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| 1 | Beyond tumorigenesis: cancer stem cells in metastasis显示文摘在肿瘤开始的癌症干细胞(CSC ) 的重要性坚定地在白血病被建立了并且最近为许多稳固的肿瘤报导了。然而,特别地关于转移,在多级式的癌症前进的 CSC 的角色有不定义 beenwell。癌症转移要求在远机关播种和 specializedCSCs 的成功的殖民。正常干细胞和 CSC 的生物学分享显著类似并且当适用于癌症的学习时,可以有重要含意转移。而且,重叠分子和小径的集合最近被识别了调整干细胞移植和癌症转移。这些分子组成两个都为移植 CSC 由主要肿瘤和养育的机关微型环境的形成便于转移前壁龛的开始的细胞的相互作用的一个复杂网络。在这评论,我们在这个动态领域里调查了最近的进展并且建议 CSC 在 tumorigenesis 和转移在假定一个中央角色的癌症前进的一个统一模型。更好作为变形串联的一个基本部件理解 ofCSCs 将对变形癌症导致新奇治疗学的策略。 | Feng Li Benjamin Tiede Joan Massague Yibin Kang | 2007 | Cell Research2007，17，1： | 85 |
| 2 | Chinese medicines for prevention and treatment of human hepatocellular carcinoma: current progress on pharmacological actions and mechanisms显示文摘Hepatocellular carcinoma(HCC) is one of leading causes of death in the world. Although various treatments have been developed, the therapeutic side effects are far from desirable. Chinese medicines(CMs, including plants, animal parts and minerals) have drawn a great deal of attention in recent years for their potential in the treatment of HCC. Most studies have shown that CMs may be able to retard HCC progression with multiple actions, either alone or in combination with other conventional therapies to improve quality of life in HCC patients. Additionally, CMs are used for preventing HCC occurrence. The aim of this study is to review the potential prophylactic and curative effects of CMs on human HCC and the possible mechanisms that underlie these pharmacological actions. Publications were collected and reviewed from Pub Med and China National Knowledge Infrastructure from 2000 to 2014. Keywords for literature searches include 'Chinese medicine', 'Chinese herb', 'traditional Chinese Medicine', 'hepatocellular carcinoma' and 'liver cancer'. CMs in forms of pure compounds, isolated fractions, and composite formulas are included. Combination therapies are also considered. Both in vitro and in vivo efficacies of CMs are being discussed and the translational potential to bedside is to be discussed with clinical cases, which show the actions of CMs on HCC may include tumor growth inhibition, antimetastatic activities, anti-inflammation, anti-liver cancer stem cells, reversal on multi-drug resistance and induction/reduction of oxidative stress. Multiple types of molecules are found to contribute in the above actions. The review paper indicated that CMs might have potential to both prevent HCC occurrence and retard HCC progression with several molecular targets involved. | Xuanbin Wang Ning Wang Fan Cheung Lixing Lao Charlie Li Yibin Feng | 2015 | Journal of Integrative Medicine2015，13，3： | 33 |
| 3 | G-CSF is a key modulator of MDSC and could be a potential therapeutic target in colitis-associated colorectal cancers显示文摘Granulocyte 刺激殖民地的因素(G-CSF ) 是嗜中性的 trafficking 的一个必要管理者并且高度在多重肿瘤被表示。Myeloid 导出 suppressor 房间(MDSC ) 由有免疫力的抑制通过多重机制支持肿瘤的前进。尽管有在结肠癌前进的 G-CSF 功能的调查结果, MDSC 规定上的 G-CSF 和它肿瘤生长上的封锁效果的精确机制仍然是调查的一个相称的区域。在这研究,我们在一只老鼠观察了 G-CSF 的 overexpression 联系大肠炎的癌症(CAC ) 当模特儿,它与在老鼠结肠纸巾的 MDSC 的累积一致。进一步,在 vitro,研究证明 G-CSF 能通过信号变换器和表明小径的抄写 3 的使活跃之物(STAT3 ) 支持 MDSC 幸存和激活。而且与适应于不同地区生活的动物控制相比, anti-G-CSF mAb 治疗表明了减少的 MDSC 累积,它在鼠标在瘤尺寸和数字导致了显著减少。我们的结果显示 G-CSF 是在迁居,增长和 MDSC 的功能维护的一个批评调整分子,它能是为联系大肠炎的癌症的一个潜在的治疗学的目标。 | Wenbin Li Xinghua Zhang Yongkang Chen Yibin Xie Jiancheng Liu Qiang Feng Yi Wang Wei Yuan Jie Ma | 2016 | Protein & Cell2016，7，2： | 29 |
| 4 | Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in China显示文摘Background and purpose:5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke(AIS)due to large vessel occlusion of the anterior circulation.This study aims to evaluate the safety and efficacy of Solitaire thrombectomy in patients with moderate-to-severe stroke in the Chinese population,which has a high prevalence of intracranial atherosclerosis.Methods and analysis:This multicentre prospective control study will involve 17 stroke centres in China,and plans to recruit 150 patients in the intervention group,and 150 patients in the medical group,in which patients meet enrolment criteria but refuse intervention.Patients with AIS due to large vessel occlusion indicated for treatment with Solitaire stent retriever within 12 hours of symptom onset,and who meet the inclusion and exclusion criteria,will be enrolled in this study.The primary efficacy endpoint is functional independence as defined by a modified Rankin Scale(mRS)score≤2 at 90 days or by functional improvement as defined by mRS,using shift analysis.The procedural efficacy endpoint is arterial recanalisation of the occluded target vessel measured by a modified Thrombolysis in Cerebral Infarction(mTICI)score equal or superior to 2b right following the use of the study device.The primary safety endpoint is symptomatic intracranial haemorrhage(sICH)within 24±3 hours postprocedure.Ethics and dissemination:The protocol was approved by the Ethics Committee at the coordinating centre and by the local Institutional Review Board of each participating centre.Trial registration number:NCT02350283. | Zhongrong Miao Xiaochuan Huo Feng Gao Xiaoling Liao Chunjuan Wang Ya Peng Yibin Cao Shengli Chen Meng Zhang Changchun Jiang Xiaoxiang Peng Cunfeng Song Liping Wei Qiyi Zhu Zaiyu Guo Li Liu Hang Lin Hua Yang Wei Wu Hui Liang Anding Xu Kangning Chen Xingquan Zhao Yuesong Pan Hao Li Liping Liu Yilong Wang Yongjun Wang EAST investigators | 2016 | Stroke & Vascular Neurology2016，1，2： | 8 |
| 5 | In vitro Study on a New High Nitrogen Nickel-free Austenitic Stainless Steel for Coronary Stents显示文摘Most commercialized coronary stents are made of 316L stainless steels due to its good combination of properties,and currently some new stents are made of cobalt-based alloy owing to its higher mechanical properties. However,the presence of high quantity of nickel and/or cobalt elements in these materials,which are known to trigger the toxic and allergic responses,has caused many concerns.Nickel-free austenitic stainless steels have been developed in order to solve these problems.In this paper,based on the development of a new Fe-Cr-Mn-Mo-N type high nitrogen nickel-free austenitic stainless steel,properties such as mechanical property,corrosion resistance in Hank s solution,and in vitro blood compatibility including the kinetic clotting time and the platelets adhesion,were investigated in comparison to the above two conventional materials,a 316L stainless steel and a Co-28Cr-6Mo alloy.The results showed that the new high nitrogen steel possessed better combination of mechanical properties,corrosion resistance and blood compatibility than those of 316L steel and the Co-28Cr-6Mo alloy,and can be a promising alternative material for manufacture of coronary stents. | Yibin Ren Peng Wan Feng Liu Bingchun Zhang Ke Yang | 2011 | Journal of Materials Science & Technology2011，27，4： | 6 |
| 6 | A hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier ocular drug delivery platform显示文摘The objective of this study was to develop a novel hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier(NLC) drug delivery platform. An ophthalmic antiinflammatory drug, baicalin(BN) was chosen as the model drug. BN –NLC was prepared using melt-emulsification combined with ultra-sonication technique. Additionally, a dual pH-and thermo-sensitive hydrogel composed of carboxymethyl chitosan(CMCS) and poloxamer 407(F127) was fabricated by a cross-linking reaction with a nontoxic crosslinker genipin(GP). GP-CMCS/F127 hydrogel was characterized by FTIR, NMR, XRD and SEM. The swelling studies showed GP-CMCS/F127 hydrogel was both pH-and thermo-sensitive. The results of in vitro release suggested BN –NLC gel can prolong the release of baicalin comparing with BN eye drops and BN –NLC. Ex vivo cornea permeation study was evaluated using Franz diffusion cells. The apparent permeability coefficient(Papp) of BN –NLC gel was much higher(4.46-fold) than that of BN eye drops. Through the determination of corneal hydration levels, BN –NLC gel was confirmed that had no significant irritation to cornea. Ex vivo precorneal retention experiments were carried out by a flow-through approach. The results indicated that the NLC-based hydrogel can prolong precorneal residence time. In conclusion, the hybrid NLCbased hydrogel has a promising potential for application in ocular drug delivery. | Yibin Yu Ruoxi Feng Jinyu Li Yuanyuan Wang Yiming Song Guoxin Tan Dandan Liu Wei Liu Xinggang Yang Hao Pan Sanming Li | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，4： | 3 |
| 7 | Engineering three-layer core–shell S-1/TS-1@dendritic-SiO_(2) supported Au catalysts towards improved performance for propene epoxidation with H_(2) and O_(2)显示文摘The advocacy of green chemical industry has led to the development of highly efficient catalysts for direct gas-phase propene epoxidation with green,sustainable and simple essence.The S-1/TS-1@dendritic-SiO_(2) material with three-layer core–shell structure was developed and used as the support for Au catalysts,which showed simultaneously fantastic PO formation rate,PO selectivity and stability(over 100 h)for propene epoxidation with H_(2) and O_(2).It is found that silicalite-1(S-1)core and the middle thin layer of TS-1 offer great mass transfer ability,which could be responsible for the excellent stability.The designed dendritic SiO_(2) shell covers part of the acid sites on the external surface of TS-1,inhibiting the side reactions and improving the PO selectivity.Furthermore,three kinds of SiO_(2) shell morphologies(i.e.,dendritic,net,mesoporous shell)were designed,and relationship between shell morphology and catalytic performance was elucidated.The results in this paper harbour tremendous guiding significance for the design of highly efficient epoxidation catalysts. | Zhaoning Song Juncong Yuan Zhenping Cai Dong Lin Xiang Feng Nan Sheng Yibin Liu Xiaobo Chen Xin Jin De Chen Chaohe Yang | 2020 | Green Energy & Environment2020，5，4： | 3 |
| 8 | Techno-Economic Analysis and Life Cycle Assessment for the Typical Intermediate Crude Refining Scheme in China显示文摘The integration of refinery and petrochemical units(IRPUs)has become an inevitable choice for the sustainable development of petrochemical industry.The utilization efficiency of petroleum resources could be improved obviously through IRPUs.However,integrating economic and environmental impacts into the model of IRPUs is still a grand challenge.Herein,a model called TEA-GHG-OPWM(Techno-Economic Analysis and GreenHouse Gases Oriented Plant-Wide Model)has been established on Aspen HYSYSTM platform to calculate the energy consumption,the technoeconomic performance,and the GHG emissions for two different kinds of schemes,viz,:VRHCU(Vacuum Residue Hydrocracking Unit)and VRDS-RFCC(Vacuum Residue Desulfurization and Residue Fluid Catalytic Cracking).Furthermore,a novel processing pathway named VGOHDT-HTMP-DC(Vacuum Gas Oil Hydrotreating,Hydrogenation and TMP coupling process and Delayed Coking)has also been developed to find methods to improve the economic performance based on a ten-million-CNY output value(TMYOV)and a reduced GHG emissions.Our results demonstrate that VRHCRU could consume more energy and emit more GHG(877.11 t of CO2 eq·TMYOV^-1·h^-1)than VRDS-RFCC(817.03 t of CO2 eq·TMYOV^-1·h^-1)and VGOHDT-HTMP-DC(721.96 t of CO2 eq·TMYOV^-1·h^-1),while obtaining a higher mass yield of petrochemicals.The VGOHDT-HTMP-DC process exhibits the lowest feedstock consumption,hydrogen consumption,energy consumption,and GHG emissions,indicating that VGOHDT-HTMP-DC has both well economic and environmentally friendly performance. | Zhou Xin Yan Hao Feng Xiang Zhao Hui Liu Yibin Chen Xiaobo Yang Chaohe | 2020 | China Petroleum Processing & Petrochemical Technology2020，22，4： | 2 |
| 9 | Deciphering suppressive effects of Lianhua Qingwen Capsule on COVID-19 and synergistic effects of its major botanical drug pairs显示文摘The COVID-19 pandemic has resulted in excess deaths worldwide.Conventional antiviral medicines have been used to relieve the symptoms,with limited therapeutic effect.In contrast,Lianhua Qingwen Capsule is reported to exert remarkable anti-COVID-19 effect.The current review aims to:1)uncover the main pharmacological actions of Lianhua Qingwen Capsule for managing COVID-19;2)verify the bioactive ingredients and pharmacological actions of Lianhua Qingwen Capsule by network analysis;3)investigate the compatibility effect of major botanical drug pairs in Lianhua Qingwen Capsule;and 4)clarify the clinical evidence and safety of the combined therapy of Lianhua Qingwen Capsule and conventional drugs.Numerous bioactive ingredients in Lianhu Qingwen,such as quercetin,naringenin,β-sitosterol,luteolin,and stigmasterol,were identified to target host cytokines,and to regulate the immune defence in response to COVID-19.Genes including androgen receptor(AR),myeloperoxidase(MPO),epidermal growth factor receptor(EGFR),insulin(INS),and aryl hydrocarbon receptor(AHR)were found to be significantly involved in the pharmacological actions of Lianhua Qingwen Capsule against COVID-19.Four botanical drug pairs in Lianhua Qingwen Capsule were shown to have synergistic effect for the treatment of COVID-19.Clinical studies demonstrated the medicinal effect of the combined use of Lianhua Qingwen Capsule and conventional drugs against COVID-19.In conclusion,the four main pharmacological mechanisms of Lianhua Qingwen Capsule for managing COVID-19 are revealed.Therapeutic effect has been noted against COVID-19 in Lianhua Qingwen Capsule. | CHEN Yuanyuan ZHANG Cheng WANG Ning FENG Yibin | 2023 | Chinese Journal of Natural Medicines2023，21，5： | 2 |
| 10 | PIWIL1 governs the crosstalk of cancer cell metabolism and immunosuppressive microenvironment in hepatocellular carcinoma显示文摘Altered energy metabolism of cancer cells shapes the immune cell response in the tumor microenvironment that faclitates tumorprogression.Herein,we reported the novel of tumor cell-expressed Piwi Like RNA-Mediated Gene Silencing 1(PWL1)in mediatingthe crosstlk of fatty acid metabolism and immune response of human hepatocellular carcinoma(HCC).PlWIL1 expression in HCCwas increased compared to normal hepatic tissues and was positively correlated with the proliferation rate of HCC cell ines.PIWL1overexpression accelerated in vitro proliferation and in vivo growth of HCC tumors,while PIWL1 knockdown showed opositeeffects.PIWL1 increased oxygen consumption and energy production via fatty acid metabolism without altering aerobic glycolysis.lnhibition of fatty acid metablism abolished PWIL1-induced HCC prolferation and growth.RNA-seq analysis revealed that immunesystem regulation might be involved,which was echoed by the experimental observation that PIWL1-overexpressing HCC cellsattracted myeloid-derived suppressor cells(MDSCs)into the tumor microenvironment.MDSCs depletion reduced the prolferationand growth of PlWIL1-overexpressing HCC tumors.Complement C3,whose secretion was induced by PIWL1 in HCC cells,mediatesthe interaction of HCC cells with MDSCs by activated p38 MAPK signaling in MDSCs,which in turn initiated expression of immunosuppressive cytokine L10.Neutralizing lL10 secretion reduced the immunosuppressive activity of MDSCs in the microenvironment of PIWL1-overexpressing HCC.Taken together,our study unraveled the critical role of PIWL1 in initiating theinteraction of cancer cell metabolism and immune cell response in HCC.Tumor cell-expressed PlIWL1 may be a potential target forthe devellopment of novel HCC treatment. | Ning Wang Hor-Yue Tan Yuanjun Lu Yau-Tuen Chan Di Wang Wei Guo Yu Xu Cheng Zhang Feiyu Chen Guoyi Tang Yibin Feng | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 2 |
| 11 | A novel red phosphor NaLa 4 (SiO 4 ) 3 F: Eu 3+显示文摘 | Guo Feng Weihui Jiang Yibin Chen Renjie Zeng | 2010 | Materials Letters2010，，1： | 1 |
| 12 | Treatment effect of Bushen Huayu extract on postmenopausal osteoporosisin vivo显示文摘 | Lu Ouyang Qiufang Zhang Xuzhi Ruan Yibin Feng Xuanbin Wang | 2014 | Experimental and Therapeutic Medicine2014，，6： | 1 |
| 13 | Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis显示文摘Tumor microenvironment contributes to poor prognosis of pancreatic adenocarcinoma(PAAD)patients.Proper regulation could improve survival.Melatonin is an endogenous hormone that delivers multiple bioactivities.Here we showed that pancreatic melatonin level is associated with patients'survival.In PAAD mice models,melatonin supplementation suppressed tumor growth,while blockade of melatonin pathway exacerbated tumor progression.This anti-tumor effect was independent of cytotoxicity but associated with tumor-associated neutrophils(TANs),and TANs depletion reversed effects of melatonin.Melatonin induced TANs infiltration and activation,therefore induced cell apoptosis of PAAD cells.Cytokine arrays revealed that melatonin had minimal impact on neutrophils but induced secretion of Cxcl2 from tumor cells.Knockdown of Cxcl2 in tumor cells abolished neutrophil migration and activation.Melatonin-induced neutrophils presented an N1-like anti-tumor phenotype,with increased neutrophil extracellular traps(NETs)causing tumor cell apoptosis through cell-to-cell contact.Proteomics analysis revealed that this reactive oxygen species(ROS)-mediated inhibition was fueled by fatty acid oxidation(FAO)in neutrophils,while FAO inhibitor abolished the anti-tumor effect.Analysis of PAAD patient specimens revealed that CXCL2 expression was associated with neutrophil infiltration.CXCL2,or TANs,combined with NET marker,can better predict patients'prognosis.Collectively,we discovered an anti-tumor mechanism of melatonin through recruiting N1-neutrophils and beneficial NET formation. | Yau-tuen Chan Hor-yue Tan Yuanjun Lu Cheng Zhang Chien-shan Cheng Junyu Wu Ning Wang Yibin Feng | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 1 |
| 14 | Enhancing the dynamic electron transfer of Au species on wormhole-like TS-1 for boosting propene epoxidation performance with H_(2) and O_(2)显示文摘Engineering unique electronic structure of catalyst to boost catalytic performance is of prime scientific and industrial importance.Herein,the identification of intrinsic electronic sensitivity for direct propene epoxidation was first achieved over highly stable Au/wormhole-like TS-1 catalyst.Results show that the electron transfer of Au species can be regulated by manipulating the dynamic evolutions and contents of Au valence states,thus resulting in different catalytic performance in 100 h time-on-stream.By DFT calculations,kinetic analysis and multicharacterizations,it is found that the Au^(0) species with higher electronic population can easily transfer more electrons to activate surface O_(2) compared with Au^(1+) and Au^(3+) species.Moreover,there is a positive correlation between Au^(0) content and activity.Based on this correlation,a facile strategy is further proposed to boost Au^(0) percentage,resulting in the reported highest PO formation rate without adding promoters.This work harbors tremendous guiding significance to the design of highly efficient Au/Ti-containing catalyst for propene epoxidation with H_(2) and O_(2). | Dong Lin Xiuhui Zheng Xiang Feng Nan Sheng Zhaoning Song Yibin Liu Xiaobo Chen Zhenping Cai De Chen Chaohe Yang | 2020 | Green Energy & Environment2020，5，4： | 1 |
| 15 | Chinese medicines as a resource for liver fibrosis treatment显示文摘 | YIBIN FENG KWOK-FAN CHEUNG | 2009 | Chinese Medi- cine2009，4，6： | 1 |
| 16 | Auto-focus based on skindetection显示文摘 | Tian Yibin Xu Zhihai Feng Huajun | 2003 | Acta Photonica Sinica2003，320，： | 1 |
| 17 | Chinese integrative medicine:inclusion of a Chinese medicine programme in a conventional medical institute显示文摘To meet community demands with optimal Chinese and conventional medical treatment, the University of Hong Kong is promoting integrative medicine by developing Chinese medicine programmes that train students of both Western and Chinese medicine.The programmes emphasize multi-disciplinary training and interaction between the two therapeutic approaches, enabling students to establish reliable, consistent, and respectful mutual cooperation in their future careers. | Hai-Yong Chen Yibin Feng Lixing Lao | 2014 | Journal of Integrative Medicine2014，12，3： | 1 |
| 18 | MTDH Activation by 8q22 Genomic Gain Promotes Chemoresistance and Metastasis of Poor-Prognosis Breast Cancer显示文摘 | Guohong Hu Robert A. Chong Qifeng Yang Yong Wei Mario A. Blanco Feng Li Michael Reiss Jessie L.-S. Au Bruce G. Haffty Yibin Kang | 2009 | Cancer Cell2009，，1： | 1 |
| 19 | Berberine-induced tumor suppressor p53 up-regulation gets involved in the regulatory network of MIR-23a in hepatocellular carcinoma显示文摘 | Ning Wang Meifen Zhu Xuanbin Wang Hor-Yue Tan Sai-wah Tsao Yibin Feng | 2014 | BBA - Gene Regulatory Mechanisms2014，，： | 1 |
| 20 | Recent progress on anti-liver fibrosis candidates in patents of herbal medicinal prod- ucts显示文摘 | Wang Xuanbin Feng Yibin Wang Ning | 2012 | Recent Pat Food Nutr Agric2012，4，： | 1 |
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