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| 1 | Impacts of a wind stress and a buoyancy flux on the seasonal variation of mixing layer depth in the South China Sea显示文摘The seasonal variation of mixing layer depth(MLD) in the ocean is determined by a wind stress and a buoyance flux.A South China Sea(SCS) ocean data assimilation system is used to analyze the seasonal cycle of its MLD.It is found that the variability of MLD in the SCS is shallow in summer and deep in winter,as is the case in general.Owing to local atmosphere forcing and ocean dynamics,the seasonal variability shows a regional characteristic in the SCS.In the northern SCS,the MLD is shallow in summer and deep in winter,affected coherently by the wind stress and the buoyance flux.The variation of MLD in the west is close to that in the central SCS,influenced by the advection of strong western boundary currents.The eastern SCS presents an annual cycle,which is deep in summer and shallow in winter,primarily impacted by a heat flux on the air-sea interface.So regional characteristic needs to be cared in the analysis about the MLD of SCS. | XIAO Xianjun WANG Dongxiao ZHOU Wen ZHANG Zuqiang QIN Yinghao HE Na ZENG Lili | 2013 | Acta Oceanologica Sinica2013，32，9： | 3 |
| 2 | SETD8 induces stemness and epithelial–mesenchymal transition of pancreatic cancer cells by regulating ROR1 expression显示文摘Pancreatic cancer(PC)is one of the most deadly diseases,and its incidence is increasing year by year.The methyltransferase SETD8 has been demonstrated to play an important role in tumor cell proliferation and metastasis.However,little is known about whether SETD8 could affect the invasion and metastasis of PC and the mechanism underlying the regulation.Based on our previous report,here,we further found that SETD8 could promote the invasion and migration of PC cells by inducing the expression of receptor tyrosine kinase-like orphan receptor 1(ROR1).ROR1 was predominantly upregulated in PC tissues and was correlated with lymph node metastasis and worse prognosis.Mechanistically,SETD8 mediated ROR1 activity and regulated PC cells invasion and migration,although promoting the expression of stemness and epithelial–mesenchymal transition-related molecules.This promotion effect disappeared when the catalytically inactive mutant SETD8 was overexpressed,which could be counteracted by the SETD8-specific methyltransferase inhibitor UNC0379.Collectively,our results demonstrate that SETD8 may be a novel prognostic factor and a therapeutic target of PC. | Mengqi Liu Yihua Shi Qiangsheng Hu Yi Qin Shunrong Ji Wensheng Liu Qifeng Zhuo Guixiong Fan Zeng Ye Changfeng Song Xianjun Yu Xiaowu Xu Wenyan Xu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 2 |
| 3 | FGFBPI-mediated crosstalk between fibroblasts and pancreatic cancer cells via FGF22/FGFR2 promotes invasion and metastasis of pancreatic cancer显示文摘Fibroblast growth factor-binding protein 1(FGFBP1)promotes fibroblast growth factor(FGF)activity by releasing FGFs from extracellular matrix storage.We previously reported that the tumor suppressor F-box and WD repeat domain-containing 7 suppresses FGFBP1 by reducing expression of c-Myc,which inhibits the proliferation and migration of pancreatic cancer cells.However,the potential mechanism by which FGFBP1 facilitates pancreatic ductal adenocarcinoma(PDAC)remains unexplored.In this study,we focused on the function of FGFBP1 in the interplay between cancer-associated fibroblasts(CAFs)and pancreatic cancer cells(PCCs).Decreased FGF22 expression was detected in CAFs co-cultured with PCCs with FGFBP1 abrogation,which was verified in the cell culture medium by enzyme-linked immunosorbent assay.Active cytokine FGF22 significantly facilitated the migration and invasion of PANC-1 and Mia PaCa-2 cells.The number of penetrating PCCs cocultured with CAFs with FGF22 abrogation was significantly less than that of the control group.Interestingly,higher expressions of FGF22 and fibroblast growth factor receptor 2(FGFR2)were associated with worse prognosis of patients with PDAC and FGFR2,an independent prognostic marker of PDAC.The PANC-1 and Mia PaCa-2 cells with silenced FGFR2 showed weaker invasion and metastasis,even if these cells were simultaneously treated with cytokine FGF22.These results revealed that FGFBPI-mediated interaction between CAFs and PCCs via FGF22/FGFR2 facilitates the migration and invasion of PCCs.FGFR2 could act as a prognostic marker for patients with PDAC. | Zheng Zhang Yi Qin Shunrong Ji Wenyan Xu Mengqi Liu Qiangsheng Hu Zeng Ye Guixiong Fan Xianjun Yu Wensheng Liu Xiaowu Xu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 2 |
| 4 | Equivalency and unbiasedness of grey prediction models显示文摘In order to deeply research the structure discrepancy and modeling mechanism among different grey prediction models, the equivalence and unbiasedness of grey prediction models are analyzed and verified. The results show that all the grey prediction models that are strictly derived from x(0)(k) +az(1)(k) = b have the identical model structure and simulation precision. Moreover, the unbiased simulation for the homogeneous exponential sequence can be accomplished. However, the models derived from dx(1)/dt + ax(1)= b are only close to those derived from x(0)(k) + az(1)(k) = b provided that |a| has to satisfy|a| < 0.1; neither could the unbiased simulation for the homogeneous exponential sequence be achieved. The above conclusions are proved and verified through some theorems and examples. | Bo Zeng Chuan Li Guo Chen Xianjun Long | 2015 | Journal of Systems Engineering and Electronics2015，26，1： | 2 |
| 5 | Remark on cone semistrictly preinvex functions显示文摘 | LONG Xianjun PENG Zaiyun ZENG Bo | 2009 | Optim Lett2009，3，： | 1 |
| 6 | Renin--angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID-19 among patients with/without hypertension显示文摘Consecutively hospitalized patients with confirmed coronavirus disease 2019(COVID-19)in Wuhan,China were retrospectively enrolled from January 2020 to March 2020 to investigate the association between the use of renin–angiotensin system inhibitor(RAS-I)and the outcome of this disease.Associations between the use of RAS-I(angiotensin-converting enzyme inhibitor(ACEI)or angiotensin receptor blocker(ARB)),ACEI,and ARB and in-hospital mortality were analyzed using multivariate Cox proportional hazards regression models in overall and subgroup of hypertension status.A total of 2771 patients with COVID-19 were included,with moderate and severe cases accounting for 45.0%and 36.5%,respectively.A total of 195(7.0%)patients died.RAS-I(hazard ratio(HR)=0.499,95%confidence interval(CI)0.325–0.767)and ARB(HR=0.410,95%CI 0.240–0.700)use was associated with a reduced risk of all-cause mortality among patients with COVID-19.For patients with hypertension,RAS-I and ARB applications were also associated with a reduced risk of mortality with HR of 0.352(95%CI 0.162–0.764)and 0.279(95%CI 0.115–0.677),respectively.RAS-I exhibited protective effects on the survival outcome of COVID-19.ARB use was associated with a reduced risk of all-cause mortality among patients with COVID-19. | Huai-yu Wang Suyuan Peng Zhanghui Ye Pengfei Li Qing Li Xuanyu Shi Rui Zeng Ying Yao Fan He Junhua Li Liu Liu Shuwang Ge Xianjun Ke Zhibin Zhou Gang Xu Ming-hui Zhao Haibo Wang Luxia Zhang Erdan Dong | 2022 | Frontiers of Medicine2022，16，1： | 0 |
| 7 | MEN1 promotes ferroptosis by inhibiting mTOR-SCD1 axis in pancreatic neuroendocrine tumors显示文摘Pancreatic neuroendocrine tumor(pNET)is the second most common malignant tumors of the pancreas.Multiple endocrine neoplasia 1(MEN1)is the most frequently mutated gene in pNETs and MEN1-encoded protein,menin,is a scaffold protein that interacts with transcription factors and chromatin-modifying proteins to regulate various signaling pathways.However,the role of MEN1 in lipid metabolism has not been studied in pNETs.In this study,we perform targeted metabolomics analysis and find that MEN1 promotes the generation and oxidation of polyunsaturated fat acids(PUFAs).Meanwhile lipid peroxidation is a hallmark of ferroptosis,and we confirm that MEN1 promotes ferroptosis by inhibiting the activation of mTOR signaling which is the central hub of metabolism.We show that stearoyl-coA desaturase(SCD1)is the downstream of MEN1-mTOR signaling and oleic acid(OA),a metabolite of SCD1,recues the lipid peroxidation caused by MEN1 overexpression.The negative correlation between MEN1 and SCD1 is further verified in clinical specimens.Furthermore,we find that BON-1 and QGP-1 cells with MEN1 overexpression are more sensitive to everolimus,a widely used drug in pNETs that targets mTOR signaling.In addition,combined use everolimus with ferroptosis inducer,RSL3,possesses a more powerful ability to kill cells,which may provide a new strategy for the comprehensive therapy of pNETs. | Zeng Ye Haidi Chen Shunrong Ji Yuheng Hu Xin Lou Wuhu Zhang Desheng Jing Guixiong Fan Yue Zhang Xuemin Chen Qifeng Zhuo Jie Chen Xiaowu Xu Xianjun Yu Jin Xu Yi Qin Heli Gao | 2022 | Acta Biochimica et Biophysica Sinica2022，54，11： | 0 |
| 8 | Recent research hotspots in sequencing and the pancreatic neuroendocrine tumor microenvironment显示文摘Multiple endocrine neoplasia 1(MEN1)syndrome,a disease arising from a genetic predisposition to tumor development caused by MEN1 loss-of-function mutations,is characterized by the combined occurrence of neuroendocrine tumors in multiple human organs.With advances in diagnostic technologies and improvements in living standards. | Junfeng Xu Wuhu Zhang Xin Lou Zeng Ye Yi Qin Jie Chen Xiaowu Xu Xianjun Yu Shunrong Ji | 2023 | Cancer Biology & Medicine2023，20，10： | 0 |
| 9 | Genetic Dissection of Quantitative Trait Loci for Panicle Traits and Heat Tolerance by High-Density Bin Map in Rice显示文摘A recombinant inbred line(RIL)with 179 lines derived from a cross between a heat tolerant line Huhan 1B and a heat sensitive line Hanhui 3 was used for QTL mapping for panicle traits and heat tolerance.A total of 52 QTLs were identified with LOD scores from 3.85 to 54.93,each explaining 0.70%to 21.48%of the phenotypic variances,including 11 for panicle length(PL),11 for seed number per panicle(SN),14 for spikelet number per panicle(SNPP),6 for seed-setting rate(SSR)under normal conditions,and 5 for seed-setting rate(SSR_HT)and 5 for relative seed-setting rate(RSSR)under heat stress,respectively. | LIU Hongyan MA Xiaosong LI Enxi ZENG Xianjun LUO Lijun | 2022 | Rice science2022，29，6： | 0 |
| 10 | Absence seizures in lesion‑related epilepsy显示文摘Background In the new International League Against Epilepsy(ILAE)classification of seizure types,generalized seizures such as absence seizures(ASs)may originate from a focal point and rapidly spread to the bilaterally distributed brain network.Increasing evidence from animal and clinical studies has indicated that focal changes may occur prior to ASs;however,the relationship of ASs with epileptogenic lesions remains unclear.Methods We retrospectively collected and analyzed the clinical,imaging,and electrophysiological data of 16 patients who had ASs and structural lesions with seizure-free outcomes after lesion resection.Results In semiology analysis,nine patients displayed focal onset;only two patients showed simple ASs,and seizure types other than ASs were observed in the remaining patients.On ictal electroencephalography(EEG),four patients showed bilateral synchronous symmetric 3 Hz generalized spike-wave discharges(GSWDs),and the remaining patients showed bilateral 1.5–2.5 Hz GSWDs.Moreover,most patients(13/16,81.3%)exhibited focal features in addition to ASs,while interictal EEG was the same in 12 patients.Furthermore,on stereoelectroencephalogram(SEEG),2/5 patients showed focal discharges before bilateral burst GSWDs.Additionally,all patients had structural lesions on imaging.In four typical AS patients,the lesions were located in deep brain regions.Notably,in 9 patients(9/16,56%),the lesions were located in the posterior cortex.All patients underwent lesion resection and had seizure-free outcomes during follow-up,and intelligence quotient(IQ)also improved by 10.71±3.90 one year after surgery.Conclusions Patients with lesion-related epilepsy may present with ASs that have a focal onset and are associated with good surgical outcomes. | Xiaoqin Sun Miao Wang Zeng He Lihong Liu Xianjun Shi Chunqing Zhang Ning An Meihua Yang Zhifeng Wu Ruodan Wang Li Wang Zhongke Wang Hui Yang Xiaolin Yang Shiyong Liu | 2023 | Acta Epileptologica2023，6，3： | 0 |
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