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| 1 | Sphingosine kinase 1 is upregulated with lysophosphatidic acid receptor 2 in human colorectal cancer显示文摘AIM: To examine the expression of Sph K1, an oncogenic kinase that produces sphingosine 1-phosphate(S1P), and its correlation with the expression of LPAR2, a major lysophosphatidic acid(LPA) receptor overexpressed in various cancers, in human colorectal cancer.METHODS: Real-time reverse-transcription polymerase chain reaction was used to measure the m RNA expression of Sph K1, LPAR2, and the three major S1 P receptors in 27 colorectal cancer samples and corresponding normal tissue samples. We also examined the correlation between the expression of Sph K1 and LPAR2.RESULTS: C o l o r e c t a l c a n c e r t i s s u e i n 2 2 o f 2 7 patients had higher levels of Sph K1 m RNA than in normal tissue. In two-thirds of the samples, Sph K1 m RNA expression was more than two-fold higher than in normal tissue. Consistent with previous reports, LPAR2 m RNA expression in 20 of 27 colorectal cancer tissue samples was higher compared to normal tissue samples. Expression profiles of all three major S1 P receptors, S1PR1, S1PR2, and S1PR3, varied without any trend, with no significant difference in expression between cancer and normal tissues. A highly significant positive correlation was found between Sph K1 and LPAR2 expression [Pearson's correlation coefficient(r) = 0.784 and P < 0.01]. The m RNA levels of Sph K1 and LPAR2 did not correlate with TNM stage.CONCLUSION: Our findings suggest that S1 P andLPA may play important roles in the development ofcolorectal cancer via the upregulation of Sph K1 andLPAR2, both of which could serve as new therapeutictargets in the treatment of colorectal cancer. | Dai Shida Satoru Inoue Yuki Yoshida Atsushi Kodaka Tsutomu Tsuji Makoto Tsuiji | 2016 | World Journal of Gastroenterology2016，22，8： | 6 |
| 2 | A unique case of collagenous colitis presenting as protein-losing enteropathy successfully treated with prednisolone显示文摘A 76-year-old woman with a 5-mo history of recurrent diarrhea and generalized edema was admitted to our hospital. Colonoscopy revealed edematous mucosa,and histopathological examination was compatible with collagenous colitis. Protein leakage from the colon,particularly in the ascending portion,was identified on 99mTc-human serum albumin scintigraphy. Collagenous colitis associated with protein-losing enteropathy (PLE) without small bowel disease was diagnosed. Prednisolone treatment ameliorated diarrhea and hypoproteinemia. Collagenous colitis should be included in the differential diagnosis of chronic diarrhea with hypoproteinemia for appropriate management. | Soichi Sano Keiko Yamagami Ayako Tanaka Minako Nishio Tomoyuki Nakamura Yuki Kubo Takeshi Inoue Wataru Ueda Kiyotaka Okawa Katsunobu Yoshioka | 2008 | World Journal of Gastroenterology2008，14，39： | 3 |
| 3 | Administration of edaravone, a free radical scavenger, during t-PA infusion can enhance early recanalization in acute stroke patients — A preliminary study显示文摘 | Kazumi Kimura Juya Aoki Yuki Sakamoto Kazuto Kobayashi Kenichi Sakai Takeshi Inoue Yasuyuki Iguchi Kensaku Shibazaki | 2011 | Journal of the Neurological Sciences2011，，1： | 2 |
| 4 | Water-assisted self-sustained burning of metallic single-walled carbon nanotubes for scalable transistor fabrication显示文摘Although aligned arrays of semiconducting single-walled carbon nanotubes(s-SWNTs) are promising for use in next-generation electronics owing to theirultrathin bodies and ideal electrical properties, even a small portion of metallic(m-) counterparts causes excessive leakage in field-effect transistors (FETs).To fully exploit the benefits of s-SWNTs for use in large-scale systems, it isnecessary to completely eliminate m-SWNTs from as-grown SWNT arrays andthereby obtain purely semiconducting large-area arrays, wherein numerousFETs can be flexibly built. In this study, we performed electrical burning ofm-SWNTs assisted by water vapor and polymer coating to eliminate m-SWNTsover a long length for the scalable fabrication of transistors from the remainings-SWNT arrays. During the electrical-breakdown process, the combination ofwater vapor and the polymer coating significantly enhanced the burning ofthe SWNTs, resulting in a self-sustained reaction along the nanotube axis. Wefound that m-SWNT segments partially remaining on the anode side resultedfrom one-way burning from the initial breakdown position, where Joule-heating-induced oxidation first occurred. The s-SWNT-enriched arrays obtained wereused to fabricate multiple FETs with a high on-off current ratio. The resultsindicate the advantages of this approach over conventional electrical breakdownfor the large-scale purification of s-SWNTs. | Keigo Otsuka Taiki Inoue Yuki Shimomura Shohei Chiashi Shigeo Maruyama | 2017 | Nano Research2017，10，9： | 2 |
| 5 | Aortic Arch Reconstruction by Transluminally Placed Endovascular Branched Stent Graft显示文摘 | Kanji Inoue Hiroaki Hosokawa Tomoyuki Iwase Mitsuru Sato Yuki Yoshida Katsuya Ueno Akiyoshi Tsubokawa Terumitsu Tanaka Shunichi Tamaki Takahiko Suzuki | 1999 | Circulation ( Suppl)1999，，19： | 1 |
| 6 | A novel mitochondrial C 1 -tetrahydrofolate synthetase is upregulated in human colon adenocarcinoma显示文摘 | Takeyuki Sugiura Yuki Nagano Tatsuya Inoue Kenji Hirotani | 2004 | Biochemical and Biophysical Research Communications2004，，1： | 1 |
| 7 | Prognostic Impact of Hypoxia-Inducible miRNA-210 in Patients with Lung Adenocarcinoma显示文摘 | Jun Osugi Yuka Kimura Yuki Owada Takuya Inoue Yuzuru Watanabe Takumi Yamaura Mitsuro Fukuhara Satoshi Muto Naoyuki Okabe Yuki Matsumura Takeo Hasegawa Athushi Yonechi Mika Hoshino Mitsunori Higuchi Yutaka Shio Hiroyuki Suzuki Mitsukazu Gotoh James L. Muls | 2015 | Journal of Oncology2015，，： | 1 |
| 8 | Reappraisal of biochemical hepatitis C aetivlty in hemodialysis patients显示文摘 | Yuki N Ishida H Inoue T | 2000 | J Clin Gastroenterol2000，30，： | 1 |
| 9 | The Optimal Illuminance for Reading:Effects of Age and Visual Acuity on Legibility and Brightness显示文摘 | Youko Inoue&Yuki Akitsuki | 1998 | Journal of Light and Visual Environment1998，20，1： | 1 |
| 10 | Allogeneic stem cell transplantation as treatment for heavily treated, refractory acute graft-versus-host disease after HLA-mismatched stem cell transplantation显示文摘 | Kazuhiro Ikegame Satoshi Yoshihara Yuki Taniguchi Katsuji Kaida Takayuki Inoue Masaya Okada Kyoko Taniguchi Hitomi Hasei Hiroya Tamaki Tatsuya Fujioka Ruri Kato Toshihiro Soma Hiroyasu Ogawa | 2011 | Experimental Hematology2011，，8： | 1 |
| 11 | Unmanipulated HLA 2–3 Antigen-Mismatched (Haploidentical) Stem Cell Transplantation Using Nonmyeloablative Conditioning显示文摘 | Hiroyasu Ogawa Kazuhiro Ikegame Satoshi Yoshihara Manabu Kawakami Tatsuya Fujioka Tomoki Masuda Yuki Taniguchi Hitomi Hasei Katsuji Kaida Takayuki Inoue Eui Ho Kim Ichiro Kawase | 2006 | Biology of Blood and Marrow Transplantation2006，，10： | 1 |
| 12 | Development of a device for dynamical measurement of the load on casting and the contraction of the casting in a sand mold during cooling 显示文摘 | Yuichi Motoyama Hiroki Takahashi Yuki Inoue ct al | 2012 | Journal of Materials Processing Technology2012，212，6： | 1 |
| 13 | Transcriptome analysis of the digestive organs of Hodotermopsis sjostedti, a lower termite that hosts mutualistic microorganisms in its hindgut 显示文摘 | Yuki M Moriya S Inoue T | 2008 | Zoological Science2008，25，4： | 1 |
| 14 | Transcriptome analysis of the digestive organs of Hodotermopsis sjostedti, a lower termite that hosts mutualistic microorganisms in its hindgut 显示文摘 | Yuki M MoriyaS Inoue T | 2008 | Zool Sci2008，25，4： | 1 |
| 15 | Ultraflexible, large-area, physiological temperature sensors for multipoint measurements显示文摘 | Yokota Tomoyuki Inoue Yusuke Terakawa Yuki Reeder Jonathan Kaltenbrunner Martin Ware Taylor Yang Kejia Mabuchi Kunihiko Murakawa Tomohiro Sekino Masaki Voit Walter Sekitani Tsuyoshi Someya Takao | 2015 | Proceedings of the National Academy of Sciences2015，，47： | 1 |
| 16 | Development of highly intense radiant power equipment with a semi-oval reflector显示文摘 | Toru Iwao Yukie Inoue Hiroshi Kanda | 2004 | Vacuum2004，73，3： | 1 |
| 17 | Field-deployable rapid multiple biosensing system for detection of chemical and biological warfare agents显示文摘The threat of biological and chemical terror acts remains a growing worldwide concern.There is therefore a need to develop appropriate technology for the detection of chemical and biological warfare agents,with early identification intended for use by first responders.Here,we disclose the developed autonomous air sampling and detection system for evaluation of the presence of chemical and biological warfare agents that can be harmful to the population.The current device utilizes the designed mist generator-assisted air collection system(338 l min^(−1))and biosensing chip technologies,such as electrochemical measurement,Au nanoparticle-based localized surface plasmon resonance,and rapid microfluidic chip PCR for detection of minute concentrations lower than the mean lethal dose(LD_(50))of nerve gases(sarin and VX),toxic proteins(BTX/A/Hc and ricin),and pathogens(anthrax simulant).An operation time of only 5–15 min is needed for the collection and detection;sample preparation is already integrated into the system without the need for direct human intervention.In addition to the system’s sensitivity and ease of use,its portability makes it highly beneficial for first responders,which could aid in immediate risk assessment and mitigation of on-site events. | Masato Saito Natsuko Uchida Shunsuke Furutani Mizuho Murahashi Wilfred Espulgar Naoki Nagatani Hidenori Nagai Yuki Inoue Tomohiko Ikeuchi Satoshi Kondo Hirotaka Uzawa Yasuo Seto Eiichi Tamiya | 2018 | Microsystems & Nanoengineering2018，4，1： | 1 |
| 18 | Stage at diagnosis of colorectal cancer through diagnostic route:Who should be screened?显示文摘BACKGROUND Colorectal cancer(CRC)is a global health concern,with advanced-stage diagnoses contributing to poor prognoses.The efficacy of CRC screening has been well-established;nevertheless,a significant proportion of patients remain unscreened,with>70%of cases diagnosed outside screening.Although identifying specific subgroups for whom CRC screening should be particularly recommended is crucial owing to limited resources,the association between the diagnostic routes and identification of these subgroups has been less appreciated.In the Japanese cancer registry,the diagnostic routes for groups discovered outside of screening are primarily categorized into those with comorbidities found during hospital visits and those with CRC-related symptoms.AIM To clarify the stage at CRC diagnosis based on diagnostic routes.METHODS We conducted a retrospective observational study using a cancer registry of patients with CRC between January 2016 and December 2019 at two hospitals.The diagnostic routes were primarily classified into three groups:Cancer screening,follow-up,and symptomatic.The early-stage was defined as Stages 0 or I.Multivariate and univariate logistic regressions were exploited to determine the odds of early-stage diagnosis in the symptomatic and cancer screening groups,referencing the follow-up group.The adjusted covariates were age,sex,and tumor location.RESULTS Of the 2083 patients,715(34.4%),1064(51.1%),and 304(14.6%)belonged to the follow-up,symptomatic,and cancer screening groups,respectively.Among the 2083 patients,CRCs diagnosed at an early stage were 57.3%(410 of 715),23.9%(254 of 1064),and 59.5%(181 of 304)in the follow-up,symptomatic,and cancer screening groups,respectively.The symptomatic group exhibited a lower likelihood of early-stage diagnosis than the follow-up group[P<0.001,adjusted odds ratio(aOR),0.23;95%confidence interval(95%CI):0.19-0.29].The likelihood of diagnosis at an early stage was similar between the follow-up and cancer screening groups(P=0.493,aOR for early-stage diagnosis in the cancer screening group vs follow-up group=1.11;95%CI=0.82-1.49).CONCLUSION CRCs detected during hospital visits for comorbidities were diagnosed earlier,similar to cancer screening.CRC screening should be recommended,particularly for patients without periodical hospital visits for comorbidities. | Nobukazu Agatsuma Takahiro Utsumi Yoshitaka Nishikawa Takahiro Horimatsu Takeshi Seta Yukitaka Yamashita Yukari Tanaka Takahiro Inoue Yuki Nakanishi Takahiro Shimizu Mikako Ohno Akane Fukushima Takeo Nakayama Hiroshi Seno | 2024 | World Journal of Gastroenterology2024，30，10： | 0 |
| 19 | Self-expanding metal stent placement and pathological alterations among obstructive colorectal cancer cases显示文摘BACKGROUND Experimental studies suggest that self-expanding metal stents(SEMSs)enhance the aggressive behavior of obstructive colorectal cancer.The influence of SEMS placement on pathological alterations remains to be elucidated.AIM To determine whether SEMS placement is associated with molecular or pathological features of colorectal carcinoma tissues.METHODS Using a nonbiased molecular pathological epidemiology database of patients with obstructive colorectal cancers,we examined the association of SEMS placement with molecular or pathological features,including tumor size,histological type,American Joint Committee on Cancer(AJCC)-pTNM stage,and mutation statuses in colorectal cancer tissues compared with the use of transanal tubes.A multivariable logistic regression model was used to adjust for potential confounders.RESULTS SEMS placement was significantly associated with venous invasion(P<0.01),but not with the other features examined,including tumor size,disease stage,mutation status,and lymphatic invasion.In both the univariable and multivariable models with adjustment for potential factors including tumor location,histological type,and AJCC-pT stage,SEMS placement was significantly associated with severe venous invasion(P<0.01).For the outcome category of severe venous invasion,the multivariable odds ratio for SEMS placement relative to transanal tube placement was 19.4(95%confidence interval:5.24–96.2).No significant differences of disease-free survival and overall survival were observed between SEMS and transanal tube groups.CONCLUSION SEMS placement might be associated with severe venous invasion in colorectal cancer tissue,providing an impetus for further investigations on the pathological alterations by SEMSs in colorectal cancer development. | Keisuke Kosumi Kosuke Mima Kosuke Kanemitsu Takuya Tajiri Toru Takematsu Yuki Sakamoto Mitsuhiro Inoue Yuji Miyamoto Takao Mizumoto Tatsuo Kubota Nobutomo Miyanari Hideo Baba | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，11： | 0 |
| 20 | Validation of the Japan Coma Scale for the prediction of mortality in children:analysis of a nationwide trauma database显示文摘Objective The Japan Coma Scale(JCS)is widely used in clinical practice to evaluate levels of consciousness in Japan.There have been several studies on the usefulness of JCS in adults.However,its usefulness in evaluating children has not been reported.Therefore,this study aimed to assess the usefulness of the JCS for the prediction of mortality in children.Methods This is a multicenter cohort study which used data from a national trauma registry(Japan Trauma Data Bank).This study included patients under 16 years of age who were treated between 2004 and 2015.The primary outcome measure was in-hospital mortality.Two models were used to examine each item of the Glasgow Coma Scale(GCS)and the JCS.Model A included the discrete levels of each index.In model B,data regarding age,sex,vital signs on arrival to hospital,the Injury Severity Score,and blunt trauma were added to each index.The effectivity of the JCS score was then evaluated using the area under the curve(AUC)for discrimination,a calibration plot,and the Hosmer-Lemeshow test for calibration.Results A total of 9045 patients were identified.The AUCs of the GCS and JCS were 0.929(95%confidence interval(CI)0.904 to 0.954)and 0.930(95%CI 0.906 to 0.954)in model A and 0.975(95%CI 0.963 to 0.987)and 0.974(95%CI 0.963 to 0.985)in model B,respectively.The results of the Hosmer-Lemeshow test were 0.00(p=1.00)and 0.00(p=1.00)in model A and 4.14(p=0.84)and 8.55(p=0.38)in model B for the GCS and JCS,respectively.Conclusions We demonstrated that the JCS is as valid as the GCS for predicting mortality.The findings of this study indicate that the JCS is a useful and relevant tool for pediatric trauma care and future research. | Yuki Enomoto Yusuke Tsutsumi Asuka Tsuchiya Takahiro Kido Koji Ishigami Masahito Togo Susumu Yasuda Yoshiaki Inoue | 2022 | World Journal of Pediatric Surgery2022，5，2： | 0 |
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