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| 1 | 在过去的十年和未来前景在中国关于城市农村的转变和农村开发的研究进行显示文摘城市农村的转变和农村开发是在关于地理,以及重要实际问题面对瓷器新都市化并且城市、农村的开发的全面计划的领域里的城市农村的关系的话题的研究的最前线的问题。地区性的农业、农村的开发的中心,在中国科学院下面的地理科学和自然资源研究的研究所的部分,在 2005 被建立。中心为在过去的十年在中国在农业地理和农村开发的区域集成研究打了稳固的基础。论文试图在过去的十年期间在中国在农村地理研究考察主要成就,在相关理论和方法分析创新开发,并且建议为支持城市农村的转变和农村地理的全面研究的前景和反措施。研究证明创新成就作为主要国家政策开发,结果的产量和决策支持在过去的十年在中国的农村地理研究被做了;新突破在象地理综合理论,陆地补习工程和技术示范工程,新都市化和城市农村的集成的如此的主要研究工程被完成了;重要进步在活跃地扩展农村地理的边疆并且在土地和资源工程推向前理论的革新被取得了;并且与在所有尊重造一个中等繁荣的社会并且在头脑完成现代化的瓷器发展目标,在农业、农村的地理的创新开发应该试图使研究更战略、系统、科学、面向安全的未来,与给在国际合作和全球农村地理上支持系统的科学研究的注意。 | LIU Yansui LONG Hualou CHEN Yufu WANG Jieyong LI Yurui LIYuheng YANG Yuanyuan ZHOU Yang | 2016 | Journal of Geographical Sciences2016，26，8： | 13 |
| 2 | Neolithic rice paddy from the Zhaojiazhuang site, Shandong, China显示文摘To identify and study the Neolithic rice paddy in Shandong, eastern China, is not only an important issue in the development of Chinese rice agriculture, but also a key part of the study on rice spread in East Asia. Due to the limitation of archaeological materials and the research methods, there have been no discoveries about the Neolithic rice paddy in Shandong Province for a long time. Based on the identification of possible rice paddy by archaeological excavation, phytolith analysis of soil samples from this 'paddy' has been systematically carried out and the results have shown a 4600—4300 years old rice paddy preserved at the Zhaojiazhuang site. This is the first examination and study of the rice paddy in North China by systematic phytolith analysis, which is very important for the Neolithic archaeological research and the study of the eastward spread of rice agricultural techniques in East Asia. | JIN GuiYun YAN ShengDong Tetsuro UDATSU LAN YuFu WANG ChunYan TONG PeiHua | 2007 | Chinese Science Bulletin2007，52，24： | 12 |
| 3 | Critical roles of chemokine receptor CCR5 in regulating glioblastoma proliferation and invasion显示文摘Glioblastoma (GBM ) 是在成年人的最流行的恶意的主要大脑肿瘤并且展出异常地好攻击的显型的一个系列。肿瘤房间增长和侵略被 chemokines 和他们的受体极其调整。最近的研究证明了 chemokine CCL5 和它的受体 CCR5 在肿瘤侵略和转移起重要作用。尽管如此,在 GBM 的 CCR5 的角色仍然保持不清楚。现在的学习提供 chemokine 受体 CCR5 高度被表示并且在人的 GBM 把预后与穷人联系了的证据。机械学地, CCL5CCR5 调停 Akt 的激活,并且随后在 U87 和 U251 房间导致增长和侵略回答。而且, CCR5 的下面规定显著地在 U87 肿瘤禁止了 glioma 的生长异种皮移植老鼠模型。最后,在 GBM 的高 CCR5 表示在耐心的样品与增加的 p-Akt 表示被相关。一起,这些调查结果建议 CCR5 是与 gliomagenesis 联系的一个批评分子的事件。 | Lanfu Zhao Yuan Wang Yafei Xue Wenhai Lv Yufu Zhang Shiming He | 2015 | Acta Biochimica et Biophysica Sinica2015，47，11： | 4 |
| 4 | Biphasic firing response of nucleus accumbens neurons elicited by THPB-18 and its correlation with DA receptor subtypes显示文摘AIM: To investigate the possibility whether THPB-18 (l-12-shloroscoulerine) possesses the D1 agonist-D2 antago- nist action on meso-accumbens-mPFC DA system. METHODS: Single unit spontaneous firing activity was re- corded in the nucleus accumbens (NAc) neurons of na?ve and unilateral-6-hydroxydopamine (6-OHDA)-lesioned Sprague-Dawley rats. The effects of drugs applied intravenously or iontophoretically were determined by the change of firing rates. RESULTS: Under normal conditions, the systemic administration of THPB-18 produced a decrease-increase biphasic firing pattern in the NAc neurons during cumulative doses. High dose of THPB-18 was capable of reversing the inhibition induced by both D2 agonist LY171555 and D1/D2 agonist APO on NAc firing activity. Spiperone pretreatment could not block the high dose of THPB-18-induced firing rate increase, which was reversed by the D1 selective antagonist SCH23390. The tested NAc neurons were effectively inhibited by iontophoretically applied THPB-18 in 90 % of 6-OHDA-lesioned rats, while THPB-18 caused variable effects on the firing of NAc neurons in the neurons of unlesioned rats. The inhibitory effect of THPB-18 was blocked by iontophoretic application of SCH23390, but not D2 antagonist spiperone. CONCLUSION: Similar to l-stepholidine, THPB-18 also possesses the “D1 agonistic-D2 antagonistic” dual action on the VTA-NAc DA system.4Now in Department of Pharmacology and Toxicology, Univer-sity of Texas Medical Branch, USA.5Now in Department of Physiology & Pharmacology, OregonHealth Sciences University, USA,4Now in Department of Pharmacology and Toxicology, Univer-sity of Texas Medical Branch, USA.5Now in Department of Physiology & Pharmacology, OregonHealth Sciences University, USA,5Now in Department of Physiology & Pharmacology, OregonHealth Sciences University, USA, | YuFU Zi-taoZHU Xing-zuZHU Guo-zhangJIN | 2004 | Acta Pharmacologica Sinica2004，25，12： | 3 |
| 5 | Involvement of Th17 and Th1 Effector Responses in Patients with Hepatitis B显示文摘 | Yufu Ye Xiaojun Xie Jiwei Yu Lin Zhou Haiyang Xie Guoping Jiang Xiaobo Yu Wenjin Zhang Jian Wu Shusen Zheng | 2010 | Journal of Clinical Immunology2010，，4： | 3 |
| 6 | Surface characterization of steel/steel contact lubricated by PA06 with novel black phosphorus nanocomposites显示文摘In the present work,two types of novel nano additives,titanium sulfonate ligand/black phosphorus(TiLi/BP)and titanium dioxide/black phosphorus(TiCVBP)nanocomposites,were prepared.The tribological behavior of the steel/steel friction pairs lubricated by polyalphaolefins type 6(PA06)containing the nanocomposites under boundary lubrication was studied.The worn surfaces were analyzed using modem surface techniques.The experimental results show that the rubbed surfaces became smooth and showed little wear with the addition of the nanocomposites.TiO_(2)/BP nanocomposites can significantly improve the lubricity of BP nanosheets under high contact stress.The synergistic roles of the load-bearing abilities and rolling effect of TiO_(2) nanoparticles,the slip induced by the BP with its layered structure,and the establishment of a tribofilm on the sliding interface are the basis of the tribological mechanisms. | Zhiheng LUO Jingyuan YU Yufu XU He XI Gang CHENG Lulu YAO Ruhong SONG Karl D DEARN | 2021 | Friction2021，9，4： | 2 |
| 7 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 8 | Culturing adequate CAR-T cells from less peripheral blood to treat B-cell malignancies显示文摘Objective:Chimeric antigen receptor-modified T(CAR-T)cells have shown impressive results against relapsed/refractory B cell malignancies.However,the traditional manufacture of CAR-T cells requires leukapheresis to isolate large amounts of peripheral blood T cells,thus making some patients ineligible for the procedure.Methods:We developed a simple method for CAR-T cell preparation requiring small volumes of peripheral blood.First,CD3+T cells isolated from 50 mL peripheral blood from patients(B-cell malignancies)were stimulated with immobilized anti-CD3/RetroNectin in 6-well plates and then transduced with CAR-expressing lentiviral vector.After 4 d,the T cells were transferred to culture bags for large-scale CAR-T cell expansion.In vitro and animal experiments were performed to evaluate the activity of the manufactured CAR-T cells.Finally,29 patients with B-cell acute lymphoblastic leukemia(B-ALL)and 9 patients with B-cell lymphoma were treated with the CAR-T cells.Results:The CAR-T cells were expanded to 1–3×10^(8) cells in 8–10 d and successfully killed B cell-derived malignant tumor cells in vitro and in vivo.For patients with B-ALL,the complete remission rate was 93%1 month after CAR-T cell infusion;after 12 months,the overall survival(OS)and leukemia-free survival rates were 69%and 31%,respectively.For patients with lymphoma,the objective response rate(including complete and partial remission)was 78%2 months after CAR-T cell infusion,and after 12 months,the OS and progression-free survival rates were 71%and 43%,respectively.Cytokine-release syndrome(CRS)occurred in 65.51%and 55.56%of patients with B-ALL and B-cell lymphoma,respectively;severe CRS developed in 20.69%of patients with B-ALL and in no patients with lymphoma.Conclusions:Our novel method can generate sufficient numbers of CAR-T cells for clinical use from 50–100 mL peripheral blood,thus providing an alternative means of CAR-T cell generation for patients ineligible for leukapheresis. | Lu Han Jian Zhou Linlin Li Keshu Zhou Lingdi Zhao Xinghu Zhu Qingsong Yin Yufu Li Hongqin You Jishuai Zhang Yongping Song Quanli Gao | 2021 | Cancer Biology & Medicine2021，18，4： | 2 |
| 9 | Spatio-temporal change of urban–rural equalized development patterns in China and its driving factors显示文摘 | Yansui Liu Shasha Lu Yufu Chen | 2013 | Journal of Rural Studies2013，，： | 2 |
| 10 | Experimental study on enhancement of the metastatic potential of portal vein tumor thrombus-originated hepatocellular carcinoma cells using portal vein serum显示文摘Objective: Portal vein metastasis of hepatocellular carcinoma(HCC) results in a poor prognosis and seriously affects the survival rate of patients. The mechanism underlying the formation of portal vein tumor thrombus(PVTT) is complex and is not yet fully understood. This study was conducted to investigate the impact of portal vein blood on the proliferation, metastasis, invasion and apoptosis of PVTT cells and to explore its possible mechanisms, which was expected to lay a foundation for ascertaining the mechanism underlying the portal vein metastasis of HCC.Methods: Peripheral blood and portal vein blood were collected from patients with HCC, and the sera from these two sources were used to culture the PVTT-originated HCC cell line CSQT-2. The cells were collected after 24 h, and flow cytometry was performed to detect cell proliferation, cell cycle stages and apoptosis. Transwell migration and invasion assays were applied to detect the metastasis and invasion of the cells in each group. The changes in the expression of MMP-2 and MMP-9 in cells were detected via Western blotting. The contents of IL-12, IFN-γ, IL-1β, IL-2 and TNF-α in the two groups of sera were quantified using corresponding kits. Results: Compared with the group of cells cultured with peripheral serum, the cells cultured with portal vein serum showed significantly lower apoptosis(P<0.01), significantly enhanced cell metastasis and invasion(P<0.01), whereas cell proliferation and the stages of the cell cycle did not differ significantly(P>0.05). A significantly increased expression level of MMP-2 has been observed in tumor cells treated portal vein serum. In addition, compared with peripheral serum, the content of IL-12 was significantly decreased in portal vein serum(P<0.05), while the contents of IFN-γ, IL-1β, IL-2, and TNF-α did not differ significantly(P>0.05). Conclusions: Portal vein serum from HCC patients could inhibit the apoptosis of PVTT-originated HCC cells and promote cell metastasis and invasion. This effect may be related to the lower level of IL-12 in portal vein serum. | Yufu Tang Hongming Yu Long Zhang Kang Wang Weixing Guo Jie Shi Shupeng Liu Mengchao Wu Hongyang Wang Shuqun Cheng | 2014 | Chinese Journal of Cancer Research2014，26，5： | 2 |
| 11 | Microinterface intensification in hydrogenation and air oxidation processes显示文摘Hydrogenations and air oxidations usually have low apparent reaction rate,generally controlled by mass transfer rate,and widely exist in the modern chemical manufacturing process.The key to increase the mass transfer rate is the reduction of the liquid film resistance 1/kLa.In this work,the original concept of microinterface intensification for mass transfer and then for these reactions has been proposed.We derived the regulation model and set up the mathematical calculation method of micron-scale gas-liquid interface structure on mass transfer and reaction,designed the mechanical energy exchange device that can produce gas-liquid microinterface system on a large scale,and established the OMIS system which is able on line to measure the diameter and distribution of millions of microbubbles,interface area a and mass transfer film thicknessδM,as well as developed a series of microinterface intensified reactor systems(MIRs)for the applications of hydrogenation and air oxidation processes.It is believed that this research will provide an up-to-date development for the intensification of hydrogenation and air oxidation reactions. | Hongliang Qian Hongzhou Tian Guoqiang Yang Gaodong Yang Lei Li Feng Zhang Zheng Zhou Weihua Huang Yufu Chen Zhibing Zhang | 2022 | Chinese Journal of Chemical Engineering2022，，10： | 2 |
| 12 | 显示文摘 | Oshitani M Yufu H Takashima K | 1989 | J Electrochim Soc1989，，136： | 1 |
| 13 | Development of a pasted nickel electrode with high active material utilization 显示文摘 | OSHITANI M YUFU H TAKASHIMA K | 1989 | J Electrochem Soc1989，136，： | 1 |
| 14 | Depolarization thresholds for hippocampal damage, ischemic preconditioning and changes in gene expression after global isehemla in the rat 显示文摘 | Halaby IA Takeda Y Yufu K | 2004 | Neurosci Lett2004，372，12： | 1 |
| 15 | Depolarization thresholds forhippocampal damage,ischemic preconditioning,and changes ingene expression after global ischemia in the rat显示文摘 | Halaby IA Takeda Y Yufu K | 2004 | Neurosci Lett2004，372，12： | 1 |
| 16 | Brachial arterial stiffness predicts coronary atherosclerosis in patients at risk for cardiovascular diseases显示文摘 | Yufu K Takahashi N Anan F | 2004 | Jpn Heart J2004，45，： | 1 |
| 17 | Brachial arterialstiffness predicts coronary atherosclerosis in patients atrisk for cardiovascular diseases显示文摘 | Yufu K Takahashi N Anan F | 2004 | Japan Heart J2004，45，： | 1 |
| 18 | Corrosion be-havior of micro-arc oxidation coating on magnesium alloyAZ91D in NazSO^ solution 显示文摘 | Guo Huixia Ma Ying Zhang Yufu | 2013 | Journal of the ChineseCeramic Society2013，41，3： | 1 |
| 19 | Discrete-time variable structure control systems显示文摘 | Gao Weibing Wang Yufu Abdollah H | 1995 | IEEE Transactions on Industrial Electronics1995，42，2： | 1 |
| 20 | 显示文摘 | Oshitani M Yufu H Takashima K | 1989 | J Electrochim Soc1989，136，： | 1 |
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