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| 1 | Isolation,Characterization,and Phylogenetic Analysis of Two New Crimean-Congo Hemorrhagic Fever Virus Strains from the Northern Region of Xinjiang Province,China显示文摘Crimean-Congo hemorrhagic fever(CCHF)caused by the CCHF virus(CCHFV)is a tick-borne natural focal disease with a mortality rate of approximately 50%.CCHFV is widely prevalent in Africa,southern Asia,the Middle East,and southeast Europe.CCHF outbreaks have been reported previously in Xinjiang province,China,especially in its southern region.Epidemiological surveys conducted on ticks and animals have revealed the presence of CCHFV strains in ticks,rodents,and infected individuals from cities and counties in southern Xinjiang.Phylogenetic analyses revealed that the Chinese CCHFV strains belong to one genotype,based on complete sequences of the S segments of its negative-stranded RNA genome.The present study reports two new CCHFV strains isolated from Hyalomma asiaticum asiaticum ticks collected from Fukang City and Wujiaqu City in the northern region of Xinjiang.Viral characteristics and their evolutionary relationships were analyzed through metagenomic and reverse-transcription PCR analyses;these analyses indicated that the genotype of both strains was different from that of other Chinese strains.Furthermore,previous reports of CCHFV in Xinjiang were reviewed and phylogenetic analyses were performed.CCHFV was found to prevail in Fukang City in Junggar Basin for more than 20 years,and that Fukang City and Wujiaqu City are considered natural reservoirs of different genotypes of CCHFV strains.Our findings facilitate the understanding of CCHFV distribution in Xinjiang province and provide insights into the evolutionary relationships among Chinese CCHFV strains. | Yanfang Zhang Shu Shen Yaohui Fang Jinliang Liu Zhengyuan Su Jinhao Liang Zhong Zhang Qiaoli Wu Cheng Wang Abulikemu Abudurexiti Zhihong Hu Yujiang Zhang Fei Deng | 2018 | Virologica Sinica2018，33，1： | 8 |
| 2 | Smad5 acts as an intracellular pH messenger and maintains bioenergetic homeostasis显示文摘环境暗示和细胞内部的 bioenergetic 状态深刻地影响细胞内部的 pH (pHi ) 。一个房间怎么对 pHi 变化作出回应维持 bioenergetic 动态平衡,留下逃犯。这里,我们显示出那 Smad5,发信号的形态基因的蛋白质(BMP ) 回答到 pHi 的骨头的一个描绘得好的下游的部件变化。冷、基本或张力亢进的条件增加 pHi,它接着在 Smad5 的 MH1 域以内声言不赞成控告的氨基酸簇,推动它到细胞质的从原子核的重定位。在另一方面,加热,酸或张力减退的条件减少 pHi,堵住 Smad5 的原子出口,并且因此引起它的原子累积。环境变化和 pHi 变化导致的 Smad5 的活跃 nucleocytoplasmic shuttling 独立于 BMP 发信号, carboxyl 终点 phosphorylation 和 Smad4。另外, Smad5 的脱离引起在区别识别了的神经发展过程人的 pluripotent 干细胞建模的细胞的 bioenergetic 动态平衡和破坏正常的长期、不可逆的 dysregulation。重要地,在 Smad5 缺乏的房间的这些新陈代谢、发展的赤字能仅仅由细胞质的 Smad5 被救。细胞质的 Smad5 身体上与 hexokinase 交往 1 并且加速 glycolysis。一起,我们的调查结果显示 Smad5 充当一个 pHi 送信人并且由调整细胞质的新陈代谢的机械维持房间的 bioenergetic 动态平衡。 | Yujiang Fang Zhongliang Liu Zhenyu Chen Xiangjie Xu Mengtao Xiao Yanyan Yu Yuanyuan Zhang Xiaobai Zhang Yanhua Du Cizhong Jiang Yuzheng Zhao Yiran Wang Beibei Fan Daniel Terheyden-Keighley Yang Liu Lei Shi Yi Hui Xin Zhang Bowen Zhang Hexi Feng Lin Ma Quanbin Zhang Guohua Jin Yi Yang Bin Xiang Ling Liu Xiaoqing Zhang | 2017 | Cell Research2017，27，9： | 2 |
| 3 | Structural insight into substrate recognition by histone demethylase LSD2/KDM1 b显示文摘 | Fei Chen Huirong Yang Zhenghong Dong Jian Fang Ping Wang Tingting Zhu Wei Gong Rui Fang Yujiang Geno Shi Ze Li Yanhui Xu | 2013 | Cell Research2013，23，2： | 2 |
| 4 | The 1920S Drought Recorded by Tree Rings and Historical Documents in the Semi-Arid and Arid Areas of Northern China显示文摘 | Eryuan Liang Xiaohong Liu Yujiang Yuan Ningsheng Qin Xiuqi Fang Lei Huang Haifeng Zhu Lily Wang Xuemei Shao | 2006 | Climatic Change (-)2006，，3： | 1 |
| 5 | The 1920S Drought Recorded by Tree Rings and Historical Documents in the Semi-Arid and Arid Areas of Northern China显示文摘 | Eryuan Liang Xiaohong Liu Yujiang Yuan Ningsheng Qin Xiuqi Fang Lei Huang Haifeng Zhu Lily Wang Xuemei Shao | 2006 | Climatic Change (-)2006，，3： | 1 |
| 6 | TET2 stabilization by 14-3-3 binding to the phosphorylated Serine 99 is deregulated by mutations in cancer显示文摘Dear Editor, The Ten-Eleven Translocation-2 (TET2) gene encodes an enzyme that catalyzes the conversion of 5-methylcytosine (5mC) to 5- hydroxymethylcytosine (5hmC), the key initial step in active DNA demethylation.1,2 TET2 and 5hmC function cooperatively as epigenetic tumor suppressors and are frequently deregulated in cancer.2 We recently reported that TET2 is a bona fide substrate of the AMP-activated kinase (AMPK)Z which phosphorylates TET2 serine 99 (S99) at its non-catalytic N-terminal region. | Hao Chen Dingdang Yu Rui Fang Kimberlie Rabidou Di Wu Di Hu Peilin Jia Zhongming Zhao Zhiping Wu Yujiang Geno Shi | 2019 | Cell Research2019，29，3： | 0 |
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