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| 1 | Helicobacter pylori infection in subjects negative for high titer serum antibody显示文摘AIM To investigate the clinicopathological features of the patients testing negative for high titer serum antiHelicobacter pylori(H. pylori) antibody.METHODS The antibody titers were measured using antigens derived from Japanese individuals. ^(13)C-urea breath test-positive individuals were defined as having H. pylori infection. We investigated the demographic characteristics, laboratory data, endoscopic findings including Kyoto classification of gastritis, and histology in negative-high titer patients without H. pylori eradication therapy. Kyoto classification consisted of scores for gastric atrophy, intestinal metaplasia, enlarged folds, nodularity, and redness.RESULTS Of the 136 subjects enrolled, 23(17%) had H. pylori infection. Kyoto classification had an excellent area under the receiver operating characteristics curve(0.886, 95% confidence interval: 0.803-0.968, P = 3.7 × 10^(-20)) for predicting H. pylori infection with a cutoff value of 2. Further, Kyoto classification, H. pylori density, and neutrophil activity had high accuracies(89.7%, 96.3%, and 94.1%, respectively). Kyoto classification was independent of the demographic and laboratory parameters in multivariate analysis.CONCLUSION Endoscopic Kyoto classification of gastritis is a useful predictor of H. pylori infection in negative-high titer antibody patients. | Osamu Toyoshima Toshihiro Nishizawa Masahide Arita Yosuke Kataoka Kosuke Sakitani Shuntaro Yoshida Hiroharu Yamashita Keisuke Hata Hidenobu Watanabe Hidekazu Suzuki | 2018 | World Journal of Gastroenterology2018，24，13： | 9 |
| 2 | Effect of double platinum agents, combination of miriplatintransarterial oily chemoembolization and cisplatinhepatic arterial infusion chemotherapy, in patients with hepatocellular carcinoma: Report of two cases显示文摘Hepatocellular carcinoma(HCC) is one of the most common cancers and the third highest cause of cancerassociated mortality worldwide. The treatment of HCC is complicated by its variable biological behavior and the frequent coexistence of chronic liver disease, particularly cirrhosis. To date, multiple treatment modalities have been developed according to the stage of the tumor and the hepatic functional reserve, including transarterial treatments such as transarterial chemoembolization, transarterial oily chemoembolization(TOCE), and hepatic arterial infusion chemotherapy(HAIC). We conducted a phase I and II study of the combination therapy with double platinum agents, miriplatin and cisplatin, and confirmed its safety and efficacy. Here, we describe two cases of unresectable HCC who were successfully treated by miriplatin-TOCE/cisplatin-HAIC combination therapy, resulting in complete responses with no significant adverse events. This report will provide that the combination therapy can be the therapeutic option for HCC patients in the advanced stage. | Kohei Ogawa Kenya Kamimura Yukari Watanabe Yosuke Motai Daisuke Kumaki Ryoya Seki Akira Sakamaki Satoshi Abe Hirokazu Kawai Takeshi Suda Satoshi Yamagiwa Shuji Terai | 2017 | World Journal of Clinical Cases2017，5，6： | 4 |
| 3 | Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis显示文摘AIM:To determine the efficacy and safety of rapid induction therapy with oral tacrolimus without a meal in steroid-refractory ulcerative colitis(UC)patients.METHODS:This was a prospective,multicenter,observational study.Between May 2010 and August 2012,49 steroid-refractory UC patients(55 flare-ups)were consecutively enrolled.All patients were treated with oral tacrolimus without a meal at an initial dose of 0.1mg/kg per day.The dose was adjusted to maintain trough whole-blood levels of 10-15 ng/m L for the first 2 wk.Induction of remission at 2 and 4 wk after tacrolimus treatment initiation was evaluated using Lichtiger’s clinical activity index(CAI).RESULTS:The mean CAI was 12.6±3.6 at onset.Within the first 7 d,93.5%of patients maintained high trough levels(10-15 ng/m L).The CAI significantly decreased beginning 2 d after treatment initiation.At 2wk,73.1%of patients experienced clinical responses.After tacrolimus initiation,31.4%and 75.6%of patients achieved clinical remission at 2 and 4 wk,respectively.Treatment was well tolerated.CONCLUSION:Rapid induction therapy with oral tacrolimus shortened the time to achievement of appropriate trough levels and demonstrated a high remission rate 28 d after treatment initiation.Rapid induction therapy with oral tacrolimus appears to be a useful therapy for the treatment of refractory UC. | Ken Kawakami Takuya Inoue Mitsuyuki Murano Ken Narabayashi Sadaharu Nouda Kumi Ishida Yosuke Abe Koji Nogami Nobuyuki Hida Hirokazu Yamagami Kenji Watanabe Eiji Umegaki Shiro Nakamura Tetsuo Arakawa Kazuhide Higuchi | 2015 | World Journal of Gastroenterology2015，21，6： | 3 |
| 4 | Association of gastric cancer risk factors with DNA methylation levels in gastric mucosa of healthy Japanese: a cross-sectional study显示文摘 | Shimazu Taichi Asada Kiyoshi Charvat Hadrien Kusano Chika Otake Yosuke Kakugawa Yasuo Watanabe Hidenobu Gotoda Takuji Ushijima Toshikazu Tsugane Shoichiro | 2015 | Carcinogenesis2015，，： | 2 |
| 5 | Soluble interleukin‐6 receptor is a serum biomarker for the response of esophageal carcinoma to neoadjuvant chemoradiotherapy显示文摘 | Yosuke Makuuchi Kazufumi Honda Yoshiaki Osaka Ken Kato Takashi Kojima Hiroyuki Daiko Hiroyasu Igaki Yoshinori Ito Sumito Hoshino Shingo Tachibana Takafumi Watanabe Koh Furuta Shigeki Sekine Tomoko Umaki Yukio Watabe Nami Miura Masaya Ono Akihiko Tsuchida | 2013 | Cancer Sci2013，，8： | 1 |
| 6 | Multicenter Study of Short- and Long-Term Outcomes of Laparoscopic Palliative Resection for Incurable, Symptomatic Stage IV Colorectal Cancer in Japan显示文摘 | Tomonori Akagi Masafumi Inomata Seigo Kitano Koya Hida Yoshiharu Sakai Suguru Hasegawa Yousuke Kinjo Kenichi Yoshimura Masaaki Ito Yosuke Fukunaga Akiyoshi Kanazawa Hitoshi Idani Masahiko Watanabe | 2013 | Journal of Gastrointestinal Surgery2013，，4： | 1 |
| 7 | Open Versus Laparoscopic Resection of Primary Tumor for Incurable Stage IV Colorectal Cancer: A Large Multicenter Consecutive Patients Cohort Study显示文摘 | Koya Hida Suguru Hasegawa Yousuke Kinjo Kenichi Yoshimura Masafumi Inomata Masaaki Ito Yosuke Fukunaga Akiyoshi Kanazawa Hitoshi Idani Yoshiharu Sakai Masahiko Watanabe | 2012 | Annals of Surgery2012，，5： | 1 |
| 8 | A comparison of the efficacy of combined ezetimibe and statin therapy with doubling of statin dose in patients with remnant lipoproteinemia on previous statin therapy显示文摘 | Takamitsu Nakamura Mitsumasa Hirano Yoshinobu Kitta Daisuke Fujioka Yukio Saito Ken-ichi Kawabata Jun-ei Obata Yosuke Watanabe Kazuhiro Watanabe Kiyotaka Kugiyama | 2012 | Journal of Cardiology2012，，1： | 1 |
| 9 | Comparison of phosphorus retention efficiency between rainbow trout ( Oncorhynchus mykiss ) fed a commercial diet and a low fish meal based diet显示文摘 | Shuichi Satoh Adrián Hernández Takatoshi Tokoro Yosuke Morishita Viswanath Kiron Takeshi Watanabe | 2003 | Aquaculture2003，，1： | 1 |
| 10 | Open Versus Laparoscopic Resection of Primary Tumor for Incurable Stage IV Colorectal Cancer: A Large Multicenter Consecutive Patients Cohort Study显示文摘 | Koya Hida Suguru Hasegawa Yousuke Kinjo Kenichi Yoshimura Masafumi Inomata Masaaki Ito Yosuke Fukunaga Akiyoshi Kanazawa Hitoshi Idani Yoshiharu Sakai Masahiko Watanabe | 2012 | Annals of Surgery2012，，5： | 1 |
| 11 | Predictive value of serial assessment of endothelial function in chronic heart failure显示文摘 | Isao Takishima Takamitsu Nakamura Mitsumasa Hirano Yoshinobu Kitta Tsuyoshi Kobayashi Daisuke Fujioka Yukio Saito Kazuhiro Watanabe Yosuke Watanabe Hideto Mishina Jyun-ei Obata Ken-ichi Kawabata Shun Tamaru Kiyotaka Kugiyama | 2011 | International Journal of Cardiology2011，，3： | 1 |
| 12 | A comparison of the efficacy of combined ezetimibe and statin therapy with doubling of statin dose in patients with remnant lipoproteinemia on previous statin therapy显示文摘 | Takamitsu Nakamura Mitsumasa Hirano Yoshinobu Kitta Daisuke Fujioka Yukio Saito Ken-ichi Kawabata Jun-ei Obata Yosuke Watanabe Kazuhiro Watanabe Kiyotaka Kugiyama | 2012 | Journal of Cardiology2012，，1： | 1 |
| 13 | Short-term progression of maximum intima-media thickness of carotid plaque is associated with future coronary events in patients with coronary artery disease显示文摘 | Mitsumasa Hirano Takamitsu Nakamura Yoshinobu Kitta Isao Takishima Juntaro Deyama Tsuyoshi Kobayashi Daisuke Fujioka Yukio Saito Kazuhiro Watanabe Yosuke Watanabe Ken-ichi Kawabata Jyun-ei Obata Kiyotaka Kugiyama | 2011 | Atherosclerosis2011，，2： | 1 |
| 14 | Mice lac- king the glutamate - cysteine ligase modifier subunit are susceptible t9 myocardial ischaemia - reperfusion injury显示文摘 | Tsuyoshi Kobayashi Yosuke Watanabe Yukio Salto | 2010 | Cardiovasc Res2010，85，： | 1 |
| 15 | Angle of covered self-expandable metallic stents after placement is a risk factor for recurrent biliary obstruction显示文摘BACKGROUND Studies have shown that covered self-expandable metallic stents(CSEMS)with a low axial forces after placement can cause early recurrent biliary obstruction(RBO)due to precipitating sludge formation.AIM To ascertain whether the angle of CSEMS after placement is a risk factor for RBO in unresectable distal malignant biliary obstruction(MBO).METHODS Between January 2010 and March 2019,261 consecutive patients underwent selfexpandable metallic stent insertion by endoscopic retrograde cholangiopancreatography at our facility,and 87 patients were included in this study.We evaluated the risk factors for RBO,including the angle of CSEMS after placement as the primary outcome.We measured the obtuse angle of CSEMS after placement on an abdominal radiograph using the SYNAPSE PACS system.We also evaluated technical and functional success,adverse events,time to RBO(TRBO),non-RBO rate,survival time,cause of RBO,and reintervention procedure as secondary outcomes.RESULTS We divided the patients into two cohorts based on the presence or absence of RBO.The angle of CSEMS after placement(per 1°and per 10°)was evaluated using the multivariate Cox proportional hazard analysis,which was an independent risk factor for RBO in unresectable distal MBO[hazard ratio,0.97 and 0.71;95%confidence interval(CI):0.94-0.99 and 0.54-0.92;P=0.01 and 0.01,respectively].For early diagnosis of RBO,the cut-off value of the angle of CSEMS after placement using the receiver operating characteristic curve was 130°[sensitivity,50.0%;specificity 85.5%;area under the curve 0.70(95%CI:0.57-0.84)].TRBO in the<130°angle group was significantly shorter than that in the≥130°angle group(P<0.01).CONCLUSION This study suggests that the angle of the CSEMS after placement for unresectable distal MBO is a risk factor for RBO.These novel results provide pertinent information for future stent management. | Kojiro Tanoue Hirotsugu Maruyama Yuki Ishikawa-Kakiya Yosuke Kinoshita Kappei Hayashi Masafumi Yamamura Masaki Ominami Yuji Nadatani Shusei Fukunaga Koji Otani Shuhei Hosomi Fumio Tanaka Noriko Kamata Yasuaki Nagami Koichi Taira Toshio Watanabe Yasuhiro Fujiwara | 2022 | World Journal of Hepatology2022，14，5： | 0 |
| 16 | Assessment of gastroesophageal reflux disease by serodiagnosis of Helicobacter pylori-related chronic gastritis stage显示文摘AIM:To evaluate the association of Helicobacter pylori(H.pylori)-related chronic gastritis stage with upper gastro-intestinal symptoms and gastro-eso-phageal reflux disease(GERD).METHODS:Subjects underwent upper gastrointestinal endoscopy,a questionnaire using a frequency scale for symptoms of GERD(FSSG),and measurements of serum H.pylori-antibody and pepsinogen(PG)levels.They were classified into the following 4 groups in terms of H.pylori-related chronic gastritis stage:Group A(n = 219),H.pylori(-)PG(-);Group B(n = 310),H.pylori(+)PG(-);Group C(n = 279),H.pylori(+)PG(+);and Group D(n = 17),H.pylori(-)PG(+).RESULTS:Reflux esophagitis occurred in 30.6% of Group A,14.5% of Group B,6.8% of Group C,and 0% of Group D(P < 0.001).Scores for acid reflux sympto-ms decreased significantly with chro-nic gastritis stage(from Group A to D)(P < 0.05),while scores for dysmotility symptoms did no-t differ significantly.The prevalence of nonerosive reflux disease(NERD)did not differ amo-ng groups.However,in subjects with GERD,the prevalence of NERD tended to increase with chronic gastritis stage(P = 0.081).CONCLUSION:Acid reflux sympto-ms and the prevalen-ce of reflux esophagitis can be assessed by measuring both serum H.pylori-antibody and PG levels. | Shotaro Enomoto Masashi Oka Hiroshi Ohata Chizu Mukoubayashi Mika Watanabe Kosaku Moribata Yosuke Muraki Naoki Shingaki Hisanobu Deguchi Kazuki Ueda Izumi Inoue Takao Maekita Mikitaka Iguchi Kimihiko Yanaoka Hideyuki Tamai Mitsuhiro Fujishiro Osamu Mohara Masao Ichinose | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，4： | 0 |
| 17 | Multistage Stack with Multiple Pore Radii Applying the Temperature Gradient to a Thermoacoustic Engine显示文摘 | Kohei Yanagimoto Shin-ichi Sakamoto Yosuke Nakano Kentaro Kuroda Yoshiaki Watanabe | 2013 | Journal of Energy and Power Engineering2013，7，8： | 0 |
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