrence,the LPLND group showed no significant benefit compared with TME group (21.4% vs 14.8%,P = 0.833).CONCLUSION Prophylactic LPLND shows no oncological benefits in patients with Stage Ⅳ low rectal cancer without clinical LPLN metastasis. | Hiroshi Tamura Yoshifumi Shimada Hitoshi Kameyama Ryoma Yagi Yosuke Tajima Takuma Okamura Mae Nakano Masato Nakano Masayuki Nagahashi Jun Sakata Takashi Kobayashi Shin-ichi Kosugi Hitoshi Nogami Satoshi Maruyama Yasumasa Takii Toshifumi Wakai | 2017 | World Journal of Clinical Oncology2017，8，5： | 4 |
| 4 | Need for pancreatic stenting after sphincterotomy in patients with difficult cannulation显示文摘AIM:To investigate the need for pancreatic stenting after endoscopic sphincterotomy(EST)in patients with difficult biliary cannulation.METHODS:Between April 2008 and August 2013,2136 patients underwent endoscopic retrograde cholangiopancreatography(ERCP)-related procedures.Among them,55 patients with difficult biliary cannulation who underwent EST after bile duct cannulation using the pancreatic duct guidewire placement method(P-GW)were divided into two groups:a stent group(n=24;pancreatic stent placed)and a no-stent group(n=31;no pancreatic stenting).We retrospectively compared the two groups to examine the need for pancreatic stenting to prevent post-ERCP pancreatitis(PEP)in patients undergoing EST after biliary cannulation by P-GW.RESULTS:No differences in patient characteristics or endoscopic procedures were observed between the two groups.The incidence of PEP was 4.2%(1/24)and29.0%(9/31)in the Stent and no-stent groups,respectively,with the no-stent group having a significantly higher incidence(P=0.031).The PEP severity was mild for all the patients in the stent group.In contrast,8 had mild PEP and 1 had moderate PEP in the no-stent group.The mean serum amylase levels(means±SD)3 h after ERCP(183.1±136.7 vs 463.6±510.4 IU/L,P=0.006)and on the day after ERCP(209.5±208.7vs 684.4±759.3 IU/L,P=0.002)were significantly higher in the no-stent group.A multivariate analysis identified the absence of pancreatic stenting(P=0.045;odds ratio,9.7;95%CI:1.1-90)as a significant risk factor for PEP.CONCLUSION:In patients with difficult cannulation in whom the bile duct is cannulated using P-GW,a pancreatic stent should be placed even if EST has been performed. | Kazunari Nakahara Chiaki Okuse Keigo Suetani Yosuke Michikawa Shinjiro Kobayashi Takehito Otsubo Fumio Itoh | 2014 | World Journal of Gastroenterology2014，20，26： | 4 |
| 5 | Overexpression of ETS-1 is associated with malignan' biological features of prostate cancer显示文摘E26 transformation-specific-1 ( ETS-1 ),一个 et 家庭抄写因素,被报导了在前列腺癌症( PCa )在 ETS-1 表示的许多生理、病理学的过程,而是临床的含意起一个重要作用,特别地高风险的案例,包括对雄激素剥夺的反应,治疗( ADT )还得被阐明。我们用针活体检视从 69 个主要先进的 PCa 病人获得的嵌入石蜡的前列腺癌织物染色的 immunohistochemical 检验了 ETS-1 的表示。ETS-1 表示与 69 个病人的 clinicopathological 特征相比,包括 25 作为主要治疗经历了 ADT。作为结果,有 ETS-1 的更高的表示的 PCa 病人是显著地,可能舞台高的更多得分(P< 0.05 ) 。在 ETS-1 表示和起始的前列腺特定的抗原(PSA ) 水平之间没有重要协会。在 ADT 对待的 25 个病人,为 ETS-1 的染色的分数显著地在 24 个月以内与阉割抵抗的疾病的快速的开发被联系(P< 0.05 ) ,而格利森分数和 PSA 水平不是。在结论,增加了 ETS-1 表示与到阉割抵抗的前进的一个更高的阶段,更高级的格利森分数和更短的时间被联系。这些数据建议为 ETS-1 的 immunostaining 能是为为 PCa 病人预言差的临床的结果的一个分子的标记,特别地那些与高风险的疾病。 | Bo Li Yosuke Shimizu Takashi Kobayashi Naoki Terada Koji Yoshimura Tomomi Kamba Yoshiki Mikami Takahiro Inoue Hiroyuki Nishiyama Osamu Ogawa | 2012 | Asian Journal of Andrology2012，14，6： | 2 |
| 6 | Covered Metal Stenting for Malignant Lower Biliary Stricture with Pancreatic Duct Obstruction: Is Endoscopic Sphincterotomy Needed?显示文摘 | Kazunari Nakahara Chiaki Okuse Keigo Suetani Yosuke Michikawa Shinjiro Kobayashi Takehito Otsubo Fumio Itoh Peter V. Draganov | 2013 | Gastroenterology Research and Practice2013，，： | 1 |
| 7 | Deletion or methylation of CDKN2A/2B and PVT1 rearrangement occur frequently in highly aggressive B-cell lymphomas harboring 8q24 abnormality显示文摘 | Yasuhiko Tsutsumi Yoshiaki Chinen Natsumi Sakamoto Hisao Nagoshi Kazuhiro Nishida Satoru Kobayashi Yuichi Yokokawa Tomohiko Taki Nana Sasaki Mio Yamamoto-Sugitani Tsutomu Kobayashi Yosuke Matsumoto Shigeo Horiike Junya Kuroda Masafumi Taniwaki | 2013 | Leukemia & Lymphoma2013，，12： | 1 |
| 8 | Application of aqueous saponin on the remediation of polycyclic aromatic hydrocarbons-contaminated soil显示文摘 | Takayuki Kobayashi Hirohisa Kaminaga RonaldR. Navarro Yosuke Iimura | 2012 | Journal of Environmental Science and Health Part A2012，，8： | 1 |
| 9 | Enteral metallic stenting by balloon enteroscopy for obstruction of surgically reconstructed intestine显示文摘We present three cases of self-expandable metallic stent(SEMS) placement using a balloon enteroscope(BE) and its overtube(OT) for malignant obstruction of surgically reconstructed intestine. A BE is effective for the insertion of an endoscope into the deep bowel. However, SEMS placement is impossible through the working channel, because the working channel of BE is too small and too long for the stent device. Therefore, we used a technique in which the BE is inserted as far as the stenotic area; thereafter, the BE is removed, leaving only the OT, and then the stent is placed by inserting the stent device through the OT. In the present three cases, a modification of this technique resulted in the successful placement of the SEMS for obstruction of surgically reconstructed intestine, and the procedures were performed without serious complications. We consider that the present procedure is extremely effective as a palliative treatment for distal bowel stenosis, such as in the surgically reconstructed intestine. | Kazunari Nakahara Chiaki Okuse Nobuyuki Matsumoto Keigo Suetani Ryo Morita Yosuke Michikawa Shun-ichiro Ozawa Kosuke Hosoya Shinjiro Kobayashi Takehito Otsubo Fumio Itoh | 2015 | World Journal of Gastroenterology2015，21，24： | 1 |
| 10 | Predictive value of serial assessment of endothelial function in chronic heart failure显示文摘 | Isao Takishima Takamitsu Nakamura Mitsumasa Hirano Yoshinobu Kitta Tsuyoshi Kobayashi Daisuke Fujioka Yukio Saito Kazuhiro Watanabe Yosuke Watanabe Hideto Mishina Jyun-ei Obata Ken-ichi Kawabata Shun Tamaru Kiyotaka Kugiyama | 2011 | International Journal of Cardiology2011，，3： | 1 |
| 11 | Bortezomib for post-allogeneic hematopoietic stem transplantation relapse and GVHD in multiple myeloma: a single institute experience显示文摘 | Junya Kuroda Tsutomu Kobayashi Yasuhiko Tsutsumi Mio Yamamoto Muneo Ohshiro Nana Sasaki Yuji Shimura Shinsuke Mizutani Hisao Nagoshi Miki Kiyota Ryuko Nakayama Hitoji Uchiyama Yosuke Matsumoto Shigeo Horiike Chihiro Shimazaki Masafumi Taniwaki | 2010 | International Journal of Hematology2010，，4： | 1 |
| 12 | Bcl-2 is a better therapeutic target than c-Myc, but attacking both could be a more effective treatment strategy for B-cell lymphoma with concurrent Bcl-2 and c-Myc overexpression显示文摘 | Nana Sasaki Junya Kuroda Hisao Nagoshi Mio Yamamoto Satoru Kobayashi Yasuhiko Tsutsumi Tsutomu Kobayashi Yuji Shimura Yosuke Matsumoto Tomohiko Taki Kazuhiro Nishida Shigeo Horiike Yukihiro Akao Masafumi Taniwaki | 2011 | Experimental Hematology2011，，8： | 1 |
| 13 | Short-term progression of maximum intima-media thickness of carotid plaque is associated with future coronary events in patients with coronary artery disease显示文摘 | Mitsumasa Hirano Takamitsu Nakamura Yoshinobu Kitta Isao Takishima Juntaro Deyama Tsuyoshi Kobayashi Daisuke Fujioka Yukio Saito Kazuhiro Watanabe Yosuke Watanabe Ken-ichi Kawabata Jyun-ei Obata Kiyotaka Kugiyama | 2011 | Atherosclerosis2011，，2： | 1 |
| 14 | Mice lac- king the glutamate - cysteine ligase modifier subunit are susceptible t9 myocardial ischaemia - reperfusion injury显示文摘 | Tsuyoshi Kobayashi Yosuke Watanabe Yukio Salto | 2010 | Cardiovasc Res2010，85，： | 1 |
| 15 | Recent Progress in Plasma Control Studies on the Improvement of Plasma Performance in Heliotron J显示文摘Recent progress in plasma control studies on the improvement of plasma performancein Heliotron J is reviewed.The supersonic molecular beam injection (SMBI)fueling issuccessfully applied to Heliotron J plasma.A supersonic H2-beam is effectively injected to increasefueling efficiency and generate a peaked density profile.Local fueling with a short-pulsedSMBI can increase the core plasma density and avoid the degradation arising from edge cooling.Second harmonic electron cyclotron current drive (ECCD)experiments were conducted by launchinga focused Gaussian beam with a parallel refractive index of-0.05≤N||≤ 0.6.Results showthat the electron cyclotron (EC)driven current is determined not only by N|| but also by localmagnetic field (B)structure where the EC power is deposited.Detailed analysis of the observedN|| and B dependences is in progress with a ray-tracing simulation using the TRAVIS code.Fastion velocity distribution was investigated using fast protons generated by ion cyclotron resonantfrequency (ICRF)minority heating.For the standard configuration in Heliotron J.charge exchangeneutral particle analysis (CX-NPA)measurements show higher effective temperature offast minority protons in the on-axis resonance case compared to that in the HFS (high field side)off-axis resonance case.However,the increase in bulk ion temperature in the HFS resonance caseis larger than that in the on-axis resonance. | Tohru MIZUUCHI Kazunobu NAGASAKI Hiroyuki OKADA Shinji KOBAYASHI Satoshi YAMAMOTO Takashi MINAMI Shinsuke OHSHIMA Masaki TAKEUCHI Kiyofumi MUKAI Hyunyong LEE Linge ZANG Kohta NOMURA Masashige SUWA Kento YAMAMOTO Hiroaki YASHIRO Hayao YOSHINO Shouhei ARAI Tasuku KAGAWA Takayuki MINAMI Kouji MIZUNO Yoshinobu WADA Hiroto WATADA Nobuhiro NISHINO Yosuke NAKASHIMA Kiyoshi HANATANI Yuji NAKAMURA Shigeru KONOSHIMA Fumimichi SANO | 2011 | Plasma Science and Technology2011，13，1： | 0 |
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