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| 1 | Induction of cytotoxic T lymphocyte respones in vivo after immunotherapy with dendritic cells in patients with nasopharyngeal carcinoma显示文摘The aim of the present study was to determine the efficacy of immunotherapy with dendritic cells to elicit EBV-specific CTL-immunity in advanced cases of EBV-positive patients with nasopharyngeal carcinoma (NPC) and to determine the safety and toxicity of this preparation. Nine cases of histologically confirmed patients with NPC undergoing treatment with radiological therapy were enrolled in this study. Dendritic cells, generated in vitro from blood monocytes of patients were cultured and matured with cytokines and then infected with recombinant adenovirus vaccine containing EBV-latent membrane protein-2 (Ad-LMP2). On 9 days' cultivation of cells, the matured DCs were harvested, irradiated with Co and then injected intradermally to patients with NPC. The injections were performed 3 times totally. After immunization, the CTL responses were assayed by means of cytotoxicity and epitope-specific IFN-γproduction. The results of this trial showed that all patients could tolerate this kind of treatment without any side effect, during which marked increase of LMP2-specific CTL-responses could be demonstrated in 5 patients of this group. And the level of IgA/VCA antibody decreased in 8 of 9 patients, thus accounting for a better prognosis for these patients. All patients will be followed up for another one year. At least, the present work shows that intradermal vaccination with autologous DCs infected with recombinant Ad-LMP2 adenovirus is a safe procedure in NPC patients, in which this procedure can enhance the LMP2-specific CTL responses in patients. These data are encouraging to develop more effective vaccine strategies for the treatment of nasopharyngeal carcinoma. | JIAN MIN ZUO LING ZHOU ZHI JIAN CHEN DE RUI LI QI WANG JIONG YU CHEN ZHAN WANG SI-IU QING WE YI ZENG | 2006 | Journal of Microbiology and Immunology2006，4，1： | 7 |
| 2 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang Nanping Wu Hainv Gao Jifang Sheng Hangping Yao Jianer Wo Qiang Fang Dawei Cui Yongcheng Li Xing Yao Yuntao Zhang Haibo Wu Shufa Zheng Hongyan Diao Shichang Xia Yanjun Zhang Kwok-Hung Chan Hoi-Wah Tsoi Jade Lee-Lee Teng We | 2013 | 2013 (9881)2013，，9881： | 2 |
| 3 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang Nanping Wu Hainv Gao Jifang Sheng Hangping Yao Jianer Wo Qiang Fang Dawei Cui Yongcheng Li Xing Yao Yuntao Zhang Haibo Wu Shufa Zheng Hongyan Diao Shichang Xia Yanjun Zhang Kwok-Hung Chan Hoi-Wah Tsoi Jade Lee-Lee Teng We | 2013 | The Lancet2013，，9881： | 1 |
| 4 | Prospective non- randomized comparison of quality of life and recurrence between high ligation and stripping and radiofrequency ablation for varicose veins显示文摘 | Hyung SP Yu Jk Bang WE | 2013 | J Korean Surg Soc2013，84，： | 1 |
| 5 | Lower extremity biomechanics during the landing of a stop-jump task 显示文摘 | Yu B Lin CF Garrett WE | 2006 | Clin Biomech2006，21，3： | 1 |
| 6 | Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance显示文摘Latent membrane protein 1(LMP1)is a major Epstein–Barr virus(EBV)-encoded oncoprotein involved in latency infection that regulates mitochondrial functions to facilitate cell survival.Recently,mitochondrial fission has been demonstrated as a crucial mechanism in oncovirus-mediated carcinogenesis.Mitochondrial dynamin-related protein 1(Drp1)-mediated mitochondrial fission has an impact on the chemoresistance of cancers.However,the mechanism by which oncogenic stress promotes mitochondrial fission,potentially contributing to tumorigenesis,is not entirely understood.The role of Drp1 in the oncogenesis and prognosis of EBV-LMP1-positive nasopharyngeal carcinoma(NPC)was determined in our study.We show that EBV-LMP1 exhibits a new function in remodeling mitochondrial morphology by activating Drp1.A high level of p-Drp1(Ser616)or a low level of p-Drp1(Ser637)correlates with poor overall survival and disease-free survival.Furthermore,the protein level of p-Drp1(Ser616)is related to the clinical stage(TNM stage)of NPC.Targeting Drp1 impairs mitochondrial function and induces cell death in LMP1-positive NPC cells.In addition,EBV-LMP1 regulates Drp1 through two oncogenic signaling axes,AMPK and cyclin B1/Cdk1,which promote cell survival and cisplatin resistance in NPC.Our findings provide novel insight into the role of EBV-LMP1-driven mitochondrial fission in regulating Drp1 phosphorylation at serine 616 and serine 637.Disruption of Drp1 could be a promising therapeutic strategy for LMP1-positive NPC. | Longlong Xie Feng Shi Yueshuo Li We Li Xinfang Yu Lin Zhao Min Zhou Jianmin Hu Xiangjian Luo Min Tang Jia Fan Jian Zhou Qiang Gao Weizhong Wu Xin Zhang Weihua Liao Ann MBode Ya Cao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 7 | Efficacy of prophylactic mastectomy in women with unilateral breast cancer:a cancer research network project显示文摘 | Herrinton L J Barlow WE Yu O | 2005 | J Clin Oncol2005，23，19： | 1 |
| 8 | The role of IL-27 in the induction of anti-tumor eytotoxic T lymphocyte response 显示文摘 | LIU Z YU J CARSON WE 3RD | 2013 | Am J Transl Res2013，5，5： | 1 |
| 9 | Efficacy of prophylactic mastectomy in women with unilateral breast cancer:a cancer re- search network project显示文摘 | Herrinton LJ Barlow WE Yu O | 2005 | J Clin Oncol2005，23，： | 1 |
| 10 | Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin 显示文摘 | Yu Z Schneider C Boeglin WE | 2006 | Arch Biochem Biophys2006，455，2： | 1 |
| 11 | Reevaluation of Limited Side-to-side Portacaval Shunt显示文摘 | Wang Yu Xu Yuandi Du We | 1990 | Chinese Medical J1990，103，： | 1 |
| 12 | Accumulation of tissue advanced glycation end products correlated with glucose exposure dose and associated with cardiovascular morbidity in patients on peritoneal dialysis显示文摘 | Jianping Jiang Pingyan Chen Jianghua Chen Xueqing Yu Di Xie Changlin Mei Fei Xiong Wei Shi Wei Zhou Xusheng Liu Shiren Sun Ping Zhang Xiao Yang Yixiang Zhang Yanmin Zhang Xinling Liang Zhimin Zhang Qizhan Lin Yan Yu Toshio Miyata Jianwei Tian Min Liang We | 2012 | Atherosclerosis2012，，1： | 1 |
| 13 | Reactive power optimisation with voltage stability consideration in power market systems显示文摘 | Lin X David A K Yu C We t al | 2003 | IEE Proceedings-Generation Transmission&Distribu-tion2003，50，3： | 1 |
| 14 | Incense smoke--characterization and dynamics in indoor environments显示文摘 | Cheng YS Bechtold WE Yu CC | 1995 | Aerosol Sci Technol1995，23，： | 1 |
| 15 | Characteristics of phenotype and genetic mutations in rice after spaceflight显示文摘 | Yu X Wu H We L J Cheng Z L Xin P Huang C L Zhang K P Sun Y Q | 2007 | Advances in Space Research2007，，40： | 1 |
| 16 | Construction of antithrombogenic polyelcctrolyte muhilayer on thermoplastic polyurethane via layer- by-layer self-assembly technique显示文摘 | Yu DG Lin WE Lin CH | 2007 | J Biomed Mater Res B Appl Biomater2007，83，1： | 1 |
| 17 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang Nanping Wu Hainv Gao Jifang Sheng Hangping Yao Jianer Wo Qiang Fang Dawei Cui Yongcheng Li Xing Yao Yuntao Zhang Haibo Wu Shufa Zheng Hongyan Diao Shichang Xia Yanjun Zhang Kwok-Hung Chan Hoi-Wah Tsoi Jade Lee-Lee Teng We | 2013 | The Lancet2013，，9881： | 1 |
| 18 | Lower extremity biomechanics during the landing of a stop-jump task显示文摘 | Yu B Lin CF Garrett WE | 2006 | Clin Biomech2006，21，3： | 1 |
| 19 | Thermal conductivity enhancement in thermal grease containing different CuO structures 显示文摘 | Yu We'i Zhao Junchang Wang Mingzhu | 2015 | Nanoscale Res Lett2015，10，1： | 1 |
| 20 | Incense smoke: characterization and dynamics in indoor environments 显示文摘 | Cheng YS Bechtold WE Yu CC | 1995 | Aerosol Science and Technology1995，23，3： | 1 |
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