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| 1 | Precise A. T to G-C Base Editing in the RiceGenome显示文摘 | Kai Hua Xiaoping Tao Fengtong Yuan Dong Wang Jian-Kang Zhu | 2018 | Molecular Plant2018，11，4： | 60 |
| 2 | Characteristics of hydrocarbon accumulation and exploration potential of the northern South China Sea deepwater basins显示文摘Although the huge potential of the northern South China Sea deepwater basins has been proven by a series of discoveries that followed the exploration breakthrough of well LW 3-1-1, recent drilling and other studies have demonstrated the uniqueness and complicated nature of hydrocarbon accumulations of the deepwater basins there. Based on a review of previous work and the latest exploration activities and studies, the purpose of this paper is to discuss the critical controls for hydrocarbon accumulations in the deepwater basins of the northern South China Sea. A terrestrial-marine transitional coal-bearing source rock is proposed to be the primary source rock for the deepwater basins. A marine source rock, which was first identified as contributing to hydro-carbon generation in this region, probably plays a significant role in the deep-and ultra-deep water basins south to the Pearl River Mouth and Qingdongnan basins. The shelf margin delta depositional systems in the Baiyun Sag, sourced from the Pearl River, are currently primary exploration targets in the deepwater part of the Pearl River Mouth Basin, whereas the western Red River delta-ic-submarine fan depositional systems, initially proven by drilling, are the possible major exploration reservoirs in the Qing-dongnan deepwater areas. Current deepwater exploration targets at the large-sized structural traps and deep and ultra-deep areas in the south of the Pearl River Mouth and Qingdongnan basins will be the future exploration focus. Deepwater exploration activities and relevant fundamental studies, supporting and promoting each other, are of great importance to the national energy supply of China, the basic regional studies of the South China Sea, advancements in technology, and development of related deepwater industries, and will safeguard national sovereignty and territorial integrity. | ZHU WeiLin ZHONG Kai LI YouChuan XU Qiang FANG DianYong | 2012 | Chinese Science Bulletin2012，57，24： | 48 |
| 3 | Soil microbial biomass carbon and nitrogen in forest ecosystems of Northeast China:a comparison between natural secondary forest and larch plantation显示文摘Aims Natural secondary forest(NSF)and larch plantation are two of the predominant forest types in Northeast China.However,how the two types of forests compare in sustaining soil quality is not well understood.This study was conducted to determine how natural secondary forest and larch plantation would differ in soil microbial biomass and soil organic matter quality.Methods Microbial biomass carbon(MBC),microbial biomass nitrogen(MBN),soil organic carbon(SOC)and total nitrogen(TN)in the 0-to 15-cm and 15-to 30-cm soil layers were investigated by making chemical and biological measurements in the montane region of eastern Liaoning Province,Northeast China,during the growing season of 2008 in stands of NSF and Larix olgensis plantation(LOP).Important Findings We found that soil MBC and MBN were significantly lower in the LOP than in the NSF.Both MBC and MBN declined significantly with increasing soil depth in the two types of stands.The ratios of MBC to SOC(MBC/SOC)and MBN to TN(MBN/TN)were also significantly lower in the LOP than in the NSF.Moreover,the values of MBC,MBC/SOC,and MBN/TN significantly varied with time and followed a similar pattern during the growing season,all with an apparent peak in summer.Our results indicate that NSF is better in sustaining soil microbial biomass and nutrients than larch plantation in the temperate Northeast China.This calls for cautions in large-scale conversions of the native forests to coniferous plantations as a forest management practice on concerns of sustaining soil productivity. | Kai Yang Jiaojun Zhu Min Zhang Qiaoling Yan Osbert Jianxin Sun | 2010 | Journal of Plant Ecology2010，3，3： | 44 |
| 4 | Gene Targeting by Homology-Directed Repair in Rice Using a Geminivirus-Based CRISPR/Cas9 System显示文摘 | Mugui Wang Yuming Lu Jose Ramon Botella Yanfei Mao Kai Hua Jian-kang Zhu | 2017 | Molecular Plant2017，10，7： | 34 |
| 5 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 6 | An in vivo study with an MRI tracer method reveals the biophysical properties of interstitial fluid in the rat brain显示文摘The nature of brain interstitial fluid (ISF) has long been a subject of controversy. Most of the previous studies on brain ISF were carried out in vitro. In the present study, a novel method was developed to characterize ISF in the living rat brain by magnetic resonance (MR) imaging using gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) as a tracer. Sprague Dawley rats (n=8) were subjected to MR scanning before and after the introduction of Gd-DTPA into the caudate nucleus. A one-way drainage of brain ISF was demonstrated on the dynamic MR images. According to the traditional diffusion model, the diffusion and clearance rate constants of the tracer within brain extracellular space (ECS) were derived as (3.38±1.07)×10-4 mm 2 s-1 and (7.60±4.18)×10-5 s-1 . Both diffusion and bulk flow contributed to the drainage of ISF from the caudate nucleus, which demonstrated an ISF-cerebrospinal fluid confluence in the subarachnoid space at the lateral and ventral surface of the brain cortex at 3 h after the injection. By using this newly developed method, the brain ECS and ISF can be quantitatively measured simultaneously in the living brain, which will enhance the understanding of ISF and improve the efficiency of drug therapy via the brain interstitium. | HAN HongBin LI Kai YAN JunHao ZHU Kai FU Yu | 2012 | Science China(Life Sciences)2012，55，9： | 25 |
| 7 | Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a hospital.based,multicenter,cross-sectional survey显示文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective. | Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai | 2017 | Chinese Journal of Cancer2017，36，8： | 25 |
| 8 | Genome Engineering in Rice Using Cas9 Variants that Recognize NG PAM Sequences显示文摘CRISPR/Cas9 genome editing relies on sgRNA-target DNA base pairing and a short downstream PAM sequence to recognize target DNA. The strict protospacer adjacent motif (PAM) requirement hinders applications of the CRISPR/Cas9 system since it restricts the targetable sites in the genomes. xCas9 and SpCas9-NG are two recently engineered SpCas9 variants that can recognize more relaxed NG PAMs, implying a great potential in addressing the issue of PAM constraint. Here we use stable transgenic lines to evaluate the efficacies of xCas9 and SpCas9-NG in performing gene editing and base editing in rice. We found that xCas9 can efficiently induce mutations at target sites with NG and GAT PAM sequences in rice. However, base editors containing xCas9 failed to edit most of the tested target sites. SpCas9-NG exhibited a robust editing activity at sites with various NG PAMs without showing any preference for the third nucleotide after NG. Moreover, we showed that xCas9 and SpCas9-NG have higher specificity than SpCas9 at the CGG PAM site. We further demonstrated that different forms of cytosine or adenine base editors containing SpCas9-NG worked efficiently in rice with broadened PAM compatibility. Taken together, our work has yielded versatile genome-engineering tools that will significantly expand the target scope in rice and other crops. | Kai Hua Xiaoping Tao Peijin Han Rui Wang Jian-Kang Zhu | 2019 | Molecular Plant2019，12，7： | 22 |
| 9 | Global blue carbon accumulation in tidal wetlands increases with climate change显示文摘Coastal tidal wetlands produce and accumulate significant amounts of organic carbon(C)that help to mitigate climate change.However,previous data limitations have prevented a robust evaluation of the global rates and mechanisms driving C accumulation.Here,we go beyond recent soil C stock estimates to reveal global tidal wetland C accumulation and predict changes under relative sea level rise,temperature and precipitation.We use data from literature study sites and our new observations spanning wide latitudinal gradients and 20 countries.Globally,tidal wetlands accumulate 53.65(95%CI:48.52-59.01)Tg C yr^(-1),which is~30%of the organic C buried on the ocean floor.Modeling based on current climatic drivers and under projected emissions scenarios revealed a net increase in the global C accumulation by2100.This rapid increase is driven by sea level rise in tidal marshes,and higher temperature and precipitation in mangroves.Countries with large areas of coastal wetlands,like Indonesia and Mexico,are more susceptible to tidal wetland C losses under climate change,while regions such as Australia,Brazil,the USA and China will experience a significant C accumulation increase under all projected scenarios. | Faming Wang Christian J.Sanders Isaac R.Santos Jianwu Tang Mark Schuerch Matthew L.Kirwan Robert E.Kopp Kai Zhu Xiuzhen Li Jiacan Yuan Wenzhi Liu Zhian Li | 2021 | National Science Review2021，8，9： | 22 |
| 10 | Perspectives on the Application of Genome-Editing Technologies in Crop Breeding显示文摘Most conventional and modern crop-improvement methods exploit natural or artificially induced genetic variations and require laborious characterization of the progenies of multiple generations derived from time-consuming genetic crosses.Genome-editing systems,in contrast,provide the means to rapidly modify genomes in a precise and predictable way,making it possible to introduce improvements directly into elite varieties.Here,we describe the range of applications available to agricultural researchers using existing genome-editing tools.In addition to providing examples of genome-editing applications in crop breeding,we discuss the technical and social challenges faced by breeders using genome-editing tools for crop improvement. | Kai Hua Jinshan Zhang Jose Ramon Botella Changle Ma Fanjiang Kong Baohui Liu Jian-Kang Zhu | 2019 | Molecular Plant2019，12，8： | 19 |
| 11 | Immunogenicity noninferiority study of 2 doses and 3 doses of an Escherichia coli-produced HPV bivalent vaccine in girls vs.3 doses in young women显示文摘A new HPV-16/18 bivalent vaccine expressed by the Escherichia coli has been proven to be efficacious in adult women.A randomized,immunogenicity noninferiority study of this candidate vaccine was conducted in December 2015 in China.Girls aged 9–14 years were randomized to receive 2 doses at months 0 and 6(n=301)or 3 doses at months 0,1 and 6(n=304).Girls aged 15–17 years(n=149)and women aged 18–26 years(n=225)received 3 doses.The objectives included noninferiority analysis of the IgG geometric mean concentration(GMC)ratio(95%CI,lower bound>0.5)to HPV-16 and HPV-18 at month 7 in girls compared with women.In the per-protocol set,the GMC ratio of IgG was noninferior for girls aged 9–17 years receiving 3 doses compared with women(1.76(95%CI,1.56,1.99)for HPV-16 and 1.93(95%CI,1.69,2.21)for HPV-18)and noninferior for girls aged 9–14 years receiving 2 doses compared with women(1.45(95%CI,1.25,1.62)for HPV-16 and 1.17(95%CI,1.02,1.33)for HPV-18).Noninferiority was also demonstrated for neutralizing antibodies.The immunogenicity of the HPV vaccine in girls receiving 3 or 2 doses was noninferior compared with that in young adult women. | Yue-Mei Hu Meng Guo Chang-Gui Li Kai Chu Wen-Gang He Jing Zhang Jian-Xiang Gu Juan Li Hui Zhao Xiang-Hong Wu Bi-Zhen Lin Zhi-Jie Lin Xing-Mei Yao Ya-Fei Li Fei-Xue Wei Yue Huang Ying-Ying Su Feng-Cai Zhu Shou-Jie Huang Hui-Rong Pan Ting Wu Jun Zhang Ning-Shao Xia | 2020 | Science China(Life Sciences)2020，63，4： | 19 |
| 12 | Effect of lipid on proliferation and activation of rat hepatic stellate cells(Ⅰ)显示文摘INTRODUCTIONDespitetheearlycontroversyovertheprimarycelularsourceofextracelularmatrixproteinsinliverfibrosis,compelinginvitro... | LU Lun Gen, ZENG Min De, LI Ji Qiang, HUA Jing, FAN Jian Gao, FAN Zhu Ping and QIU De Kai | 1998 | World Journal of Gastroenterology1998，4，6： | 18 |
| 13 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 14 | Deep Reinforcement Learning Based Mobile Robot Navigation:A Review显示文摘Navigation is a fundamental problem of mobile robots,for which Deep Reinforcement Learning(DRL)has received significant attention because of its strong representation and experience learning abilities.There is a growing trend of applying DRL to mobile robot navigation.In this paper,we review DRL methods and DRL-based navigation frameworks.Then we systematically compare and analyze the relationship and differences between four typical application scenarios:local obstacle avoidance,indoor navigation,multi-robot navigation,and social navigation.Next,we describe the development of DRL-based navigation.Last,we discuss the challenges and some possible solutions regarding DRL-based navigation. | Kai Zhu Tao Zhang | 2021 | Tsinghua Science and Technology2021，26，5： | 15 |
| 15 | Cancer immune checkpoint blockade therapy and its associated autoimmune cardiotoxicity显示文摘有免疫力的检查点分子在进化被出现由激活的 T 房间保护主人免受自我攻击的伤害。然而,癌症房间熬过并且膨胀的策略,能劫持这些分子和机制压制 T 调停房间的有免疫力的回答。因此,堵住检查点分子提高宿主免疫系统的反肿瘤活动的一个想法被开发了并且在禁止的 T 细胞合作受体的发现以后适用于癌症治疗,细胞毒素的T淋巴细胞联系了蛋白质 4 ( CTLA-4 ),并且进一步在 PD-1 和它的 ligands 的鉴定上提高了。自从 2010,几个检查点禁止者被食物及药品管理局同意了,许多更多在临床的试用。在先进癌症的治疗,这些禁止者显著地增加了反应率和幸存好处。然而,与惹人注目的结果伴随了,广泛地发生在许多机关的免疫者相关的不利事件(irAEs ) 被观察并且报导,其中一些是致命的。此处,我们首先在癌症治疗在有免疫力的检查点分子的研究和他们的堵住的抗体的应用程序考察最近的前进,然后讨论治疗和策略导致到监视器的心脏的毒性,当它发生时,管理这个不利事件。 | Jiu-cheng Zhang Wei-dong Chen Jean Bustamante Alvarez Kelly Jia Lei Shi Qiang Wang Ning Zou Kai He Hua Zhu | 2018 | Acta Pharmacologica Sinica2018，39，11： | 14 |
| 16 | Response of Pinus koraiensis seedling growth to different light conditions based on the assessment of photosynthesis in current and one-year-old needles显示文摘As one of the three major five-leaved pines in the northern hemisphere,Pinus koraiensis is the most important dominant tree species in the natural mixed-broadleaved Korean pine forests.However,the regeneration of P.koraiensis under the canopy of secondary forest stands is poor because of the light limitation.This study was conducted to understand how P.koraiensis seedlings adapt to different light intensities and what would be the optimum light level for their establishment and growth.Three repetition plots with four light intensities(15%,30%,60%and 100%of the natural incident irradiances,achieved by suspending layers of black nylon net above and surrounding the plots)were set up under natural climate conditions in a montane region in eastern Liaoning Province,Northeast China.A total of 80 P.koraiensis seedlings with similar height and root collar diameter were transplanted into four plots.After one year of acclimation to the specific light conditions,the seasonal variations of the photosynthetic variables and needle traits of the current and one-year-old needles,and the growth parameters were observed under four light intensities.The results indicated that:(1)The seedling at60%treatment exhibited the greatest growth,which agreed with the response of the light-saturated photosynthetic rates(Amax)and the dark respiration rate(Rd)in the current and one-year-old needles,i.e.,Rd at60%treatment was significantly lower than that at 100%treatment,but Amax did not differ between the seedlings at 100%and 60%treatments.(2)The P.koraiensis seedlings have a certain photosynthetic plasticity to adapt the light conditions by adjusting their needle traits and regulating the physiological processes,because Amax,Rd,light saturation point and compensation point,the needle mass area,needle nitrogen and chlorophyll contents were significantly(p<0.05)correlated with the light intensities.Especially,Amax at 100%and 60%treatments was significantly higher(p<0.05)than that at 30%and 15%treatments for both current and one-year-old needles.(3)The needles of different ages played a commutative role during the growing season,i.e.,the one-year-old needles played a major role for the photosynthesis in the early growing season;the current year needles did in the later growing season.This ensured the effective photosynthesis throughout the growing season.These findings suggest that P.koraiensis is the in-between heliophilous and shade-tolerant tree species at least for the seedlings up to 8 years. | Jiaojun Zhu Kai Wang Yirong Sun Qiaoling Yan | 2014 | Journal of Forestry Research2014，25，1： | 13 |
| 17 | Effect of fixing distal radius fracture with volar locking palmar plates while preserving pronator quadratus显示文摘 | Fan Jian Chen Kai Zhu Hui Jiang Bo Yuan Feng Zhu Xiaozhong Mei Jiong Yu Guangrong | 2014 | Chinese Medical Journal2014，，16： | 13 |
| 18 | The transcription factor ICE1 functions in cold stress response by binding to the promoters of CBF and COR genes显示文摘A recent paper by Kidokoro et al.(2020)in The Plant Cell reported a transgene-dependent transcriptional silencing phenomenon in the dominant ice1-1 Arabidopsis mutant containing the CBF3-LUC reporter,and questioned whether ICE1 may regulate CBF genes and may be involved in plant cold response.Here,we evaluate available evidence supporting the involvement of ICE1 in plant cold response,and provide ChIP-seq data showing ICE1 binding to the promoters of CBF genes and other regulatory genes known to be critical for cold response as well as to the promoters of some COR genes. | Kai Tang Lun Zhao Yuying Ren Shuhua Yang Jian-Kang Zhu Chunzhao Zhao | 2020 | Journal of Integrative Plant Biology2020，62，3： | 13 |
| 19 | Abnormal function of the posterior cingulate cortex in heroin addicted users during resting-state and drug-cue stimulation task显示文摘 | LI Qiang YANG Wei-chuan WANG Ya-rong HUANG Yu-fang LI Wei ZHU Jia ZHANG Yi ZHAO Li-yan QIN Wei YUAN Kai Karen M. von Deneen WANG Wei TIAN Jie | 2013 | Chinese Medical Journal2013，，4： | 12 |
| 20 | Comparison of breast-conserving surgery and mastectomy in early breast cancer using observational data revisited:a propensity score-matched analysis显示文摘Recent observational studies showed that breast-conserving surgery(BCS) resulted in superior survival compared to mastectomy in breast cancer patients. This study compared the clinical outcomes of BCS and mastectomy using propensity score(PS)matching analysis, which had advantages over conventional methods in reducing bias. Nonmetastatic breast cancer patients who underwent BCS and mastectomy were matched 1:1 based on their PS. We used the Kaplan-Meier method and Cox-regression model to estimate the treatment effects. A total of 2,866 patients with a median follow-up time of 67 months were included in the original study population. Although the mastectomy cohort(N=1,219) had more advanced disease compared to the BCS cohort(N=1,647), LRFS was similar between the two groups(93.8% vs. 92.4%, P>0.05). BCS(vs. mastectomy) was associated with improved DFS(73.8% vs. 58.7%, P<0.01) and CSS(91% vs. 78.2%, P<0.01) in the original population. In the PS-matched population(N=1,668), clinicopathological features were equally distributed between the two cohorts. BCS(vs. mastectomy) was not associated with improved DFS(70.7% vs. 66.9%, P>0.05) or CSS(87.5% vs. 84.9%, P>0.05). We found that PS methods reduce bias when estimating treatment effects using observational data. BCS and mastectomy show equivalent outcomes in nonmetastatic breast cancer patients. | Kai Chen Zihao Pan Liling Zhu Tingting Hu Min Peng Weijuan Jia Fengxi Su Shunrong Li Erwei Song | 2018 | Science China(Life Sciences)2018，61，12： | 12 |
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