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| 1 | Higher PD-1 expression concurrent with exhausted CD8+ T cells in patients with de novo acute myeloid leukemia显示文摘Objective: To investigate the association between the T cell inhibitory receptor programmed death 1(PD-1)and T cell exhaustion status in T cells from patients with de novo acute myeloid leukemia(AML) and AML in complete remission(CR).Methods:Surface expression of PD-1 and the exhaustion and immunosenescence markers CD244 and CD57 on CD3+,CD4+ and CD8+ T cells from peripheral blood samples from 20 newly diagnosed,untreated AML patients and 10 cases with AML in CR was analyzed by flow cytometry.Twenty-three healthy individuals served as control.Results:A significantly higher percentage of PD-1+ cells were found for CD3+ T cells in the de novo AML group compared with healthy controls.In addition,an increased level of PD-1+ CD8+ T cells,but not PD-1+ CD4+,was found for CD3+ T cells in the de novo AML and AML-CR samples.A higher percentage of CD244+ CD4+,CD244+ CD8+,CD57+ CD4+ and CD57+ CD8+ T cells was found in CD3+ T cells in samples from those with de novo AML compared with those from healthy controls.Strong increased PD-1+ CD244+ and PD-1+ CD57+ coexpression was found for CD4+ and CD8+ T cells in the de novo AML group compared with healthy controls.Conclusions:We characterized the major T cell defects,including co-expression of PD-1 and CD244,CD57-exhausted T cells in patients with de novo AML,and found a particular influence on CD8+ T cells,suggesting a poor anti-leukemia immune response in these patients. | Jiaxiong Tan Shaohua Chen Yuhong Lu Danlin Yao Ling Xu Yikai Zhang Lijian Yang Jie Chen Jing Lai Zhi Yu Kanger Zhu Yangqiu Li | 2017 | Chinese Journal of Cancer Research2017，29，5： | 10 |
| 2 | The mechanism of neogambogic acid-induced apoptosis in human MCF-7 cells显示文摘Neogambogic 酸(NGA ) ,在 garcinia 的活跃成分,能在 anticancer 效果禁止一些稳固的肿瘤和结果的生长。我们假设那 NGA 可能为人的乳癌房间线 MCF-7 房间的增长的抑制负责。在 vitro 调查它的 anticancer 机制, MCF-7 房间与 NGA 的各种各样的集中被对待。试金显示出的 MTT (甲基 thiazolyl tetrazolum ) 的结果有 NGA 的那治疗显著地以一种剂量依赖者方式减少了 MCF-7 房间的增长。NGA 能增加 anti-apoptotic 蛋白质 Bcl-2 的表示由 mitochondrial transmembrane 损坏伴随了的 apoptosis 相关的蛋白质 FasL, caspase-3, caspase-8, caspase-9,和 Bax 和减少的表示。MCF-7 房间上的 NGA 的 antiproliferative 效果由于 Fas/FasL 和细胞色素 C 小径的 G0/G1 拘捕,增加的 apoptosis 和激活。这些结果提供重要卓见进 NGA 通过损害乳癌房间的增长的细胞、分子的机制。 | Keming Wang Yuhong Tang Ming Sun Binbin Lu Hongqin Zhu Ou Ji Qun Shen | 2011 | Acta Biochimica et Biophysica Sinica2011，43，9： | 9 |
| 3 | Efficacy and advantages of modified Traditional Chinese Medicine treatments based on'kidney reinforcing'for chronic aplastic ane-mia:a randomized controlled clinical trial显示文摘OBJECTIVE:To compare the efficacy of modified treatments based on 'kidney reinforcing' in the management of chronic aplastic anemia(CAA),and explore their advantages and specialties.METHODS:One hundred and eleven patients with CAA were randomly divided into three groups:kidney reinforcing alone(KA),'kidney reinforcing and Qi tonifying'(KQ),and 'kidney reinforcing and blood circulation invigorating'(KC).Normal and positive control groups were also formed.All patients were treated for 6 months(two courses).Hemograms,Traditional Chinese Medicine(TCM) syndrome scores,and therapeutic effects were assessed,and changes in T-lymphocyte subsets,regulatory T cells and cytokines were detected.RESULTS:The KQ and KC groups had lower TCM syndrome scores than the positive control group after 6 months(P < 0.05).The KQ group had a higher overall efficacy than the positive control group after 3 months(P < 0.05),while platelet counts increased in the KC group after 6 months(P < 0.05).CD3+ T-lymphocyte ratios decreased only in the KQ group,while CD3 + CD4 + CD8-Tlymphocytes increased only in the KC group after 6 months(P <0.05).Levels of interferon-γ,tumor necrosis fac-tor-α,interleukin(IL)-2 and IL-6 decreased and levels of IL-4 and IL-10 increased in all treated groups after 6 months.Levels of IL-6 in the KQ and KC groups were lower than those in the positive control group(P < 0.05).CONCLUSION:Treatments based on kidney reinforcing have a rebalancing effect on cytotoxic and T helper cells,and regulate expression of interferon-γ,IL-2,IL-6 and IL-4.KQ may be more effective in treating CAA,and KC may have an advantage in platelet recovery. | Wu Dijiong Shen Yiping Ye Baodong Fang Bingmu Lin Shengyun Chen Zhilu Jiang Huifang Feng Changwei He Lüyuan Gao Yanting Liu Yonglin Liu Yonghua Zhu Jiajia Wu Liqiang Shao Keding Zhou Yuhong | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 6 |
| 4 | The origin and distribution of natural gas in the frontal uplift area of the Kuqa depression,Tarim Basin显示文摘The frontal uplift of the Kuqa depression is an important oil and gas producing area. In this study, the distribution and origin of natural gas were discussed based on natural gas components and isotope data. The main components of natural gas were hydrocarbons with relatively high contents of C2+ component. Most gases were derived from terrestrial source rocks, and some came from marine rocks. The contents of non-hydrocarbon gases were high in the central part of the frontal uplift area and low in the two terminals. The distribution of oil composition was similar to that of natural gas, which was mainly controlled by the types of source rocks. Dry coefficient and maturity of natural gas in the frontal uplift were lower than those of gas in the Kelasu tectonic belt of the Kuqa depression, which was mainly affected by the difference of tectonic movements in both areas. In the frontal uplift, the traps were formed in the early stage and could capture the early formed oil and gas, and structural adjustment was slight in later stages, so the oil and gas could be effectively preserved. Multiperiodic oil and gas filling led to the complex distribution of natural gas. | CUI Jie ZHU Guangyou ZHANG Bin SU Jin LU Yuhong MA Chenglong | 2010 | Chinese Journal Of Geochemistry2010，29，3： | 5 |
| 5 | Effects of Sc Addition and Annealing Treatment on the Microstructure and Mechanical Properties of the As-rolled Mg-3Li alloy显示文摘The microstructures and mechanical properties of the as-rolled Mg-3Li and Mg-3Li-1Sc (wt%) alloys before and after annealing treatment have been investigated. Results show that the grains are refined evidently and the recrystallization temperature is improved for more than 100°C by adding 1 wt% Sc into the Mg-3Li alloy. After complete recrystallization, both the strength and ductility of the Mg-3Li alloy are improved evidently with the addition of minor Sc. The brittle fracture tendency of Mg-3Li-1Sc alloy also reduces obviously. | Guiying Sha Xiaoguang Sun Teng Liu Yuhong Zhu Tao Yu | 2011 | Journal of Materials Science & Technology2011，27，8： | 5 |
| 6 | Boosting photocatalytic degradation of RhB via interfacial electronic effects between Fe-based ionic liquid and g-C_3N_4显示文摘The Fe-based ionic liquid doped g-C_3N_4(Fee CN) photocatalyst was firstly prepared base on ultrathin g-C_3N_4 obtained by multiple calcination method with a metal-based reactive ionic liquid [Omim]FeCl_4 for the degradation of Rhodamine B(RhB). Experimental results revealed that Fe3+species were doped into the framework of g-C_3N_4. The effect of the amount of Fe-doping on the catalytic activity was performed. The result showed that the Fee CN could effectively degrade RhB under the condition of visible light irradiation. The photocurrent analysis showed that the incorporation of Fe^(3+)into g-C_3N_4 material could accelerate the separation of the photogenerated carriers significantly.At the same time, the reactive species generated during the photodegradation process were tested by radicals trapping experiments and electron spin resonance(ESR). It was proposed that the synergistic effect of■ and ·OH contributed to degrade RhB efficiently. | Xiaowei Li Bin Wang Yuhong Huang Jun Di Jiexiang Xia Wenshuai Zhu Huaming Li | 2019 | Green Energy & Environment2019，4，2： | 4 |
| 7 | Range-angle-dependent beamforming for FDA-MIMO radar using oblique projection显示文摘Frequency diverse array(FDA)-multiple-input and multiple-output(MIMO)radar is characterized with a range-angle-dependent transceive beampattern by introducing incremental frequencies among the transmit array elements and separating the transmitted waveforms with matched filtering in the receiver.In this respect,the paper aims to control the range-angle-dependent transceive beampattern for FDA-MIMO radar by designing the weight vector according to the desired response.At the design stage,the weight vectors to control the beampattern responses of different regions are devised by performing the orthogonal decomposition technique.Then,a filtering matrix using the oblique projection operator is constructed to filter the weight vectors for different regions,where two iterative algorithms are developed either considering concurrent or successive control of multiple regions.In such a way,a desired range-angle-dependent transceive beampattern is formed with simultaneously broadened nulls and a flat-top mainlobe.At the analysis stage,the method has been applied to interference mitigation in FDA-MIMO radar,where the mismatch exists both in the sidelobes and mainlobe.Simulated and measured results are provided to corroborate the effectiveness of the proposed methods. | Lan LAN Guisheng LIAO Jingwei XU Shengqi ZHU Yuhong ZHANG | 2022 | Science China(Information Sciences)2022，65，5： | 3 |
| 8 | Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival显示文摘Genome-wide association studies have suggested a link between primary open-angle glaucoma and the function of ABCA1.ABCA1 is a key regulator of cholesterol efflux and the biogenesis of high-density lipoprotein(HDL) particles. Here, we showed that the POAG risk allele near ABCA1 attenuated ABCA1 expression in cultured cells. Consistently, POAG patients exhibited lower ABCA1 expression, reduced HDL, and higher cholesterol in white blood cells. Ablation of Abca1 in mice failed to form HDL, leading to elevated cholesterol levels in the retina. Counting retinal ganglion cells(RGCs) by using an artificial intelligence(AI) program revealed that Abca1-deficient mice progressively lost RGCs with age. Single-cell RNA sequencing(scRNA-seq) revealed aberrant oxidative phosphorylation in the Abca1-/-retina, as well as activation of the mTORC1 signaling pathway and suppression of autophagy. Treatment of Abca1-/-mice using atorvastatin reduced the cholesterol level in the retina,thereby improving metabolism and protecting RGCs from death. Collectively, we show that lower ABCA1 expression and lower HDL are risk factors for POAG. Accumulated cholesterol in the Abca1-/-retina causes profound aberrant metabolism, leading to a POAG-like phenotype that can be prevented by atorvastatin. Our findings establish statin use as a preventive treatment for POAG associated with lower ABCA1 expression. | Jialiang Yang Yuhong Chen Tongdan Zou Bai Xue Fang Yang Xiangzhou Wang Yibo Huo Boyun Yan Yuxia Xu Shiyu He Yi Yin Jing Wang Xiong Zhu Lin Zhang Yu Zhou Zhengfu Tai Ping Shuai Man Yu Qian Luo Yilian Cheng Bo Gong Xianjun Zhu Jing Zhang Xinghuai Sun Ying Lin Houbin Zhang Zhenglin Yang | 2023 | Science China(Life Sciences)2023，66，2： | 2 |
| 9 | Geochemical Characteristics of Heavy Metals in Riparian Sediment Pore Water of Songhua River, Northeast China显示文摘This study reports the geochemical characteristics of zinc (Zn), copper (Cu), lead (Pb), nickel (Ni), mercury (Hg), iron (Fe), and manganese (Mn) in the riparian sediment pore water of the Songhua River, Northeast China. In total, 36 pore water samples and 18 surface water samples from three typical sections were collected and analyzed in June 2009. Cluster analysis of heavy metals was performed to analyze the pollution sources of the metals. Results showed that Hg concentrations in the pore water were greater than those in the surface water, indicating a potential ability of Hg release from riparian sediment system to river water. However, concentrations of Fe and Mn in the surface water were greater than those in the pore water, demonstrating that the microenvironments of riparian and riverbed sediment systems were quite different. Variations of Zn, Cu, Pb and Ni between the surface and the pore water were different in each section. Most metals had similar horizontal and profile distribution characteristics in the three sections except for Zn and Ni. Hg, Fe and Mn concentrations in the pore water increased gradually with the increase in horizontal distance from water body, in contrast to this, Cu decreased, and Pb presented a fluctuating trend. With the increase in depth, Pb and Fe, Cu and Mn showed the same trends, and Hg showed a variable trend. The above distribution characteristics could mainly be attributed to the properties and the interactions of metals, pH and oxidation-reduction conditions, and the complex pollution sources and hydrologic regime in history. The probable sources of metals include the historical and ongoing discharge of industrial wastewater, mining activities, sewage irrigation for agricultural production, and atmospheric deposition from coal-fired plants. | ZHU Hui YAN Baixing PAN Xiaofen YANG Yuhong WANG Lixia | 2011 | Chinese Geographical Science2011，21，2： | 2 |
| 10 | Detection and Classification of Small Traffic Signs Based on Cascade Network显示文摘Research on the traffic sign detection is significant for driverless technology,which provides useful navigation information.Existing object detection methods are only applicable to large-size objects or small-scale specific types of traffic signs,and the performance of detecting traffic signs in street views is not adequate.In this regard,we propose a method to detect and classify small traffic signs by constructing a cascaded network.Specifically,the RetinaNet network is adopted firstly to integrate multi-layer information to identify small traffic signs in traffic scene images.The focal loss function is used to balance the biased distribution of traffic sign categories.Then,a two-class network is cascaded after the RetinaNet,which helps identify valid traffic signs from the first-stage prediction results.Experiments show that our cascaded network structure could achieve the balance of different categories of predictions and an improvement in precision and recall. | ZHANG Shufang WANG Qinyu ZHU Tong LIU Yuhong | 2021 | Chinese Journal of Electronics2021，30，4： | 2 |
| 11 | System Design and Signal Processing for Frequency Diverse Array Radar显示文摘Frequency diverse array(FDA)radar has been studied for more than 15 years and has attracted a lot of attention due to its potential advantages over the well-known phased array radar.The representative feature of FDA is range-angle-time-dependent transmit beampattern and its underlying properties are continuously revealed in the research.The formulation and exploitation of the transmit diversity with a frequency increment is the fundamental principle,which brings extra degrees-of-freedom(DOFs)in the transmit dimension.As the FDA radar carries additional information in range,it provides more flexibility in signal processing and also brings in new technical issues.This article overviews the state-of-the-art in FDA radar area and its applications,mainly based on the progress in our group.There are two main catalogs in FDA radar area,namely coherent FDA and FDA-MIMO(multiple-input multiple-output)radars.Potential applications including target parameter estimation,ambiguous clutter suppression,and deceptive jammer suppression are discussed. | Jingwei Xu Lan Lan Xiongpeng He Shengqi Zhu Cao Zeng Guisheng Liao Yuhong Zhang | 2021 | Journal of Beijing Institute of Technology2021，30，1： | 2 |
| 12 | Ecological responses of typical Antarctic marine organisms to climate change and anthropogenic impacts显示文摘To improve our understanding and ability to predict biological responses to global climate change, it is important to be able to distinguish the influences of natural forcing from anthropogenic impacts. In the ice-free areas of Antarctica, lake and terrestrial sediments that contain penguin guanos, seal excrement and other biological remains provide natural archives of ecological, geological and climatic information that range from hundreds to thousands of years old. Our review focuses on the paleoecology of typical Antarctic marine organisms(penguins, seals and Antarctic krill) and their responses to climate change and human activities over centennial and millennial timescales. Land-based seabirds and marine mammals play an important role in linking the marine and terrestrial ecosystems and act as bio-vectors, transporting large amounts of nutrients and contaminants from ocean to land. | YANG Lianjiao HUANG Tao XIE Zhouqing LIU Xiaodong ZHU Renbin CHU Zhuding WANG Yuhong SUN Liguang | 2017 | Advances in Polar Science2017，28，2： | 2 |
| 13 | Direct growth of graphene on vertically standing glass by a metal-free chemical vapor deposition method显示文摘A new method to directly grow graphene on quartz glass substrate by atmospheric-pressure chemical vapor deposition(CVD) without using any catalyst was developed. The prime feature of this method is to build a vertical-glass model in the quartz tube to significantly increase the collision probability of the carbon precursors and reactive fragments between each other with the glass surface. The growth rate of high-quality graphene on glass remarkably increases compared with the conventional gas flow CVD technique. The optical transmittance and sheet resistance of the graphene glass can be readily adjusted by regulating growth time. When growth time is 35 min, the graphene glass presents an intriguing sheet resistance of about 1.48 kΩ sq^(-1) at a transmittance of 93.08% and exhibits an excellent hydrophobic performance. The method is simple and scalable, and might stimulate various potential applications of transparent and conductive graphene glass in practical fields. | Zhongtao Chen Xinli Guo Long Zhu Long Li Yuanyuan Liu Li Zhao Weijie Zhang Jian Chen Yao Zhang Yuhong Zhao | 2018 | Journal of Materials Science & Technology2018，34，10： | 2 |
| 14 | Composite silicone rubber of high piezoresistance repeatability filled with nanoparticles显示文摘The ruthenium oxide nanoparticles with size less than 20 nm were fabricated by annealing the metallic ruthenium nanoparticles in air,which were synthesized by using the thermal reduction in the polyol solution.The rutile structure of the ruthenium oxide was proved by using transmission electron microscopy(TEM)and X-ray photoelectron spectroscopy(XPS).The oxide has good electron conductivity. The surface of the ruthenium oxide was modified by a vinyl silane coupling agent.The assembling of the silane to the oxide surface was proved by Infrared(IR)absorption spectroscopy.By mixing the nanoparticles with poly(methylvinylsiloxane)(PMVS)silicone rubber,a composite filled with dispersive conducting phase was fabricated.The temperature dependent conductivity shows that the electron transportation through composite is mainly dominated by tunneling.The measurement of piezoresistance shows that the composite at low strain has high piezoresistance repeatability.The 3D reconstruction images of the composite filled with carbon black or ruthenium oxide show that the aggregation of the nanoparticles differs much for two composites.The narrow distribution range of the particle size was thought to be the main factor for the high piezoresistance recurrence. | WU JuYing ZHOU ChengXi ZHU QingWen LI EnRong DAI Ge BA Long HUANG YuHong Mei Jun | 2009 | Science China(Technological Sciences)2009，52，12： | 1 |
| 15 | A pulse of the Earth: A 27.5-Myr underlying cycle in coordinated geological events over the last 260 Myr显示文摘We performed spectral analyses on the ages of 89 well-dated major geological events of the last 260 Myr from the recent geologic literature. These events include times of marine and non-marine extinctions,major ocean-anoxic events, continental flood-basalt eruptions, sea-level fluctuations, global pulses of intraplate magmatism, and times of changes in seafloor-spreading rates and plate reorganizations. The aggregate of all 89 events shows ten clusters in the last 260 Myr, spaced at an average interval of ~ 26.9 Myr, and Fourier analysis of the data yields a spectral peak at 27.5 Myr at the ≥96% confidence level. A shorter period of ~ 8.9 Myr may also be significant in modulating the timing of geologic events.Our results suggest that global geologic events are generally correlated, and seem to come in pulses with an underlying ~ 27.5-Myr cycle. These cyclic pulses of tectonics and climate change may be the result of geophysical processes related to the dynamics of plate tectonics and mantle plumes, or might alternatively be paced by astronomical cycles associated with the Earth’s motions in the Solar System and the Galaxy. | Michael R.Rampino Ken Caldeira Yuhong Zhu | 2021 | Geoscience Frontiers2021，12，6： | 1 |
| 16 | TLR2 and TLR4 in the Brain Injury Caused by Cerebral Ischemia and Reperfusion显示文摘 | Ying Wang Pengfei Ge Yuhong Zhu Andrew Maclean | 2013 | <journal-title>Mediators of Inflammation2013，，： | 1 |
| 17 | 显示文摘 | Zhu Zhenghou Huang Yuhong Jiang Daguo | 2009 | Journal of Wuhan University of Technology2009，24，1： | 1 |
| 18 | Combined General/Epidural Anesthesia (Ropivacaine 0.375%) Versus General Anesthesia for Upper Abdominal Surgery显示文摘 | Yuhong Li Shengmei Zhu Meijuan Yan | 2008 | Anesthesia & Analgesia2008，，5： | 1 |
| 19 | 显示文摘 | Zhu Zhenghou Huang Yuhong Jiang Daguo | 2009 | Journal of Wuhan university of Technology2009，24，1： | 1 |
| 20 | Formation of coke in thermal cracking of jet fuel under supercritical conditions显示文摘 | Zhu Yuhong Yu Caixiang Li Zimu | 2008 | Frontiers of Chemical Engineering in China2008，2，1： | 1 |
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