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| 1 | Evaluation of miR-122-regulated suicide gene therapy for hepatocellular carcinoma in an orthotopic mouse model显示文摘Objective:Intratumoral administration of adenoviral vector encoding herpes simplex virus(HSV)thymidine kinase(TK)gene(Ad-TK)followed by systemic ganciclovir(GCV)is an effective approach in treating experimental hepatocellular carcinoma(HCC).However,hepatotoxicity due to unwanted vector spread and suicide gene expression limited the application of this therapy.miR-122 is an abundant,liver-specific microRNA whose expression is decreased in human primary HCC and HCC-derived cell lines.These different expression profiles provide an opportunity to induce tumor-specific gene expression by miR-122 regulation.Methods:By inserting miR-122 target sequences(miR-122T)in the 3'untranslated region(UTR)of TK gene,we constructed adenovirus(Ad)vectors expressing miR-122-regulated TK(Ad-TK-122T)and report genes.After intratumoral administration of Ad vectors into an orthotopic miR-122-deficient HCC mouse model,we observed the miR-122-regulated transgene expression and assessed the antitumor activity and safety of Ad-TK-122T.Results:Insertion of miR-122T specifically down-regulated transgene expression in vitro and selectively protected the miR-122-positive cells from killing by TK/GCV treatment.Insertion of miR-122T led to significant reduction of tansgene expression in the liver without inhibition of its expression in tumors in vivo,resulting in an 11-fold improvement of tumor-specific transgene expression.Intratumoral injection of Ad vectors mediated TK/GCV system led to a vector dosage-dependent regression of tumor.The insertion of miR-122T does not influence the antitumor effects of suicide gene therapy.Whereas mice administrated with Ad-TK showed severe lethal hepatotoxicity at the effective therapeutic dose,no liver damage was found in Ad-TK-122T group.Conclusions:miR-122-regulated TK expression achieved effective anti-tumor effects and increased the safety of intratumoral delivery of adenovirus-mediated TK/GCV gene therapy for miR-122-deficient HCC. | Gang Wang Xiaoyan Dong Wenhong Tian Yue Lu Jianyan Hu Yunfan Liu Jie Yuchi Xiaobing Wu | 2013 | Chinese Journal of Cancer Research2013，25，6： | 5 |
| 2 | Microstructure and composition engineering Yb single-filled CoSb_(3) for high thermoelectric and mechanical performances显示文摘A broad tunability of the thermoelectric and mechanical properties of CoSb_(3) has been demonstrated by adjusting the composition with the addition of an increasing number of elements.However,such a strategy may negatively impact processing repeatability and composition control.In this work,singleelement-filled skutterudite is engineered to have high thermoelectric and mechanical performances.Increased Yb filling fraction is found to increase phonon scattering,whereas cryogenic grinding contributes additional microstructural scattering.A peak zT of 1.55 and an average zT of about 1.09,which is comparable to the reported results of multiple-filled SKDs,are realized by the combination of simple composition and microstructure engineering.Furthermore,the mechanical properties of Yb single-filled CoSb_(3) skutterudite are improved by manipulation of the microstructure through cryogenic grinding.These findings highlight the realistic prospect of producing high-performance thermoelectric materials with reduced compositional complexity. | Zhenxing Zhou Matthias T.Agne Qihao Zhang Shun Wan Qingfeng Song Qing Xu Xiaofang Lu Shijia Gu Yuchi Fan Wan Jiang Gerald Jeffrey Snyder Lianjun Wang | 2019 | Journal of Materiomics2019，5，4： | 4 |
| 3 | Enhanced TE properties of Cu@Ag/Bi2Te3 nanocomposites by decoupling electrical and thermal properties显示文摘Cu@Ag/Bi2Te3 nanocomposites were prepared for the first time by ultrasonic dispersion-rapid freezedrying method combined with spark plasma sintering(SPS).By changing the content of Cu@Ag nanoparticle,we could modulate the temperature dependent thermoelectric properties.The highest ZT value can be obtained at 450 K for 1 vol%Cu@Ag/Bi2Te3,which is benefited from the decoupling of electrical and thermal properties.With the increase of electrical conductivity,the absolute value of Seebeck coefficient lifts while the thermal conductivity declines.Meanwhile,the average ZT value between 300 K and 475 K was 0.61 for 1 vol%Cu@Ag/Bi2Te3,which is much higher than that of pristine Bi2 Te3.Therefore,the decoupling effect of Cu@Ag nanoparticles incorporation could be a promising method to broaden the application of Bi2Te3 based thermoelectric materials. | Xiaofang Lu Qi Zheng Shijia Gu Rui Guo Li Su Jiancheng Wang Zhenxing Zhou Yuchi Fan Wan Jiang Lianjun Wang | 2020 | Chinese Chemical Letters2020，31，3： | 1 |
| 4 | New interpretation on the provenance changes of the upper Pinghu–lower Huagang Formation within Xihu Depression,East China Sea Shelf Basin显示文摘Both Pinghu and Huagang formations are important hydrocarbon reservoirs of the Xihu Depression in the East China Sea Shelf Basin.Clarifying the source suppliers and restoring source-to-sink transport routes are of great significance to the future petroleum and gas undertakings.Previous researchers were largely confined by either limitation of geological records,highly dependence on a singular method or low-precision dating techniques.Our study integrated heavy mineral assemblages,geochemical analyses and detrital zircon U-Pb dating to reconstruct multiple source-to-sink pathways,and to provide a better understanding on the provenance evolution for the upper Pinghu–lower Huagang depositions of the Xihu Depression.At least three major provenances have been confirmed and systematically investigated for their separate compositional features.The Hupijiao Uplift(or even farther northern area)was dominated by a major Paleoproterozoic population peaked at ca.1830 Ma along with minor Mesozoic clusters.The Haijiao Uplift to the west and the Yushan Low Uplift to the southwest,on the other hand,generate opposite U-Pb age spectra with apparently larger peaks of Indosinian and Yanshanian-aged zircons.To be noted,both Indosinian and Paleoproterozoic peaks are almost identical in proportion for the Haijiao Uplift.The overall sedimentary pattern of late Eocene-early Oligocene was featured by both spatial and temporal distinction.The Hupijiao Uplift was likely to cast limited impact during the late Eocene,whereas the broad southern Xihu Depression was transported by a large abundance of materials from the nearby Haijiao and Yushan Low Uplifts.The northern source substantially extended its influence to the farther south during the early Oligocene by delivering plentiful sediments of higher-degree metamorphic parent rocks.Combined with the proximal western and southwestern suppliers,the overall Xihu Depression was under control from both distant and local provenances. | Jinshui Liu Shuai Li Kaifei Liao Yuchi Cui Lei Shao Peijun Qiao Yi Lu Yuanli Hou Thian Lai Goh Yongjian Yao | 2023 | Acta Oceanologica Sinica2023，42，3： | 1 |
| 5 | An Investigation Report on Production Conditions of Sugarcane in Guangxi in 2016显示文摘To predict and assess production conditions of sugarcane in Guangxi in 2016,by using methods of field survey and data collection,the seedling situation,breed structure,planting area,planting period,plant diseases and insect pests of sugarcane in six major sugarcane producing cities of Guangxi were surveyed. The results show that the overall situation of sugarcane seedlings in Guangxi in 2016 became slightly worse than that in 2015,but there were enough good sugarcane seedlings in 2016. The dead heart rate of sugarcane decreased in most sugarcane regions from 2015 to 2016,that is,the comprehensive control of borers gave initial results; the smut infection rate of sugarcane rose from 2015 to 2016 and tended to increase. The situation of decrease in the planting area of sugarcane in three consecutive years was controlled,and the planting area of sugarcane increased slightly from 2015 to 2016. Due to the construction of ' double high' bases,the breed variety of sugarcane in Guangxi was improved further in 2016. It is necessary to strengthen field management and conduct chemical weeding,prevention and control of borers and aphids in the later period in time. | Yuchi DENG Weizan WANG RonghuaZHANG Shiyun TANG Shanhai LIN Qiang LIANG Weixing DUAN Xiang LI Guoying LU Shijian HAN Youzong HUANG Yebin YANG Yanni HUANG Lunwang WANG | 2017 | Asian Agricultural Research2017，9，6： | 0 |
| 6 | A Survey Report on Sugarcane Production in Guangxi Zhuang Autonomous Region in 2013显示文摘In order to fully understand sugarcane production in Guangxi in 2013,the sample survey combined with data collection and field survey was carried out in sugarcane production areas in Nanning,Hechi,Liuzhou,Chongzuo,Baise and Laibin from May 28 to June 36 in2013. It was found that the sugarcane growing area in Guangxi in 2013 declined compared with that in 2012; the rate of emergence remained the same as previous year,and as for the plant number of plant crop and ratoon crop per hectare,there was a decline of 4000 and 2000 seedlings respectively compared with the figure in 2012; borer damage rate declined on the whole while the incidence of sugarcane smut increased.Due to the growth in the cost of planting,the growers were less enthusiastic for management. According to the findings,the fertilization and sugarcane field management should be accelerated; borer prevention work was also required,so as to reduce borer damage and dieback rate;the planting structure of varieties had to be adjusted and the cultivated area of ' Guitang' as a fine sugarcane variety should also be enlarged;meanwhile other active measures needed to be taken to prevent and control the outburst of pest attack in local areas. | Xiang LI Yangrui LI Yuchi DENG Lunwang WANG Liu YANG Weihua HUANG Qiang LIANG Ronghua ZHANG Guoying LU Shijian HAN Pingwu LIU Changning LI Cuifang YANG | 2014 | Asian Agricultural Research2014，6，12： | 0 |
| 7 | Commissioning experiment of the high-contrast SILEX-Ⅱ multi-petawatt laser facility显示文摘The results of a commissioning experiment on the SILEX-Ⅱlaser facility(formerly known as CAEP-PW)are reported.SILEX-Ⅱis a complete optical parametric chirped-pulse amplification laser facility.The peak power reached about 1 PWin a 30 fs pulse duration during the experiment.The laser contrast was better than 1010 at 20 ps ahead of the main pulse.In the basic laser foil target interaction,a set of experimental data were collected,including spatially resolved x-ray emission,the image of the coherent transition radiation,the harmonic spectra in the direction of reflection,the energy spectra and beam profile of accelerated protons,hot-electron spectra,and transmitted laser energy fraction and spatial distribution.The experimental results show that the laser intensity reached 531020 W/cm^(2) within a 5.8μm focus(FWHM).Significant laser transmission did not occur when the thickness of theCHfoil was equal to or greater than 50 nm.The maximum energy of the accelerated protons in the target normal direction was roughly unchanged when the target thickness varied between 50 nm and 15μm.The maximum proton energy via the target normal sheath field acceleration mechanism was about 21 MeV.We expect the on-target laser intensity to reach 10^(22) W/cm^(2) in the near future,after optimization of the laser focus and upgrade of the laser power to 3 PW. | Wei Hong Shukai He Jian Teng Zhigang Deng Zhimeng Zhang Feng Lu Bo Zhang Bin Zhu Zenghai Dai Bo Cui Yuchi Wu Dongxiao Liu Wei Qi Jinlong Jiao Faqiang Zhang Zuhua Yang Feng Zhang Bi Bi Xiaoming Zeng Kainan Zhou Yanlei Zuo Xiaojun Huang Na Xie Yi Guo Jingqin Su Dan Han Ying Mao Leifeng Cao Weimin Zhou Yuqiu Gu Feng Jing Baohan Zhang Hongbo Cai Minqing He Wudi Zheng Shaoping Zhu Wenjun Ma Dahui Wang Yinren Shou Xueqing Yan Bin Qiao Yi Zhang Congling Zhong Xiaohui Yuan and Wenqing Wei | 2021 | Matter and Radiation at Extremes2021，6，6： | 0 |
| 8 | Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity显示文摘Dear Editor,In the nematode Caenorhabditis elegans,the systemic RNA interference defective protein 1(SID-1)plays a crucial role in systemic RNA interference(RNAi)by facilitating the transport of exogenous double-stranded RNA(dsRNA)into the cytoplasm.^(1)Human SIDT1 and SIDT2 are closely related members of the SID-1 transmembrane family,and have been implicated in various biological processes such as glucose and lipid metabolism,innate immunity,and tumorigenesis. | Le Zheng Tingting Yang Hangtian Guo Chen Qi Yuchi Lu Haonan Xiao Yan Gao Yue Liu Yixuan Yang Mengru Zhou Henry CNguyen Yun Zhu Fei Sun Chen-Yu Zhang Xiaoyun Ji | 2024 | Cell Research2024，34，1： | 0 |
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