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| 1 | Cryo-EM structure and biochemical analysis reveal the basis of the functional difference between human PI3KC3-C1 and-C2显示文摘Phosphatidylinositol 3 磷酸盐(PI3P ) 在小囊的 trafficking,细胞器生物的续生说和 autophagy 起必要作用。二班 III phosphatidylinositol 3-kinase (PI3KC3 ) 建筑群在哺乳动物, ATG14L 建筑群(PI3KC3-C1 ) 和 UVRAG 建筑群(PI3KC3-C2 ) 被识别了。PI3KC3-C1 为 autophagosome 生物的续生说是关键的,并且 PI3KC3-C2 涉及各种各样的膜 trafficking 事件。这里,我们在亚纳米分辨率报导人的 PI3KC3-C1 和 PI3KC3-C2 的 cryo 他们结构。二结构与不同特征分享普通塑造 L 的全面体系结构。他们检查直接表明 PI3KC3-C1 在类脂化合物单层上站起来,与 ATG14L 蝙蝠领域和 VPS34 C 终端领域(CTD ) 联系膜。生物化学的解剖显示 ATG14L 蝙蝠领域负责膜抛锚,而 VPS34 的 CTD 决定取向。而且, PI3KC3-C2 比 PI3KC3-C1 更微弱地绑在包含 PI liposomes 和净化的 endoplasmic 蜂窝胃(嗯) 泡,被 ATG14L 明确地决定的一个性质打领域。在里面 vivo 嗯本地化分析显示蝙蝠领域被要求为嗯 PI3KC3 的本地化。我们建议不同类脂化合物绑定能力是在 autophagy 区分 PI3KC3-C1 和 PI3KC3-C2 的函数的关键因素。 | Meisheng Ma Jun-Jie Liu Nan Li Yuwei Huang Na Ta Yang Chen Hua Fu Ming-Da Ye Yuehe Ding Weijiao Huang Jia Wang Meng-Qiu Dong Li Yu Hong-Wei Wang | 2017 | Cell Research2017，27，8： | 7 |
| 2 | Radiomic analysis of pulmonary ground-glass opacity nodules for distinction of preinvasive lesions, invasive pulmonary adenocarcinoma and minimally invasive adenocarcinoma based on quantitative texture analysis of CT显示文摘Objective: To identify the differences among preinvasive lesions, minimally invasive adenocarcinomas(MIAs)and invasive pulmonary adenocarcinomas(IPAs) based on radiomic feature analysis with computed tomography(CT).Methods: A total of 109 patients with ground-glass opacity lesions(GGOs) in the lungs determined by CT examinations were enrolled, all of whom had received a pathologic diagnosis. After the manual delineation and segmentation of the GGOs as regions of interest(ROIs), the patients were subdivided into three groups based on pathologic analyses: the preinvasive lesions(including atypical adenomatous hyperplasia and adenocarcinoma in situ) subgroup, the MIA subgroup and the IPA subgroup. Next, we obtained the texture features of the GGOs. The data analysis was aimed at finding both the differences between each pair of the groups and predictors to distinguish any two pathologic subtypes using logistic regression. Finally, a receiver operating characteristic(ROC) curve was applied to accurately evaluate the performances of the regression models.Results: We found that the voxel count feature(P<0.001) could be used as a predictor for distinguishing IPAs from preinvasive lesions. However, the surface area feature(P=0.040) and the extruded surface area feature(P=0.013) could be predictors of IPAs compared with MIAs. In addition, the correlation feature(P=0.046) could distinguish preinvasive lesions from MIAs better.Conclusions: Preinvasive lesions, MIAs and IPAs can be discriminated based on texture features within CT images, although the three diseases could all appear as GGOs on CT images. The diagnoses of these three diseases are very important for clinical surgery. | Wei Li Xuexiang Wang Yuwei Zhang Xubin Li Qian Li Zhaoxiang Ye | 2018 | Chinese Journal of Cancer Research2018，30，4： | 6 |
| 3 | A green and effective corrosion inhibitor of functionalized carbon dots显示文摘In this work, a green and effective corrosion inhibitor of functionalized carbon dots(FCDs) was synthesized by the conjugation of imidazole and citric acid carbon dots(CA-CDs). The corrosion inhibition behavior of FCDs for Q235 steel in 1 M HCl solution was systematically investigated by electrochemical analysis, corrosion morphology and adsorption isotherm. The electrochemical results implied that the as-prepared FCDs inhibitor could effectively suppress the corrosion of Q235 steel in 1 M HCl solution. At the same time, the inhibition efficiency of steel in 1 M HCl solution was more than 90% when the inhibitor concentration exceeded 100 mg/L. This excellent property was attributed to the coverage of adsorption film on the steel surface, which conformed to the Langmuir adsorption model. In addition, the analysis of adsorption isotherm displayed that the adsorption mechanism was the physicochemical interaction at the steel/solution interface. | Yuwei Ye Dongping Yang Hao Chen | 2019 | Journal of Materials Science & Technology2019，35，10： | 6 |
| 4 | Study on self-healing and corrosion resistance behaviors of functionalized carbon dot-intercalated graphene-based waterborne epoxy coating显示文摘Functionalized carbon dots(CDs)obtained from citric acid derivative were selected as intercalatorto modify graphene and then dispersed into epoxy matrix to prepare CDs modified graphene/epoxy(CDs-G/EP)coatings.Meanwhile,their microstructure,self-healing and corro sion resistance behaviors were analyzed deeply.Structural characterizations indicated the formation of'π-π'interaction between functionalized carbon dots and graphene.By observation,the dispersion and interface compatibility of graphene were greatly enhanced by CDs.The change rules of electrochemistry results implied that the addition of 0.5 wt.%CDs-G in EP coating(CDs-G0.5%/EP)demonstrated a superior protective property on steel,which was attributed to the physical barrier of highly dispersed graphene and the self-healing ability of CDs.After 50 days immersion,the oxygen permeability coefficient and water absorption of CDs-G0.5%/EP coating were only 4.27×10^(-13)cm^(3)cm cm^(-2)s^(-1)Pa^(-1) and 4.4%,respectively. | Yuwei Ye Hao Chen Yangjun Zou Haichao Zhao | 2021 | Journal of Materials Science & Technology2021，，8： | 5 |
| 5 | Evaluation of the inhibition behavior of carbon dots on carbon steel in HCl and NaCl solutions显示文摘An eco-friendly and effective corrosion inhibitor(N-CDs)was acquired by hydrothermal method in methacrylic acid and ethyl(methyl)amine precursors.Afterwards,the weight loss and electrochemistry measurement were chosen to appraise the corrosion inhibition behavior of as-prepared N-CDs for Q235 steel in Cl-contained solutions.The change rules of EIS and Tafel data displayed that the as-prepared N-CDs revealed a high-efficiency protection for steel in all test environments.Meanwhile,the inhibition efficiency of steel reached up to 93.93%(1 M HCl)and 88.96%(3.5 wt%Na Cl)at 200 mg/L of N-CDs.Furthermore,the N-CDs could form the adsorption film on steel surface to avoid the strong attack of Cl-.By analysis,the adsorption mechanism of as-prepared N-CDs on steel surface was physicochemical interaction,which strictly complied with the Langmuir adsorption model in both solutions. | Yuwei Ye Zilong Jiang Yangjun Zou Hao Chen Shengda Guo Qiumin Yang Liyong Chen | 2020 | Journal of Materials Science & Technology2020，36，8： | 3 |
| 6 | Integrated bioinformatics identifies the dysregulation induced by aberrant gene methylation in colorectal carcinoma显示文摘Colorectal carcinoma(CRC)is one of the most common cancers,and is associated with a poor dlinical outcome.The key genes and potential prognostic markers in colorectal carcinoma remain to be identfed and explored for clinical application.DNA expression/methyl-ation profles were downloaded from the Gene Expression Omnibus(GEO)database to identify differentially expressed/methylated genes(DEGs and DEMs).A total of 255 genes and 372 genes were identified as being up-regulated and down-regulated,respectively,in GSE113513,GSE81558,and GSE89076.There were a total of 3350 hypermethylated genes and 443 hypomethylated genes identifed in GSE 48684.Twenty genes were found to be hypermethylated as well as down-regulated,and a functional enrichment analysis revealed that these genes were mainly involved in cancer-related pathways.Among these 20 genes,GPM6A,HAND2 and C2orf40 were related to poor outcomes in cancer patients based on a survival analysis.Concurrent decreases of GPM6A,HAND2 and C2orf40 protein expression were observed in highly-dif ferentiated colorectal carcinoma tissues,and higher expression levels were found in undifferentiated or minimally-differentiated colorectal carcinoma tissues.In conclusion,20 genes were found to be downregulated and hypermethylated in CRC,among which GPM6A,HAND2 and C2orf40 were explored for their potential prognostic value. | Zhenyu Ye Yecheng Li Jiaming Xie Zhenyu Feng Xiaodong Yang Yong Wu Yuwei Pu Jiawei Gao Xiangrong Xu Zhaobi Zhu Wei Li Wei Chen Chungen Xing | 2021 | Genes & Diseases2021，8，4： | 2 |
| 7 | Prognostic and Predictive Value of CpG Island Methylator Phenotype in Patients with Locally Advanced Nonmetastatic Sporadic Colorectal Cancer显示文摘 | Yuwei Wang Yadong Long Ye Xu Zuqing Guan Peng Lian Junjie Peng Sanjun Cai Guoxiang Cai Qi Li | 2014 | Gastroenterology Research and Practice2014，，： | 1 |
| 8 | Unfavorable effect of small tumor size on cause-specific survival in stage IIA colon cancer, a SEER-based study显示文摘 | Yuwei Wang Changhua Zhuo Debing Shi Hongtu Zheng Ye Xu Weilie Gu Sanjun Cai Guoxiang Cai | 2015 | International Journal of Colorectal Disease2015，，1： | 1 |
| 9 | Understanding corrosion and tribology behaviors of VN and VCN coatings in seawater显示文摘VN and VCN coatings were prepared using multi-arc ion plating technique on 316L stainless steel and single silicon sub-strates.Microstructures,mechanical performances,corrosion behaviors and tribology properties of VN and VCN coatings in the atmosphere,distilled water and seawater were contrastively tested.It was confirmed that the VCN coating had a typi-cal nanocystallite/amorphous structure.Moreover,the hardness increased from 30.5 to 36.5 GPa and the corrosion current density decreased from 2.16×10^(−6) to 0.82×10^(−6)A cm^(−2) after carbon was doped into the VN coating.Compared with the VN coating,the VCN coating had the lowest friction coefficient of 0.26 and wear rate of 0.68×10^(−6)mm^(3)Nm^(−1) in seawater,which could be ascribed to the lubrication of graphitization transfer film and improvement of the comprehensive performance. | Hao Chen Xiaohao Xie Yun Wang Yanliang Wang Yuwei Ye | 2019 | Tungsten2019，1，1： | 0 |
| 10 | Improving innovation and entrepreneurship education in higher institutions: the impact of “Mass Entrepreneurship and Innovation” education on undergraduates’ entrepreneurial intentions显示文摘The exploration of the way'mass entrepreneurship and innovation'(MEI)education influences students'aspirations to become entrepreneurs has grown into an important area of analysis in studies related to higher education.This research intends to examine the consequences of MEI education on students'tendency towards entrepreneurship,and to put forward methods for augmenting the teaching of innovation and entrepreneurship in private higher educational establishments.To achieve this objective,questionnaires and semi-structured interviews were employed in the study,which involved a total of 197 students and five education experts.The statistical analysis of the questionnaire data revealed that MEI education was positively related to students'entrepreneurial intentions,and that both entrepreneurial experience and family entrepreneurial background played moderating roles in this relationship.The interview findings indicated that private universities could enhance educational reforms by designing talent training programs,developing diversified curricula,and developing more professional entrepreneurial platforms to encourage students'entrepreneurial intentions.This study offers fresh insights for improving and perfecting the mechanism of innovation and entrepreneurship education in private universities. | ShaoYing Lu Sun Ye XiaoShu Xu Yuwei Zhao | 2024 | 教育技术与创新2024，6，1： | 0 |
| 11 | Activated carbon fiber mediates efficient activation of peroxymonosulfate systems:Modulation of manganese oxides and cycling of manganese species显示文摘Manganese oxides show a strong catalytic activity in the peroxymonosulfate(PMS)advanced oxidation process but have poor chemical stability and a propensity to cause the aggregation of nanoparticles.Here,a novel composite material(abbreviated as MnO_(x)@ACF)was synthesized,characterized,and applied.Activated carbon fiber(ACF)was selected as a carrier,which modulated the composition of manganese oxides.The results showed that MnO_(x)@ACF had a strong adsorption ability and successfully activated PMS to degrade tetracycline hydrochloride(TCH),with a removal eficiency of 89.0%in 30 min.Influencing factors such as pH and coexisting ion species were investigated,and a five-cycle test was conducted.Singlet oxygen(^(1)O_(2))was predominated in the MnO_(x)@ACF/PMS system.A possible explanatory pathway of TCH was proposed based on the results of the high performance liquid chromatography-mass spectrometry.It was concluded that this study provides a novel insight into the activation of PMS for the degradation of organic matter by carbon-loaded multivalent manganese oxides. | Lixi Xiao Yuwei Deng Huo Zhou Fengjun Lu Chong Ke Yuxuan Ye Xuanyuan Pei Dongsheng Xia Fei Pan | 2023 | Chinese Chemical Letters2023，34，12： | 0 |
| 12 | Transient temperature characteristics of friction clutch disc considering thermal contact conductance under sliding conditions显示文摘High temperatures are generated due to the sliding contacts between the rubbing surfaces of the friction clutch system.In this work,by considering the effective thermal contact conductance under sliding conditions,a simulation model of a two-dimensional transient temperature field of the clutch disc was developed.A numerical solution to obtain the surface temperature at different radii was presented based on the finite difference method.Compared with the experimental data,the proposed model for estimating the surface temperature is more accurate than the conventional prediction method.The results showed that the errors of the calculated temperatures at radii of 114 and 106 mm have obviously reduced by 12.98%and 12.60%,respectively.In addition,the influences of pressure and relative speed on the surface temperature were investigated.The temperature increases with the increase of the relative speed and pressure during the sliding period,and there is an interaction effect between pressure and speed on the surface temperature rise. | Yuwei LIU Yuanzhi SUN Ziyin GAO Fuhao YE Pei TANG | 2023 | Friction2023，11，12： | 0 |
| 13 | LIMK2 is required for membrane cytoskeleton reorganization of contracting airway smooth muscle显示文摘Airway smooth muscle(ASM)has developed a mechanical adaption mechanism by which it transduces force and responds to environmental forces,which is essential for periodic breathing.Cytoskeletal reorganization has been implicated in this process,but the regulatory mechanism remains to be determined.We here observe that ASM abundantly expresses cytoskeleton regulators Limk1 and Limk2,and their expression levels are further upregulated in chronic obstructive pulmonary disease(COPD)animals.By establishing mouse lines with deletions of Limk1 or Limk2,we analyse the length-sensitive contraction,F/Gactin dynamics,and F-actin pool of mutant ASM cells.As LIMK1 phosphorylation does not respond to the contractile stimulation,LIMK1-deficient ASM develops normal maximal force,while LIMK2 or LIMK1/LIMK2 deficient ASMs show approximately 30%inhibition.LIMK2 deletion causes a significant decrease in cofilin phosphorylation along with a reduced F/G-actin ratio.As LIMK2 functions independently of cross-bridge movement,this observation indicates that LIMK2 is necessary for F-actin dynamics and hence force transduction.Moreover,LIMK2-deficient ASMs display abolishes stretching-induced suppression of 5-hydroxytryptamine(5-HT)but not acetylcholine-evoks force,which is due to the differential contraction mechanisms adopted by the agonists.We propose that LIMK2-mediated cofilin phosphorylation is required for membrane cytoskeleton reorganization that is necessary for ASM mechanical adaption including the 5-HT-evoked length-sensitive effect. | Yeqiong Li Yuwei Zhou Pei Wang Tao Tao Lisha Wei Ye Wang Wei Wang Yanyan Zheng Zhihui Jiang Tiantian Qiu Wei Zhao Jie Sun Xin Chen Xue-Na Zhang Min-Sheng Zhu | 2021 | Journal of Genetics and Genomics2021，48，6： | 0 |
| 14 | Temporal and spatial variation of cloud cover in arid regions of Central Asia in the last 40 years显示文摘Water resources are one of the key factors restricting the development of arid areas,and cloud water resources is an important part of water resources.The arid region of central Asia is the core region of the current national green silk road construction,and is the largest arid region in the world.Based on cloud cover data of ECMWF,the current study analyzed temporal and spatial characteristics of cloud properties in arid regions of Central Asia between 1980 and 2019.Our findings show that:(1)From the point of view of spatial distribution,total cloudiness in arid regions of Central Asia was low in the south and high in the north.The distribution of high cloud frequency and medium cloud frequency was higher in the south and lower in the north,while low cloud frequency distribution was low in the south and high in the north.(2)In terms of time,the variation of cloud cover and cloud type frequency had obvious seasonal characteristics.From winter to spring,cloud cover increased,and the change of cloud type frequency increased.From spring to summer,cloud cover continued to increase and the change of cloud type frequency increased further.Cloud cover began to decrease from summer to autumn,and the change of cloud type frequency also decreased.(3)Generally,average total cloud cover decreased in most of central Asia,and high and medium cloud cover increased while low cloud cover decreased.This study provides a reference for the rational development of cloud resources in the region. | KaiLiang Zhao GuoFeng Zhu LiYuan Sang JiaWei Liu Lei Wang YuWei Liu YuanXiao Xu XinRui Lin WenHao Zhang LinLin Ye | 2023 | Research in Cold and Arid Regions2023，15，2： | 0 |
| 15 | Author Correction:Cryo-EM structure and biochemical analysis reveal the basis of the functional difference between human PI3KC3-C1 and-C2显示文摘We apologize for errors that we inadvertently introduced in Fig.4C and Supplementary infoirnation,Figs.S5F,S4E and S6C,of the paper published online on July 21*2017.The bands of Ha-P150_C2-BATsw in Fig.4C,/,a-Beclin1_C1/,in Supplementary information,Fig.S5F,and'a-P150_C2+6%PI(4,5)P2'in Supplementary information,Fig.S6C were incorrectly cropped from the original western blot images.The labeling of'a-VPS34—VPS34 ACTD'and'0-VPS34—ATGML ABATs'in Supplementary information,Fig.S4E were flipped.The corrected figures are provided below. | Meisheng Ma Jun-Jie Liu Yan Li Yuwei Huang Na Ta Yang Chen Hua Fu Ming-Da Ye Yuehe Ding Weijiao Huang Jia Wang Meng-Qiu Dong Li Yu and Hong-Wei Wang | 2020 | Cell Research2020，30，6： | 0 |
| 16 | Non-woven cotton fabric based intimately coupling of photocatalysis and biodegradation system for efficient removal of Cu(Ⅱ)complex in water显示文摘The efficient remediation of heavy metal complexes in water has become a difficult and challenging task owing to their high stability and strong mobility.In this study,a novel strategy was employed for highly efficient removal of Cu-citrate by using intimately coupled photocatalysis and biodegradation(ICPB)system with non-woven cotton fabric as a carrier.Experimental results showed that the ICPB system caused94%Cu removal,which was higher than those of single photocatalysis.After 5 cycles,Cu removal efficiency could still reach 78%within 5 h.The existence of 0–40 mg/L citrate had negligible influence,whereas the presence of 60–100 mg/L citrate exhibited a limited adverse effect on Cu removal(~70%).The decomplexation of Cu-citrate was realized via the function of free radicals and microorganisms.Two main processes,such as bio-adsorption of Cu^(2+) by microorganisms,deposition of Cu^(0) on the surface of material,played important role in Cu removal from aqueous solution.The dominant microorganisms in the system were Proteobacteria,Actinobacteria,Bacteroidetes,Chloroflexi,Chlorophyta,Planctomycetes,and Verrucomicrobia.Furthermore,the performance of ICPB system was also validated through treatment of other heavy metal complexes.This study provided a feasible strategy for the decontamination of heavy metal complexes in wastewater. | Yuxuan Ye Peng Yang Yuwei Deng Yezhi Yang Kun Zhang Yueying Wang Wenjing Shang Qiang Li Lei Sun Fei Pan Dongsheng Xia | 2022 | Chinese Chemical Letters2022，33，6： | 0 |
| 17 | Photo-induced Ag modulating carbon dots:Greatly improved fluorescent properties and derived sensing application显示文摘Carbon dots(CDs)have been attracted much attention and widely studied due to their excellent fluorescence(FL)properties,better biocompatibility and outstanding photo/chemical stability.However,the disadvantage of lower quantum yield(QY)still limits its wide application.Herein,we reported a novel and convenient strategy to prepare photo-induced Ag/CDs(p-Ag/CDs)by irradiating the mixed Ag+and hydrophobic CDs(h-CDs)acetone solution with ultraviolet(UV)light.The obtained p-Ag/CDs exhibit a greatly enhanced FL emission together with a blue shift(460 nm)than h-CDs(520 nm).The QY of p-Ag/CDs is measured to be 51.1%,which is 10.4 times higher than that of h-CDs(4.9%),indicating that photo-induced Ag modulation can effectively improve the optical properties of CDs.The mechanisms for the FL enhancement and blue shift of h-CDs are studied in detail.The results prove that the greatly enhanced FL emission is from the generated Ag nanoparticles(AgNPs)by UV light irradiation based on metal-enhanced fluorescence(MEF),and the increased oxygen-contained groups in this process lead to the blue shift in CDs fluorescence.Interestingly,the p-Ag/CDs exhibit higher sensitivity and selectivity for sulfide ions(S2-)detection than that of h-CDs,which have a lower response to S2-.This work not only offers a novel strategy to improve the FL properties of materials but also endows them with new functions and broadens their application fields. | Yuwei Wang Ye Li Guixiang Yang Xiaofeng Yang Chenglu Yan Huaqiao Peng Huiyong Wang Juan Du Baozhan Zheng Yong Guo | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
| 18 | OCT4’s role and mechanism underlying oral squamous cell carcinoma显示文摘Oral squamous cell carcinoma(OSCC),a common malignancy of the head and neck,ranks sixth worldwide in terms of cancers with the most negative impact,owing to tumor relapse rates,cervical lymphnode metastasis,and the lack of an efficacious systemic therapy.Its prognosis is poor,and its mortality rate is high.Octamer-binding transcription factor 4(OCT4)is a member of the Pit-Oct-Unc(POU)family and is a key reprogramming factor that produces a marked effect in preserving the pluripotency and self-renewal state of embryonic stem cells(ESCs).According to recent studies,OCT4 participates in retaining the survival of OSCC cancer stem cells(CSCs),which has far-reaching implications for the occurrence,recurrence,metastasis,and prognosis of oral carcinogenesis.Therefore,we summarize the structure,subtypes,and function of OCT4 as well as its role in the occurrence,progression,and prognosis of OSCC. | Yuwei DAI Ziqiong WU Yitong CHEN Xinjian YE Chaowei WANG Huiyong ZHU | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，9： | 0 |
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