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| 1 | An in vivo study with an MRI tracer method reveals the biophysical properties of interstitial fluid in the rat brain显示文摘The nature of brain interstitial fluid (ISF) has long been a subject of controversy. Most of the previous studies on brain ISF were carried out in vitro. In the present study, a novel method was developed to characterize ISF in the living rat brain by magnetic resonance (MR) imaging using gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) as a tracer. Sprague Dawley rats (n=8) were subjected to MR scanning before and after the introduction of Gd-DTPA into the caudate nucleus. A one-way drainage of brain ISF was demonstrated on the dynamic MR images. According to the traditional diffusion model, the diffusion and clearance rate constants of the tracer within brain extracellular space (ECS) were derived as (3.38±1.07)×10-4 mm 2 s-1 and (7.60±4.18)×10-5 s-1 . Both diffusion and bulk flow contributed to the drainage of ISF from the caudate nucleus, which demonstrated an ISF-cerebrospinal fluid confluence in the subarachnoid space at the lateral and ventral surface of the brain cortex at 3 h after the injection. By using this newly developed method, the brain ECS and ISF can be quantitatively measured simultaneously in the living brain, which will enhance the understanding of ISF and improve the efficiency of drug therapy via the brain interstitium. | HAN HongBin LI Kai YAN JunHao ZHU Kai FU Yu | 2012 | Science China(Life Sciences)2012，55，9： | 25 |
| 2 | Progress and prospect for high temperature single-phased magnetic ferroelectrics显示文摘Magnetic ferroelectrics are one of the most important functional materials. The present bottleneck lim- iting applications of them is lacking of high-temperature single-phased ferromagnetic-ferroelectric multiferroics with strong magnetoelectric coupling effect. Here, those progresses of the mechanism for coexistence of ferroelectric and magnetic order, experimental and theoretical studies on single-phased magnetic ferroelectrics, and the relationship between magnetic structure and crystal symmetry are summarized. With examples of BiFeO3, BiMnO3 and Bi2FeCrO6, the difficulties encountered in this field are analyzed. At last, some prospects to develop high-temperature single-phased ferromagnetic-ferro- electric multiferroics are also presented. | YU Jian CHU JunHao | 2008 | Chinese Science Bulletin2008，53，14： | 7 |
| 3 | Room temperature preparation of highly stable cesium lead halide perovskite nanocrystals by ligand modification for white lightemitting diodes显示文摘The poor stability of halide perovskite nanocrystals(NCs)has severely hindered future practical application.Herein,we proposed a facile and effective ligand modification route to synthesize stable CsPbBr_(3) nanocrystals by introducing a double-terminal ligand,namely 4,4'-Azobis(4-cyanovalericacid)(CA),to replace the conventional oleic acid(OA)ligand at room temperature.The as-synthesized CsPbBr_(3)-CA not only possesses high photoluminescence quantum yield(72%)related to the reduced trap defects,but also shows significantly improved stability exposure to water,ethanol,light,and/or heat benefiting from the CA ligand anchored to NC surfaces tightly.The photoluminescence intensity of CsPbBr_(3)-CA maintains about 80%and 75%of its initial emission intensity after immersed in water or ethanol for 360 min,respectively,whereas that of the CsPbBr_(3)-OA was quenched completely within a few minutes.Moreover,an all-inorganic white light-emitting diode(LED)covered 126%National Television System Committee(NTSC)standard and 92%Rec.2020 standard was fabricated by combining the green CsPbBr_(3)-CA and commercial red-emitting K2SiF6:Mn4+(KSF)phosphors onto a blue LED chip.Thus,the presented work initiates the development of the room temperature preparation of high quality CsPbBr_(3) and shows prospect for next-generation displays. | Yu Zhang Guishun Li Changkun She Shaohua Liu Fangyu Yue Chengbin Jing Ya Cheng Junhao Chu | 2021 | Nano Research2021，14，8： | 3 |
| 4 | The soybean Dof‐type transcription factor genes, GmDof4 and GmDof11, enhance lipid content in the seeds of transgenic Arabidopsis plants显示文摘 | Hui‐WenWang BoZhang Yu‐JunHao JianHuang Ai‐GuoTian YongLiao | 2007 | The Plant Journal2007，，4： | 2 |
| 5 | Wheat WRKY genes TaWRKY2 and TaWRKY19 regulate abiotic stress tolerance in transgenic Arabidopsis plants显示文摘 | CAN‐FANGNIU WEIWEI QI‐YUNZHOU AI‐GUOTIAN YU‐JUNHAO WAN‐KEZHANG BIAOMA QINGLIN ZHENG‐BINZHANG JIN‐SONGZHANG SHOU‐YICHEN | 2012 | Plant Cell & Environment2012，，6： | 1 |
| 6 | Serological AFP/Golgi protein 73 could be a new diagnostic parameter of hepatic diseases显示文摘 | Liyuan Tian Yu Wang Dabin Xu Junhao Gui Xingwang Jia Hongli Tong Xinyu Wen Zhennan Dong Yaping Tian | 2011 | Int J Cancer2011，，8： | 1 |
| 7 | Electrical Conduc- tivity of CaC12-KC1-NaC1 System at 1 080 K显示文摘 | Chen Zhiyuan Liu Junhao Yu Ziyou | 2012 | Thermochimica Acta2012，53，4： | 1 |
| 8 | Shen Qi Wan attenuates renal interstitial fibrosis through upregulating AQP1显示文摘Renal interstitial fibrosis(RIF)is the crucial pathway in chronic kidney disease(CKD)leading to the end-stage renal failure.However,the underlying mechanism of Shen Qi Wan(SQW)on RIF is not fully understood.In the current study,we investigated the role of Aquaporin 1(AQP1)in SQW on tubular epithelial-to-mesenchymal transition(EMT).A RIF mouse model induced by adenine and a TGF-β1-stimulated HK-2 cell model were etablished to explore the involvement of AQP 1 in the protective effect of SQW on EMT in vitro and in vivo.Subsequently,the molecular mechanism of SQW on EMT was explored in HK-2 cells with AQP1 knockdown.The results indicated that SQW alleviated kidney injury and renal collagen deposition in the kidneys of mice induced by adenine,increased the protein expression of E-cadherin and AQP1 expression,and decreased the expression of vimentin andα-smooth muscle actin(α-SMA).Similarly,treatmement with SQW-containing serum significantly halted EMT process in TGF-β1 stimulated HK-2 cells.The expression of snail and slug was significantly upregulated in HK-2 cells after knockdown of AQP1.AQP1 knockdown also increased the mRNA expression of vimentin andα-SMA,and decreased the expression of E-cadherin.The protein expression of vimentin increased,while the expression of E-cadherin and CK-18 significantly decreased after AQP1 knockdown in HK-2 cells.These results revealed that AQP1 knockdown promoted EMT.Furthermore,AQP1 knockdown abolished the protective effect of SQW-containing serum on EMT in HK-2 cells.In sum,SQW attentuates EMT process in RIF through upregulation of the expression of AQP1. | LIN Yiyou WEI Jiale ZHANG Yehui HUANG Junhao WANG Sichen LUO Qihan YU Hongxia JI Liting ZHOU Xiaojie LI Changyu | 2023 | Chinese Journal of Natural Medicines2023，21，5： | 1 |
| 9 | In vivo imaging of the neuronal response to spinal cord injury:a narrative review显示文摘Deciphering the neuronal response to injury in the spinal cord is essential for exploring treatment strategies for spinal cord injury(SCI).However,this subject has been neglected in part because appropriate tools are lacking.Emerging in vivo imaging and labeling methods offer great potential for observing dynamic neural processes in the central nervous system in conditions of health and disease.This review first discusses in vivo imaging of the mouse spinal cord with a focus on the latest imaging techniques,and then analyzes the dynamic biological response of spinal cord sensory and motor neurons to SCI.We then summarize and compare the techniques behind these studies and clarify the advantages of in vivo imaging compared with traditional neuroscience examinations.Finally,we identify the challenges and possible solutions for spinal cord neuron imaging. | Junhao Deng Chang Sun Ying Zheng Jianpeng Gao Xiang Cui Yu Wang Licheng Zhang Peifu Tang | 2024 | Neural Regeneration Research2024，19，4： | 0 |
| 10 | Understanding the Conformational Interconversions of a Polymer Chain in a Liquid Environment at the Single-molecule Level显示文摘The conformational interconversions of polymer chains have been of great interest as a basic scientific issue.Single-molecule force spectroscopy(SMFS)is a powerful tool for molecular manipulation,which enables experimental studies on the single-chain behaviors of polymers.The SMFS results show that an individual polymer chain in a liquid environment may have similar properties to an ideal chain,which contradicts the traditional theoretical view.Herein,by taking into account the collisions of solvent molecules,the conformational interconversions of a single polymer chain in a liquid environment have been analyzed.The conformational interconversion frequency of a carbon-carbon bond of an alkane chain can be estimated by establishing the relationship between the internal rotation barriers of small molecules(monomers)and the corresponding macromolecules.Since the time scale of conformational interconversions of the polymer backbone is much shorter than that of SMFS experiments,most polymers with C-C backbones behave as ideal chains in liquid environments. | SHAO Yue WEI Junhao BAO Yu CAI Wanhao QIAN Lu CUI Shuxun | 2023 | Chemical Research in Chinese Universities2023，39，5： | 0 |
| 11 | Clinical outcomes of sildenafil application in patients of poor endometrial development显示文摘Objective:To determine whether sildenafil has an efect on pregnancy outcomes in patients with poor endometrial development.Mathods:This study included 472 infertility patients who underwent in viro fer tilization/intracytoplasmadc spemm injection and frozen-thawed embryo tr ansfer(IVF/ICSI-FET)and subsequently sufered from poor endo-metral dewelopment during homnone replacement cycle(HRC)from April 2017 to July 2019.The patients were divided into two groups:the sildenafl group(n=88)and the control group(n=384).We analyzed endometrial thicknuess and types on endometrial transformation day,as well as pregnancy outcomes after FET(biochemical pregnancy,clinical pregnancy,early abortion,late abortion,and live birth rates)between the two groups.Results:After adjusting for confounding factors,we found no significant differences in endometrial thicknesses and types on endometrial transfomation day between the sildenafil group and the control group(0.79±0.08 vs 0.81±0.09,P=0.144;79.76%vs83.87%,P=0.402).There were also no statistcally significant differences in biochemical pregnancy rate(75.0%vs76.8%,P=0.892),clinical pregnancy rate(59.09%vs 69.53%,P=0.087),early abortion rate(17.31%vs 14.61%,P=0.557),late abortion rate(3.85%vs 4.49%,P=0.859),or live birth rate(45.45%vs 55.47%,P=0.101)between the two groups.In subgroup analysis,the application of sildenafil was unable to improve endometrial thickness(group one:0.80±0.08 cm vs 0.82±0.08 cm;group two:0.78±0.08 cm vs 0.80±0.10 cm;group three:0.75±0.11 cm vs 0.77±0.08 cm,p>0.05)and type endometrium on transfomation day(group one:78.57%vs 86.78%;group two:80.65%vs 77.78%;group three:81.82%ws.83.78%,p>0.05).Moreover,sildenafil use was not closely associated with clinical pregnancy outcomes,clinical pregnancy rate,early abortion rate,late abortion rate,and live birth rate(p>0.05).Conclusions:Sildenafl did not benefit endometrial development and pregnancy outcomes in patients with poor endometr:ial development during the hormone replacement cycle. | Meiling Guo Yuchen Yan Jianan Lv Hua Xin Wei Zhou Na Yu Mingdi Xia Jing Li Qian Zhang Junhao Yan | 2022 | Gynecology and Obstetrics Clinical Medicine2022，2，1： | 0 |
| 12 | Tracking gassing behavior in pouch cell by operando on-line electrochemical mass spectrometry显示文摘As the rapid development of more powerful and safer lithiumion batteries, the mechanism study of gases evolution is attacking more and more attention in recent years. Especially under overcharge/discharge and/or high-temperature working condition. | Haitang Zhang Jianken Chen Baodan Zhang Xiaohong Wu Zhengang Li Leiyu Chen Junhao Wang Xiaoyu Yu Haiyan Luo Jiyuan Xue Yu-Hao Hong Yu Qiao Shi-Gang Sun | 2023 | Journal of Energy Chemistry2023，，9： | 0 |
| 13 | Thermoelectric Properties of n-type Full-Heusler Fe_(2-2x)Co_(2x) TiSn Prepared by an Ultra-fast Synthesis Process显示文摘Full-Heusler alloy Fe_(2)TiSn was predicted to be a potential thermoelectric material with high mechanical properties and stability.Fe_(2)TiSn was usually prepared by arc-melting followed by annealing for 2 weeks,which takes a long time and consumes a large amount of energy.In this paper,Fe_(2)TiSn was prepared by an ultra-fast method,self-propagating high-temperature synthesis (SHS) combined with spark plasma sintering.The bulk materials with uniform element distribution,well controlled composition and relative densities of over 97.5% were prepared.The undoped Fe_(2)TiSn samples show p-type transport behavior.Co was heavily doped at the Fe site to prepare n-type Fe_(2-2x)Co_(2x) TiSn samples.The thermoelectric properties measurements carried out on the Co-doped samples show a highest ZT=0.02 at 300 K,which is about tripe the performance of the pristine Fe_(2)TiSn.This study provides a new approach for the rapid and low-cost preparation of full-Heusler thermoelectric materials. | 赵东艳 陈艳宁 WANG Yubo ZHANG Haifeng FU Zhen WANG Shuaipeng YU Wen DU Jian WANG Wenhe QIU Junhao 鄢永高 | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，4： | 0 |
| 14 | A Statistical Analysis on Recent Tidal Triggering of the Earthquake in the Tianshan Seismic Zone显示文摘A statistical analysis is done to study the spatio-temporal features of earthquake activity in the Tianshan seismic belt triggered by tide,based on Schusters test. The data we choose is the M L≥2. 0 earthquakes from January 1,2010 to August 31,2012 in eastern Tianshan,and the calculation is on tidal body stress. The results show that the p-value based on the time window smoothing of Schusters test corresponds better with the strong earthquakes in the Tianshan seismic belt,especially for a long time before the November 1,2011 Nilka M S6. 0 earthquake,when the p-value of the Schusters test was always lower than the threshold of 0. 05 for tidal trigger of earthquake,but after the Nilka M S6. 0 earthquake,that value was quickly restored to a high level,which reflects a close relationship between the Nilka M S6. 0 earthquake and the Earth tide. According to the p-value based on the spatial window smoothing of Schusters test,the Nilka M S6. 0 earthquake was at or near the tidal triggering area. Thus we can see from the spatio-temporal results that the Nilka M S6. 0 earthquake was obviously triggered by Earth tide. | Li Jin Jiang Haikun Qu Junhao Huang Yu Gao Chaojun | 2015 | Earthquake Research in China2015，29，2： | 0 |
| 15 | Lithium elemental and isotopic disequilibrium in minerals from peridotite xenoliths from Shangzhi, NE China: products of recent melt/fluid-peridotite interaction显示文摘Lithium elemental and isotopic disequilibrium has frequently been observed in the continental and oceanic mantle xenoliths, but its origin remains controversial. Here,we present a combined elemental and Li isotopic study on variably metasomatised peridotite xenoliths entrained in the Cenozoic basalts from Shangzhi in Northeast (NE) China that provides insight into this issue. Li concentration (0.3–2.7 ppm) and δ7 Li (mostly 2‰–6‰) in olivine from the Shangzhi peridotites are similar to the normal mantle values and show roughly negative correlations with the indices of melt extraction(such as modal olivine and whole rock MgO). These features are consistent with variable degrees of partial melting. In contrast, clinopyroxene from the Shangzhi xenoliths shows significant Li enrichment (0.9–6.1 ppm) and anomalously light δ7 Li (-13.8‰ to7.7‰) relative to normal mantle values. Such features can be explained by Li diffusion from silicate melts or Li-rich fluids occurring over a very short time(several minutes to several hours). Moreover, the light Li isotopic compositions preserved in some bulk samples also indicate that these percolated melts/fluids have not had enough time to isotopically equilibrate with the bulk peridotite. We thus emphasize that Li isotopic fractionation in the Shangzhi mantle xenoliths is mainly related to Li diffusion from silicate melts or Li-rich fluids that took place shortly before or coincident with their entrainment into the host magmas. | Shenghua Zhou Songyue Yu Ting Zhou Jiangbo Lan Jian Kang Liemeng Chen Junhao Hu | 2018 | Acta Geochimica2018，37，5： | 0 |
| 16 | Vision Enhanced Generative Pre-trained Language Model for Multimodal Sentence Summarization显示文摘Multimodal sentence summarization(MMSS)is a new yet challenging task that aims to generate a concise summary of a long sentence and its corresponding image.Although existing methods have gained promising success in MMSS,they overlook the powerful generation ability of generative pre-trained language models(GPLMs),which have shown to be effective in many text generation tasks.To fill this research gap,we propose to using GPLMs to promote the performance of MMSS.Notably,adopting GPLMs to solve MMSS inevitably faces two challenges:1)What fusion strategy should we use to inject visual information into GPLMs properly?2)How to keep the GPLM′s generation ability intact to the utmost extent when the visual feature is injected into the GPLM.To address these two challenges,we propose a vision enhanced generative pre-trained language model for MMSS,dubbed as Vision-GPLM.In Vision-GPLM,we obtain features of visual and textual modalities with two separate encoders and utilize a text decoder to produce a summary.In particular,we utilize multi-head attention to fuse the features extracted from visual and textual modalities to inject the visual feature into the GPLM.Meanwhile,we train Vision-GPLM in two stages:the vision-oriented pre-training stage and fine-tuning stage.In the vision-oriented pre-training stage,we particularly train the visual encoder by the masked language model task while the other components are frozen,aiming to obtain homogeneous representations of text and image.In the fine-tuning stage,we train all the components of Vision-GPLM by the MMSS task.Extensive experiments on a public MMSS dataset verify the superiority of our model over existing baselines. | Liqiang Jing Yiren Li Junhao Xu Yongcan Yu Pei Shen Xuemeng Song | 2023 | Machine Intelligence Research2023，20，2： | 0 |
| 17 | Improvement on Gamma Energy Resolution of Plastic Scintillator by Adding PMMA Light Guider or Chamfer显示文摘Traditional plastic scintillator has respectively low gamma energy resolution.Space radiation detection need the plastic scintillator to keep a relatively better energy resolution for gamma.Thus we did experiments to study how to get it enhanced by adding light guider and chamfer.A 9000 Bq radioactive source 60 Co has been utilized to make the experiment and results came that when keeping other conditions same,the height of poly methyl methacrylate(PMMA)light guider changes from 12 mm to 40 mm and the energy resolutions varied from 72.3%to63.5% respectively.Furthermore,another contrast experiment was made to decide whether plastic scintillator with light guiders or integrated chamfer can get better energy resolution.In conclusion the plastic scintillator with integrated chamfer got 55.0%.Through the study of adding light guider or chamfer to plastic scintillator,the gamma energy resolution has been improved greatly from 72.3%to 55.0%. | Wang Yi Wei Zhiyong Fang Meihua Guo Yipan Yu Junhao | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，S1： | 0 |
| 18 | Water Changes and Sources of Siling Co Using Landsat and GRACE Data since 1972显示文摘The inland lakes on the Tibetan Plateau(TP)are undergoing significant changes due to their sensitivity to climate.The largest lake in Tibet,Siling Co,has expanded most dramatically during recent decades.Using Landsat,GRACE and meteorological data,the expansion of Siling Co was detailed in four stages and the process was further explained.The results show that the lake area increased from 1647.30 km^(2)in 1972 to 2438.99 km^(2)in 2020.It experienced a slow growth at a rate 6.03 km^(2)/yr from 1972 to 1988,while fluctuating at 1.44 km^(2)/yr during 1989–1997,then accelerated at 60.28 km^(2)/yr between 1998 and 2005,and expanded slowly again at 11.40 km^(2)/yr since 2006.The continued expansion led to its merger with nearby Yagain Co in 2003.Terrestrial water storage(TWS)increase was also observed from GRACE(0.65 cm/yr),with about 0.75 coefficient of determination between the TWS and lake area during 2002–2020.The long-term expansion of Siling Co is related to the increasing trends of temperature and precipitation,but their contributions vary with time span.Specifically,the accelerated stage between 1998 and 2005 can be explained by the increased temperature and precipitation accompanied by a drop in evaporation,while the slow expansion since 2006 was due to the decrease in precipitation and temperature and the rise in evaporation.There is no obvious mass loss of glaciers revealed by GRACE during 2002–2020,which may be related to the negative trend of the temperature.Furthermore,the precipitation may still make a major contribution in this phase,as its average is about 93.9 mm higher than that in 1988–1997. | Chuya Wang Yuande Yang Fei Li Junhao Wang Leiyu Li Huiting Yu | 2024 | Journal of Earth Science2024，35，2： | 0 |
| 19 | Angiography findings and endovascular management of acute nonvariceal gastrointestinal bleeding:A pictorial essay显示文摘Patients with acute nonvariceal gastrointestinal bleeding(GIB)not treatable via endoscopic therapy require angiography and endovascular management.If the source of the bleeding can be identified on angiography,the bleeding can be controlled with minimal complications by endovascular treatments such as intra-arterial infusion of vasopressin,embolization,covered stent placement,or a combination thereof.This pictorial essay reviews the angiographic findings for and the endovascular management of acute nonvariceal GIB. | Haiyang Yu Junhao Mei Lihao Qin Zhongzhi Jia | 2022 | Journal of Interventional Medicine2022，5，1： | 0 |
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