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| 1 | Monte Carlo simulation based on Geant4 of single event upset induced by heavy ions显示文摘The present work is a computational simulation of single event upset(SEU) induced by heavy ions passing through the device with Geant4-tool based on Monte Carlo transport code.Key parameters affecting SEU occurrence are examined,and related geometrical construction and critical charge are quantified.The MUlti-Functional Package for SEU Analysis(MUFPSA) has been successfully programmed and applied for SEU occurrence after the completion of device geometrical construction,critical charge,and SEU cross section calculation.The proposed MUFPSA has yielded a good agreement with MRED.Specifically,the results show that higher LET incident ions lead to increased SEU vulnerability due to more diffusion and higher energy deposition.In addition,the analytical method of radial ionization profile provides a good complementary interpretation. | GENG Chao LIU Jie ZHANG ZhanGang HOU MingDong SUN YouMei XI Kai GU Song DUAN JingLai YAO HuiJun MO Dan LUO Jie | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，6： | 6 |
| 2 | Automatic analytical approach for the determination of 12 illicit drugs and nicotine metabolites in wastewater using on-line SPE-UHPLC-MS/MS显示文摘In this study,we developed a novel on-line solid phase extraction(SPE)-ultra-high-performance liquid chromatography tandem mass spectrometry(UHPLC-MS/MS)-based analytical method for simultaneously quantifying 12 illicit drugs and metabolites(methamphetamine,amphetamine,morphine,codeine,6-monoacetylmorphine,benzoylecgonine,3,4-methylenedioxymethamphetamine,3,4-methylenedioxyamphetamine,cocaine,ketamine,norketamine,and methcathinone)and cotinine(COT)in wastewater samples.The analysis was performed by loading 2 m L of the sample onto an Oasis hydrophilic-lipophilic balance cartridge and using a cleanup step(5%methanol)to eliminate interference with a total run time of 13 min.The isotope-labeled internal standard method was used to quantify the target substances and correct for unavoidable losses and matrix effects during the on-line SPE process.Typical analytical characteristics used for method validation were sensitivity,linearity,precision,repeatability,recovery,and matrix effects.The limit of detection(LOD)and limit of quantification(LOQ)of each target were set at 0.20 ng/L and 0.50 ng/L,respectively.The linearity was between 0.5 ng/L and250 ng/L,except for that of COT.The intra-and inter-day precisions were<10.45%and 25.64%,respectively,and the relative recovery ranged from 83.74%to 162.26%.The method was used to analyze various wastewater samples from 33 cities in China,and the results were compared with the experimental results of identical samples analyzed using off-line SPE.The difference rate was between 19.91%and-20.44%,and the error range could be considered acceptable.These findings showed that on-line SPE is a suitable alternative to off-line SPE for the analysis of illicit drugs in samples. | Jingyuan Wang Likai Qia Chenzhi Hou Tingting Zhang Mengyi Chen Haitao Meng Mengxiang Su Hui Xu Zhendong Hua Youmei Wang Bin Di | 2021 | Journal of Pharmaceutical Analysis2021，11，6： | 5 |
| 3 | LEARN HOW TO LEARN-COMPARATIVE RESEARCH ON LEARNING STYLE PREFERENCES显示文摘This paper discusses the necessity and feasibility of adaptingteaching styles to accommodate diverse styles in the process oflearning English as a foreign language. It also looks atdifferences in learning style between Chinese students andstudents of other linguistic and cultural backgrounds. | Gao Youmei | 2001 | Chinese Journal of Applied Linguistics2001，24，4： | 5 |
| 4 | Key technologies for the construction of the Xiluodu high arch dam on the Jinsha River in the development of hydropower in western China显示文摘Hydropower development in China is concentrated in the country's western regions.Among all the rivers in China,the lower course of the Jinsha River contains the richest hydro-energy resource,and therefore,4 mammoth hydropower plants are under construction on this particular section of the river at Wudongde,Baihetan,Xiluodu,and Xiangjiaba.The water-blocking structures of the hydropower facilities at Wudongde,Baihetan and Xiluodu are all arch dams of around 300 m high.In view of changes in the geological conditions at the foundation of the Xiluodu dam on the riverbed after excavation started,the designs of expanding foundation surface excavation and dovetailing the dam body and foundation rock on both upstream and downstream sides were introduced,allowing the arch dam and foundation to fit each other and improving the stress conditions of the dam body and foundation.By dividing the dam body into various concrete sections,the dynamic properties of concrete were adequately adjusted to the distribution of stress in the dam body.In addition,the use of the most optimal concrete material and mixture ratio allowed thermodynamics of concrete to satisfy the requirements of the strength,durability,temperature control and crack prevention of the concrete.Moreover,rigorous temperature control measures were introduced to prevent harmful cracking,thus enhancing the integrity of the arch dam.Furthermore,sophisticated construction machinery,scientific testing methods,and sound construction techniques were employed to ensure the uniformity and reliability of concrete placement.The 'Digital Dam' for the Xiluodu project,which is based on the theory of total life cycle,has supplied strong support for construction process control and decision-making. | Lu Youmei Fan Qixiang Zhou Shaowu Li Bingfeng Li Wenwei | 2012 | Engineering Sciences2012，10，2： | 3 |
| 5 | Protein-tyrosine phosphatase (PTP) wedge domain peptides:A novel approach for inhibition of PTP function and augmentation of protein-tyrosine kinase function显示文摘 | STEPHEN M MASS A | 2006 | J Biol Chem2006，281，16： | 1 |
| 6 | Bifunctional Catalysts for Conversion of Synthesis Gas to Dimethyl Ether显示文摘 | Qingjie Ge Youmei Huang and Fengyan Qiu Shuben Li | 1998 | Appl Catal1998，167，： | 1 |
| 7 | Effect of ZrO2 on the stability of Cu-ZnO-ZrO2/HZSM-5 catalyst for syngas to dimethyl ether显示文摘 | Qingjie Ge Youmei Huang Shuben Liu | 1998 | Chem Lett1998，3，2： | 1 |
| 8 | Bifunctional catalysts for conversion of synthesis gas to dimethyl ether显示文摘 | Qingjie Ge Youmei Huang Fengyan Qiu Shuben Li | 1998 | Appl Catal1998，167，： | 1 |
| 9 | Tramadol hydrochloride/montmorillonite composite : Preparation and controlled drug release显示文摘 | Youmei Chen Anning Zhou Bo Liu | 2010 | Appl Clay Sci2010，49，3： | 1 |
| 10 | Effect of additives in the salt bath on glassstrengthening显示文摘 | JIANG Youmei JIANG Linge | 1986 | J Non-Cryst Solids1986，80，： | 1 |
| 11 | A study of the suppression of the high-temperature helium embrittlement in an oxide-particle dispersion strengthened alloy显示文摘In this paper,an investigation on the micro-structure of an Fe-base oxide-dispersion-strengthened(ODS) alloy irradiated with high-energy 20Ne ions to different doses at a temperature around 0.5Tm(Tm is the melting point of the alloy) is presented.Investigation with the transmission electron microscopy found that the accelerated growth of voids at grain-boundaries,which is usually a concern in conven-tional Fe-base alloys under conditions of inert-gas implantation,was not observed in the ODS alloy irradiated even to the highest dose(12000 at.ppm Ne).The reason is ascribed to the enhanced recom-bination of point defects and strong trapping of Ne atoms at the interfaces of the nano-scale oxide par-ticles in grains.The study showed that ODS alloys have good resistance to the high-temperature in-ter-granular embrittlement due to inert-gas accumulation,exhibiting prominence of application in harsh situations of considerable helium production at elevated temperatures like in a fusion reactor. | ZHANG ChongHong JANG J. S. YANG YiTao SONG Yin SUN YouMei CHO H. D. JIN YunFan | 2008 | Chinese Science Bulletin2008，53，21： | 1 |
| 12 | Projection type neural network and its convergence analysis显示文摘为优化问题的神经网络有的设计类型为更少参数,低寻找空格尺寸和简单结构在另外的网络上有利。在这篇论文,由适当地构造 Lyapunov 精力功能,当被用来优化在一个关上的凸的集合上定义的连续地可辨的凸的功能时,我们证明了这个网络的全球集中。结果解决网络的广泛的适用性。几个数字例子被给验证网络的效率。 | Youmei LI Feilong CAO | 2006 | 控制理论与应用(英文版)2006，4，3： | 1 |
| 13 | Brain-targeting,acid-responsive antioxidant nanoparticles for stroke treatment and drug delivery显示文摘Stroke is the leading cause of death and disability.Currently,there is no effective pharmacological treatment for this disease,which can be partially attributed to the inability to efficiently deliver therapeutics to the brain.Here we report the development of natural compound-derived nanoparticles(NPs),which function both as a potent therapeutic agent for stroke treatment and as an efficient carrier for drug delivery to the ischemic brain.First,we screened a collection of natural nanomaterials and identified betulinic acid(BA)as one of the most potent antioxidants for stroke treatment.Next,we engineered BA NPs for preferential drug release in acidic ischemic tissue through chemically converting BA to betulinic amine(BAM)and for targeted drug delivery through surface conjugation of AMD3100,a CXCR4 antagonist.The resulting AMD3100-conjugated BAM NPs,or A-BAM NPs,were then assessed as a therapeutic agent for stroke treatment and as a carrier for delivery of NA1,a neuroprotective peptide.We show that intravenous administration of A-BAM NPs effectively improved recovery from stroke and its efficacy was further enhanced when NA1 was encapsulated.Due to their multifunctionality and significant efficacy,we anticipate that A-BAM NPs have the potential to be translated both as a therapeutic agent and as a drug carrier to improve the treatment of stroke. | Shenqi Zhang Bin Peng Zeming Chen Jiang Yu Gang Deng Youmei Bao Chao Ma Fengyi Du Wendy C.Sheu W.Taylor Kimberly J.Marc Simard Daniel Coman Qianxue Chen Fahmeed Hyder Jiangbing Zhou Kevin N.Sheth | 2022 | Bioactive Materials2022，7，10： | 1 |
| 14 | Correlation Between the Structure Modification and Conductivity of 3 MeV Si Ion-irradiated Polyimide 显示文摘 | SUN Youmei ZHU Zhiyong LI Changlin | 2002 | Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms2002，191，14： | 1 |
| 15 | Design of a novel chimeric peptide via dual blockade of CD47/SIRPαand PD-1/PD-L1 for cancer immunotherapy显示文摘Although immune checkpoint inhibition has been shown to effectively activate antitumor immunity in various tumor types,only a small subset of patients can benefit from PD-1/PD-L1 blockade.CD47 expressed on tumor cells protects them from phagocytosis through interaction with SIRPαon macrophages,while PD-L1 dampens T cell-mediated tumor killing.Therefore,dual targeting PD-L1 and CD47 may improve the efficacy of cancer immunotherapy.A chimeric peptide Pal-DMPOP was designed by conjugating the double mutation of CD47/SIRPαblocking peptide(DMP)with the truncation of PD-1/PD-L1 blocking peptide OPBP-1(8-12)and was modified by a palmitic acid tail.Pal-DMPOP can significantly enhance macrophage-mediated phagocytosis of tumor cells and activate primary T cells to secret IFN-γin vitro.Due to its superior hydrolysis-resistant activity as well as tumor tissue and lymph node targeting properties,Pal-DMPOP elicited stronger anti-tumor potency than Pal-DMP or OPBP-1(8-12)in immune-competent MC38 tumor-bearing mice.The in vivo anti-tumor activity was further validated in the colorectal CT26 tumor model.Furthermore,Pal-DMPOP mobilized macrophage and T-cell anti-tumor responses with minimal toxicity.Overall,the first bispecific CD47/SIRPαand PD-1/PD-L1 dual-blockade chimeric peptide was designed and exhibited synergistic anti-tumor efficacy via CD8^(+)T cell activation and macrophage-mediated immune response.The strategy could pave the way for designing effective therapeutic agents for cancer immunotherapy. | Zheng Hu Wanqiong Li Shaomeng Chen Danhong Chen Ran Xu Danlu Zheng Xin Yang Shuzhen Li Xiuman Zhou Xiaoshuang Niu Youmei Xiao Zhuoying He Huihao Li Juan Liu Xinghua Sui Yanfeng Gao | 2023 | Science China(Life Sciences)2023，66，10： | 1 |
| 16 | A new catalyst for direct synthesis of dimethyl ether from synthesis gas显示文摘 | Qingjie Ge Youmei Huang Fengyan Qiu | 1998 | Reaction Kinetics and Catalysis Letters1998，，1： | 1 |
| 17 | OPTIMUM DESIGN OF HIGH-SPEED RAILWAY LOCOMOTIVE TRACTION GEAR显示文摘OPTIMUMDESIGNOFHIGH-SPEEDRAILWAYLOCOMOTIVETRACTIONGEARLiLixing;WangXiuqi;HeWeidong;ZhaoWenzhong;QianYuanmei(DalianRailwayInst... | Li Lixing Wang Xiuqi He Weidong Zhao Wenzhong Qian Yuanmei (Dalian Railway Institute) Liu Youmei Gui Linfang Xiao Peng Pan Xiaoming Xu Zongxiang (Zhuzhou Electric Locomotive Works ) | 1996 | Chinese Journal of Mechanical Engineering1996，9，4： | 1 |
| 18 | 显示文摘 | Huang Youmei Qiu Fengyan | 1998 | Appl Catal A1998，167，： | 1 |
| 19 | Geographic Information and Node Selfish-Based Routing Algorithm for Delay Tolerant Networks显示文摘In Delay Tolerant Networks(DTNs), some routing algorithms ignore that most nodes are selfish, i.e.,nodes are willing to use their own resources to forward messages to nodes with whom they have a relationship. In view of this phenomenon, we propose a routing algorithm based on Geographic Information and Node Selfishness(GINS). To choose a forwarding node, GINS combines nodes' willingness to forward and their geographic information to maximize the possibility of contacting the destination. GINS formulates the message forwarding process as a 0-1 Knapsack Problem with Assignment Restrictions to satisfy node demands for selfishness.Extensive simulations were conducted, and results show that GINS can achieve a high delivery ratio and a lower hop count compared with GRONE and LPHU. Furthermore, its overhead ratio is 25% and 30% less than that of GRONE and LPHU, respectively. | Fang Lu Jianbo Li Shan Jiang Youmei Song Fushu Wang | 2017 | Tsinghua Science and Technology2017，22，3： | 1 |
| 20 | Synthesis of hyperbranched polymers via a facile self-condensing vinyl polymerization system glycidyl methacrylate/Cp2TiClz/Zn 显示文摘 | Liua Xiaohui Youmei Baoa Tang Xinlan | 2010 | Polymer2010，，51： | 1 |
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