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| 1 | Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model显示文摘Osteoarthritis(OA) is a degenerative joint disease and a major cause of pain and disability in older adults. We have previously identified epidermal growth factor receptor(EGFR) signaling as an important regulator of cartilage matrix degradation during epiphyseal cartilage development. To study its function in OA progression, we performed surgical destabilization of the medial meniscus(DMM) to induce OA in two mouse models with reduced EGFR activity, one with genetic modification(EgfrWa5/1mice) and the other one with pharmacological inhibition(gefitinib treatment). Histological analyses and scoring at 3 months post-surgery revealed increased cartilage destruction and accelerated OA progression in both mouse models. TUNEL staining demonstrated that EGFR signaling protects chondrocytes from OA-induced apoptosis, which was further confirmed in primary chondrocyte culture. Immunohistochemistry showed increased aggrecan degradation in these mouse models, which coincides with elevated amounts of ADAMTS5 and matrix metalloproteinase 13(MMP13), the principle proteinases responsible for aggrecan degradation, in the articular cartilage after DMM surgery. Furthermore, hypoxia-inducible factor 2a(HIF2a), a critical catabolic transcription factor stimulating MMP13 expression during OA, was also upregulated in mice with reduced EGFR signaling. Taken together, our findings demonstrate a primarily protective role of EGFR during OA progression by regulating chondrocyte survival and cartilage degradation. | Xianrong Zhang Ji Zhu Fei Liu Yumei Li Abhishek Chandra L Scott Levin Frank Beier Motomi Enomoto-Iwamoto Ling Qin | 2014 | Bone Research2014，2，3： | 9 |
| 2 | Numerical simulation of effect of rotational tool with screw on material flow behavior of friction stir welding of Ti6Al4V alloy显示文摘The rotational tool is put forward, which is composed of the one-spiral-flute shoul-der and the rotational pin with screw. Using the turbulent model of the FLUENT software, material plastic flow behavior during the process of friction stir welding of Ti6Al4V alloy is researched by the numerical simulation method and then the effect of rotational tool geometry on material flow during the welding process is attained. The results show that the flow direction of the material near the rotational tool is mainly the same as the rotational direction of the tool while the material near tool flows more violently than the other regions. For the tapered rotational pin, the flow velocity of material inside the workpiece decreases with the increase of the distance away from the workpiece surface because of the change of pin diameter. For the rotational tool, the flute added to the shoulder and the screw added to the pin can greatly increase the flow velocity of material during the welding process while the peak value of the flow velocity of material appears on the flute or the screw. Moreover, the rotational tool with the one-spiral-flute shoulder is better than the tool with the concentric-circles-flute shoulder. Decreasing the width of pin screw and increasing the diameter of pin tip are both good for the increase of flow velocity. | Shude JI Aili ZOU Yumei YUE Guohong L UAN Yanye JIN Fu LI | 2012 | Acta Metallurgica Sinica(English Letters)2012，25，5： | 2 |
| 3 | 15-HETE suppresses K+channel activity and inhibits apoptosis in pulmonary artery smoothmuscle cells显示文摘 | Yumei L Qian L Zhigang W | 2009 | Apoptosis2009，14，： | 1 |
| 4 | Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum显示文摘 | Liang Guo Jianhui Xie Yuanyuan Ruan Lei Zhou Haiyan Zhu Xiaojing Yun Yan Jiang Long Lü Kangli Chen Zhihui Min Yumei Wen Jianxin Gu | 2009 | International Immunopharmacology2009，，10： | 1 |
| 5 | Prediction and identification-based prediction of Chinese hepatitis C viral-specific cytotoxic T lymphocyte epitopes 显示文摘 | Duan L Lei P Yumei X | 2011 | J Med Virol2011，83，8： | 1 |
| 6 | Miscibility, morphology, thermal, and mechanical properties of a DGEBA based epoxy resin toughened with a liquid rubber显示文摘 | Thomas R Yumei D He Y L | 2008 | Polymer2008，49，1： | 1 |
| 7 | Component and simulation of the 4,000-year-old noodles excavated from the archaeological site of Lajia in Qinghai,China显示文摘Noodles are a global food,but the periods when and places where they were made and originated,as well as their ingredients and the cooking methods used to manufacture them,have remained contentious.In the 2005 edition of the journal Nature,we wrote a summary of the millet noodle specimens found in the Late Neolithic Qijia cultural stratum of the Lajia archaeological site in Qinghai Province,China.However,how the ancient people made millet noodles remains controversial.This paper provides a systematic analysis of the remains of noodles found withinan earthenware bowl at the Lajia ‘‘noodle house'' in terms of their plant composition including phytoliths,starch and biomarkers.It provides evidence of how people used millet4,000 years ago and,most specifically,of the principal methods used for producing millet-based noodles.Further,we show how we used traditional hele tools to make hele millet noodles,with especial reference to the gelatinized hydrogel-forming method,to simulate morphology consistent with the composition and form of the unearthed millet noodles.The results of this study provide new evidence and new insights into the cultural characteristics of the prehistoric human diet. | Houyuan L Yumei Li Jianping Zhang Xiaoyan Yang Maolin Ye Quan Li Can Wang Naiqin Wu | 2014 | Chinese Science Bulletin2014，59，35： | 1 |
| 8 | Prediction and identification-based prediction of Chinese hepatitis C viral-specific cytotoxic Tlymphocyte epitopes显示文摘 | Duan L Lei P Yumei X | 2011 | J Med Virol2011，83，8： | 1 |
| 9 | Preliminary Study of the Characteristics of Several Glossy Cabbage(Brassica oleracea var. capitata L.) Mutants显示文摘To determine the characteristics and potential practical applications of glossy cabbage(Brassica oleracea var. capitata L.) mutants, five different glossy mutants were studied. The amount of epicuticular wax covering the mutant leaves was only approximately 30% that of the wild-type(WT) leaves. The wax crystals of WT plants were columnar and linear, while they were granular and rod-shaped in the mutants. Additionally, in WT cabbage, the primary wax components were alkanes, alcohols, fatty acids, ketones, and aldehydes. There was a significant decrease in the abundance of alkanes and ketones in the wax of the mutants. The glossy-green trait of the mutants may be the result of an inhibited alkane-forming pathway. Higher rates of chlorophyll leaching and water loss demonstrate that the mutant leaves were more permeable and sensitive to drought stress than the WT leaves. Growth curve results indicated that the growth rate of mutant-1 and mutant-3 was slower than that of the corresponding WT cabbage, resulting in shorter plants. However, the growth rate of mutant-2 was not influenced by the lack of coating wax. An investigation of the agronomic traits and heterosis of the glossy cabbage mutants indicated that all five mutants had glossy-green leaves, which was a favorable characteristic. The F1 plants derived from crosses involving mutant-2 exhibited obvious heterosis, suggesting the observed glossy-green trait is controlled by a dominant gene. Therefore, mutant-2 may be useful as a source of genetic material for future cabbage breeding experiments. | TANG Jun LIU Dongming LIU Zezhou YANG Limei FANG Zhiyuan LIU Yumei ZHUANG Mu ZHANG Yangyong Lü Honghao YI Dengxia SUN Peitian | 2015 | Horticultural Plant Journal2015，1，2： | 0 |
| 10 | Effect of Continuous Cooling Conditions on Microstructure and Mechanical Properties of High Carbon Steel Rod显示文摘lintroductionElltectoidsteelhasafullypearliticmicrostructure.Fromdirectobservationandindirectdeductioninearlystage,theformingofpearliteterritoryisaprocessofaandFe,Cnucleationandgrowthalternately[1--2].SinceprioraustenitegrainsizeisoneofthefeatUrestha... | QingWu Cai1 Yumei Pu2 Di Tang1 Zhenli Mi1 Yuzhou Zhu2(l Material Science and Engineering School, University of Science and Technology Beijing, Beijing 100083, China2 Maanshan iron and Steel Co. Ltd., Maanshan 243000, China) | 1999 | International Journal of Minerals,Metallurgy and Materials1999，13，4： | 0 |
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