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| 1 | Quality control of Semen Ziziphi Spinosae standard decoction based on determination of multi-components using TOF-MS/MS and UPLC-PDA technology显示文摘A sensitive,fast and comprehensive method for the quality assessment of Semen Ziziphi Spinosae(SZS)standard decoction with characterization of its chemical components was developed and validated.UPLC-Q/TOF-MS/MS system was used to identify thirty-six chemical components of SZS standard decoction which included nucleosides,phenolic acids,alkaloids,and flavonoids.Furthermore,a UPLC-PDA method was validated to simultaneously determine adenosine,protocatechuic acid,magnoflorine,catechin,protocatechin,vicenin II,spinosin,kaempferol-3-rutinoside,and 6'''-feruloylspinosin which represent four species of characteristic compounds.The qualitative method had been validated according to Chinese Pharmacopoeia(2015 edition)in terms of lineary,repeatability,recovery and stability for all analytes,with the results showing good precision,accuracy and stability.In conclusion,the method using UPLC combined with MS and PDA provided a novel way for the standardization and identification of SZS standard decoction,and also offered a basis for qualitative analysis and quality assessment of the preparations for SZS standard decoction. | Di Wang Qing Li Ran Liu Huarong Xu Yidi Yin Yifan Wang Huijia Wang Kaishun Bi | 2019 | Journal of Pharmaceutical Analysis2019，9，6： | 6 |
| 2 | Spleen-Yang-deficiency patients with polycystic ovary syndrome have higher levels of visfatin显示文摘OBJECTIVE:To study serum visfatin levels in women with polycystic ovary syndrome(PCOS)grouped by Traditional Chinese Medicine(TCM)patterns.To study the correlations of serum visfatin levels with homeostatic model assessment insulin resistance(HOMA-IR),fasting plasma glucose(FPG),fasting insulin(FINS),body mass index(BMI),testosterone(T),total cholesterol(TC),and triglycerides(TG).METHODS:Two hundred and twelve PCOS patients were placed into the following TCM pattern subgroups:Kidney-Yang deficiency(KYD)group,Spleen-Yang deficiency(SYD)group,stagnant Liver-Qi transforming into heat(SLQTH)group,and Kidney-Yin deficiency(KYIND)group.The correlations between serum visfatin levels and HOMA-IR,FPG,FINS,BMI,T,TC,andTG were analyzed.RESULTS:Of all patients with PCOS,there were 82in the KYD group(38.6%),67 in the SYD group(31.6%),37 in the SLQTH group(17.5%),and 26 in the KYIND group(12.3%).Visfatin levels in all PCOS subgroups were higher than those in the control group(P<0.01 or P<0.05).Among these subgroups,the visfatin levels in the SYD group were significantly higher than those in the other three TCM pattern groups(P<0.05).There were no statistical differences among the remaining three pattern groups.The levels of BMI,FINS,HOMA-IR,T,and TG were significantly higher in all subgroups than those in the control group(P<0.05).There were no significant differences in FPG and TC between all PCOS subgroups and the control group(P>0.05).The SYD group had higher levels of FINS and HOMA-IR compared with the KYD,SLQTH,and KYIND groups(P<0.05).In all subgroups,after controlling for BMI,TG,TC,and age,visfatin was positively correlated with FINS(r=0.197,P=0.015)and HOMA-IR(r=0.173,P=0.033),and was not correlated with T.CONCLUSION:KYD and SYD patterns are most common in PCOS patients.Increased visfatin is a common pathophysiologic manifestation in PCOS patients.The SYD group had the highest levels of visfatin,and visfatin was positively correlated with FINS and HOMA-IR. | Huijia Fu Yan Qiu Feng Wei Li Yang Min Xia Huiyu He | 2014 | Journal of Traditional Chinese Medicine2014，34，1： | 5 |
| 3 | Effect of thermodynamic parameters on prediction of phase behavior and process design of extractive distillation显示文摘Extractive distillation was investigated for separation of the minimum azeotrope of n-propanol/water, via the Aspen Plus simulation platform. Experimental data of n-propanol/water, which could pass the thermodynamic consistency test, were regressed to get suitable binary interaction parameters(BIPs) by the UNIQUAC thermodynamic model. The azeotrope system was heterogeneous in the simulation with built-in BIPs, which was contrary to the experimental data. The study focused on the effect of thermodynamic parameters on the prediction of phase behavior, and process design of extractive distillation. N-methyl-2-pyrrolidone(NMP) and ethylene glycol were used as solvents to implement the separation. Processes with built-in and regressed BIPs were explored,based on the minimum total annual cost(TAC). There were significant differences in the phase behavior simulation using different thermodynamic parameters, which showed the importance of BIPs in the design and optimization of extractive distillation. | HuiJia Huixin Wang Kang Ma Mengxiao Yu Zhaoyou Zhu Yinglong Wang | 2018 | Chinese Journal of Chemical Engineering2018，26，5： | 2 |
| 4 | Polymorphisms of the vascular endothelial growth factor A gene and susceptibility to sporadic brain arteriovenous malformation in a Chinese population显示文摘 | Hongyan Chen Yuxiang Gu Wenting Wu Dan Chen Peiliang Li Weiwei Fan Daru Lu Fan Zhao Nidan Qiao Huijia Qiu Chaowei Fu Ying Mao Yao Zhao | 2010 | Journal of Clinical Neuroscience2010，，4： | 1 |
| 5 | DNA Methylation Suppresses Expression of the Urea Cycle Enzyme Carbamoyl Phosphate Synthetase 1 (CPS1) in Human Hepatocellular Carcinoma显示文摘 | Hongyan Liu Huijia Dong Keith Robertson Chen Liu | 2011 | The American Journal of Pathology2011，，2： | 1 |
| 6 | Efficiently photothermal conversion in a MnO_(x)-based monolithic photothermocatalyst for gaseous formaldehyde elimination显示文摘Volatile organic compound(VOC)pollution has a serious impact on human and urgently needs to be controlled through the development of new methods and catalytic materials.Compared with traditional thermal catalytic oxidation,the synergistic photothermocatalysis is regarded as a green and environmen-tally friendly strategy for organic compound pollutant removal,which can promote spontaneous heating of the surface of catalysts to achieve thermal catalytic reaction conditions via harvesting light irradia-tion.In this paper,a monolithic photothermocatalyst was synthesized through coating graphene oxide(GO)and MnOx in turn on a commercially available melamine sponge,where the GO mainly acted as a photothermal conversion layer to heat the catalytically active MnO_(x).This monolithic catalyst presented excellent photo-induced activity for formaldehyde elimination under ambient conditions(∼90%degrada-tion ratio in 20 min for∼160 ppm initial concentration formaldehyde),and meanwhile possessed a high catalytic durability for multiple cycles.The kinetic study demonstrated that this photothermocatalytic process followed a pseudo-second-order kinetics.Finally,we proposed a possible formaldehyde degrada-tion pathway based on in situ DRIFTS examination. | Pengfei Sun Huijia Yu Tingting Liu Yingshuang Li Zhongsen Wang Yufei Xiao Xiaoping Dong | 2022 | Chinese Chemical Letters2022，33，5： | 1 |
| 7 | Web spam identification with user browsing graph 显示文摘 | YU Huijia LIU Yiqun ZHANG Min | 2009 | Lecture Notes in Computer Science2009，5839，： | 1 |
| 8 | Y_(2)O_(3) nanosheets as slurry abrasives for chemical-mechanical planarization of copper显示文摘Continued reduction in feature dimension in integrated circuits demands high degree of flatness after chemical mechanical polishing.Here we report using new yttrium oxide(Y_(2)O_(3))nanosheets as slurry abrasives for chemical-mechanical planarization(CMP)of copper.Results showed that the global planarization was improved by 30%using a slurry containing Y_(2)O_(3) nanosheets in comparison with a standard industrial slurry.During CMP,the two-dimensional square shaped Y_(2)O_(3) nanosheet is believed to induce the low friction,the better rheological performance,and the laminar flow leading to the decrease in the within-wafer-non-uniformity,surface roughness,as well as dishing.The application of the two-dimensional nanosheets as abrasive in CMP would increase the manufacturing yield of integrated circuits. | Xingliang HE Yunyun CHEN Huijia ZHAO Haoming SUN Xinchun LU Hong LIANG | 2013 | Friction2013，1，4： | 1 |
| 9 | Flatness maintenance and roughness reduction of silicon mirror in chemical mechanical polishing process显示文摘As an important optical component in laser system,silicon mirror surface is required to have micron-level flatness and subnanometer-level roughness.The research concentrates on how to improve roughness as far as possible while maintaining flatness of silicon mirror surface during chemical mechanical polishing(CMP)process.A polishing edge effect model is established to explain the reason of flatness deterioration,and a roughness theoretical model is set up to get the limit of perfect surface roughness.Based on the models above,a polishing device is designed to maintain the surface flatness,and the optimized polishing process parameters are obtained by orthogonal tests to get a near-perfect surface roughness.Finally the maintenance of flatness and the improvement of roughness can be achieved at the same time in one step of CMP process.This work can be a guide for silicon mirror manufacture to improve optical reflection performance significantly. | JIANG BoCheng ZHAO DeWen WANG BingQuan ZHAO HuiJia LIU YuHong LU XinChun | 2020 | Science China(Technological Sciences)2020，63，1： | 1 |
| 10 | Hepatitis C Virus Triggers Apoptosis of a Newly Developed Hepatoma Cell Line Through Antiviral Defense System显示文摘 | Haizhen Zhu Huijia Dong Erika Eksioglu Alan Hemming Mengde Cao James M. Crawford David R. Nelson Chen Liu | 2007 | Gastroenterology2007，，5： | 1 |
| 11 | Using log mining to analyze user behavior on search engine显示文摘用户行为分析成为了最重要的研究话题之一,特别以性能优化,体系结构分析,和系统维护,由于搜索引擎用户的快速的生长。由足够地在木头数据上执行分析,研究人员和因特网公司能得到指导到更好的搜索引擎。在这篇论文,我们基于从一个真实商业搜索引擎的木头获得的搜索请求的约 7.5 亿个条目执行我们的分析。用户行为的几个方面被学习,包括询问长度,询问精制的比率,建议存取等等。不同信息需要可以导致不同行为,并且我们在这篇论文探讨这讨论。我们坚定地相信这些分析将与改进搜索引擎的有效性和效率的尊重是有用的。 | Ke XIE Huijia YU Rongwei CEN | 2012 | Frontiers of Electrical and Electronic Engineering in China2012，7，2： | 1 |
| 12 | CC genotype donors for the interleukin‐28B single nucleotide polymorphism are associated with better outcomes in hepatitis C after liver transplant显示文摘 | Roberto J. Firpi Huijia Dong Virginia C. Clark Consuelo Soldevila‐Pico Giuseppe Morelli Roniel Cabrera Oxana Norkina Jonathan J. Shuster David R. Nelson Chen Liu | 2012 | Liver Int2012，，1： | 1 |
| 13 | 背景匹配的和破坏性的色彩之间的相互作用:利用人类的天敌和虚拟螃蟹实验显示文摘破坏性的着色和猎物和背景光斑尺寸之间的匹配之间的相互作用,在两个实验所用的时间由人类“捕食者”找到人工猎物操纵(虚拟蟹变种)对异构背景作为衡量他们的伪装。实验1,在该点及其布局模仿对蟹Carcinus maenas的安排,测试是否高和低对比度的点接触身体的轮廓(破坏性的“边缘”的变种)的人工猎物比更难检测点时,未触及的轮廓(非破坏性的“内在”的变种)对三不同的背景:'小','中间'和'大'的光斑尺寸。在实验2中,光斑的大小和位置的范围(边缘'和'内')对螃蟹的变体不同来确定最有效的组合对中为背景。总共有640名志愿者参加了这些计算机试验,代表着高度的独立复制。所有图案的变种检测比普通的变种非常困难,这表明至少具有一定程度的背景匹配可以提供伪装。实验表明,不同的变种,但不具有相同的尺寸为背景,有类似的或更好的生存与匹配大小的点——表明优化玛伪装不是来自背景匹配的孤独。在实验2中,边破坏形态始终需要更长的时间来找到比他们的非破坏性的同行。边缘破裂,对比的相对影响,和背景/猎物光斑尺寸显然是上下文相关的,突出的猎物隐藏[当前生态61的复杂性(4):718-728,2015 ]。 | Peter A. TODD Huijia PHUA Kok Ben TOH | 2015 | Current Zoology2015，61，4： | 1 |
| 14 | Scalably Revealing the Dynamics of Soft Community Structure in Complex Networks显示文摘Revealing the dynamics of community structure is of great concern for scientists from many fields. Specifically, how to quantify the dynamic details of soft community structure is a very interesting topic. In this paper, the authors propose a novel framework to study the scalable dynamic behavior of the soft community structure. First, the authors model the Potts dynamics to detect community structure using a 'soft' Markov process. Then the soft stability of in a multiscale view is proposed to naturally uncover the local uniform behavior of spin values across multiple hierarchical levels. Finally, a new partition index is developed to detect fuzzy communities based on the stability and the dynamical information. Experiments on the both synthetically generated and real-world networks verify that the framework can be used to uncover hierarchical community structures effectively and efficiently. | LI Huijia LI Huiying | 2016 | Journal of Systems Science & Complexity2016，29，4： | 0 |
| 15 | Electroencephalogram and brainstem auditory evoked potential in 539 patients with central coordination disorder显示文摘BACKGROUND: Electroencephalogram (EEG) and brainstem auditory evoked potential (BAEP) are objective non-invasive means of measuring brain electrophysiology. OBJECTIVE: To analyze the value of EEG and BAEP in early diagnosis, treatment and prognostic evaluation of central coordination disorder. DESIGN, TIME AND SETTING: This case analysis study was performed at the Rehabilitation Center of Hunan Children’s Hospital from January 2002 to January 2006. PARTICIPANTS: A total of 593 patients with severe central coordination disorder, comprising 455 boys and 138 girls, aged 1–6 months were enrolled for this study. METHODS: EEG was monitored using electroencephalography. BAEP was recorded using a Keypoint electromyogram device. Intelligence was tested by professionals using the Gesell scale. MAIN OUTCOME MEASURES: (1) The rate of abnormal EEG and BAEP, (2) correlation of abnormalities of EEG and BAEP with associated injuries, (3) correlation of abnormalities of EEG and BAEP with high risk factors. RESULTS: The rate of abnormal EEG was 68.6% (407/593 patients), and was increased in patients who also had mental retardation (P < 0.05). The rate of abnormal BAEP was 21.4% (127/593 patients). These 127 patients included 67 patients (52.8%) with peripheral auditory damage and 60 patients (47.2%) with central and mixed auditory damage. The rate of abnormal BAEP was significantly increased in patients who also had mental retardation (P < 0.01). Logistic regression analysis showed that asphyxia (P < 0.05), jaundice, preterm delivery, low birth weight and the umbilical cord around the neck were closely correlated with abnormal EEG in patients with central coordination disorder. Intracranial hemorrhage, jaundice (P < 0.05), low birth weight and intrauterine infection (P < 0.05) were closely correlated with abnormal BAEP in patients with central coordination disorder. CONCLUSION: Central coordination disorder is often associated with abnormal EEG and BAEP. The rate of EEG or BAEP abnormality is positively associated with the size of the brain injury. Asphyxia is a high risk factor for abnormal EEG in central coordination disorder. Jaundice and intrauterine infection are high risk factors for abnormal BAEP in central coordination disorder. | Huijia Zhang Hua Yan Paoqiu Wang Jihong Hu Hongtao Zhou Rong Qin | 2008 | Neural Regeneration Research2008，3，12： | 0 |
| 16 | Cretaceous ants shed new light on the origins of worker polymorphism显示文摘Dear editor,Polymorphism refers to two or more clearly different phenotypes coexisting in the population of a species. It has been observed and studied among ants, bees, wasps, termites,dung beetles and stag beetles (Trible and Kronauer, 2017;Zhao et al., 2019). Size and shape variation of these holometabolic insects, especially ants, usually happen in larval development rather than adult stage. | Huijia Cao Brendon E.Boudinot Chungkun Shih Dong Ren Taiping Gao | 2020 | Science China(Life Sciences)2020，63，7： | 0 |
| 17 | Study on the Anti-aging Efficacy of the Active Ingredients in Aqueous Extract of Ganoderma lucidum显示文摘[Objective] The research aimed to develop anti-aging masks with aqueous extracts of Ganoderma lucidum and to study the clinical efficacy on the delaying of skin aging. [Method] The anti-aging efficacy of the aqueous extract of Ganoderma lucidum was evaluated by sensory evaluation,safety evaluation,instrumental measurements,etc. [Result] The results of sensory evaluation showed that after continuous application of the test materials for 12 weeks,the skin dryness,elasticity,surface sheen,fine wrinkles and smoothness were well improved,and the improvement rates were 91. 17%,91. 17%,94. 12%,11. 76% and 91. 18%,respectively. The measurement results by specialized instrument showed that the skin hydration on the target site increased continuously with the prolonging of the using time. Significant differences existed between each time point after using the products and the time before using. There was no significant difference existed in elasticity index R2 and R5 compared with before using. [Result] Clinical data showed that the active ingredients in aqueous extract of Ganoderma lucidum had a certain effect on the delaying of skin aging. | Shouyao HUANG Chunwei JIAO Huijia LIANG Yongshan YANG Jiaming CHEN Minglong ZHANG Yaqi HONG Yizhen XIE | 2015 | Agricultural Biotechnology2015，4，5： | 0 |
| 18 | Bi_(2)O_(2)Se nanoplates for broadband photodetector and full-color imaging applications显示文摘Broadband light detection and sensing are widely applied in modern technology.As a promising candidate for next-generation two-dimensional(2D)optoelectronic material,bismuth oxyselenide(Bi_(2)O_(2)Se)nanoplates exhibit many prospects in the application of visible light detection due to their peculiar properties.In this work,we report the photodetection performance of single-crystal 2D Bi_(2)O_(2)Se nanoplates grown on SiO_(2)based on a ternary-alloy growth model by utilizing chemical vapor deposition(CVD).The Bi_(2)O_(2)Se nanoplates were found to have an even and uniform square shape with side lengths up to 15μm and an approximate thickness of 15 nm.A visible-light photodetector was fabricated based on a CVD-grown Bi_(2)O_(2)Se nanoplate,and characterized by a set of illumination experiments using a 400 nm laser at temperatures ranging from 77 to 370 K.The device exhibited superior performance at the temperature of 77 K,with a responsivity of 523 A/W,a specific detectivity of 1.37×10^(11)Jones,a response time of 0.2175 ms,an external quantum efficiency of 162,119.44%,resulting in high-quality and fullcolor imaging in the visible spectrum.These results indicate that the single-crystalline Bi_(2)O_(2)Se nanoplates have excellent potential in broadband photodetection and non-cryogenic imaging. | Han Wang Songqing Zhang Xingxuan Wu Huijia Luo Junliang Liu Zesheng Mu Ruirui Liu Guang Yuan Yujun Liang Jin Tan Yongling Ren Wen Lei | 2023 | Nano Research2023，16，5： | 0 |
| 19 | Assessing urban resilience to public health disaster using the rough analytic hierarchy process method:A regional study in China显示文摘In the context of frequent occurrences of disasters worldwide,disaster-coping capability is imperative for risk reduction and contemporary emergency management.The global COVID-19 pandemic since 2020 has further highlighted the significance of resilience construction at different geographical scales.Overall,the conceptual cognition of resilience in disaster management covers multiple elements and has diverse yielding on regional assessment.This study assesses the local resilience to the public health disaster in the prefecture-level cities,focusing on two dimensions consisting of vulnerability and capability in the targeted provincial region of Jiangsu in China.To this end,based on the vulnerability-capability framework,the Rough Analytic Hierarchy Process(Rough AHP)method was applied to the resilience assessment.Drawing upon the criteria derived from literature,the criteria weights were determined with the RAHP method and we assessed urban resilience with census data.In addition,the hierarchical factors contributing to urban resilience were determined using robustness analysis.This research provides constructive ideas for regional disaster reduction and contributes to the government’s capability to improve urban resilience. | Zezhao Liu Rui Ma HuiJia Wang | 2022 | Journal of Safety Science and Resilience2022，3，2： | 0 |
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