|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 2 | Meta-analysis of cognitive function in Chinese first-episode schizophrenia: MATRICS Consensus Cognitive Battery (MCCB) profile of impairment显示文摘Background Compromised neurocognition is a core feature of schizophrenia. With increasing studies researching cognitive function of Chinese patients with first-episode schizophrenia (FES) using MATRICS Consensus Cognitive Battery (MCCB), it is not clear about the level and pattern of cognitive impairment among this population. Aim To provide a meta-analysis systematically analysing studies of neurocognitive function using MCCB in Chinese patients with FES. Methods An independent literature search of both Chinese and English databases up to 13 March 2019 was conducted by two reviewers. Standardised mean difference (SMD) was calculated using the random effects model to evaluate the effect size. Results 56 studies (FES=3167, healthy controls (HC)=3017) were included and analysed. No study was rated as 'high quality' according to Strengthening the Reporting of Observational Studies in Epidemiology. Compared with HCs, Chinese patients with FES showed impairment with large effect size in overall cognition (SMD=-1.60,95% Cl -1.82 to -1.38,厂=67%) and all seven cognitive domains, with the SMD ranging from -0.87 to -1.41. In nine MCCB subtests, patients with FES showed significant difference in Symbol Coding (SMD=-1.90), Trail Making Test (TMT)(SMD=-1.36), Continuous Performance Test-Identical Pairs (SMD=-1.33), Hopkins Verbal Learning Test (SMD=-1.24), Brief Visuospatial Memory Test (SMD=-1.18), Mazes (SMD=-1.16), Category Fluency (SMD=-1.01), Spatial Span (SMD=-0.69) and Mayer-Salovey-Caruso Emotional Intelligence Test (SMD=-0.38). Conclusions Our meta-analysis demonstrates that Chinese patients with FES show neurocognitive deficits across all seven MCCB cognitive domains and all nine subtests, particularly in two neurocognitive domains: speed of processing and attention/vigilance, with the least impairment shown in social cognition. Symbol Coding and TMT may be the most sensitive tests to detect cognitive deficit in Chinese patients with FES. | Huijuan Zhang Yao Wang Yuliang Hu Yikang Zhu Tian hong Zhang Jijun Wang Ke Ma Chuan Shi Xin Yu Chunbo Li | 2019 | General Psychiatry2019，32，3： | 13 |
| 3 | Microstructure,texture evolution and mechanical properties of cold rolled Ti-32.5Nb-6.8Zr-2.7Sn biomedical beta titanium alloy显示文摘Ti-32.5 Nb-6.8 Zr-2.7 Sn(TNZS,wt%) alloy was produced by using vacuum arc melting method,followed by solution treatment and cold rolling with the area reductions of 50% and 90%.The effects of cold rolling on the microstructure,texture evolution and mechanical properties of the experimental alloy were investigated by optical microscopy,X-ray diffraction,transmission electron microscopy and universal material testing machine.The results showed that the grains of the alloy were elongated along rolling direction and stress-induced α'' martensite was not detected in the deformed samples.The plastic deformation mechanisms of the alloy were related to {112} 111 type deformation twinning and dislocation slipping.Meanwhile,the transition from γ-fiber texture to α-fiber texture took place during cold rolling and a dominant {001} 110_(α-fiber) texture was obtained after 90% cold deformation.With the increase of cold deformation degree,the strength increased owing to the increase of microstrain,dislocation density and grain refinement,and the elastic modulus decreased owing to the increase of dislocation density as well as an enhanced intensity of {001} 110_(α-fiber)texture and a weakened intensity of {111} 112_(γ-fiber)texture.The 90% cold rolled alloy exhibited a great potential to become a new candidate for biomedical applications,since it possesses low elastic modulus(47.1 GPa),moderate strength(883 MPa) and high elastic admissible strain(1.87%),which are superior than those of Ti-6 Al-4 V alloy. | Chunbo Lan Yu Wu Lili Guo Huijuan Chen Feng Chen | 2018 | Journal of Materials Science & Technology2018，34，5： | 10 |
| 4 | 3-epi-bufotalin suppresses the proliferation in colorectal cancer cells through the inhibition of the JAK1/STAT3 signaling pathway显示文摘Traditional Chinese medicine(TCM)has been increasingly employed in the last decades in China for both preventing and treating a variety of cancers.3-epi-bufotalin is an active ingredient of TCM“Chanpi”with anti-tumor potential.However,the effect and mechanism of 3-epi-bufotalin on colorectal cancers were not well disclosed.The present study demonstrated that 3-epi-bufotalin could reduce viability,trigger apoptosis,and block the cell cycle at the G2/M stage in colorectal cancer cell lines HT29,RKO,and COLO205 in vitro.Moreover,3-epi-bufotalin inhibited the JAK1/STAT3 signaling pathway.These results indicated the anti-proliferation ability of 3-epi-bufotalin in colorectal cancer cells. | SANHUA LI QINGHONG KONG XIAOKE ZHANG XINTING ZHU CHUNBO YU CHANGYAN YU NIAN JIANG JING HUI LINGJIE MENG YUN LIU | 2022 | BIOCELL2022，46，11： | 2 |
| 5 | Taking the pulse of COVID-19:a spatiotemporal perspective显示文摘The sudden outbreak of the Coronavirus disease(COVID-19)swept across the world in early 2020,triggering the lockdowns of several billion people across many countries,including China,Spain,India,the U.K.,Italy,France,Germany,Brazil,Russia,and the U.S.The transmission of the virus accelerated rapidly with the most confirmed cases in the U.S.,India,Russia,and Brazil.In response to this national and global emergency,the NSF Spatiotemporal Innovation Center brought together a taskforce of international researchers and assembled implementation strategies to rapidly respond to this crisis,for supporting research,saving lives,and protecting the health of global citizens.This perspective paper presents our collective view on the global health emergency and our effort in collecting,analyzing,and sharing relevant data on global policy and government responses,human mobility,environmental impact,socioeconomical impact;in developing research capabilities and mitigation measures with global scientists,promoting collaborative research on outbreak dynamics,and reflecting on the dynamic responses from human societies. | Chaowei Yang Dexuan Sha Qian Liu Yun Li Hai Lan Weihe Wendy Guan Tao Hu Zhenlong Li Zhiran Zhang John Hoot Thompson Zifu Wang David Wong Shiyang Ruan Manzhu Yu Douglas Richardson Luyao Zhang Ruizhi Hou You Zhoua Cheng Zhong Yifei Tian Fayez Beaini Kyla Carte Colin Flynn Wei Liu Dieter Pfoser Shuming Bao Mei Li Haoyuan Zhang Chunbo Liu Jie Jiang Shihong Du Liang Zhao Mingyue Lu Lin Li Huan Zhou Andrew Ding | 2020 | International Journal of Digital Earth2020，13，10： | 2 |
| 6 | Arsenic Trioxide Increases the Sensitivity of 786–0 Renal Carcinoma Cells to Radiotherapy显示文摘 | Yu Su XiaoMin Wang WanHai Xu Li Xue ChunBo He DeJun Yang RuiHua An | 2012 | Cancer Investigation2012，，2： | 1 |
| 7 | 显示文摘 | Liu Chunbo Yu Liansheng Jiang Xianliang | 2007 | Transactions of Nonferrous Metals Society of China2007，17，5： | 1 |
| 8 | Particle growth mechanism of nanocrystalline zirconia powder during high temperature heat treatment 显示文摘 | LILT Chunbo YU Liansheng JIANG Xianliang | 2007 | Trans Nonferrous Met Soc China2007，17，： | 1 |
| 9 | Stability and bifurcation analysis in a basic model of the immune response with delays显示文摘 | Chunbo Yu Junjie Wei | 2008 | Chaos Solitons and Fractals2008，，3： | 1 |
| 10 | Visible light photocatalytic activity of BiVO 4 particles with different morphologies显示文摘 | Xue Lin Lili Yu Lina Yan Hongji Li Yongsheng Yan Chunbo Liu Hongju Zhai | 2014 | Solid State Sciences2014，，： | 1 |
| 11 | NANLUOGUXIANG:A WELL-KNOWN HUTONG IN BEIJING显示文摘Nanluoguxiang used to be an ordinary hutong(traditional Beijing alley)in the capital city.Today,however,the alley has become one of the top 25 must-visit destinations in all of Asia. | Yu Chunbo Brad Green | 2021 | Beijing2021，，28： | 0 |
| 12 | A genetically engineered Escherichia coli that senses and degrades tetracycline antibiotic residue显示文摘Due to the abuse of antibiotics,antibiotic residues can be detected in both natural environment and various industrial products,posing threat to the environment and human health.Here we describe the design and implementation of an engineered Escherichia coli capable of degrading tetracycline(Tc)-one of the commonly used antibiotics once on humans and now on poultry,cattle and fisheries.A Tcdegrading enzyme,TetX,from the obligate anaerobe Bacteroides fragilis was cloned and recombinantly expressed in E.coli and fully characterized,including its Km and kcat value.We quantitatively evaluated its activity both in vitro and in vivo by UVeVis spectrometer and LC-MS.Moreover,we used a tetracycline inducible amplification circuit including T7 RNA polymerase and its specific promoter PT7 to enhance the expression level of TetX,and studied the dose-response of TetX under different inducer concentrations.Since the deployment of genetically modified organisms(GMOs)outside laboratory brings about safety concerns,it is necessary to explore the possibility of integrating a kill-switch.Toxin-Antitoxin(TA)systems were used to construct a mutually dependent host-plasmid platform and biocontainment systems in various academic and industrious situations.We selected nine TA systems from various bacteria strains and measured the toxicity of toxins(T)and the detoxifying activity of cognate antitoxins(A)to validate their potential to be used to build a kill-switch.These results prove the possibility of using engineered microorganisms to tackle antibiotic residues in environment efficiently and safely. | Zepeng Mu Zhuoning Zou Ye Yang Wenbo Wang Yue Xu Jianyi Huang Ruiling Cai Ye Liu Yajin Mo Boyi Wang Yiqun Dang Yongming Li Yushan Liu Yueren Jiang Qingyang Tan Xiaohong Liu Cheng Hu Hua Li Sha Wei Chunbo Lou Yang Yu Jiangyun Wang | 2018 | Synthetic and Systems Biotechnology2018，3，3： | 0 |
| 13 | THE CULTURAL REBIRTH显示文摘The activation and utilisation of cultural elics is a hot topic today.Recently,Xicheng District approved an activation and utilisation project involving the first six cultural monuments:Shexian County Guild Hall,Jinjiang.Guild Hall,Peking Opera Guild Hall,Old Xidan Hotel,Old Jushunhe Warehouse Store of Goods from Southern China and New Urban Tai'anli. | Yu Chunbo Jin Jianhui | 2021 | Beijing2021，，23： | 0 |
| 14 | THE 25TH ARMY DURING THE LONG MARCH显示文摘On November 16,1934,a document titled Declaration of the Chinese Workers'and Peasants'Red Army on Marching North to Resist Japanese Aggression was circulated in the Dabie Mountain area.The document read that Japanese aggressors had occupied Northeast China for several years,and that they had even invaded North China and Inner Mongolia.It continued on to say that although the Chinese Workers'and Peasants'Red Army was countering the Fifth Encirclement by the Kuomintang government,the army could not allow the Kuomintang to sell China to Japanese aggressors. | Yu Chunbo Brad Green | 2021 | Beijing2021，，42： | 0 |
| 15 | LTULICHANG CUETURAL STREET:A SACRED PLACE FOR TRADITIONAL CHINESE CULTURE显示文摘To the southeast ofTian'anmen Gate,Liulichang Cultural Street stretches a length of roughly 1,500 metres(m),and is one of the most famous cultural streets in China.However,despite its popularity,few people actually know the origins of the street's name. | Yu Chunbo Brad Green Ma Ke | 2021 | Beijing2021，，42： | 0 |
| 16 | XIANYUKOU: TIME-HONOURED COMMERCIAL STREET显示文摘Oposite Beijing's famous Dashilar Street is a hutong(alley)of a similar width and size.Known as Xianyukou,the hutong does not have Dashilar's outstanding reputation,but those familiar with the Qianmen area knowthat Xianyukou is not inferiorin market position.In fact,Xianyukou was once more prosperous than Dashilar.An old saying goes that Xianyukou established itself before Dashilar. | Yu Chunbo Ma Ke | 2021 | Beijing2021，，24： | 0 |
| 17 | OLD BANKNOTES AND COINS PORTRAY HISTORICAL CHANGES显示文摘0n August 18,an exhibition co-sponsored by the Bejing Numismatic Society and the Bejing Central Axis Protection Centre(at the site of the former Bejing Ancient Numismatic Museum)opened in the exhibition hall on the fourth floor of the Embrasured Watchtower of Desheng Gate.The theme of the exhibition is'Witness:Exhibition of Banknotes and Coins in Celebration of the Centenary of the Communist Party of China' | Yu Chunbo(Translated) Brad Green | 2021 | Beijing2021，，36： | 0 |
| 18 | Hongfo Pagoda in Ningxia:Treasure Trove of Artefacts from the Xixia Kingdom显示文摘An ancient,weather-beaten pagoda in Wangchengpu village in Helan County,Ningxia Hui Autonomous Region,was referred to by locals as Wangcheng Pagoda.However,afterresearch by scholars,it has been identified as Hongfo Pagoda,built during the late period of theXixia Kingdom(Western Xia,1038-1227).Its special shape is unique and rarely seen in other locations throughout the country. | Yu Chunbo(Translated) Brad Green | 2021 | Beijing2021，，36： | 0 |
| 19 | A ribosomal gene panel predicting a novel synthetic lethality in non-BRCAness tumors显示文摘Poly(ADP-ribose)polymerase(PARP)inhibitors are one of the most exciting classes of targeted therapy agents for cancers with homologous recombination(HR)deficiency.However,many patients without apparent HR defects also respond well to PARP inhibitors/cisplatin.The biomarker responsible for this mechanism remains unclear.Here,we identified a set of ribosomal genes that predict response to PARP inhibitors/cisplatin in HR-proficient patients.PARP inhibitor/cisplatin selectively eliminates cells with high expression of the eight genes in the identified panel via DNA damage(ATM)signaling-induced pro-apoptotic ribosomal stress,which along with ATM signaling-induced pro-survival HR repair constitutes a new model to balance the cell fate in response to DNA damage.Therefore,the combined examination of the gene panel along with HR status would allow for more precise predictions of clinical response to PARP inhibitor/cisplatin.The gene panel as an independent biomarker was validated by multiple published clinical datasets,as well as by an ovarian cancer organoids library we established.More importantly,its predictive value was further verified in a cohort of PARP inhibitor-treated ovarian cancer patients with both RNA-seq and WGS data.Furthermore,we identified several marketed drugs capable of upregulating the expression of the genes in the panel without causing HR deficiency in PARP inhibitor/cisplatin-resistant cell lines.These drugs enhance PARP inhibitor/cisplatin sensitivity in both intrinsically resistant organoids and cell lines with acquired resistance.Together,our study identifies a marker gene panel for HR-proficient patients and reveals a broader application of PARP inhibitor/cisplatin in cancer therapy. | Chao Zhang Qiang Guo Lifeng Chen Zheming Wu Xiao-Jian Yan Chengyang Zou Qiuxue Zhang Jiahong Tan Tian Fang Qunxian Rao Yang Li Shizhen Shen Min Deng Liewei Wang Huanyao Gao Jia Yu Hu Li Cheng Zhang Somaira Nowsheen Jake Kloeber Fei Zhao Ping Yin Chunbo Teng Zhongqiu Lin Kun Song Shuzhong Yao Liangqing Yao Lingying Wu Yong Zhang Xiaodong Cheng Qinglei Gao Jian Yuan Zhenkun Lou Jin-San Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 20 | GUIJIE:A BUSY LATE-NIGHT FOOD STREET显示文摘Gujie Street's name is written as'簋街'in Chinese characters.Many people unfamiliar with Beijing can likely not read out the character'簋'or write it after hearing its pronunciation.Even thosewho can correctly read and write the character likely do not understand the meaning of thename ofthestreet. | Yu Chunbo(Translated) Alistair Baker-Brian | 2021 | Beijing2021，，37： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员