|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Helicobacter pylori infection and risk of gastric cancer in Changle County,Fujian Province,China显示文摘AIM To evaluate the effects of Helicobacterpylori infection and other environmental factorson the development of gastric cancer.METHODS A population-based case-controlstudy was conducted in Changle County,FujianProvince.The primary gastric cancer cases werehistologically confirmed or diagnosed by surgerybetween,January 1996 and March 1998.Healthycontrols were randomly selected and matched byage,sex,and neighborhood of residence.Atotal of 101 pairs were included in the study.Specially trained interviewers conducted face-to-face interviews with the subjects according toa standardized questionnaire.Helicobacterpylori infections were measured by serum IgGantibody to Helicobacter pylori.ConditionalLogistic Regression analysis was used.RESULTS The presence of IgG antibody toHelicobacter pylori was 63.7% in studysubjects,56.0% in patients with cardiac cancer,and 60.5% in patients with non-cardiac gastriccancer.The risk factors of gastric cancer inChangle County were identified such as loweducational level[OR=3.864;95% confidenceinterval(95% CI)1.604-9.311],lowconsumption of fresh vegetables(OR=4.925;95%Cl 1.356-17.885),high intake of fish sauce(OR=10.587;95% Cl 2.821-39.738),unscheduled meals(OR=4.254;95%Cl 1.445- 12.552),and Helicobacter pylori infection(OR=3.453;95%Cl 0.901-13.224).CONCLUSION Helicobacter pylori infectionmay be important in the etiology of gastriccancer,but major risk factors other thanHelicobacter pylori are responsible for the highgastric morbidity in Changle County. | Lin Cai Shun Zhang Yu Zuo Feng Zhang | 2000 | World Journal of Gastroenterology2000，6，3： | 74 |
| 2 | Neural mechanism of gastric motility regulation by electroacupuncture at RN12 and BL21: A paraventricular hypothalamic nucleus-dorsal vagal complex-vagus nervegastric channel pathway显示文摘AIM: To study the neural mechanism by which electroacupuncture(EA) at RN12(Zhongwan) and BL21(Weishu) regulates gastric motility.METHODS: One hundred and forty-four adult Sprague Dawley rats were studied in four separate experiments. Intragastric pressure was measured using custommade rubber balloons, and extracellular neuron firing activity, which is sensitive to gastric distention in the dorsal vagal complex(DVC), was recorded by an electrophysiological technique. The expression levels of c-fos, motilin(MTL) and gastrin(GAS) in the paraventricular hypothalamic nucleus(PVN) were assayed by immunohistochemistry, and the expression levels of motilin receptor(MTL-R) and gastrin receptor(GAS-R) in both the PVN and the gastric antrum were assayed by western blotting.RESULTS: EA at RN12 + BL21(gastric Shu and Mu points), BL21(gastric Back-Shu point), RN12(gastric Front-Mu point), resulted in increased neuron-activating frequency in the DVC(2.08 ± 0.050, 1.17 ± 0.023, 1.55 ± 0.079 vs 0.75 ± 0.046, P < 0.001) compared with a model group. The expression of c-fos(36.24 ± 1.67, 29.41 ± 2.55, 31.79 ± 3.00 vs 5.73 ± 2.18, P < 0.001), MTL(22.48 ± 2.66, 20.76 ± 2.41, 19.17 ± 1.71 vs 11.68 ± 2.52, P < 0.001), GAS(24.99 ± 2.95, 21.69 ± 3.24, 23.03 ± 3.09 vs 12.53 ± 2.15, P < 0.001), MTL-R(1.39 ± 0.05, 1.22 ± 0.05, 1.17 ± 0.12 vs 0.84 ± 0.06, P < 0.001), and GAS-R(1.07 ± 0.07, 0.91 ± 0.06, 0.78 ± 0.05 vs 0.45 ± 0.04, P < 0.001) increased in the PVN after EA compared with the model group. The expression of MTL-R(1.46 ± 0.14, 1.26 ± 0.11, 0.99 ± 0.07 vs 0.65 ± 0.03, P < 0.001), and GAS-R(1.63 ± 0.11, 1.26 ± 0.16, 1.13 ± 0.02 vs 0.80 ± 0.11, P < 0.001) increased in the gastric antrum after EA compared with the model group. Damaging the PVN resulted in reduced intragastric pressure(13.67 ± 3.72 vs 4.27 ± 1.48, P < 0.001). These data demonstrate that the signals induced by EA stimulation of acupoints RN12 and BL21 are detectable in the DVC and the PVN, and increase the levels of gastrointestinal hormones and their receptors in the PVN and gastric antrum to regulate gastric motility. CONCLUSION: EA at RN12 and BL21 regulates gastric motility, which may be achieved through the PVN-DVCvagus-gastric neural pathway. | Hao Wang Wen-Jian Liu Guo-Ming Shen Meng-Ting Zhang Shun Huang Ying He | 2015 | World Journal of Gastroenterology2015，21，48： | 27 |
| 3 | Characterization of drug responses of mini patient-derived xenografts in mice for predicting cancer patient clinical therapeutic response显示文摘Background:Patient-derived organoids and xenografts(PDXs)have emerged as powerful models in functional diag-nostics with high predictive power for anticancer drug response.However,limitations such as engraftment failure and time-consuming for establishing and expanding PDX models followed by testing drug efficacy,and inability to subject to systemic drug administration for ex vivo organoid culture hinder realistic and fast decision-making in selecting the right therapeutics in the clinic.The present study aimed to develop an advanced PDX model,namely MiniPDX,for rapidly testing drug efficacy to strengthen its value in personalized cancer treatment.Methods:We developed a rapid in vivo drug sensitivity assay,OncoVee®MiniPDX,for screening clinically relevant regimens for cancer.In this model,patient-derived tumor cells were arrayed within hollow fiber capsules,implanted subcutaneously into mice and cultured for 7 days.The cellular activity morphology and pharmacokinetics were systematically evaluated.MiniPDX performance(sensitivity,specificity,positive and negative predictive values)was examined using PDX as the reference.Drug responses were examined by tumor cell growth inhibition rate and tumor growth inhibition rate in PDX models and MiniPDX assays respectively.The results from MiniPDX were also used to evaluate its predictive power for clinical outcomes.Results:Morphological and histopathological features of tumor cells within the MiniPDX capsules matched those both in PDX models and in original tumors.Drug responses in the PDX tumor graft assays correlated well with those in the corresponding MiniPDX assays using 26 PDX models generated from patients,including 14 gastric cancer,10 lung cancer and 2 pancreatic cancer.The positive predictive value of MiniPDX was 92%,and the negative predictive value was 81%with a sensitivity of 80%and a specificity of 93%.Through expanding to clinical tumor samples,Min-iPDX assay showed potential of wide clinical application.Conclusions:Fast in vivo MiniPDX assay based on capsule implantation was developed-to assess drug responses of both PDX tumor grafts and clinical cancer specimens.The high correlation between drug responses of paired MiniPDX and PDX tumor graft assay,as well as translational data suggest that MiniPDX assay is an advanced tool for personalized cancer treatment. | Feifei Zhang Wenjie Wang Yuan Long Hui Liu Jijun Cheng Lin Guo Rongyu Li Chao Meng Shan Yu Qingchuan Zhao Shun Lu Lili Wang Haitao Wang Danyi Wen | 2018 | Cancer Communications2018，38，1： | 20 |
| 4 | Fish sauce and gastric cancer:an ecological study in Fujian Province,China显示文摘AIM To explore the relationship betweenconsumption of fish sauce and the risk of gastriccancer in Fujian Province.METHODS An ecological study was carriedout.A total of 11000 subjects from 55 townshipswere randomly selected from 10 counties withinFujian Province.All subjects were localresidents who had been living in Fujian Provincefor more than 20 years,within the age group of45-74 years.Trained interviewers conductedface-to-face interviews with a standardizedquestionnaire,which covered the frequency andamount of food intake,dietary habit,tobaccoand alcohol consumption and history of chronicgastric diseases.Univariate and multivariateanalyses were performed using Epi-info and SASstatistical packages,respectively.RESULTS A significant correlation betweenmonthly consumption of fish sauce and mortalityof gastric cancer was found.Pearson’scoefficient of correlation was statisticallysignificant with r=0.7356 for males,r=0.5246for females(P<0.01).In the multivariateanalysis,consumption of fish sauce still showedan association with the risk of gastric cancer.No significant positive correlation betweenesophagus cancer,liver cancer,colon cancerand consumption of fish sauce were observed.CONCLUSION Long-term intake of fish saucemay be related to high mortality of gastriccancer.Consumption of fish sauce might be oneof important and unique etiologic factors ofgastric cancer in Fujian Province.Furtherstudies are needed to confirm this ecologicalstudy. | Lin Cai Shun Zhang Yu Wei Min Ye Ying Nan Yi | 2000 | World Journal of Gastroenterology2000，6，5： | 18 |
| 5 | Altitudinal changes of surface pollen and vegetation on the north slope of the Middle Tianshan Mountains,China显示文摘To provide information on vegetation patterns and altitudinal distributions of pollen assemblage in surface soil layers,their complicated relationships in a dryland mountain-basin system in northwestern China and a realistic basis for paleovegetational reconstruction,we investigated 86 vegetation quadrats and analyzed 80 soil samples from the surface soil layers along an altitudinal transect on the north slope of the Middle Tianshan Mountains from alpine cushion vegetation at 3,510 m near glacier to desert vegetation at 460 m in the Gurbantunggut Desert.According to surface pollen assemblages and the results of the detrended correspondence analysis,the transect can be divided into six major altitudinal pollen zones as alpine cushion vegetation,alpine and subalpine meadows,montane Picea forest,forest-steppe ecotone,Artemisia desert and typical desert,which basically reflect the characteristics of the mountainous vegetation patterns on the north slope of the Middle Tianshan Mountains.However,Picea pollen also exists outside the spruce forest,Chenopodiaceae and Artemisia pollen appeared above the elevation of 1,300 m,indicating that most of them might be introduced from lower elevations by upslope winds.Airborne pollen researches from three regions at different elevations further suggest that a high-frequency northwest anabatic wind has a remarkable influence on the transportation and dispersion of surface pollen in the area. | YANG Zhenjing ZHANG Yun REN Haibao YAN Shun KONG Zhaochen MA Keping NI Jian | 2016 | Journal of Arid Land2016，8，5： | 17 |
| 6 | Anticancer effect of aloe-emodin on cervical cancer cells involves G_2/M arrest and induction of differentiation显示文摘目的:这研究的目的是调查芦荟泻素的效果,从感冒 palmatum 的根和根茎的自然混合物在人的颈的癌症房间的生长上, HeLa.Methods : HeLa 房间为 1-5 d 与芦荟泻素的各种各样的集中被对待,并且细胞生长被3-( 4,5-dimethylthiazol-2-yl )测量 -2,5-diphenyl tetrazolium 溴化物试金。长期的生长效果被结晶紫试金调查。细胞周期和 apoptosis 的分布被流动 cytometry.The 分析硷性磷酸酯酶(高山) 活动被一个化学分析器分析。最后,西方的弄污被用来显示蛋白质激酶 C ( PKC )的丰富的变化, c-myc , cyclins ,cyclin依赖的家族 ases ( CDK ),并且增殖细胞原子抗原( PCNA ) .Results :芦荟泻素在在分析显示出的 2.5 和 40 亩 mol/L.The 流动 cytometric 之间变化的集中以一种剂量依赖者方式禁止了 HeLa 细胞的生长 HeLa 细胞在 G2/M 阶段被逮捕。这效果在 cyclin 与减少被联系 A 和 CDK2,和 cyclin B1 和 CDK1.More 的增加重要地, ALP 活动被发现到被芦荟泻素处理增加,并且由 PCNA 表示的抑制伴随了。另外,芦荟泻素压制了 PKC 高山的表示哈并且 c-myc.Conclusion : 这些调查结果为生长提供可能的机械学的解释禁止在 HeLa 上芦荟泻素完成,它包括细胞周期拘捕和导致的区别。 | Jun-ming GUO Bing-xiu XIAO Qiong LIU Shun ZHANG Dong-hai LIU Zhao-hui GONG | 2007 | Acta Pharmacologica Sinica2007，28，12： | 15 |
| 7 | Chromosome-scale genome assembly provides insights into the evolution and flavor synthesis of passion fruit (Passiflora edulis Sims)显示文摘Passion fruit(Passiflora edulis Sims)is an economically valuable fruit that is cultivated in tropical and subtropical regions of the world.Here,we report an~1341.7Mb chromosome-scale genome assembly of passion fruit,with 98.91%(~1327.18Mb)of the assembly assigned to nine pseudochromosomes.The genome includes 23,171 protein-coding genes,and most of the assembled sequences are repetitive sequences,with long-terminal repeats(LTRs)being the most abundant.Phylogenetic analysis revealed that passion fruit diverged after Brassicaceae and before Euphorbiaceae.Ks analysis showed that two whole-genome duplication events occurred in passion fruit at 65 MYA and 12 MYA,which may have contributed to its large genome size.An integrated analysis of genomic,transcriptomic,and metabolomic data showed that‘alpha-linolenic acid metabolism’,‘metabolic pathways’,and‘secondary metabolic pathways’were the main pathways involved in the synthesis of important volatile organic compounds(VOCs)in passion fruit,and this analysis identified some candidate genes,including GDP-fucose Transporter 1-like,Tetratricopeptide repeat protein 33,protein NETWORKED 4B isoform X1,and Golgin Subfamily A member 6-like protein 22.In addition,we identified 13 important gene families in fatty acid pathways and eight important gene families in terpene pathways.Gene family analysis showed that the ACX,ADH,ALDH,and HPL gene families,especially ACX13/14/15/20,ADH13/26/33,ALDH1/4/21,and HPL4/6,were the key genes for ester synthesis,while the TPS gene family,especially PeTPS2/3/4/24,was the key gene family for terpene synthesis.This work provides insights into genome evolution and flavor trait biology and offers valuable resources for the improved cultivation of passion fruit. | Zhiqiang Xia Dongmei Huang Shengkui Zhang Wenquan Wang Funing Ma Bin Wu Yi Xu Bingqiang Xu Di Chen Meiling Zou Huanyu Xu Xincheng Zhou Rulin Zhan Shun Song | 2021 | Horticulture Research2021，8，1： | 15 |
| 8 | Calcium-binding ability of soy protein hydrolysates显示文摘This present study investigated the ability of various soy protein hydrolysates(SPHs)in binding calcium.It was demonstrated that the amount of Ca-bound depended greatly on the SPHs obtained using different proteases,which included:neutrase, flavourzyme,protease M and pepsin.The maximum level of Ca-bound(66.9 mg/g)occurred when protease M was used to hydrolyze soy protein.Peptide fragments exhibiting high Ca-binding capacity had molecular weights of either 14.4 or 8-9 kDa.The level of Ca-bound increased linearly with the increment of carboxyl content in SPHs,and further deamidation on SPHs from protease M improved Ca-binding of the hydrolysate. | Xiao Lan Bao Mei Song Jing Zhang Yang Chen Shun Tang Guo | 2007 | Chinese Chemical Letters2007，18，9： | 14 |
| 9 | MCP-1-induced ERK/GSK-3β/Snail signaling facilitates the epithelial-mesenchymal transition and promotes the migration of MCF-7 human breast carcinoma cells显示文摘Monocyte chemoattractant protein-1(MCP-1)is a chemotactic cytokine that can bind to its receptor cysteine-cysteine chemokine receptor 2(CCR2)and plays an important role in breast cancer cell metastasis.However,the molecular mechanisms underlying MCP-1-induced alterations in cellular functions during tumor progression are poorly understood.Here,we showed that MCP-1 stimulated the epithelial-mesenchymal transition(EMT)and induced the tumorigenesis of breast cancer cells by downregulating E-cadherin,upregulating vimentin and fibronectin,activating matrix metallopeptidase-2(MMP-2),and promoting migration and invasion.Moreover,MCP-1 treatment reduced glycogen synthase kinase-3β(GSK-3β)activity via the MEK/ERK-mediated phosphorylation of serine-9 in MCF-7 cells.The inhibition of MEK/ERK by U0126 attenuated the MCP-1-induced phosphorylation of GSK-3βand decreased the expression of Snail,an EMT-related transcription factor,leading to the inhibition of MCF-7 cell migration and invasion.Inactivation of GSK-3βby LiCl(lithium chloride)treatment notably increased MMP-2 activity,vascular endothelial growth factor expression and EMT of MCF-7 cells.These findings revealed that MCP-1-induced EMT and migration are mediated by the ERK/GSK-3β/Snail pathway,and identified a potential novel target for therapeutic intervention in breast cancer. | Shun Li Juan Lu Yu Chen Niya Xiong Li Li Jing Zhang Hong Yang Chunhui Wu Hongjuan Zeng Yiyao Liu | 2017 | Cellular & Molecular Immunology2017，14，7： | 14 |
| 10 | Analysis of ionospheric anomalies before the 2011 M_w 9.0 Japan earthquake显示文摘On March 11, 2011, a large earthquake of Mw=9.0 occurred near the east coast of Honshu, Japan. This paper investigates preearthquake ionospheric anomalies during the earthquake period, using data from global navigation satellite systems and ionosonde stations near the epicenter. A clear anomaly that occurred on March 8 lasted 6 hours. Eliminating ionospheric anomalies that may have been caused by solar activities and magnetic storms, we believe that a positive anomaly on March 8 was very possibly an ionospheric precursor. The affected ionospheric area on March 8, which is evident on a vertical total electron content distribution map, extended to 50° in longitude and 20° in latitude, with length ratio approximately 3:1. The anomaly peak arose from 15:00-19:00 LT, and its location did not coincide with the vertical projection of the epicenter, but was instead to its south. Corresponding ionospheric anomalies are also observed in the magnetically conjugated region. There were no obvious ionospheric anomalies in other parts of the world. To analyze changes in the ionospheric anomaly, computerized ionospheric tomography technology was used to invert the spatial and temporal distribution of electron density in the ionosphere. The ionospheric anomaly on March 8, 2011 is suggested to be an ionospheric precursor of the March 11 earthquake in Japan. | YAO YiBin CHEN Peng WU Han ZHANG Shun PENG WenFei | 2012 | Chinese Science Bulletin2012，57，5： | 14 |
| 11 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 12 | Clinical value of serum CA19-9 levels in evaluating resectability of pancreatic carcinoma显示文摘AIM:To evaluate the clinical value of serum CA19-9 levels in predicting the respectability of pancreatic carcinoma according to receiver operating characteristic(ROC) curve analysis. METHODS:Serum CA19-9 levels were measured in 104 patients with pancreatic cancer which were possible to be resected according to the imaging. ROC curve was plotted for the CA19-9 levels. The point closest to the upper left-hand corner of the graph were chosen as the cut-off point. The sensitivity,specificity,positive and negative predictive values of CA19-9 at this cut-off point were calculated. RESULTS:Resectable pancreatic cancer was detected in 58(55.77%) patients and unresectable pancreatic cancer was detected in 46(44.23%) patients. The area under the ROC curve was 0.918 and 95% CI was 0.843-0.992. The CA19-9 level was 353.15 U/mL,and the sensitivity and specificity of CA19-9 at this cut-off point were 93.1% and 78.3%,respectively. The positive and negative predictive value was 84.38% and 90%,respectively. CONCLUSION:Preoperative serum CA19-9 level is a useful marker for further evaluating the resectability of pancreatic cancer. Obviously increased serum levels of CA19-9(> 353.15 U/mL) can be regarded as an ancillary parameter for unresectable pancreatic cancer. | Shun Zhang Yi-Ming Wang Chuan-Dong Sun Yun Lu Li-Qun Wu | 2008 | World Journal of Gastroenterology2008，14，23： | 13 |
| 13 | Microstructure and properties of Al_2O_3 dispersion-strengthened copper fabricated by reactive synthesis process显示文摘Al2O3 dispersion-strengthened copper alloy was prepared by reactive synthesis and spark plasma sintering(SPS) process. Studies show that nano-sized c-Al2O3 particles with 27.4 nm mean size and 50-nm interval are homogeneously distributed in copper matrix. The density of SPS alloy is about 99 %, meanwhile, the electrical conductivity of sintered alloy is 72 % IACS and the Rockwell hardness can reach to HRB 91. | Xue-Hui Zhang Chen-Guang Lin Shun Cui Zeng-De Li | 2014 | Rare Metals2014，33，2： | 13 |
| 14 | Pemetrexed monotherapy versus pemetrexed plus platinum combination as second-line treatment for advanced non-small cell lung cancer显示文摘背景 Pemetrexed 是有多重目标的一个新奇 folic 酸对手,它广泛地在非小的房间肺癌症(NSCLC ) 的治疗被使用了。这研究的目的是在加一个铂联合代理人与 pemetrexed monotherapy 对 pemetrexed 对待的 NSCLC 病人比较效果和毒性,以便为标准第二线的化疗提供一个基础。从 2006 年 8 月进入上海胸医院到 2008 年 10 月的有 NSCLC 的 52 个病人的临床的数据回顾地被分析的方法。52 个病人中的十个收到了 pemetrexed monotherapy,并且另外的 42 个病人加铂政体收到了 pemetrexed。主要结束点是全面幸存(OS ) 。没有前进的幸存时间(PFS ) 被分析,效果和毒性被估计。幸存分析被 Kaplan-Meier 方法评估。单个因素分析和 COX 回归模型被做分析在有影响的因素和疾病的预后之间的关系。老病人(> 60 岁) 作为亚群独立被分析。结果 OS 的没有统计上重要的增加(X^2=0.09, P=0.76 ) , PFS (X^2=0.15, P=0.70 ) ,疾病控制率(DCR )(X^2=0.06, P=-0.81 ) 或 1 年的幸存率(X^2=0.33, P=-0.57 ) 在二政体之间被发现。单个因素分析证明包括外科历史,在治疗前的 PS 分数,临床的阶段,和对第二线的治疗的反应的因素影响了 NSCLC 的预后(所有 P < 0.05 ) 。在治疗(P=0.043 ) 可以与幸存被联系以前,艇长回归分析表明了那外科历史(P=0.041 ) 和表演地位(PS ) 分数。二政体的毒性是类似的。在老病人的亚群,在 OS 0 的没有重要差别(2=0.01, P=0.94 ) , PFS (X^2=0.14, P=0.70 ) , DCR (X^2=0.004, P=-0.95 ) ,或 1 年的幸存率(X^2=0.03, P=0.87 ) 在二政体之间被发现。联合治疗的毒性以 hematologic 是显著地更高的(X^2=9.95, P=-0.01 ) 并且胃肠的不利事件(X^2=7.66, P=0.03 ) 在那里的 .Conclusiona 不是在在这二政体之间的幸存或副作用的重要差别。为老病人(60 ) , pemetrexed monotherapy 看类似的功效和更好的安全侧面是否与 pemetrexed 相比联合治疗。 | ZHANG Yi-fei CHEN Zhi-wei LU Shun | 2009 | Chinese Medical Journal2009，，20： | 12 |
| 15 | Association of Optic Radiation Integrity with Cortical Thickness in Children with Anisometropic Amblyopia显示文摘Previous studies have indicated regional abnormalities of both gray and white matter in amblyopia.However, alterations of cortical thickness associated with changes in white matter integrity have rarely been reported.In this study, structural magnetic resonance imaging and diffusion tensor imaging(DTI) data were obtained from 15 children with anisometropic amblyopia and 15 age- and gender-matched children with normal sight. Combining DTI and surface-based morphometry, we examined a potential linkage between disrupted white matter integrity and altered cortical thickness. The fractional anisotropy(FA) values in the optic radiations(ORs) of children with anisometropic amblyopia were lower than in controls(P \ 0.05). The cortical thickness in amblyopic children was lower than controls in the following subregions: lingual cortex, lateral occipitotemporal gyrus, cuneus, occipital lobe, inferior parietal lobe, and temporal lobe(P \ 0.05, corrected), but was higher in the calcarine gyrus(P \ 0.05, corrected). Node-by-node correlation analysis of changes in cortical thickness revealed a significant association between a lower FA value in the OR and diminished cortical thickness in the following subregions:medial lingual cortex, lateral occipitotemporal gyrus, lateral, superior, and medial occipital cortex, and lunate cortex. We also found a relationship between changes of cortical thickness and white matter OR integrity in amblyopia. These findings indicate that developmental changes occur simultaneously in the OR and visual cortex in amblyopia, and provide key information on complex damage of brain networks in anisometropic amblyopia. Our results also support the hypothesis that the pathogenesis of anisometropic amblyopia is neurodevelopmental. | Shun Qi Yun-Feng Mu Long-Biao Cui Rong Li Mei Shi Ying Liu Jun-Qing Xu Jian Zhang Jian Yang Hong Yin | 2016 | Neuroscience Bulletin2016，32，1： | 12 |
| 16 | Transfer printing techniques for flexible and stretchable inorganic electronics显示文摘Transfer printing is an emerging deterministic assembly technique for micro-fabrication and nano-fabrication,which enables the heterogeneous integration of classes of materials into desired functional layouts.It creates engineering opportunities in the area of flexible and stretchable inorganic electronics with equal performance to conventional wafer-based devices but the ability to be deformed like a rubber,where prefabricated inorganic semiconductor materials or devices on the donor wafer are required to be transfer-printed onto unconventional flexible substrates.This paper provides a brief review of recent advances on transfer printing techniques for flexible and stretchable inorganic electronics.The basic concept for each transfer printing technique is overviewed.The performances of these transfer printing techniques are summarized and compared followed by the discussions of perspectives and challenges for future developments and applications. | Changhong Linghu Shun Zhang Chengjun Wang Jizhou Song | 2018 | npj Flexible Electronics2018，2，1： | 11 |
| 17 | Pollen record and environmental evolution of Caotanhu wetland in Xinjiang since 4550 cal. a BP显示文摘This paper presents a multi-proxy reconstruction of the climate change in Caotanhu wetland using pollen, phytolith and charcoal records, and the data of loss of ignition (LOI), grain size analysis, and susceptibility. Results reveal that between 4550 and 2500 cal. a BP, a dry climatic condition was not favorable for the accumulation of peat. Since 2500 cal. a BP, the climate became humid and the wetland developed with abundant freshwater aquatic plants, which contributed to peat accumulation. Never-theless, alternate periods of rain and dry climate occurred during that period. Between 2500 and 1810 cal. a BP (550 BC―140 AD), the climate was more humid than at present. A lot of emerged plants, such as Phragmites, Typha and Sparganium, and freshwater green algae grew in the wetland which was sur-rounded by desert-steppe vegetation composed mainly of Chenopodiaceae, Artemisia, Compositae and Thalictrum. However, from 1810 to 1160 cal. a BP (140―790 AD), the water level started to decrease and hydrophyte species reduced greatly, but some Phragmites still grew in the wetland and around it was desert vegetation with high proportion of Chenopodiaceae and Artemisia. Then from 1160 to 650 a BP (790―1300 AD), it entered a period of desert-steppe with abundant mesic and xerophytic plants. And a lot of aquatic plants prevailed in the wetland. Here, what is noticeable is that percentages of arboreal pollen, consisting mainly of Betula and Picea, increased greatly and reached a maximal value of 27.2%, in which, Betula percentages rose to 23.2%. Hence, it is reasonable to conclude that Betula grew in the highland of the wetland, or Picea timberline shifted downward resulting in the increase of percentages of Betula and Picea pollen, which were transported into the wetland by flood or wind. But since 650 cal. a BP, desert vegetation prevailed around the wetland again with dominant Chenopodiaceae and Ar-temisia, and the climate was similar to modern one. Despite some aquatic plants still growing in the wetland at that time, their amounts diminished greatly. | ZHANG Yun KONG ZhaoChen NI Jian YAN Shun YANG ZhenJing | 2008 | Chinese Science Bulletin2008，53，7： | 11 |
| 18 | A Discussion on the Origin of Shale Reservoir Inter-Laminar Fractures in the Shahejie Formation of Paleogene, Dongying Depression显示文摘This paper was conducted on the shale reservoir in the Dongying depression in the Shahejie Formation of Paleogene. Based on detailed core description, rock thin sections, argon ion polishing, scanning electron microscopy(SEM) analysis, CT scanning and carbon-oxygen isotopic test, the formation mechanism of the inter-laminar fractures(or seams) and their development conditions were discussed by comprehensive analysis of the diagenetic evolution features and the reservoir space evolution characteristics. The results show that the laminated composite pattern in Dongying depression was dominated by vertical distribution of laminated calcite and clay minerals. Contrasted to the traditional understanding, development degree of inter-laminar fractures was much lower. Pure fluid between layers cannot exist without framework minerals, and the pre-existing well connected pore or horizontal overpressure micro seam was favorable paths of fluid migration. From the points of inter-laminar fractures origin mechanism and its evolution, the so called seams, were much more complex than traditional understanding that hydrocarbon generation raised the pore pressure and led to the parallel microfractures. But the inter-laminar fractures had little relationship with that whether the lamination was developed or bedding boundary was clear or not. In fact, the shale reservoir inter-laminar fractures were not rigorous fracture. They were controlled by pre-existing inter-granular pore(or seam) or dissolved pore, which distributed along carbonate laminae boundary and were connected by later super pressure, dissolution and the seepage force. And the development conditions were burial depth(bigger than 3 000 m) and the Ro value(>0.6%). Discussion on its origin and evolution has important petroleum geological significance on optimizing reservoir segment and favorable target areas selection. | Huimin Liu Shun Zhang Guoqi Song Shoupeng Zhang Xuefeng Hao Zhonghuai Xie Ningning Xu Peng Liu | 2017 | Journal of Earth Science2017，28，6： | 10 |
| 19 | Predominant expression of Th1-type cytokines in primary hepatic cancer and adjacent liver tissues显示文摘BACKGROUND: Research has revealed a shift towards Th2 in many types of malignant tumor, but the state of Th1/Th2 is not clear in patients with primary hepatic cancer (PHC). This study was designed to determine the expression of Th1- versus Th2-type cytokines in primary hepatic cancer and the adjacent liver tissue in order to provide evidence for treatment of the Th1/Th2 shift. METHODS: Samples were collected from 11 patients with PHC. The gene expression of Th1/Th2 cytokines was detected by reverse transcriptase polymerase chain reaction (RT-PCR) using IFN-γ and IL-2 as Th1-type cytokine genes, and IL-4 and IL-10 as Th2-type cytokine genes. RESULTS: Th1-type cytokines were expressed in 7/11 PHCs and 9/11 adjacent liver tissues, while Th0 type cytokines occurred in 4/11 PHCs and 2/11 adjacent liver tissues. CONCLUSION: Th1-type cytokines are expressed predominantly in primary hepatic cancer and the adjacent liver tissue. | Qiu, Fa-Bo Wu, Li-Qun Lu, Yun Zhang, Shun Zhang, Bing-Yuan | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，1： | 10 |
| 20 | Fluctuation of Picea timberline and paleoenvironment onthe northern slope of Tian-shan Mountains during the late Holocene显示文摘As a good indicator of Holocene climate, the fluctuation of alpine timberline is a synthetical result of impacts of many environmental factors dur-ing geological and historical periods and modern times. As the dominant tree species of mountainous conifer forests on the northern slope of Tianshan Mountains in Xinjiang, the distribution of Picea schrenkiana and its population size are sensitive to climatic change. The typical natural profile of Huashuwozi and the nearby Xiaoxigou archaeologi-cal profile, located in Quanzijie Township, Jimusaer County in Xinjiang, were chosen to analyze and compare the relative high-resolution pollen records, and to measure 14C dating and SEM (scanning elec-tron microscope) microstructure for charcoal frag-ments contained in Xiaoxigou profile’s cultural layers. The results show that in these two profiles, the high percentages of Picea (more than 20% and 35%, re-spectively) appeared in the stratum of the same pe-riod (2000-1300 a BP), which corresponds to the charcoal fragment’s age of Picea schrenkiana con-tained in Xiaoxigou cultural layers. These results convincingly revealed that during the period of 2000-1300 a BP, the timberline for Picea schrenkiana on the northern slope of Tianshan Mountains in Xinjiang declined by about 330m compared with the present. | ZHANG Yun KONG Zhaochen YAN Shun YANG Zhenjing NI Jian | 2006 | Chinese Science Bulletin2006，51，14： | 9 |
您所在的机构暂未开通此部分的功能，请联系管理员