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| 1 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 2 | No expenditure difference among patients with liver cancer at stageⅠ-ⅣV:Findings from a multicenter cross-sectional study in China显示文摘Objective:The number of liver cancer patients in China accounts for more than half of the world.However,China currently lacks national,multicenter economic burden data,and meanwhile,measuring the differences among different subgroups will be informative to formulate corresponding policies in liver cancer control.Thus,the aim of the study was to measure the economic burden of liver cancer by various subgroups.Methods:A hospital-based,multicenter and cross-sectional survey was conducted during 2012・2014,covering 39 hospitals and 21 project sites in 13 provinces across China.The questionnaire covers clinical information,sociology,expenditure,and related variables.All expenditure data were reported in Chinese Yuan(CNY)using 2014 values.Results:A total of 2,223 liver cancer patients were enrolled,of whom 59.61%were late-stage cases(III-IV),and 53.8%were hepatocellular carcinoma.The average total expenditure per liver cancer patient was estimated as 53,220 CNY,including 48,612 CNY of medical expenditures(91.3%)and 4,608 CNY of non-medical expenditures(8.7%).The average total expenditures in stage I,H,m and stage IV were 52,817 CNY,50,877 CNY,50,678 CNY and 54,089 CNY(P>0.05),respectively.Non-medical expenditures including additional meals,additional nutrition care,transportation,accommodation and hired informal nursing were 1,453 CNY,839 CNY,946 CNY,679 CNY and 200 CNY,respectively.The one-year out-of-pocket expenditure of a newly diagnosed patient was 24,953 CNY,and 77.2%of the patients suffered an unmanageable financial burden.Multivariate analysis showed that overall expenditure differed in almost all subgroups(P<0.05),except for sex,clinical stage,and pathologic type.Conclusions:There was no difference in treatment expenditure for liver cancer patients at different clinical stages,which suggests that maintaining efforts on treatment efficacy improvement is important but not enough.To fiirtherly reduce the overall economic burden from liver cancer,more effort should be given to primary and secondary prevention strategies. | Haike Lei Lin Lei Jufang Shi Yongzhong Wu Ling Liang Huiyao Huang Mei He Fangzhou Bai Maomao Cao Hui Qiu Yuting Wang Chengcheng Liu Jia Du Hong Wang Yan Zhang Mengdi Cao Ji Peng Ni Li Chunfeng Qu Min Dai Wanqing Chen Jie He | 2020 | Chinese Journal of Cancer Research2020，32，4： | 7 |
| 3 | Chemical formation and source apportionment of PM_(2.5) at an urban site at the southern foot of the Taihang mountains显示文摘The region along the Taihang Mountains in the North China Plain(NCP) is characterized by serious fine particle pollution. To clarify the formation mechanism and controlling factors, an observational study was conducted to investigate the physical and chemical properties of the fine particulate matter in Jiaozuo city, China. Mass concentrations of the water-soluble ions(WSIs) in PM_(2.5) and gaseous pollutant precursors were measured on an hourly basis from December 1, 2017, to February 27, 2018. The positive matrix factorization(PMF) method and the FLEXible PARTicle(FLEXPART) model were employed to identify the sources of PM_(2.5). The results showed that the average mass concentration of PM_(2.5) was 111 μg/m^(3) during the observation period. Among the major WSIs, sulfate, nitrate, and ammonium(SNA) constituted 62% of the total PM_(2.5) mass, and NO_(3)^(-) ranked the highest with an average contribution of 24.6%. NH_(4)^(+) was abundant in most cases in Jiaozuo. According to chemical balance analysis, SO_(2)-4, NO_(3)^(-), and Cl^(-) might be present in the form of(NH_4)_(2)SO_4, NH_4NO_3, NH_4Cl, and KCl. The liquid-phase oxidation of SO_(2) and NO_(2) was severe during the haze period. The relative humidity and pH were the key factors influencing SO_(4)^(2-) formation. We found that NO_(3)^(-) mainly stemmed from homogeneous gas-phase reactions in the daytime and originated from the hydrolysis of N_(2)O_5 in the nighttime, which was inconsistent with previous studies. The PMF model identified five sources of PM_(2.5) : secondary origin(37.8%), vehicular emissions(34.7%), biomass burning(11.5%), coal combustion(9.4%), and crustal dust(6.6%). | Xiaoyong Liu Mingshi Wang Xiaole Pan Xiyue Wang Xiaolong Yue Donghui Zhang Zhigang Ma Yu Tian Hang Liu Shandong Lei Yuting Zhang Qi Liao Baozhu Ge Dawei Wang Jie Li Yele Sun Pingqing Fu Zifa Wang Hong He | 2021 | Journal of Environmental Sciences2021，33，5： | 5 |
| 4 | Dynamic response analysis under atmospheric disturbances for helicopters based on elastic blades显示文摘A flight dynamics model based on elastic blades for helicopters is developed.Modal shape analysis is used to describe the rotating elastic blades for the purpose of reducing the elastic degrees of freedom for blades.The analytical result is employed to predict the rotor forces and moments.The equilibrium equation of the flight dynamics model is then constructed for the elastic motion for blades and the rigid motion for other parts.The nonlinear equation is further simplified,and the gradient descent algorithm is adopted to implement the trim simulation.The trim analysis shows that the effect of blade elasticity on the accuracy of rotor forces and moments is apparent at high speed,and the proposed method presents good accuracy for trim performance.The timedomain response is realized by a combination of the Newmark method and the adaptive RungeKutta method.The helicopter control responses of collective pitch show that the response accuracy of the model at a yaw-and-pitch attitude is improved.Finally,the influence of blade elasticity on the helicopter dynamic response in low-altitude wind shear is investigated.An increase in blade elasticity reduces the oscillation amplitude of the yaw angle and the vertical speed by more than 70%.Compared with a rigid blade,an elastic blade reduces the vibration frequency of the angular velocity and results in a fast return of the helicopter to its stable flight. | Tong Liu Yuting Dai Guanxin Hong Linpeng Wang | 2017 | Chinese Journal of Aeronautics2017，30，2： | 4 |
| 5 | A male-ABCD algorithm for hepatocellular carcinoma risk prediction in HBs Ag carriers显示文摘Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBs Ag-positive male adults.Methods: HBs Ag-positive males of 35-69 years old(N=6,153) were included from a multi-center populationbased liver cancer screening study. Randomly, three centers were set as training, the other three centers as validation. Within 2 years since initiation, we administrated at least two rounds of HCC screening using Bultrasonography and α-fetoprotein(AFP). We used logistic regression models to determine potential risk factors,built and examined the operating characteristics of a point-based algorithm for HCC risk prediction.Results: With 2 years of follow-up, 302 HCC cases were diagnosed. A male-ABCD algorithm was constructed including participant's age, blood levels of GGT(γ-glutamyl-transpeptidase), counts of platelets, white cells,concentration of DCP(des-γ-carboxy-prothrombin) and AFP, with scores ranging from 0 to 18.3. The area under receiver operating characteristic was 0.91(0.90-0.93), larger than existing models. At 1.5 points of risk score,26.10% of the participants in training cohort and 14.94% in validation cohort were recognized at low risk, with sensitivity of identifying HCC remained 100%. At 2.5 points, 46.51% of the participants in training cohort and 33.68% in validation cohort were recognized at low risk with 99.06% and 97.78% of sensitivity, respectively. At 4.5 points, only 20.86% of participants in training cohort and 23.73% in validation cohort were recognized at high risk,with positive prediction value of 22.85% and 12.35%, respectively.Conclusions: Male-ABCD algorithm identified individual's risk for HCC occurrence within short term for their HCC precision surveillance. | Yuting Wang Minjie Wang He Li Kun Chen Hongmei Zeng Xinyu Bi Zheng Zhu Yuchen Jiao Yong Wang Jian Zhu Hui Zhao Xiang Liu Chunyun Dai Chunsun Fan Can Zhao Deyin Guo Hong Zhao Jianguo Zhou Dongmei Wang Zhiyuan Wu Xinming Zhao Wei Cui Xuehong Zhang Jianqiang Cai Wanqing Chen Chunfeng Qu | 2021 | Chinese Journal of Cancer Research2021，33，3： | 3 |
| 6 | Heavy ion and X-ray irradiation alter the cytoskeleton and cytomechanics of cortical neurons显示文摘Heavy ion beams with high linear energy transfer exhibit more beneficial physical and biological performance than conventional X-rays, thus improving the potential of this type of radiotherapy in the treatment of cancer. However, these two radiotherapy modalities both cause inevitable brain injury. The objective of this study was to evaluate the effects of heavy ion and X-ray irradiation on the cytoskeleton and cytomechanical properties of rat cortical neurons, as well as to determine the potential mechanism of neuronal injury after irradiation. Cortical neurons from 30 new-born mice were irradiated with heavy ion beams at a single dose of 2 Gy and X-rays at a single dose of 4 Gy; subsequent evaluation of their effects were carried out at 24 hours after irradiation. An immunofluorescence assay showed that after irradiation with both the heavy ion beam and X-rays, the number of primary neurons was significantly decreased, and there was evidence of apoptosis. Radiation-induced neuronal injury was more apparent after X-irradiation. Under atomic force microscopy, the neuronal membrane appeared rough and neuronal rigidity had increased. These cell changes were more apparent following exposure to X-rays. Our findings indicated that damage caused by heavy ion and X-ray irradiation resulted in the structural distortion and rearrangement of the cytoskeleton, and affected the cytomechanical properties of the cortical neurons. Moreover, this radiation injury to normal neurons was much severer after irradiation with X-rays than after heavy ion beam irradiation. | Yuting Du Jie Zhang Qian Zheng Mingxin Li Yang Liu Baoping Zhang Bin Liu Hong Zhang Guoying Miao | 2014 | Neural Regeneration Research2014，9，11： | 3 |
| 7 | Scaling of interaction lengths for hypersonic shock wave/turbulent boundary layer interactions显示文摘The interaction length induced by Shock Wave/Turbulent Boundary-Layer Interactions(SWTBLIs)in the hypersonic flow was investigated using a scaling analysis,in which the interaction length normalized by the displacement thickness of boundary layer was correlated with a corrected non-dimensional separation criterion across the interaction after accounting for the wall temperature effects.A large number of hypersonic SWTBLIs were compiled to examine the scaling analysis over a wide range of Mach numbers,Reynolds numbers,and wall temperatures.The results indicate that the hypersonic SWTBLIs with low Reynolds numbers collapse on the supersonic SWTBLIs,while the hypersonic cases with high Reynolds numbers show a more rapid growth of the interaction length than that with low Reynolds numbers.Thus,two scaling relationships are identified according to different Reynolds numbers for the hypersonic SWTBLIs.The scaling analysis provides valuable guidelines for engineering prediction of the interaction length,and thus,enriches the knowledge of hypersonic SWTBLIs. | Yuting HONG Zhufei LI Jiming YANG | 2021 | Chinese Journal of Aeronautics2021，34，5： | 3 |
| 8 | Topological electronic states in HfRuP family superconductors显示文摘Based on the first-principles calculations and experimental measurements,we report that the hexagonal phase of ternary transition metal pnictides TT’X(T=Zr,Hf;T’=Ru;X=P,As),which are well-known noncentrosymmetric superconductors with relatively high transition temperatures,host nontrivial bulk topology.Before the superconducting phase transition,we find that HfRuP belongs to a Weyl semimetal phase with 12 pairs of type-II Weyl points,while ZrRuAs,ZrRuP and HfRuAs belong to a topological crystalline insulating phase with trivial Fu-Kane Z_(2) indices but nontrivial mirror Chern numbers.High-quality single crystal samples of the noncentrosymmetric superconductors with these two different topological states have been obtained and the superconductivity is verified experimentally.The wide-range band structures of ZrRuAs have been identified by ARPES and reproduced by theoretical calculations.Combined with intrinsic superconductivity,the nontrivial topology of the normal state may generate unconventional superconductivity in both bulk and surfaces.Our findings could largely inspire the experimental searching for possible topological superconductivity in these compounds. | Yuting Qian Simin Nie Changjiang Yi Lingyuan Kong Chen Fang Tian Qian Hong Ding Youguo Shi Zhijun Wang Hongming Weng Zhong Fang | 2019 | npj Computational Materials2019，，1： | 1 |
| 9 | Measuring thematurity of risk management in large-scale constructionprojects显示文摘 | Guangshe Jia Xiaochuan Ni Zhen Chen Baonan Hong Yuting Chen Fangjun Yang Chen Lin | 2012 | Automation in Construction2012，，： | 1 |
| 10 | Cross-boundary transport and source apportionment for PM_(2.5) in a typical industrial city in the Hebei Province,China:A modeling study显示文摘Cross-boundary transport of air pollution is a difficult issue in pollution control for the North China Plain.In this study,an industrial district(Shahe City)with a large glass manufactur-ing sector was investigated to clarify the relative contribution of fine particulate matter(PM_(2.5))to the city's high levels of pollution.The Nest Air Quality Prediction Model System(NAQPMS),paired with Weather Research and Forecasting(WRF),was adopted and applied with a spatial resolution of 5 km.During the study period,the mean mass concentrations of PM_(2.5),SO_(2),and NO_(2)were observed to be 132.0,76.1,and 55.5μg/m^(3),respectively.The model reproduced the variations in pollutant concentrations in Shahe at an acceptable level.The simulation of online source-tagging revealed that pollutants emitted within a 50-km radius of downtown Shahe contributed 63.4%of the city's total PM_(2.5)concentration.This contribu-tion increased to 73.9±21.2%when unfavorable meteorological conditions(high relative hu-midity,weak wind,and low planetary boundary layer height)were present;such conditions are more frequently associated with severe pollution(PM_(2.5)≥250μg/m^(3)).The contribution from Shahe was 52.3±21.6%.The source apportionment results showed that industry(47%),transportation(10%),power(17%),and residential(26%)sectors were the most important sources of PM_(2.5)in Shahe.The glass factories(where chimney stack heights were normally<70 m)in Shahe contributed 32.1%of the total PM_(2.5)concentration in Shahe.With an in-crease in PM_(2.5)concentration,the emissions from glass factories accumulated vertically and narrowed horizontally.At times when pollution levels were severe,the horizontally influ-enced area mainly covered Shahe.Furthermore,sensitivity tests indicated that reducing emissions by 20%,40%,and 60% could lead to a decrease in themass concentration of PM_(2.5) of of 12.0%,23.8%,and 35.5%,respectively. | Xiaoyong Liu Xiaole Pan Jie Li Xi Chen Hang Liu Yu Tian Yuting Zhang Shandong Lei Weijie Yao Qi Liao Yele Sun Zifa Wang Hong He | 2022 | Journal of Environmental Sciences2022，34，5： | 1 |
| 11 | Measuring thematurity of risk management in large-scale constructionprojects显示文摘 | Guangshe Jia Xiaochuan Ni Zhen Chen Baonan Hong Yuting Chen Fangjun Yang Chen Lin | 2012 | Automation in Construction2012，，： | 1 |
| 12 | Epigenomic profiling identifies the role of Nr5a2 and CYP1B1 in hepatocellular carcinoma stemness maintenance显示文摘Cancer stem cells (CSCs) are largely responsible for the formation of tumor heterogeneity and tumor’s resistance to traditional treatments such as chemotherapy due to its self-renew capability and multi-lineage differentiation potential (1)However, it remains elusive how the CSCs maintain their stemness, thus restricting the development of therapeutic treatments specifically targeting the CSCs. | Jun Cao Hong Jiang Ran Zhang Amr.R.Ghanam Honghai Xia Yuting Zhu Zhen Yang Xiaoyuan Song | 2019 | Science Bulletin2019，64，16： | 0 |
| 13 | Unidirectional transport in amorphous topological photonic crystals显示文摘Many works on topological insulators have focused on periodic lattice systems,where short-and long-range order is considered.Here we construct a two-dimensional amorphous photonic crystal with short-range order and a controllable level of long-range order and experimentally investigate the transport of topological edge states in this amorphous system.We demonstrate that topology properties remain constant with unidirectional edge state propagation,immune to specific disorder strength.The partition phenomena of edge states are also observed at the intersection of four topological channels in microwave experiments.This proposed amorphous configuration provides new opportunities to explore the relationship between short-range order and topology and may alleviate the fabrication difficulties of topological optical devices for practical applications. | Yuting Yang Xinyue Qian Liwei Shi Xiaopeng Shen Zhi Hong Hang | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，7： | 0 |
| 14 | CUL4B orchestrates mesenchymal stem cell commitment by epigenetically repressing KLF4 and C/EBPδ显示文摘Dysregulated lineage commitment of mesenchymal stem cells(MSCs)contributes to impaired bone formation and an imbalance between adipogenesis and osteogenesis during skeletal aging and osteoporosis.The intrinsic cellular mechanism that regulates MSC commitment remains unclear.Here,we identified Cullin 4B(CUL4B)as a critical regulator of MSC commitment.CUL4B is expressed in bone marrow MSCs(BMSCs)and downregulated with aging in mice and humans.Conditional knockout of Cul4b in MSCs resulted in impaired postnatal skeletal development with low bone mass and reduced bone formation.Moreover,depletion of CUL4B in MSCs aggravated bone loss and marrow adipose accumulation during natural aging or after ovariectomy.In addition,CUL4B deficiency in MSCs reduced bone strength.Mechanistically,CUL4B promoted osteogenesis and inhibited adipogenesis of MSCs by repressing KLF4 and C/EBPδexpression,respectively.The CUL4B complex directly bound to Klf4 and Cebpd and epigenetically repressed their transcription.Collectively,this study reveals CUL4B-mediated epigenetic regulation of the osteogenic or adipogenic commitment of MSCs,which has therapeutic implications in osteoporosis. | Ruiqi Yu Hong Han Shuxian Chu Yijun Ding Shiqi Jin Yufeng Wang Wei Jiang Yuting Liu Yongxin Zou Molin Wang Qiao Liu Gongping Sun Baichun Jiang Yaoqin Gong | 2023 | Bone Research2023，11，2： | 0 |
| 15 | Design of RTD temperature acquisition module based on ADuCM361显示文摘 | PAN Yuting CHEN Yuchen YUAN Zhiqiang TAN Hong | 2016 | International English Education Research2016，，1： | 0 |
| 16 | Multi-View & Transfer Learning for Epilepsy Recognition Based on EEG Signals显示文摘Epilepsy is a central nervous system disorder in which brain activity becomes abnormal.Electroencephalogram(EEG)signals,as recordings of brain activity,have been widely used for epilepsy recognition.To study epilep-tic EEG signals and develop artificial intelligence(AI)-assist recognition,a multi-view transfer learning(MVTL-LSR)algorithm based on least squares regression is proposed in this study.Compared with most existing multi-view transfer learning algorithms,MVTL-LSR has two merits:(1)Since traditional transfer learning algorithms leverage knowledge from different sources,which poses a significant risk to data privacy.Therefore,we develop a knowledge transfer mechanism that can protect the security of source domain data while guaranteeing performance.(2)When utilizing multi-view data,we embed view weighting and manifold regularization into the transfer framework to measure the views’strengths and weaknesses and improve generalization ability.In the experimental studies,12 different simulated multi-view&transfer scenarios are constructed from epileptic EEG signals licensed and provided by the Uni-versity of Bonn,Germany.Extensive experimental results show that MVTL-LSR outperforms baselines.The source code will be available on http://gffzz188fe103f8f1460as0pq50fx5wf6u6055.ffgz.tsg.suse.edu.cn/didid5/MVTL-LSR. | Jiali Wang Bing Li Chengyu Qiu Xinyun Zhang Yuting Cheng Peihua Wang Ta Zhou Hong Ge Yuanpeng Zhang Jing Cai | 2023 | Computers, Materials & Continua2023，，6： | 0 |
| 17 | PET imaging on neurofunctional changes after optogenetic stimulation in a rat model of panic disorder显示文摘Panic disorder (PD) is an acute paroxysmal anxiety disorder with poorly understood pathophysiology. The dorsal periaqueductal gray (dPAG) is involved in the genesis of PD. However, the downstream neurofunctional changes of the dPAG during panic attacks have yet to be evaluated in vivo. In this study, optogenetic stimulation to the dPAG was performed to induce panic-like behaviors, and in vivo positron emission tomography (PET) imaging with ,8F-flurodeoxyglucose (18F-FDG) was conducted to evaluate neurofunctional changes before and after the optogenetic stimulation. Compared with the baseline, post-optogenetic stimulation PET imaging demonstrated that the glucose metabolism significantly increased (P < 0.001) in dPAG, the cuneiform nucleus, the cerebellar lobule, the cingulate cortex, the alveus of the hippocampus, the primary visual cortex, the septohypothalamic nucleus, and the retrosplenial granular cortex but significantly decreased (P < 0.001) in the basal ganglia, the frontal cortex, the forceps minor corpus callosum, the primary somatosensory cortex, the primary motor cortex, the secondary visual cortex, and the dorsal lateral geniculate nucleus. Taken together, these data indicated that in vivo PET imaging can successfully detect downstream neurofunctional changes involved in the panic attacks after optogenetic stimulation to the dPAG. | Xiao He Chentao Jin Mindi Ma Rui Zhou Shuang Wu Haoying Huang Yuting Li Qiaozhen Chen Mingrong Zhang Hong Zhang Mei Tian | 2019 | Frontiers of Medicine2019，13，5： | 0 |
| 18 | Magnetic wallpaper Dirac fermions and topological magnetic Dirac insulators显示文摘Topological crystalline insulators(TCIs)can host anomalous surface states which inherits the characteristics of crystalline symmetry that protects the bulk topology.Especially,the diversity of magnetic crystalline symmetries indicates the potential for novel magnetic TCIs with distinct surface characteristics.Here,we propose a topological magnetic Dirac insulator(TMDI),whose two-dimensional surface hosts fourfold-degenerate Dirac fermions protected by either the p'_(c)4mm or p40 g0 m magnetic wallpaper group.The bulk topology of TMDIs is protected by diagonal mirror symmetries,which give chiral dispersion of surface Dirac fermions and mirror-protected hinge modes.We propose candidate materials for TMDIs including Nd_(4)Te_(8)Cl_(4)O_(2)0 and DyB_(4) based on first-principles calculations,and construct a general scheme for searching TMDIs using the space group of paramagnetic parent states.Our theoretical discovery of TMDIs will facilitate future research on magnetic TCIs and illustrate a distinct way to achieve anomalous surface states in magnetic crystals. | Yoonseok Hwang Yuting Qian Junha Kang Jehyun Lee Dongchoon Ryu Hong Chul Choi Bohm-Jung Yang | 2023 | npj Computational Materials2023，，1： | 0 |
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