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| 1 | Review to better understand the macroscopic subtypes and histogenesis of intrahepatic cholangiocarcinoma显示文摘Intrahepatic cholangiocarcinoma is macroscopically classified into three subtypes, mass-forming-type, periductal infiltrating-type, and intraductal growth-type. Each subtype should be preoperatively differentiated to perform the valid surgical resection. Recent researches have revealed the clinical, radiologic, pathobiological characteristics of each subtype. We reviewed recently published studies covering various aspects of intrahepatic cholangiocarcinoma(ICC), focusing especially on the macroscopic subtypes and stem cell features to better understand the pathophysiology of ICC and to establish the valid therapeutic strategy. | Yuichi Sanada Yujo Kawashita Satomi Okada Takashi Azuma Shigetoshi Matsuo | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 3 |
| 2 | Ongoing myocardial damage relates to cardiac sympathetic nervous disintegrity in patients with heart failure显示文摘 | Takanori Arimoto Yasuchika Takeishi Takeshi Niizeki YO Koyama Hidenobu Okuyama Naoki Nozaki Osamu Hirono Yuichi Tsunoda Takehiko Miyashita Tetsuro Shishido Akio Okada Kazuei Takahasm Isao Kubota | 2005 | Annals of Nuclear Medicine2005，，7： | 1 |
| 3 | Evaluation of cych life performance of ralve-regulated had-acid battery 'GRE100-12' for grid-connected photovoltaic power gengration systems显示文摘 | Masaji Adachi Yuichi Okada Masaaki Shiomi | 1998 | GS News Technical Report1998，57，1： | 1 |
| 4 | ,Evaluation of Cycle Life Performanceof valve-regulated Lead-acid Battery 'GRE100-12' forGrid-connected PhotovoltaicPower GenerationSystems显示文摘 | Masaji Adah Yuichi Okada Masaaki Shiomi | 1998 | GS News Technical Report1998，57，1： | 1 |
| 5 | Efficacy and safety of endoscopic submucosal dissection under general anesthesia显示文摘AIM: To evaluate the efficacy and safety of endoscopic submucosal dissection(ESD) under general anesthesia.METHODS: From January 2011 to July 2014, 206 consecutive patients had undergone ESD under general anesthesia for neoplasms of the stomach, esophagus, and colorectum were enrolled in this retrospective study. The efficacy and safety of ESD under general anesthesia were assessed.RESULTS: The en bloc resection rate of esophageal, gastric, and colorectal lesions was 100.0%, 98.3%, and 96.1%, respectively. The complication rate of perforationand bleeding were 0.0% and 0.0% in esophageal ESD, 1.7% and 1.7% in gastric ESD, and 3.9% and 2.0% in colorectal ESD, respectively. No cases of aspiration pneumonia were observed. All complications were managed by conservative treatment, with no surgical intervention required.CONCLUSION: With the cooperation of an anesthesiologist, ESD under general anesthesia appears to be a useful method, decreasing the risk of complications. | Kanefumi Yamashita Hironari Shiwaku Toshihiro Ohmiya Hideki Shimaoka Hiroki Okada Ryo Nakashima Richiko Beppu Daisuke Kato Takamitsu Sasaki Seiichiro Hoshino Satoshi Nimura Ken Yamaura Yuichi Yamashita | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，13： | 1 |
| 6 | Angiotensin II type 1 receptor antagonist prevents hepatic carcinoma in rats with nonalcoholic steatohepatitis显示文摘 | Yosui Tamaki Yukiomi Nakade Taeko Yamauchi Yuichi Makino Shiro Yokohama Mitsuyoshi Okada Kazunobu Aso Hiroyuki Kanamori Tomohiko Ohashi Ken Sato Haruhisa Nakao Masakazu Haneda Masashi Yoneda | 2013 | Journal of Gastroenterology2013，，4： | 1 |
| 7 | Beneficial effect of an omega-6 PUFA-rich diet in non-steroidal anti-inflammatory drug-induced mucosal damage in the murine small intestine显示文摘AIM: To investigate the effect of a fat rich diet onnon-steroidal anti-inflammatory drug(NSAID)-induced mucosal damage in the murine small intestine.METHODS: C57BL6 mice were fed 4 types of diets with or without indomethacin.One group was fed standard laboratory chow.The other groups were fed a fat diet consisting of 8% w/w fat,beef tallow(rich in SFA),fish oil,(rich in omega-3 PUFA),or safflower oil(rich in omega-6 PUFA).Indomethacin(3 mg/kg) was injected intraperitoneally from day 8 to day 10.On day 11,intestines and adhesions to submucosal microvessels were examined.RESULTS: In the indomethacin-treated groups,mucosal damage was exacerbated by diets containing beef tallow and fish oil,and was accompanied by leukocyte infiltration(P < 0.05).The mucosal damage induced by indomethacin was significantly lower in mice fed the safflower oil diet than in mice fed the beef tallow or fish oil diet(P < 0.05).Indomethacin increased monocyte and platelet migration to the intestinal mucosa,whereas safflower oil significantly decreased monocyte and platelet recruitment(P < 0.05).CONCLUSION: A diet rich in SFA and omega-3 PUFA exacerbated NSAID-induced small intestinal damage via increased leukocyte infiltration.Importantly,a diet rich in omega-6-PUFA did not aggravate inflammation as monocyte migration was blocked. | Toshihide Ueda Ryota Hokari Masaaki Higashiyama Yuichi Yasutake Koji Maruta Chie Kurihara Kengo Tomita Shunsuke Komoto Yoshikiyo Okada Chikako Watanabe Shingo Usui Shigeaki Nagao Soichiro Miura | 2015 | World Journal of Gastroenterology2015，21，1： | 0 |
| 8 | Invasive ductal carcinoma of the pancreas showing exophytic growth显示文摘BACKGROUND:Invasive pancreatic carcinoma generally appears as poorly defined mass reflecting the infiltrative growth.We aimed to identify the histological and immunohistochemical features in a rare case of pancreatic carcinoma showing exophytic growth. METHODS:A 67-year-old woman presented with a mass of 5.0 cm in diameter in the pancreatic head.Preoperative computed tomography revealed a well-demarcated, primarily solid mass with a central low-density area. Magnetic resonance cholangiopancreatography revealed neither encasement nor dilation of the main pancreatic duct.An incorrect preoperative diagnosis was made of solid pseudopapillary tumor of the pancreas.Elevated serum carcinoembryonic antigen(CEA)levels and abnormal FDG positron emmission tomography accumulation suggested that the tumor had malignant potential requiring a pancreatoduodenectomy. RESULTS:The head of the pancreas contained a well- circumscribed encapsulated mass of 5.0 cm in diameter, comprising 50%adenocarcinoma,with mucinous carci- noma in the center and anaplastic carcinoma at the periphery.The anaplastic carcinoma comprised pleo- morphic cells(PCs)and pleomorphic giant cells(PGCs). The PGCs phagocytozed mononuclear PCs and lymphocytes adjacent to the capsule without infiltrating the capsule itself.Immunohistochemistry revealed that the anaplastic carcinoma cells including PGCs were positive for the tumor antigen Mucin 1 and CEA but negative for vimentin. CONCLUSION:Our observations suggest anaplastic carcinoma components in the present tumor have a ductal origin and that the exophytic tumor growth is associated with the phagocytotic activity of PGCs. | Yuichi Sanada Kazuhiro Yoshida Masaoki Itoh Riki Okita Morihito Okada | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，1： | 0 |
| 9 | Solar power sail mission of OKEANOS显示文摘The solar power sail is an original Japanese concept in which electric power is generated by thin-film solar cells attached on the solar sail membrane.Japan Aerospace Exploration Agency(JAXA)successfully demonstrated the world’s first solar power sail technology through IKAROS(Interplanetary Kite-craft Accelerated by Radiation of the Sun)mission in 2010.IKAROS demonstrated photon propulsion and power generation using thin-film solar cells during its interplanetary cruise.Scaled up,solar power sails can generate enough power to drive high specific impulse ion thrusters in the outer planetary region.With this concept,we propose a landing or sample return mission to directly explore a Jupiter Trojan asteroid using solar power sail-craft OKEANOS(Oversize Kite-craft for Exploration and AstroNautics in the Outer Solar System).After rendezvousing with a Trojan asteroid,a lander separates from OKEANOS to collect samples,and perform in-situ analyses in three proposed mission sequences,including sending samples back to Earth.This paper proposes a system design for OKEANOS and includes analyses of the latest mission. | Osamu Mori Jun Matsumoto Toshihiro Chujo Masanori Matsushita Hideki Kato Takanao Saiki Yuichi Tsuda Jun'ichiro Kawaguchi Fuyuto Terui Yuya Mimasu Go Ono Naoko Ogawa Yuki Takao Yuki Kubo Kaoru Ohashi Ahmed Kiyoshi Sugihara Tatsuaki Okada Takahiro Iwata Hajime Yano | 2020 | Astrodynamics2020，4，3： | 0 |
| 10 | Hayabusa2’s station-keeping operation in the proximity of the asteroid Ryugu显示文摘The Japanese interplanetary probe Hayabusa2 was launched on December 3,2014 and the probe arrived at the vicinity of asteroid 162173 Ryugu on June 27,2018.During its 1.4 years of asteroid proximity phase,the probe successfully accomplished numbers of record-breaking achievements including two touchdowns and one artificial cratering experiment,which are highly expected to have secured surface and subsurface samples from the asteroid inside its sample container for the first time in history.The Hayabusa2 spacecraft was designed not to orbit but to hover above the asteroid along the sub Earth line.This orbital and geometrical configuration allows the spacecraft to utilize its high-gain antennas for telecommunication with the ground station on Earth while pointing its scientific observation and navigation sensors at the asteroid.This paper focuses on the regular station-keeping operation of Hayabusa2,which is called“home position”(HP)-keeping operation.First,together with the spacecraft design,an operation scheme called HP navigation(HPNAV),which includes a daily trajectory control and scientific observations as regular activities,is introduced.Following the description on the guidance,navigation,and control design as well as the framework of optical and radiometric navigation,the results of the HP-keeping operation including trajectory estimation and delta-V planning during the entire asteroid proximity phase are summarized and evaluated as a first report.Consequently,this paper states that the HP.keeping operation in the framework of HPNAV had succeeded without critical incidents,and the number of trajectory control delta-V was planned fficiently throughout the period. | Yuto Takei Takanao Saiki Yukio Yamamoto Yuya Mimasu Hiroshi Takeuchi Hitoshi Ikeda Naoko Ogawa Fuyuto Terui Go Ono Kent Yoshikawa Tadateru Takahashi Hirotaka Sawada Chikako Hirose Shota Kikuchi Atsushi Fuji Takahiro Iwata Satoru Nakazawa Masahiko Hayakawa Ryudo Tsukizaki Satoshi Tanaka Masanori Matsushita Osamu Mori Daiki Koda Takanobu Shimada Masanobu Ozaki Masanao Abe Satoshi Hosoda Tatsuaki Okada Hajime Yano Takaaki Kato Seiji Yasuda Kota Matsushima Tetsuya Masuda Makoto Yoshikawa Yuichi Tsuda | 2020 | Astrodynamics2020，4，4： | 0 |
| 11 | Thyroid hormone alterations in trauma patients requiring massive transfusion: An observational study显示文摘BACKGROUND: Although non-thyroidal illness syndrome(NTIS) is considered a negative prognostic factor, the alterations in free triiodothyronine(f T3) levels in trauma patients requiring massive transfusion have not been reported.METHODS: A prospective observational study comparing 2 groups of trauma patients was conducted. Group M comprised trauma patients requiring massive transfusions(>10 units of packed red blood cells) within 24 hours of emergency admission. Group C comprised patients with an injury severity score >9 but not requiring massive transfusions. Levels of f T3, free thyroxine(f T4), and thyroidstimulating hormone(TSH) were evaluated on admission and on days 1, 2, and 7 after admission. The clinical backgrounds and variables measured including total transfusion amounts were compared and the inter-group prognosis was evaluated. Results are presented as mean±standard deviation.RESULTS: Nineteen patients were enrolled in each group. In both groups, 32 were men, and the mean age was 50±24 years. In group C one patient died from respiratory failure. The initial f T3 levels in group M(1.95±0.37 pg/m L) were signifi cantly lower than those in group C(2.49±0.72 pg/m L; P<0.01) and remained low until 1 week after admission. Initial inter-group f T4 and TSH levels were not significantly different. TSH levels at 1 week(1.99±1.64 μIU/m L) were higher than at admission(1.48±0.5 μIU/m L) in group C(P<0.05).CONCLUSION: Typical NTIS was observed in trauma patients requiring massive transfusions. When initial resuscitation achieved circulatory stabilization, prognosis was not strongly associated with NTIS. | Toru Hifumi Ichiro Okada Nobuaki Kiriu Eiju Hasegawa Tomoko Ogasawara Hiroshi Kato Yuichi Koido Junichi Inoue Yuko Abe Kenya Kawakita Masanobu Hagiike Yasuhiro Kuroda | 2014 | World Journal of Emergency Medicine2014，5，4： | 0 |
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