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| 1 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 2 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 3 | Recent advances in high-loading catalysts for low-temperature fuel cells: From nanoparticle to single atom显示文摘Low-temperature fuel cells(LTFCs)are considered to be one of the most promising power sources for widespread application in sustainable and renew-able energy conversion technologies.Although remarkable advances have been made in the mass activity of catalysts,mass transport impedance needs to be urgently addressed at a well-designed membrane electrode assembly(MEA)scale.Increasing the loading of electrocatalysts is conducive to prepare thinner and more efficient MEAs owing to the resulting enhanced reactant permeability,better proton diffusion,and lower electrical resistance.Herein,recent progress in high-loading(≥40 wt.%)Pt nanoparticle catalysts(NPCs)and high-loading(≥2 wt.%)single-atom catalysts(SACs)for LTFC applications are reviewed.A summary of various synthetic approaches and support materials for high-loading Pt NPCs and SACs is systematically presented.The influences of high surface area and appropriate surface functionalization for Pt NPCs,as well as coordina-tion environment,spatial confinement effect,and strong metal-support interac-tions(SMSI)for SACs are highlighted.Additionally,this review presents some ideas regarding challenges and future opportunities of high-loading catalysts in the application of LTFCs. | Lixiao Shen Miao Ma Fengdi Tu Zigang Zhao Yunfei Xia Kokswee Goh Lei Zhao Zhenbo Wang Guangjie Shao | 2021 | SusMat2021，1，4： | 3 |
| 4 | Long- versus short-interval follow-up after resection of hepatocellular carcinoma: a retrospective cohort study显示文摘Background:Average postoperative follow-up intervals vary in patients undergoing hepatocellular carcinoma(HCC)resection because of limited evidence regarding the optimal interval.We aimed to compare the associations of long-versus short-interval follow-up with survival and recurrence in risk-stratified HCC patients.Methods:We performed a retrospective cohort study between 2007 and 2014.In total,1227 patients treated by curative resection of Barcelona Clinic Liver Cancer stage A or B HCC were stratified as having a low(n=865)or high(n=362)risk of early recurrence(within the first 2 years after resection)based on prognostic factors identified by the least absolute shrinkage and selection operation algorithm.Patients were further classified into long-interval(every 4-6 months)and short-interval(every 2-4 months)follow-up subgroups based on follow-up within 2 years after resection(low risk,long vs.short:n=390 vs.n=475;high-risk,long vs.short:n=149 vs.n=213).Results:The short-interval follow-up did not prolong overall survival in either the low-risk(hazard ratio[HR]=1.152;95%confidence interval[CI]0.720-1.843)or high-risk(HR=1.213;95%CI 0.702-2.094)patients.Early recurrence occurred in 401 patients.For high-risk patients,the short-interval follow-up subgroup exhibited smaller intrahepatic recurrence than did the long-interval group(2.6 vs.3.5 cm,respectively,P=0.045).However,no significant difference in the rate of Barcelona Clinic Liver Cancer stage 0/A recurrence was found between the long-and short-interval follow-up groups in either low-or high-risk patients(63.1%vs.68.2%,respectively,P=0.580;31.3%vs.41.5%,respec-tively,P=0.280).The rate of curative intent treatment for recurrence(34.5%vs.39.7%,respectively,P=0.430;14.6%vs.20.3%,respectively,P=0.388)was also similar between the follow-up groups for low-and high-risk patients.Conclusions:Shortening the postoperative follow-up interval from every 4-6 months to every 2-4 months within the first 2 years after resection did not increase the rate of curative intent treatment or prolong the overall survival of patients with Barcelona Clinic Liver Cancer stage A or B HCC. | Wei He Yun Zheng Ruhai Zou Jingxian Shen Junping Yang Jiliang Qiu Qiang Tao Wenwu Liu Zhiwen Yang Yuanping Zhang Binkui Li Yunfei Yuan | 2018 | Cancer Communications2018，38，1： | 2 |
| 5 | Effect of high hydrostatic pressure on physicochemical, thermal and morphological properties of mung bean ( Vigna radiata L.) starch显示文摘 | Wenhao Li Fusheng Zhang Peilin Liu Yunfei Bai Lin Gao Qun Shen | 2010 | Journal of Food Engineering2010，，4： | 1 |
| 6 | Numerical simulation of sliding wear for self-lubricating spherical plain bearings 显示文摘 | SHEN Xuejin LIU Yunfei CAO Lei | 2012 | Journal of Materials Research & Technology2012，13，1： | 1 |
| 7 | Numerical simulation of sliding wear for self-lubricating spherical plain bearings显示文摘 | SHEN Xuejin LIU Yunfei CAO Lei | 2012 | Journal of Materials Research and Technology2012，1，1： | 1 |
| 8 | Effect of High Hydrostatic Pressure on Physicochemical and Structural Properties of Rice Starch显示文摘 | Wenhao Li Yunfei Bai Saleh Mousaa Qing Zhang Qun Shen | 2012 | Food and Bioprocess Technology2012，，6： | 1 |
| 9 | Effect of high hydrostatic pressure on physicochemical, thermal and morphological properties of mung bean ( Vigna radiata L.) starch显示文摘 | Wenhao Li Fusheng Zhang Peilin Liu Yunfei Bai Lin Gao Qun Shen | 2010 | Journal of Food Engineering2010，，4： | 1 |
| 10 | Numerical simulation of sliding wear for self-lubricating spherical plain bearings 显示文摘 | Shen Xuejin Liu Yunfei Cao Lei | 2012 | Journal of Materials Research and Technology2012，4，： | 1 |
| 11 | The MYB Transcription Factor Superfamily of Arabidopsis: Expression Analysis and Phylogenetic Comparison with the Rice MYB Family显示文摘 | Chen Yanhui Yang Xiaoyuan He Kun Liu Meihua Li Jigang Gao Zhaofeng Lin Zhiqiang Zhang Yunfei Wang Xiaoxiao Qiu Xiaoming Shen Yunping Zhang Li Deng Xiaohui Luo Jingchu Deng Xing-Wang Chen Zhangliang Gu Hongya Qu Li-Jia | 2006 | Plant Molecular Biology2006，，1： | 1 |
| 12 | Quality assessment of Flos Chrysanthemi Indici from different growing areas in China by solid-phase microextraction-gas chromatography-mass spectrometry显示文摘 | Shen Shun Sha Yunfei Deng Chunhui | 2004 | Journal of Chromatography A2004，1047，2： | 1 |
| 13 | Quality assess- ment of Flos Chrysanthemi Indici from different growing areas in China by solid-phase microextraction-gas chromatography-mass spectrometry显示文摘 | Shen Shun Sha Yunfei Deng Chunhui | 2004 | J Chromatogr A2004，1047，2： | 1 |
| 14 | Characteristics of soil organic carbon andtotal nitrogen storages for differentland-use types in Central Yunnan Plateau显示文摘Two-factor analysis of variance and redundancy analysis were used to analyze the characte-ristics of soil organic carbon total nitrogen storage in garden land,forestland,grassland,farmland,and bare land in the Dachunhe watershed of Jinning District,Kunming City,Yunnan Province,China.The effects of the soil organic carbon,total nitrogen stratification ratio,soil physical and chemical factors on the storage characteristics of organic carbon and total nitrogen of different land-use types were analyzed.The results show that the rates of carbon and nitrogen stratification in soil from 0-20 cm and 40-60 cm of the same land-use types differed are statistically significant(P<0.05).The organic carbon and total nitrogen stratification ratio SR1 of garden land soil are 38.5%and 25.3%,respectively,which are higher than SR^(2).The soil organic carbon and total nitrogen stratification ratio SR^(2) of different land-use types are greater than SR1.There are statistically significant differences in the SR^(2) soil organic carbon and total nitrogen stratification ratios(P<0.05).Soil organic carbon and total nitrogen storage of diffe-rent land-use types gradually decrease with increasing soil depth,with the maximum soil organic carbon and total nitrogen storage in the 0-20 cm soil layer.Soil organic carbon and total nitrogen sto-rage at the same soil depth are significantly different(P<0.05).Soil organic carbon and total nitrogen storage in the garden land are greater than those in the other land-use types.Soil organic carbon and total nitrogen storage in 0-20 cm garden land are 4.96 and 3.19 times than those in bare land,respectively;soil organic carbon and total nitrogen storage are explained by 93.66%and 1.53%in redundancy analysis RDA1 and RDA2,respectively.All physicochemical factors except Available Phosphorus and pH are statistically significance with carbon and nitrogen storage(P<0.05).Soil cationic exchange capacity,Available Phosphorus,C/N ratio,and Moisture Content are positively correlated with organic carbon and total nitrogen storage.In contrast,soil Bulk Density is negatively correlated with organic carbon storage and total nitrogen storage.Available Phosphorus,C/N ratio,and Moisture Content are the main factors promoting soil organic carbon and total nitrogen accumulation. | SHEN Fangyuan TUO Yunfei WANG Qian WANG Fei ZHENG Yang DU Wenjuan XIANG Ping | 2022 | 排灌机械工程学报2022，40，5： | 1 |
| 15 | Preparation and microstructural analysis of poly(ethylene oxide) comb‐type grafted poly( N ‐isopropyl acrylamide) hydrogels crosslinked by poly(?‐caprolactone)显示文摘 | Lei Miao Mangeng Lu Chaolong Yang Yunfei Zhang Tengfei Shen Jianying Ma | 2012 | J Appl Polym Sci2012，，1： | 1 |
| 16 | 肝癌切除术后的长间隔与短间隔随访:一项回顾性队列研究显示文摘背景与目的由于缺乏证据证明肝细胞癌(hepatocellular carcinoma,HCC)切除术后的最佳随访间隔,术后患者接受随访的平均时间间隔不同。我们的目的是比较长间隔随访和短间隔随访与生存和复发的相关性在不同风险分层肝癌患者中的差异。方法我们在2007年至2014年期间进行了一项回顾性队列研究。共有1227例巴塞罗那临床肝癌分期A期或B期的患者接受了根治性切除术。根据最小绝对收缩和选择操作算法为基础的预后因素分析,我们将患者分层为有低风险(n=865)或高风险(n=362)早期复发(切除术后2年内)的2组。根据切除术后2年内的随访情况,患者进一步分为长间隔(每4–6个月)随访和短期间隔(每2–4个月)随访的亚组(低风险,长期vs.短期:n=390 vs. n=475;高风险,长期vs.短期:n=149 vs. n=213)。结果不管在低风险[风险比(hazard ratio,HR)=1.152;95%置信区间(confidenceinterval,CI):0.720–1.843]还是高风险(HR=1.213;95%CI:0.702–2.094)患者中,短间隔随访没有延长患者的总生存期。401例患者出现早期复发。在高风险患者中,与长间隔随访组相比,短间隔组肝内复发肿瘤较小(2.6 cm vs. 3.5 cm,P=0.045)。但是,对于巴塞罗临床肝癌分期0/A期,长间隔与短间隔随访不管在低风险还是高风险患者中复发率(63.1%vs. 68.2%,P=0.580;31.3%vs. 41.5%,P=0.280)差异均无统计学意义。类似的,根治性切除术后,长间隔或短间隔随访分别在低风险和高风险患者中的复发率(34.5%vs. 39.7%,P=0.430;14.6%vs. 20.3%,P=0.388)差异也均无统计学意义。结论对于巴塞罗那临床肝癌分期A期或B期的患者,在接受了根治性切除术后的前2年内,将随访时间从4–6月缩短为2–4个月并不能增加根治性切除术的成功率或延长患者生存时间。 | Wei He Yun Zheng Ruhai Zou Jingxian Shen Junping Yang Jiliang Qiu Qiang Tao Wenwu Liu Zhiwen Yang Yuanping Zhang Binkui Li Yunfei Yuan | 2018 | 癌症2018，37，12： | 0 |
| 17 | A thermal activation based constitutive model for the dynamic deformation of AA5083 processed by large-scale equal-channel angular pressing显示文摘Aluminum alloy 5083(AA5083)processed by large-scale Equal-channel angular pressing(ECAP)is an excellent engineering material with great prospects for industrial applications.An accurate assessment of the underlying constitutive relationships with easily determined material constants is critical for the predictive design and informed processing of such structural materials.To develop such a design framework,uniaxial dynamic compressive tests over a wide range of temperatures(293-573 K)were carried out for an ECAP-processed AA5083 alloy.Additionally,the microstructure before and after dynamic loading was characterized by SEM and TEM.Based on the experimental results,a new dynamic constitutive model,based on thermal activation theory,was established to describe the plastic flow behavior of the AA5083 alloy that incorporates the effects of plastic strain,temperature,and strain rate.The input parameters of the new model were determined using a particle swarm optimization(PSO)method.The model predictions show excellent agreement with experimental results,which suggests that the current predictive constitutive model is highly effective in reproducing the dynamic deformation behavior of the large-scale ECAP-processed AA5083. | Yunfei WANG Minjie WANG Biao CHEN Huijie SUN Katsuyoshi KONDOH Laszlo JKECSKES Jianghua SHEN | 2023 | Chinese Journal of Aeronautics2023，36，5： | 0 |
| 18 | Salt-assisted vapor-liquid-solid growth of high-quality ultrathin nickel oxide flakes for artificial synapses in image recognition applications显示文摘Transition metal oxides have attracted intense interest owing to their abundant physical and chemical properties.The controlled preparation of large-area,high-quality two-dimensional crystals is essential for revealing their inherent properties and realizing high-performance devices.However,fabricating two-dimensional(2D)transition metal oxides using a general approach still presents substantial challenges.Herein,we successfully achieve highly crystalline nickel oxide(NiO)flakes with a thickness as thin as 3.3 nm through the salt-assisted vapor-liquid-solid(VLS)growth method,which demonstrated exceptional stability under ambient conditions.To explore the great potential of the NiO crystal in this work,an artificial synapse based on the NiO-flake resistive switching(RS)layer is investigated.Short-term and long-term synaptic behaviors are obtained with external stimuli.The artificial synaptic performance provides the foundation of the neuromorphic application,including handwriting number recognition based on artificial neuron network(ANN)and the virtually unsupervised learning capability based on generative adversarial network(GAN).This pioneering work not only paves new paths for the synthesis of 2D oxides in the future but also demonstrates the substantial potential of oxides in the field of neuromorphic computing. | Hui Zhang Zongjie Shen Alei Li Lin Wang Qinan Wang Yunfei Li Yunlei Zhong Juntong Zhu Yong Zhang Mengjiao Han Dan Tian Chun Zhao Lixing Kang Qingwen Li | 2024 | Nano Research2024，17，5： | 0 |
| 19 | Dynamic emission characteristics and control strategies of air pollutants from motor vehicles in downtown Beijing,China显示文摘This study combined the real-time monitoring and investigation of traffic flows to comprehensively analyze the road traffic flow and vehicle structure in downtown Beijing.A dynamic emission inventory of motor vehicle air pollutants in downtown Beijing in 2021 was established,and the impact of these emissions on air quality was simulated and quantified,and different emission reduction control scenarios were proposed to evaluate their environmental improvement effects and explore measures to mitigate the impact of pollution emissions.The results show that the high traffic flow and the structure of the motor vehicle emissions in downtown Beijing are the main causes of severe motor vehicle pollution.Monitoring data shows that traffic flow in central Beijing is dominated by small passenger vehicles,while the vehicle mix is better than in other regions,with 72.0%of vehicles meeting'National V'or higher emission standards.However,to achieve higher air quality goals,further reducing vehicle emissions is necessary.Based on dynamic traffic flow,the average daily emissions of nitrogen oxides(NOX),particulate matters(PM_(2.5))and volatile organic compounds(VOC)from motor vehicles in central Beijing are 17.7 tons,0.6 tons and 14.0 tons,respectively,accounting for 23.0%of the city’s average daily motor vehicle emissions.If a zero-emission zone for motor vehicles were implemented in central Beijing,the annual average emission level of pollutants will be reduced by 10.4%to 21.0%.The designation of ultra-low emission zones for motor vehicles could be effective in improving the air quality in the center of Beijing. | Yan Shen Tongran Wu Aiping Lian Jie Gao Fei Peng Guohua Song Xuefang Wu Yangyang Cui Xinyu Liu Yunfei Wan Jing Yan Yifeng Xue | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 20 | A Fast Method for Shortest-Path Cover Identification in Large Complex Networks显示文摘Fast identifying the amount of information that can be gained by measuring a network via shortest-paths is one of the fundamental problem for networks exploration and monitoring.However,the existing methods are time-consuming for even moderate-scale networks.In this paper,we present a method for fast shortest-path cover identification in both exact and approximate scenarios based on the relationship between the identification and the shortest distance queries.The effectiveness of the proposed method is validated through synthetic and real-world networks.The experimental results show that our method is 105 times faster than the existing methods and can solve the shortest-path cover identification in a few seconds for large-scale networks with millions of nodes and edges. | Qiang Wei Guangmin Hu Chao Shen Yunfei Yin | 2020 | Computers, Materials & Continua2020，，5： | 0 |
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