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| 1 | Targeting orthotopic gliomas with renal-clearable luminescent gold nanoparticles显示文摘在 nanomedicine 的主要临床的翻译挑战是在主要机关与举起和非可能减解的 nanoparticles (NP ) 的长期的保留联系的毒性的潜力。经历肾的清理的无机的 NP 的发展能潜在地解决这颗重要 biosafety 担心。然而,能被肾排泄的无机的 NP 是否仍然保持能够与差的渗透指向肿瘤,仍然保持不清楚。Glioblastoma multiforme,最恶意的 orthotopic 大脑肿瘤,因为血大脑障碍和反应 microglia 和 macroglia 的柔韧的血肿瘤障碍,在肿瘤微型环境为 NP 交货提出唯一的挑战。此处,我们使用了 orthotopic 调查在直径的 3 nm 的谷胱甘肽涂的金 nanoparticles (AuNPs ) 的被动指向的鼠科的 glioma 模型经历没能经历肾的清理的肾的清理和 18-nm AuNPs。显著地,我们报导 3-nm AuNPs 能与更高的效率指向 intracranial 肿瘤纸巾(2.3ver 在 1.0 妈骑车的 100 | Chuanqi Peng Xiaofei Gao Jing Xu Bujie Du Xuhui Ning Shaoheng Tang Robert M. Bachoo Mengxiao Yu Woo-Ping Ge Jie Zheng | 2017 | Nano Research2017，10，4： | 3 |
| 2 | Effect of thermodynamic parameters on prediction of phase behavior and process design of extractive distillation显示文摘Extractive distillation was investigated for separation of the minimum azeotrope of n-propanol/water, via the Aspen Plus simulation platform. Experimental data of n-propanol/water, which could pass the thermodynamic consistency test, were regressed to get suitable binary interaction parameters(BIPs) by the UNIQUAC thermodynamic model. The azeotrope system was heterogeneous in the simulation with built-in BIPs, which was contrary to the experimental data. The study focused on the effect of thermodynamic parameters on the prediction of phase behavior, and process design of extractive distillation. N-methyl-2-pyrrolidone(NMP) and ethylene glycol were used as solvents to implement the separation. Processes with built-in and regressed BIPs were explored,based on the minimum total annual cost(TAC). There were significant differences in the phase behavior simulation using different thermodynamic parameters, which showed the importance of BIPs in the design and optimization of extractive distillation. | HuiJia Huixin Wang Kang Ma Mengxiao Yu Zhaoyou Zhu Yinglong Wang | 2018 | Chinese Journal of Chemical Engineering2018，26，5： | 2 |
| 3 | FRET-based sen- sor for imaging chromium(III) in living cells显示文摘 | Zhiguo Zhou Mengxiao Yu Hong Yang | 2008 | Chem Commun2008，，： | 1 |
| 4 | Near‐Infrared Emitting Radioactive Gold Nanoparticles with Molecular Pharmacokinetics显示文摘 | Chen Zhou Guiyang Hao Patrick Thomas Jinbin Liu Mengxiao Yu Shasha Sun Orhan K. ?z Xiankai Sun Jie Zheng | 2012 | Angew. Chem. Int. Ed2012，，40： | 1 |
| 5 | Facile epoxidation strategy for producing amphiphilic up-converting rare-earth nanophosphors as biological labels 显示文摘 | Hu He Yu Mengxiao Li Fuyou | 2008 | Chem Mater2008，20，： | 1 |
| 6 | Fluorine-18-la- beled Gd3+/Yb3+/Er^3+ co-doped NaYF4 nanophosphors for multimodality PET/MR/UCL imaging显示文摘 | Zhou Jing Yu Mengxiao Sun Yun | 2011 | Biomaterials2011，32，： | 1 |
| 7 | Fluorine-18 la- beled rare-earth nanoparticles for positron emission tomo- graphy(PET) imaging of sentinel lymph node显示文摘 | Sun Yun Yu Mengxiao Liang Sheng | 2011 | Biomate- rials2011，32，： | 1 |
| 8 | Utility of TPP-manufactured biophysical restrictions to probe multiscale cellular dynamics显示文摘Biophysical restrictions regulate protein diffusion,nucleus deformation,and cell migration,which are all universal and important processes for cells to perform their biological functions.However,current technologies addressing these multiscale questions are extremely limited.Herein,through two-photon polymerization(TPP),we present the precise,low-cost,and multiscale microstructures(micro-fences)as a versatile investigating platform.With nanometer-scale printing resolution and multiscale scanning capacity,TPP is capable of generating micro-fences with sizes of 0.5-1000μm.These micro-fences are utilized as biophysical restrictions to determine the fluidity of supported lipid bilayers(SLB),to investigate the restricted diffusion of Src family kinase protein Lck on SLB,and also to reveal the mechanical bending of cell nucleus and T cell climbing ability.Taken together,the proposed versatile and low-cost micro-fences have great potential in probing the restricted dynamics of molecules,organelles,and cells to understand the basics of physical biology. | Panyu Fei Haibo Ding Yu Duan Xinyi Wang Wei Hu Peng Wu Mengxiao Wei Zhengchun Peng Zhongze Gu Wei Chen | 2021 | Bio-Design and Manufacturing2021，4，4： | 0 |
| 9 | Gap-free genome assembly and CYP450 gene family analysis reveal the biosynthesis of anthocyanins in Scutellaria baicalensis显示文摘Scutellaria baicalensis Georgi,a member of the Lamiaceae family,is a widely utilized medicinal plant.The flavones extracted from S.baicalensis contribute to numerous health benefits,including anti-inflammatory,antiviral,and anti-tumor activities.However,the incomplete genome assembly hinders biological studies on S.baicalensis.This study presents the first telomere-to-telomere(T2T)gap-free genome assembly of S.baicalensis through the integration of Pacbio HiFi,Nanopore ultra-long and Hi-C technologies.A total of 384.59 Mb of genome size with a contig N50 of 42.44 Mb was obtained,and all sequences were anchored into nine pseudochromosomes without any gap or mismatch.In addition,we analysed the major cyanidin-and delphinidin-based anthocyanins involved in the determination of blue-purple flower using a widely-targeted metabolome approach.Based on the genome-wide identification of Cytochrome P450(CYP450)gene family,three genes(SbFBH1,2,and 5)encoding flavonoid 3′-hydroxylases(F3′Hs)and one gene(SbFBH7)encoding flavonoid 3′5′-hydroxylase(F3′5′H)were found to hydroxylate the B-ring of flavonoids.Our studies enrich the genomic information available for the Lamiaceae family and provide a toolkit for discovering CYP450 genes involved in the flavonoid decoration. | Tianlin Pei Sanming Zhu Weizhi Liao Yumin Fang Jie Liu Yu Kong Mengxiao Yan Mengying Cui Qing Zhao | 2023 | Horticulture Research2023，10，12： | 0 |
| 10 | Rational Design of Electrocatalyst with Abundant Co/MoN Heterogeneous Domains for Accelerating Hydrogen Evolution Reaction显示文摘Developing efficient and durable electrocatalysts for water splitting, which has long been regarded as one of the most promising patterns to produce green hydrogen, is of great significance but still challenging. Herein,ample Co/MoN heterogeneous domains/nitrogen-doped carbon(Co/MoN/NC) nanosheet arrays as high-performance hydrogen evolution reaction(HER) electrocatalyst via a typical nitriding-carbonization strategy are successfully prepared on nickel foam(NF), which exhibits a low overpotential of 29 m V at 10 m A cm, together with excellent durability at 20 m A cmfor 90 h in alkaline solution. Such excellent catalytic property for HER can be attributed to the generation of abundant Co/Mo N heterogeneous structures. Additionally, the high conductivity of Co/Mo N and NC also increases the charge transfer rate, further helping accelerate the reaction rate of HER. This work presents an efficient method for improving the catalytic hydrogen evolution activity in basic solution. | Yu Qiu Jinzheng Liu Mengxiao Sun Jifa Yang Junzhe Liu Xiaoyan Zhang Xuejun Liu Lixue Zhang | 2022 | Chinese Journal of Structural Chemistry2022，41，7： | 0 |
| 11 | Linkage of microbial living communities and residues to soil organic carbon accumulation along a forest restoration gradient in southern China显示文摘Background:Forest restoration has been considered an effective method to increase soil organic carbon(SOC),whereas it remains unclear whether long-term forest restoration will continuously increase SOC.Such large uncertainties may be mainly due to the limited knowledge on how soil microorganisms will contribute to SOC accumulation over time.Methods:We simultaneously documented SOC,total phospholipid fatty acids(PLFAs),and amino sugars(AS)content across a forest restoration gradient with average stand ages of 14,49,70,and>90 years in southern China.Results:The SOC and AS continuously increased with stand age.The ratio of fungal PLFAs to bacterial PLFAs showed no change with stand age,while the ratio of fungal AS to bacterial AS significantly increased.The total microbial residue-carbon(AS-C)accounted for 0.95-1.66% in SOC across all forest restoration stages,with significantly higher in fungal residue-C(0.68-1.19%)than bacterial residue-C(0.05-0.11%).Furthermore,the contribution of total AS-C to SOC was positively correlated with clay content at 0-10 cm soil layer but negatively related to clay content at 10-20 cm soil layer.Conclusions:These findings highlight the significant contribution of AS-C to SOC accumulation along forest restoration stages,with divergent contributions from fungal residues and bacterial residues.Soil clay content with stand age significantly affects the divergent contributions of AS-C to SOC at two different soil layers. | Shuo Zhang Qi Deng Ying-Ping Wang Ji Chen Mengxiao Yu Xi Fang Hongbo He Jinlei Chen Pingping Xu Shenhua Wang Junhua Yan | 2021 | Forest Ecosystems2021，8，4： | 0 |
| 12 | Surface-ligand effect on radiosensitization of ultrasmall luminescent gold nanoparticles显示文摘Gold nanoparticles(AuNPs)could serve as pot ential radiother apy sensitizers because of their exceptional biocompatibility and high.Z material nature;however,since in vitro and in vivo behaviors of AuNPs are determined not only by their particle size but also by their surface chemistries,whether surface ligands can affect their radiosensitization has seldom been investi-gated in the radiosensitization of AuNPs.By conducting head-to-head comparison on radio-sensitization of two kinds of ultrasmall(~2 nm)near-infrared(NIR)emitting AuNPs that are coated with zwitterionic glutathione and neutr al polyethylene glyol(PEG)ligands,respectively,we found that zwitterionic glut athione coated AuNPs(GS-AuNPs)can reduce survival rates of MCF-7 cells under irr adiation of clinically used megavoltage photon beam at low dosage of~2.25 Gy.On the other hand,PEG-AuNPs can serve as a radiation-protecting agent and enabled MCF-7 cells more resistant to the irradiation,clearly indicating the key role of surface cheistry in radiosensitization of AuNPs.More detailed studies suggested that such difference was inde-pendent of cellular uptake and its eficiency,but might be related to the ligand-induced difference in photoelectron generation and/or inter actions between AuNPs and X-ray triggered reactive oxygen species(ROS). | Xingya Jiang Bujie Du Mengxiao Yu Xun Jia Jie Zheng | 2016 | Journal of Innovative Optical Health Sciences2016，9，4： | 0 |
| 13 | Plant above-ground biomass and litter quality drive soil microbial metabolic limitations during vegetation restoration of subtropical forests显示文摘Changes in litter quality(carbon:nitrogen,C:N)and above-ground biomass(AGB)following vegetation restoration significantly impact soil physicochemical properties,yet their effects on soil microbial metabolic limitations remain unclear.We measured litter quality,AGB,soil physicochemical properties,and extracellular enzyme activity(EEA)along a vegetation restoration gradient(7,14,49,70 years,and nearly climax evergreen broadleaved forests)in southern China.We also evaluated soil microbial metabolic limitations by a vector analysis of the EEA.Results revealed the soil microbial metabolisms were co-limited by C and phosphorus(P).The microbial C limitation initially decreased(before 14 years)and then increased,while the microbial P limitation initially increased(before 49 years)and then decreased.Partial least squares path modeling(PLS-PM)showed that the microbial C limitation was mainly attributed to microbial C use efficiency induced by litter quality,suggesting that microorganisms may transfer cellular energy between microbial growth and Cacquiring enzyme production.The microbial P limitation was primarily correlated with AGB-driven change in soil elements and their stoichiometry,highlighting the importance of nutrient stoichiometry and balance in microbial metabolism.The shifts between microbial C and P limitations and the strong connections of plant–soil-microbe processes during vegetation restoration revealed here will provide us with helpful information for optimal management to achieve forest restoration success. | Shuo Zhang Ying-Ping Wang Xi Fang Jinlei Chen Nannan Cao Pingping Xu Mengxiao Yu Xin Xiong Xiangping Tan Qi Deng Junhua Yan | 2023 | Soil Ecology Letters2023，5，2： | 0 |
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