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| 1 | Target delineation and dose prescription of adaptive replanning intensity-modulated radiotherapy for nasopharyngeal carcinoma显示文摘Dear Editor,Intensity-modulated radiotherapy(IMRT)has a distinct advantage of high conformity and is an appropriate tech-nique for treating nasopharyngeal carcinoma(NPC).Pre-vious studies have demonstrated that anatomical changes in the external contour,shape,and location of the target and critical structures are significant and result in dosi-metric changes[1,2].Patients’quality of life and clini-cal outcomes might be improved by IMRT replanning[3].Therefore,replanning strategies should be consid-ered instead of single-planning strategies throughout the entire course of radiotherapy.However,there are sub-stantial controversies on(1)the appropriate time for tar-get redelineation,(2)how to modify the target volumes,and(3)how to evaluate the modified plans.The present study provides a new perspective in replanning with regard to these three aspects. | Dehuan Xie Wanqin Cheng Shaowen Lv Rui Zhong Lei Wang Jiang Hu Mingli Wang Shaomin Huang Yong Su Yunfei Xia | 2019 | Cancer Communications2019，39，1： | 7 |
| 2 | Urea combustion synthesis of LiNi_(0.5)Mn_(1.5)O_4 as a cathode material for lithium ion batteries显示文摘LiNi0.5Mn1.5O4 was synthesized by combustion synthesis(UCS) using urea as fuel.X-ray diffraction and scanning electron microscope measurements showed that the spinel structure LiNi0.5Mn1.5O4 with the space group Fd3m was formed during urea combustion.Both structure and particle size could be adjusted by the amount of urea and the heat treatment temperature used in the UCS.For the LiNi0.5Mn1.5O4 sample prepared with a urea/Li molar ratio of 0.57 and a heat treatment temperature of 900 C,the particle-size distribution fell in a narrow range of 1-2 m.Electrochemical tests indicated that this LiNi0.5Mn1.5O4 sample delivered a discharge capacity of 133.6 mAh/g with a capacity retention rate of 99.6% after 20 cycles at 0.5 C. | Kedi Yang Jing Su Li Zhang Yunfei Long Xiaoyan Lv Yanxuan Wen | 2012 | Particuology2012，10，6： | 3 |
| 3 | Optimal control problem in an epidemic disease SIS model with stages and delays显示文摘 | Yongzhen Pei Miaomiao Chen Xiyin Liang Zhumei Xia Yunfei Lv Changguo Li | 2016 | International Journal of Biomathematics2016，9，5： | 2 |
| 4 | Advanced lanthanide doped upconversion nanomaterials for lasing emission显示文摘Microlasers are narrow-band and coherent light from small cavities,which have been widely applied in biomedicine,optical interconnection,integration devices,etc.Lanthanide doped upconversion materials are potential gain media for microlasers from near infrared(NIR)to visible and UV regimes due to their multi ladder-like metastable energy levels and superior optical frequency conversion capability.The optical feedback from photon scattering of the porous upconversion nanoparticles clusters has been reported to produce upconversion random lasers.The light bouncing back and forth between two reflective surfaces or internal surface has been utilized to achieve modulated upconversion lasing emission.In addition,photon lattices and plasmonic cavities with enhanced electromagnetic fields can amplify the upconversion process within the sub-diffraction volumes and produce highly efficient upconverting lasers.In this review,the recent advances on using lanthanide doped upconversion materials for random,whispering gallery mode(WGM)/Fabry-Perot(FP)cavity and photon lattice/plasmonic cavity modulated upconversion microlasers are overviewed.Current challenges and future directions of the upconverting lasers are also discussed. | Yunfei Shang Tong Chen Tianhui Ma Shuwei Hao Weiqiang Lv Dechang Jia Chunhui Yang | 2022 | Journal of Rare Earths2022，40，5： | 2 |
| 5 | Experimental Research onthe Anti-tumor Effect of Moxibustion Serum 显示文摘 | Chen Yunfei Zhao Cuiying Lv Qiyong | 2011 | J Acupunct TuinaSci2011，9，6： | 1 |
| 6 | SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches显示文摘Estrogen receptor (ER)-positive luminal breast cancer is a subtype with generally lower risk of metastasis to most distant organs. However, bone recurrence occurs preferentially in luminal breast cancer. The mechanisms of this subtype-specific organotropism remain elusive. Here we show that an ER-regulated secretory protein SCUBE2 contributes to bone tropism of luminal breast cancer. Single-cell RNA sequencing analysis reveals osteoblastic enrichment by SCUBE2 in early bone-metastatic niches. SCUBE2 facilitates release of tumor membrane-anchored SHH to activate Hedgehog signaling in mesenchymal stem cells, thus promoting osteoblast differentiation. Osteoblasts deposit collagens to suppress NK cells via the inhibitory LAIR1 signaling and promote tumor colonization. SCUBE2 expression and secretion are associated with osteoblast differentiation and bone metastasis in human tumors. Targeting Hedgehog signaling with Sonidegib and targeting SCUBE2 with a neutralizing antibody both effectively suppress bone metastasis in multiple metastasis models. Overall, our findings provide a mechanistic explanation for bone preference in luminal breast cancer metastasis and new approaches for metastasis treatment. | Qiuyao Wu Pu Tian Dasa He Zhenchang Jia Yunfei He Wenqian Luo Xianzhe Lv Yuan Wang Peiyuan Zhang Yajun Liang Wenjin Zhao Jun Qin Peng Su Yi-Zhou Jiang Zhi-Ming Shao Qifeng Yang Guohong Hu | 2023 | Cell Research2023，33，6： | 1 |
| 7 | School Perform- ance and School Behavior School performance and school behav- ior of children affected by Acquired Immune Deficiency Syndrome AIDS (AIDS) in China显示文摘 | Xiaoming Tu Yunfei Lv Xiaoming Li | 2009 | Vulnerable Children and Youth Studies2009，4，3： | 1 |
| 8 | Anticarin-β shows a promising antiosteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis显示文摘Unlike healthy, non-transformed cells, the proteostasis network of cancer cells is taxed to produce proteins involved in tumor development. Cancer cells have a higher dependency on molecular chaperones to maintain proteostasis. The chaperonin T-complex protein ring complex(TRiC) contains eight paralogous subunits(CCT1-8), and assists the folding of as many as 10% of cytosolic proteome.TRiC is essential for the progression of some cancers, but the roles of TRiC subunits in osteosarcoma remain to be explored. Here, we show that CCT4/TRiC is significantly correlated in human osteosarcoma,and plays a critical role in osteosarcoma cell survival. We identify a compound anticarin-β that can specifically bind to and inhibit CCT4. Anticarin-β shows higher selectivity in cancer cells than in normal cells. Mechanistically, anticarin-β potently impedes CCT4-mediated STAT3 maturation. Anticarin-β displays remarkable antitumor efficacy in orthotopic and patient-derived xenograft models of osteosarcoma.Collectively, our data uncover a key role of CCT4 in osteosarcoma, and propose a promising treatment strategy for osteosarcoma by disrupting CCT4 and proteostasis. | Gan Wang Min Zhang Ping Meng Chengbo Long Xiaodong Luo Xingwei Yang Yunfei Wang Zhiye Zhang James Mwangi Peter Muiruri Kamau Zhi Daic Zunfu Ke Yi Zhang Wenlin Chen Xudong Zhao Fei Ge Qiumin Lv Mingqiang Rong Dongsheng Li Yang Jin Xia Sheng Ren Lai | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 9 | Design and properties of a novel nucleating agent for isotactic polypropylene显示文摘 | Lv Zhiping Yang Yunfei Wu Ran | 2012 | Materials & design2012，37，5： | 1 |
| 10 | Design and properties of a novel nucleating agent for isotactic polypropylene显示文摘 | Zhiping Lv Yunfei Yang Ran Wu Yuchao Tong | 2011 | Materials and Design2011，，： | 1 |
| 11 | Investigation on the Cracking Mechanism of Melt Growth Alumina/Aluminum Titanate Ceramics Prepared by Laser Directed Energy Deposition显示文摘Oxide melt growth ceramics(OMGCs)exhibit excellent performance and microstructure stability near their melt-ing point and are expected to become a new structural material for long-term stable service in extremely high-temperature water-oxygen environments.Owing to its unique advantages of high efficiency,flexible manufac-turing,and near-net shaping,laser directed energy deposition(LDED)has become a promising technology for the rapid preparation of high-performance OMGCs.However,owing to the limited understanding of the crack-ing mechanism,the severe cracking problem that hinders OMGCs-LDED towards engineering applications has not been resolved.Alumina/aluminum titanate(Al_(2)O_(3)/Al_(x)Ti_(y)O_(z),A/AT)ceramics are prepared using an LDED system and their cracking characteristics are investigated.Subsequently,numerical simulations are conducted to reveal the dominant factors and influencing mechanisms of the cracking behavior.The results demonstrate that the cracking nucleation process is mainly controlled by solidification defects,whereas the cracking propagation process is determined primarily by both the microstructure and stress level.This study provides a theoretical basis for the development of appropriate cracking suppression methods for OMGCs-LDED. | Yunfei Huang Dongjiang Wu Chengxin Li Weijie Lv Guangyi Ma Cong Zhou Fangyong Niu | 2023 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2023，2，4： | 0 |
| 12 | Enhanced unipolar electrical fatigue resistance and related mechanism in grain-oriented Pb(Mg_(1/3)Nb_(2/3))O_(3)-Pb(Zr,Ti)O_(3)piezoceramics显示文摘Piezoceramics with high and fatigue-resisted piezoelectric properties are strongly desired for actuator ap-plications.In this work,textured Pb(Mg_(1/3)Nb_(2/3))O_(3)-Pb(Zr,Ti)O_(3)ceramics with Lotgering factor F_(001)∼98%were fabricated by templated grain growth technique.Strong[001]c-grain orientation(f∼90%and r∼0.22)of the textured ceramics effectively produced about 230%enhanced piezoelectric coefficient d_(33)^(∗)(i.e.,S_(max)/E_(max))and substantially improved unipolar electrical fatigue resistance.Unipolar polarization P max and d_(33)^(∗)of the textured ceramics were nearly maintained up to 106 unipolar cycles,while 19%and 14%degradations were respectively observed from randomly oriented counterparts.Especially,normal-ized d_(33)^(∗)of the textured ceramics shows better unipolar fatigue resistance than those of piezoceramics reported previously.Much lower bipolar strain asymmetryγs(∼4%)was observed from the textured samples fatigued after 106 unipolar cycles as compared toγs∼23%for randomly oriented counterparts.While charged defect accumulation model described the serious fatigue deteriorations in randomly ori-ented ceramics,the current work revealed that substantially enhanced unipolar fatigue resistance of the textured ceramics is mainly associated with the inherent fatigue anisotropy,weakened local bias fields owing to both enhanced domain mobility and lower defect density near grain boundaries/interfaces,and increased intrinsic contribution due to more tetragonal content.These superior characteristics suggest the great potential of textured ceramics for high-performance and robust actuator applications. | Linjing Liu Bin Yang Rui Lv Qiangwei Kou Shuai Yang Hang Xie Yuan Sun Yunfei Chang Shan-Tao Zhang Fei Li | 2023 | Journal of Materials Science & Technology2023，，14： | 0 |
| 13 | Biodegradable calcium sulfide-based nanomodulators for H_(2)S-boosted Ca^(2+)-involved synergistic cascade cancer therapy显示文摘Hydrogen sulfide(H_(2)S)is the most recently discovered gasotransmitter molecule that activates multiple intracellular signaling pathways and exerts concentration-dependent antitumor effect by interfering with mitochondrial respiration and inhibiting cellular ATP generation.Inspired by the fact that H_(2)S can also serve as a promoter for intracellular Ca^(2+)influx,tumor-specific nanomodulators(I-CaS@PP)have been constructed by encapsulating calcium sulfide(CaS)and indocyanine green(ICG)into methoxy poly(ethylene glycol)-b-poly(lactide-co-glycolide)(PLGA-PEG).I-CaS@PP can achieve tumor-specific biodegradability with high biocompatibility and pH-responsive H_(2)S release.The released H_(2)S can effectively suppress the catalase(CAT)activity and synergize with released Ca^(2+)to facilitate abnormal Ca^(2+)retention in cells,thus leading to mitochondria destruction and amplification of oxidative stress.Mitochondrial dysfunction further contributes to blocking ATP synthesis and downregulating heat shock proteins(HSPs)expression,which is beneficial to overcome the heat endurance of tumor cells and strengthen ICG-induced photothermal performance.Such a H_(2)S-boosted Ca^(2+)-involved tumor-specific therapy exhibits highly effective tumor inhibition effect with almost complete elimination within 14-day treatment,indicating the great prospect of CaS-based nanomodulators as antitumor therapeutics. | Chuchu Lin Chenyi Huang Zhaoqing Shi Meitong Ou Shengjie Sun Mian Yu Ting Chen Yunfei Yi Xiaoyuan Ji Feng Lv Meiying Wu Lin Mei | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 0 |
| 14 | Modeling and analysis of a predator-prey model with state-dependent delay显示文摘 | Yunfei Lv Yongzhen Pei Rong Yuan | 2018 | International Journal of Biomathematics2018，11，2： | 0 |
| 15 | MOF-derived Se doped MnS/Ti_(3)C_(2)T_(x) as cathode and Zn-Ti_(3)C_(2)T_(x) membrane as anode for rocking-chair zinc-ion battery显示文摘Mn-based zinc ion battery has the advantages of low cost and high performance,which makes it the promising energy storage system.However,the poor conductivity and the agglomeration in the synthesis process of manganese-based materials restrict the performance of batteries.Herein,the Se-doped MnS/Ti_(3)C_(2)T_(x)(Se-MnS/Ti_(3)C_(2)T_(x))composite material derived from Mn-based metal-organic framework is reported.Electrochemical tests show that Se-doped could generate S defects and enhance the electrochemical activity of MnS.At the same time,the introduction of Ti_(3)C_(2)T_(x) substrate is conducive to exposing more sulfur defects and improving the utilization rate of defects.In the mechanism study,it is found that Se-MnS/Ti_(3)C_(2)T_(x) is transformed into S/Se co-doped Mn3O_(4) at the first charge,which innovatively elucidated the behavior of S/Se during activation.In the electrochemical performance test,the specific capacity can reach 74.7 mAh·g^(-1) at 5.0 A·g^(-1).In addition,the Zn-Ti_(3)C_(2)T_(x) membrane electrode is prepared by vacuum filtration as the zinc-poor anode,which is assembled into the rocking chair full battery to avoid dendrite growth and exhibit excellent rate performance.The addition of Zn2+weakens the electrostatic repulsion between the interlayers of MXene,and the formation of the folded morphology aids the penetration of the electrolyte.At 1.0 A·g^(-1),the capacity can reach 50.6 mAh·g^(-1).This work is helpful to promote the research and development of the reaction mechanism of manganese based rocking chair batteries. | Kaisheng Sun Zemao Xiao Yunfei Shen Heng Lv Jianpeng Zhu Jianxiang Pang Yang Zheng Wenwen Kong Long Chen | 2024 | Nano Research2024，17，4： | 0 |
| 16 | Microwave-assisted polyol synthesis of LiMnPO4/C and its use as a cathode material in lithium-ion batteries显示文摘 | Yunfei Long Zhihua Zhang Zhi Wu Jing su Xiaoyan Lv Yanxuan Wen | 2017 | Particuology2017，15，4： | 0 |
| 17 | Study on the influence of the subsurface buoy's vibration on the vector sensor due to ocean current显示文摘 | 师俊杰 Sun Dajun Lv Yunfei Lan Hualin Mei Jidan | 2014 | High Technology Letters2014，20，3： | 0 |
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