|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Traditional Chinese medicine in COVID-19显示文摘COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARSCo V-2)has spread across the globe,posing an enormous threat to public health and safety.Traditional Chinese medicine(TCM),in combination with Western medicine(WM),has made important and lasting contributions in the battle against COVID-19.In this review,updated clinical effects and potential mechanisms of TCM,presented in newly recognized three distinct phases of the disease,are summarized and discussed.By integrating the available clinical and preclinical evidence,the efficacies and underlying mechanisms of TCM on COVID-19,including the highly recommended three Chinese patent medicines and three Chinese medicine formulas,are described in a panorama.We hope that this comprehensive review not only provides a reference for health care professionals and the public to recognize the significant contributions of TCM for COVID-19,but also serves as an evidence-based in-depth summary and analysis to facilitate understanding the true scientific value of TCM. | Ming Lyu Guanwei Fan Guangxu Xiao Taiyi Wang Dong Xu Jie Gao Shaoqin Ge Qingling Li Yuling Ma Han Zhang Jigang Wang Yuanlu Cui Junhua Zhang Yan Zhu Boli Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 14 |
| 2 | Distributed Finite-Time Integral Sliding-Mode Control for Multi-Agent Systems with Multiple Disturbances Based on Nonlinear Disturbance Observers显示文摘This paper proposes a finite-time consensus control algorithm based on nonlinear integral sliding-mode control for second-order multi-agent systems(MASs)with mismatched and matched disturbances.Firstly,a nonlinear finite-time disturbance observer is established to estimate the states and mismatched disturbances of the agent.Secondly,a dynamic integral sliding-mode(ISM)surface is designed by employing the estimates of mismatched disturbances.Then,based on the designed ISM and disturbance observer,the discontinuous or continuous campsite control protocols are respectively developed to guarantee the consensus for MASs in finite time with active anti-disturbance control.Finally,numerical simulation results illustrate the effectiveness of the proposed consensus control algorithm. | YANG Yize LIU Fan YANG Hongyong LI Yuling LIU Yuanshan | 2021 | Journal of Systems Science & Complexity2021，34，3： | 4 |
| 3 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 4 | CALTPP:A general program to calculate thermophysical properties显示文摘A program CALTPP(CALculation of ThermoPhysical Properties)is developed in order to provide various thermophysical properties such as diffusion coefficient,interfacial energy,thermal conductivity,viscosity and molar volume mainly as function of temperature and composition.These thermophysical properties are very important inputs for microstructure simulations and mechanical property predictions.The general structure of CALTPP is briefly described,and the CALPHAD-type models for the description of these thermophysical properties are presented.The CALTPP program contains the input module,calculation and/or optimization modules and output module.A few case studies including(a)the calculation of diffusion coefficient and optimization of atomic mobility,(b)the calculation of solid/liquid,coherent solid/solid and liquid/liquid interfacial energies,(c)the calculation of thermal conductivity,(d)the calculation of viscosity,and(e)the establishment of molar volume database in binary and ternary alloys are demonstrated to show the features of CALTPP.It is expected that CALTPP will be an effective contribution in both scientific research and education. | Yuling Liu Cong Zhang Changfa Du Yong Du Zhoushun Zheng Shuhong Liu Lei Huang Shiyi Wen Youliang Jin Huaqing Zhang Fan Zhang George Kaptay | 2020 | Journal of Materials Science & Technology2020，42，7： | 2 |
| 5 | RNA modifications:importance in immune cell biology and related diseases显示文摘RNA modifications have become hot topics recently.By influencing RNA processes,including generation,transportation,function,and metabolization,they act as critical regulators of cell biology.The immune cell abnormality in human diseases is also a research focus and progressing rapidly these years.Studies have demonstrated that RNA modifications participate in the multiple biological processes of immune cells,including development,differentiation,activation,migration,and polarization,thereby modulating the immune responses and are involved in some immune related diseases.In this review,we present existing knowledge of the biological functions and underlying mechanisms of RNA modifications,including N6-methyladenosine(m^(6)A),5-methylcytosine(m^(5)C),N1-methyladenosine(m1 A),N7-methylguanosine(m^(7)G),N4-acetylcytosine(ac^(4)C),pseudouridine(Ψ),uridylation,and adenosine-to-inosine(A-to-I)RNA editing,and summarize their critical roles in immune cell biology.Via regulating the biological processes of immune cells,RNA modifications can participate in the pathogenesis of immune related diseases,such as cancers,infection,inflammatory and autoimmune diseases.We further highlight the challenges and future directions based on the existing knowledge.All in all,this review will provide helpful knowledge as well as novel ideas for the researchers in this area. | Lian Cui Rui Ma Jiangluyi Cai Chunyuan Guo Zeyu Chen Lingling Yao Yuanyuan Wang Rui Fan Xin Wang Yuling Shi | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 2 |
| 6 | Effect of blocking Ras signaling pathway with K-Ras siRNA on apoptosis in esophageal squamous carcinoma cells显示文摘OBJECTIVE: To study the effect of RNAi silencing of the K-Ras gene on Ras signal pathway activity in EC9706 esophageal cancer cells. METHODS: EC9706 cells were treated in the following six groups: blank group (no transfection), negative control group (transfection no-carrier), transfection group (transfected with pSilencer-siK-ras), taxol chemotherapy group, taxol chemotherapy plus no-carrier group, taxol chemotherapy plus transfection group. Immunocytochemistry, Reverse transcription-polymerase chain reaction and western blotting were used to analyze the expression of MAPK1 (mitogen-activated protein kinases 1) and cyclin D1 in response to siRNA (small interfering RNA) transfection and taxol treatment. RESULTS: K-Ras (K-Ras gene) siRNA transfection of EC9706 esophageal squamous carcinoma cells decreased the expression of K-Ras, MAPK1 and cyclinD1 at the mRNA and protein level. Reverse transcription-polymerase chain reaction indicated that the expression levels of MAPK1 and cyclin D1 mRNAs were significantly lower in the transfection group than in the blank group (P<0.05). Western blotting showed that 72 h after EC9706 cell transfection, the expression levels of MAPK1 and cyclin D1 proteins had decreased in all groups, and the expression levels in the transfection group were significantly inhibited as compared with the blank group. Apoptosis increased significantly in the transfection group or after addition of taxol as compared with the blank group and the no-carrier group. The degree of apoptosis in the taxol plus transfection group was more severe. CONCLUSION: Apoptosis increased significantly in EC9706 esophageal carcinoma cells after siRNA-mediated inhibition of Ras signaling, with the most obvious increase observed in the transfection plus taxol chemotherapy group. Ras knockdown therefore increased cellular sensitivity to the chemotherapeutic agent, taxol. Ras knockdown also down-regulated the expression of the downstream genes, MAPK1 and cyclin D1, thus inhibiting the growth, proliferation and metabolism of esophageal cancer cells. | Xinjie Wang Yuling Zheng Qingxia Fan Xudong Zhang | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 2 |
| 7 | Trajectory Optimization and Power Allocation Scheme Based on DRL in Energy Efficient UAV-Aided Communication Networks显示文摘With flexibility, convenience and mobility, unmanned aerial vehicles(UAVS) can provide wireless communication networks with lower costs, easier deployment, higher network scalability and larger coverage.This paper proposes the deep deterministic policy gradient algorithm to jointly optimize the power allocation and flight trajectory of UAV with constrained effective energy to maximize the downlink throughput to ground users. To validate the proposed algorithm, we compare with the random algorithm, Q-learning algorithm and deep Q network algorithm. The simulation results show that the proposed algorithm can effectively improve the communication quality and significantly extend the service time of UAV. In addition, the downlink throughput increases with the number of ground users. | WANG Chaowei CUI Yuling DENG Danhao WANG Weidong JIANG Fan | 2022 | Chinese Journal of Electronics2022，31，3： | 1 |
| 8 | Global genome expression analysis of rice in response to drought and high-salinity stresses in shoot, flag leaf, and panicle显示文摘 | Junli Zhou Xiangfeng Wang Yuling Jiao Yonghua Qin Xigang Liu Kun He Chen Chen Ligeng Ma Jian Wang Lizhong Xiong Qifa Zhang Liumin Fan Xing Wang Deng | 2007 | Plant Molecular Biology2007，，5： | 1 |
| 9 | Synthesis, crystal structures and fluorescence properties of 3-(2-pyridyl)coumarin derivatives显示文摘 | Tianzhi Yu Sidan Yang Yuling Zhao Hui Zhang Xiaoqian Han Duowang Fan Yongqing Qiu Lili Chen | 2010 | Journal of Photochemistry & Photobiology A: Chemistry2010，，1： | 1 |
| 10 | Low- bandgap conjugated polymer for high efficient photovoltaic applications显示文摘 | Chen Yichun Yu Chaoying Fan Yuling | 2010 | Chem Commun2010，，： | 1 |
| 11 | Development of a target capture sequencing SNP genotyping platform for genetic analysis and genomic breeding in rapeseed显示文摘Rapeseed(Brassica napus)is an oil crop grown worldwide,making it a key plant species in molecular breeding research.However,the complexity of its polyploid genome increases sequencing costs and reduces sequencing accuracy.Target capture coupled with high-throughput sequencing is an efficient approach for detecting genetic variation at genomic regions or loci of interest.In this study,588 resequenced accessions of rapeseed were used to develop a target capture sequencing SNP genotyping platform named BnaPan50T.The platform comprised 54,765,with 54,058 resequenced markers from the pan-genome,and 855 variant trait-associated markers for 12 agronomic traits.The capture quality of BnaPan50T was demonstrated well in 12 typical accessions.Compared with a conventional genotyping array,BnaPan50T has a high SNP density and a high proportion of SNPs in unique physical positions and in annotated functional genes,promising wide application.Target capture sequencing and wholegenome resequencing in 90 doubled-haploid lines yielded 60%specificity,78%uniformity within tenfold coverage range,and 93%genotyping accuracy for the platform.BnaPan50T was used to construct a genetic map for quantitative trait loci(QTL)mapping,identify 21 unique QTL,and predict several candidate genes for yield-related traits in multiple environments.A set of 132 core SNP loci was selected from BnaPan50T to construct DNA fingerprints and germplasm identification resources.This study provides genomics resources to support target capture sequencing,genetic analysis and genomic breeding of rapeseed. | Xiaodong Li Xumei Liu Yonghai Fan Shengting Li Mengna Yu Mingchao Qian Yuling Chen Hongqiao Chen Xinchun Li Bei Liu Xinfu Xu Cunmin Qu Jiana Li Kun Lu | 2023 | The Crop Journal2023，11，2： | 1 |
| 12 | Synthesis and rare earth metal ion-sensing properties of aza-crown derivative incorporating with diaryl-1,3,4-oxadiazole显示文摘 | Tianzhi Yu Jing Meng Yuling Zhao Hui Zhang Xiaoqian Han Duowang Fan | 2010 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2010，，1： | 1 |
| 13 | An effective energycriterion on fatigue crack growth of metal materials显示文摘 | HE Yuling LI Feng FAN Chaohua | 2007 | Key Engineering Materials2007，35，3354355356357358： | 1 |
| 14 | Changes in the relationship between species richness and belowground biomass among grassland types and along environmental gradients in Xinjiang, Northwest China显示文摘The association between biodiversity and belowground biomass(BGB) remains a central debate in ecology.In this study, we compared the variations in species richness(SR) and BGB as well as their interaction in the top(0–20 cm), middle(20–50 cm) and deep(50–100 cm) soil depths among 8 grassland types(lowland meadow, temperate desert, temperate desert steppe, temperate steppe desert, temperate steppe, temperate meadow steppe, mountain meadow and alpine steppe) and along environmental gradients(elevation, energy condition(annual mean temperature(AMT) and potential evapotranspiration(PET)), and mean annual precipitation(MAP)) based on a 2011–2013 survey of 379 sites in Xinjiang, Northwest China.The SR and BGB varied among the grassland types.The alpine steppe had a medium level of SR but the highest BGB in the top soil depth, whereas the lowland meadow had the lowest SR but the highest BGB in the middle and deep soil depths.The SR and BGB in the different soil depths were tightly associated with elevation, MAP and energy condition;however, the particular forms of trends in SR and BGB depended on environmental factors and soil depths.The relationship between SR and BGB was unimodal in the top soil depth, but SR was positively related with BGB in the middle soil depth.Although elevation, MAP, energy condition and SR had significant effects on BGB, the variations in BGB in the top soil depth were mostly determined by elevation, and those in the middle and deep soil depths were mainly affected by energy condition.These findings highlight the importance of environmental factors in the regulations of SR and BGB as well as their interaction in the grasslands in Xinjiang. | YANG Yuling LI Minfei MA Jingjing CHENG Junhui LIU Yunhua JIA Hongtao LI Ning WU Hongqi SUN Zongjiu FAN Yanmin SHENG Jiandong JIANG Ping'an | 2019 | Journal of Arid Land2019，11，6： | 0 |
| 15 | Energy-Efficient Optimal Guaranteed Cost Intermittent-Switch Control of a Direct Expansion Air Conditioning System显示文摘To improve the energy efficiency of a direct expansion air conditioning(DX A/C) system while guaranteeing occupancy comfort, a hierarchical controller for a DX A/C system with uncertain parameters is proposed. The control strategy consists of an open loop optimization controller and a closed-loop guaranteed cost periodically intermittent-switch controller(GCPISC). The error dynamics system of the closed-loop control is modelled based on the GCPISC principle. The difference,compared to the previous DX A/C system control methods, is that the controller designed in this paper performs control at discrete times. For the ease of designing the controller, a series of matrix inequalities are derived to be the sufficient conditions of the lower-layer closed-loop GCPISC controller. In this way, the DX A/C system output is derived to follow the optimal references obtained through the upper-layer open loop controller in exponential time, and the energy efficiency of the system is improved. Moreover, a static optimization problem is addressed for obtaining an optimal GCPISC law to ensure a minimum upper bound on the DX A/C system performance considering energy efficiency and output tracking error. The advantages of the designed hierarchical controller for a DX A/C system with uncertain parameters are demonstrated through some simulation results. | Jun Mei Zhenyu Lu Junhao Hu Yuling Fan | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，11： | 0 |
| 16 | Study on Control Effect of Invasive Banana Fusarium Disease(Fusarium oxysporum f.sp.cubense tropical race 4)by Different Varieties and Fertilization Treatments显示文摘[Objective]The paper was to understand the field resistance performance of different banana varieties and the prevention and control ef-fect of different fertilizers,so as to provide technical reference for the prevention and control of Fusarium wilt.[Method]Field trials were set up with three treatments:shrimp peptide organic fertilizer+shrimp peptide special protection+shrimp peptide fruit Yekang(simplified as shrimp peptide organic fertilizer treatment),conventional organic fertilizer+microbial preparations(simplified as microbial treatment),and conventional or-ganic fertilizer(simplified as control).Four different banana varieties of Brazilian banana,Guijiao No.1,Nantianhuang,and Yunjiao No.1 were se-lected for the field trial.The disease incidence of Fusarium wilt and the control effects of three fertilizers were investigated during four time periods.[Result]The disease incidence of four varieties in three treatments varied.The disease incidence of Nantianhuang and Yunjiao No.1 were signifi-cantly lower than that of other two varieties.There was also significant difference in disease incidence of three treatments.The disease incidence from high to low was control>shrimp peptide organic fertilizer treatment>microbial treatment.The average monthly TR4 pathogen content in heavily infected banana plantation was more than 2000 copies,while the highest one reached 15148.9 copies.[Conclusion]Microbial agents reduced the disease incidence of Fusarium wilt to some content.Nantianhuang and Yunjiao No.1 showed the highest disease resistance compared with other varieties.However,their resistance needs to be further improved before practical application. | Long Yuan Yang Baoming Huang Yuling Bai Tingting Xu Shengtao Yin Kesuo Fan Huacai Zeng Li Li Xundong Guo Zhixiang Li Yongping Yang Derong Li Jinping Zheng Sijun | 2020 | Plant Diseases and Pests2020，11，1： | 0 |
| 17 | Development Characteristics,Problems and Recommendations of Sweet Potato Industry in Fuyang City显示文摘The development of sweet potato industry in Fuyang City takes on following characteristics:increase in planting area of specialized households and professional cooperatives;increase in production input and yield;constant optimization of planting varieties;diversified planting modes.Sweet potato industry has made significant contribution to Fuyang City:(1)enriching types of agricultural products and promoting healthy diet;(2)driving development of agricultural product processing industry and increasing the employment rate of rural labor;(3)increasing financial revenue and rate of export-making foreign exchange of agricultural products;(4)increasing farmers'income and promoting new socialist countryside construction.In line with comparative advantages and existing problems of sweet potato industry in Fuyang City,it presents corresponding industrial development recommendations. | Zemin FAN Xinliang LIU Yuling ZHU Xiumei WANG Xiaolu JIANG Fengwu XING | 2013 | Asian Agricultural Research2013，5，12： | 0 |
| 18 | Generation of pigs with humanized type Ⅱ collagen by precise human COL2A1 gene knock-in显示文摘Osteoarthritis(OA)is the most common chronic disease,characterized by progressive cartilage breakdown,subchondral bone sclerosis,and aberrant bone outgrowth(Yucesoy et al.,2015;Hussain et al.,2016).OA is one of the leading causes of cartilage damage.Patients with severe cartilage damage require transplantation of articular cartilage to improve their quality of life.Type Ⅱ collagen is a major component of articular cartilage and intervertebral discs and plays an important role in the structure and strength of connective tissues that support muscles and joints(Byers,1994). | Ting Lan Yuling Zheng Yangyang Suo Yuhui Wei Hui Shi Quanmei Yan Zhenpeng Zhuang Huangyao Chen Quanjun Zhang Nana Fan Yu Zhao Zhen Ouyang Chengdan Lai Zhaoming Liu Jizeng Zhou Chengcheng Tang Nam-Hyung Kim Qingjian Zou Xiaomin Wang | 2023 | Journal of Genetics and Genomics2023，50，3： | 0 |
| 19 | PUMD:a PU learning-based malicious domain detection framework显示文摘Domain name system(DNS),as one of the most critical internet infrastructure,has been abused by various cyber attacks.Current malicious domain detection capabilities are limited by insufficient credible label information,severe class imbalance,and incompact distribution of domain samples in different malicious activities.This paper proposes a malicious domain detection framework named PUMD,which innovatively introduces Positive and Unlabeled(PU)learning solution to solve the problem of insuffcient label information,adopts customized sample weight to improve the impact of class imbalance,and effectively constructs evidence features based on resource overlapping to reduce the intra-class distance of malicious samples.Besides,a feature selection strategy based on permutation importance and binning is proposed to screen the most informative detection features.Finally,we conduct experiments on the open source real DNS traffic dataset provided by QI-ANXIN Technology Group to evaluate the PUMD framework's abil-ity to capture potential command and control(C&C)domains for malicious activities.The experimental results prove that PUMD can achieve the best detection performance under different label frequencies and class imbalance ratios. | Zhaoshan Fan Qing Wang Haoran Jiao Junrong Liu Zelin Cui Song Liu Yuling Liu | 2023 | Cybersecurity2023，6，1： | 0 |
| 20 | Fluorescent Property of Triethylene-glycol Di (7-(N,N'-diethylamino))-Coumarin-3-Carboxylate显示文摘Introduction Coumarines have been recently paid much attention for their physiological activities and fluorescent properties.They have outstanding optical properties,including high photostability,extended spectral range,high quantum yield of photoluminescence. | Zhang Hui Yu Tianzhi Zhao Yuling Qian Long Fan Duowang | 2007 | 兰州交通大学学报2007，26，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员