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| 1 | Chromosome-scale genome assembly provides insights into the evolution and flavor synthesis of passion fruit (Passiflora edulis Sims)显示文摘Passion fruit(Passiflora edulis Sims)is an economically valuable fruit that is cultivated in tropical and subtropical regions of the world.Here,we report an~1341.7Mb chromosome-scale genome assembly of passion fruit,with 98.91%(~1327.18Mb)of the assembly assigned to nine pseudochromosomes.The genome includes 23,171 protein-coding genes,and most of the assembled sequences are repetitive sequences,with long-terminal repeats(LTRs)being the most abundant.Phylogenetic analysis revealed that passion fruit diverged after Brassicaceae and before Euphorbiaceae.Ks analysis showed that two whole-genome duplication events occurred in passion fruit at 65 MYA and 12 MYA,which may have contributed to its large genome size.An integrated analysis of genomic,transcriptomic,and metabolomic data showed that‘alpha-linolenic acid metabolism’,‘metabolic pathways’,and‘secondary metabolic pathways’were the main pathways involved in the synthesis of important volatile organic compounds(VOCs)in passion fruit,and this analysis identified some candidate genes,including GDP-fucose Transporter 1-like,Tetratricopeptide repeat protein 33,protein NETWORKED 4B isoform X1,and Golgin Subfamily A member 6-like protein 22.In addition,we identified 13 important gene families in fatty acid pathways and eight important gene families in terpene pathways.Gene family analysis showed that the ACX,ADH,ALDH,and HPL gene families,especially ACX13/14/15/20,ADH13/26/33,ALDH1/4/21,and HPL4/6,were the key genes for ester synthesis,while the TPS gene family,especially PeTPS2/3/4/24,was the key gene family for terpene synthesis.This work provides insights into genome evolution and flavor trait biology and offers valuable resources for the improved cultivation of passion fruit. | Zhiqiang Xia Dongmei Huang Shengkui Zhang Wenquan Wang Funing Ma Bin Wu Yi Xu Bingqiang Xu Di Chen Meiling Zou Huanyu Xu Xincheng Zhou Rulin Zhan Shun Song | 2021 | Horticulture Research2021，8，1： | 15 |
| 2 | Calcium-binding ability of soy protein hydrolysates显示文摘This present study investigated the ability of various soy protein hydrolysates(SPHs)in binding calcium.It was demonstrated that the amount of Ca-bound depended greatly on the SPHs obtained using different proteases,which included:neutrase, flavourzyme,protease M and pepsin.The maximum level of Ca-bound(66.9 mg/g)occurred when protease M was used to hydrolyze soy protein.Peptide fragments exhibiting high Ca-binding capacity had molecular weights of either 14.4 or 8-9 kDa.The level of Ca-bound increased linearly with the increment of carboxyl content in SPHs,and further deamidation on SPHs from protease M improved Ca-binding of the hydrolysate. | Xiao Lan Bao Mei Song Jing Zhang Yang Chen Shun Tang Guo | 2007 | Chinese Chemical Letters2007，18，9： | 14 |
| 3 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 4 | Transfer printing techniques for flexible and stretchable inorganic electronics显示文摘Transfer printing is an emerging deterministic assembly technique for micro-fabrication and nano-fabrication,which enables the heterogeneous integration of classes of materials into desired functional layouts.It creates engineering opportunities in the area of flexible and stretchable inorganic electronics with equal performance to conventional wafer-based devices but the ability to be deformed like a rubber,where prefabricated inorganic semiconductor materials or devices on the donor wafer are required to be transfer-printed onto unconventional flexible substrates.This paper provides a brief review of recent advances on transfer printing techniques for flexible and stretchable inorganic electronics.The basic concept for each transfer printing technique is overviewed.The performances of these transfer printing techniques are summarized and compared followed by the discussions of perspectives and challenges for future developments and applications. | Changhong Linghu Shun Zhang Chengjun Wang Jizhou Song | 2018 | npj Flexible Electronics2018，2，1： | 11 |
| 5 | A Discussion on the Origin of Shale Reservoir Inter-Laminar Fractures in the Shahejie Formation of Paleogene, Dongying Depression显示文摘This paper was conducted on the shale reservoir in the Dongying depression in the Shahejie Formation of Paleogene. Based on detailed core description, rock thin sections, argon ion polishing, scanning electron microscopy(SEM) analysis, CT scanning and carbon-oxygen isotopic test, the formation mechanism of the inter-laminar fractures(or seams) and their development conditions were discussed by comprehensive analysis of the diagenetic evolution features and the reservoir space evolution characteristics. The results show that the laminated composite pattern in Dongying depression was dominated by vertical distribution of laminated calcite and clay minerals. Contrasted to the traditional understanding, development degree of inter-laminar fractures was much lower. Pure fluid between layers cannot exist without framework minerals, and the pre-existing well connected pore or horizontal overpressure micro seam was favorable paths of fluid migration. From the points of inter-laminar fractures origin mechanism and its evolution, the so called seams, were much more complex than traditional understanding that hydrocarbon generation raised the pore pressure and led to the parallel microfractures. But the inter-laminar fractures had little relationship with that whether the lamination was developed or bedding boundary was clear or not. In fact, the shale reservoir inter-laminar fractures were not rigorous fracture. They were controlled by pre-existing inter-granular pore(or seam) or dissolved pore, which distributed along carbonate laminae boundary and were connected by later super pressure, dissolution and the seepage force. And the development conditions were burial depth(bigger than 3 000 m) and the Ro value(>0.6%). Discussion on its origin and evolution has important petroleum geological significance on optimizing reservoir segment and favorable target areas selection. | Huimin Liu Shun Zhang Guoqi Song Shoupeng Zhang Xuefeng Hao Zhonghuai Xie Ningning Xu Peng Liu | 2017 | Journal of Earth Science2017，28，6： | 10 |
| 6 | Erlotinib as a salvage treatment for patients with advanced non-small cell lung cancer after failure of gefitinib treatment显示文摘背景几临床的试用证明 erlotinib 在在先进非小的房间肺癌症(NSCLC ) 的 gefitinib 的失败以后是有效的。这研究的目的是从我们的医院基于数据在 gefitinib 的失败以后评估 erlotinib 治疗的可行性。从 2007 年 8 月进入上海胸医院到 2008 年 12 月的有先进 NSCLC 的 20 个病人的临床的数据回顾地被分析的方法。所有在 gefitinib 的失败以后病人被给 erlotinib 治疗。幸存分析被 Kaplan-Meier 方法做。艇长回归模型被执行分析在有影响的因素和 erlotinib 之间的关系没有前进的幸存(PFS ) 。结果五个病人有部分回答(PR ) ,九个病人有稳定的疾病(SD ) ,六个病人与 gefitinib 治疗有进步疾病(PD ) 。中部的 PFS 是 277 天(95% C/0-566 ) 。没有病人与 erlotinib 治疗有 PR,七有的 SD 和十四 PD。中部的 PFS 是 31 天(95% Cl 9.1-52.9 ) 。反应率(RR ) 是 0,并且疾病控制率(DCR ) 是 35%(7/20 ) 。考克斯回归分析表明了那性(P=0.96 ) ,年龄(P=0.89 ) ,吸烟历史(P=0.78 ) ,表演地位(PS )(P=0.98 ) , gefitinib 功效(P=0.90 ) 并且化疗是否用二药(P=0.45 ) 被使用在之间,没与 erlotinib PFS 有重要关联。十五个病人有因素受体(EGFR ) 变化地位决定了的表皮的生长。有五个盒子有在十个变化的 erlotinib 治疗的得到的 SD 否定(野类型) 病人。没有 SD 在五个变化被记录积极病人。在 gefitinib 失败以后的 erlotinib 治疗的功效被限制的结论。然而,是 EGFR 变化的病人否定罐头可能在 gefitinib 以后得益于 erlotinib 治疗失败。 | SONG Zheng-bo YU Yong-feng CHEN Zhi-wei LU Shun | 2011 | Chinese Medical Journal2011，，15： | 8 |
| 7 | Association between Metabolic Syndrome and Carotid Atherosclerosis: A Cross-sectional Study in Northern China显示文摘Objective Increased carotid artery intima-media thickness(CIMT)and carotid plaque as manifestations of carotid atherosclerosis have been used as markers of cardiovascular disease(CVD).The components of metabolic syndrome(Met S)are linked to CVD,but the association between Met S and CVD is controversial.Methods A total of 8,933 Chinese adults aged 40 years or older from 2010 to 2014 were selected from the Jidong and Kailuan communities.Met S was defined by the International Diabetes Federation criteria.CIMT and carotid plaque were measured using color Doppler ultrasound.Logistic regression models were used to assess the association of Met S with carotid plaque and CIMT.Results Met S was found among 3,461(3,461/8,933)participants.The odds ratio and 95%confidence internal(CI)for carotid plaques in participants with Met S was 1.16(1.03-1.30).The risk of carotid plaques increased with the number of Met S components.The average CIMT was higher in participants with Met S(β=0.020,95%CI,0.014-0.027)and in participants with more Met S components.Conclusion Individuals with Met S are at an increased risk for carotid atherosclerosis compared to those without MetS. | ZHOU Ping An ZHANG Chen Huan CHEN Yan Ru LI Dong SONG Dai Yu LIU Hua Min ZHOU Ming Yue SONG Guo Shun CHEN Sheng Yun | 2019 | Biomedical and Environmental Sciences2019，32，12： | 6 |
| 8 | Everolimus and zoledronic acid——a potential synergistic treatment for lung adenocarcinoma bone metastasis显示文摘Non-small-cell 肺癌症(NSCLC ) 经常转移到骨头。zoledronic 酸是到肿瘤,和 everolimus 的 cytostatic,这被知道,为 rapamycin 的哺乳动物的目标的禁止者,能禁止癌症的许多类型。此处,我们在在 vitro 并且在 vivo 对待肺腺癌骨头转移上与 everolimus 独自并且在联合评估了 zoledronic 酸的效果。与 everolimus 在联合与 zoledronic 酸对待的老鼠有更多的 apoptotic 肺癌症房间,更多的房间在 G1/G0 阶段被逮捕。p70S6K 的 phosphorylation 在联合治疗组被禁止。肺癌症房间侵略显著地也在 vitro 与联合治疗在这个组被禁止。骨头原子扫描在联合治疗组与那些相比在控制揭示了更变形的损害。骨头扫描和 X 光线照相术的图象显示那联合治疗显著地减少了骨头转移。中等幸存率建议药联合是 synergistic,它能推迟 NSCLC 骨头转移并且在 vivo 延长幸存。 | Yongfeng Yu Zhengbo Song Shunfang Yang Xiaohua Yang Jie Zhang Shun Lu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 5 |
| 9 | Microstructure and composition engineering Yb single-filled CoSb_(3) for high thermoelectric and mechanical performances显示文摘A broad tunability of the thermoelectric and mechanical properties of CoSb_(3) has been demonstrated by adjusting the composition with the addition of an increasing number of elements.However,such a strategy may negatively impact processing repeatability and composition control.In this work,singleelement-filled skutterudite is engineered to have high thermoelectric and mechanical performances.Increased Yb filling fraction is found to increase phonon scattering,whereas cryogenic grinding contributes additional microstructural scattering.A peak zT of 1.55 and an average zT of about 1.09,which is comparable to the reported results of multiple-filled SKDs,are realized by the combination of simple composition and microstructure engineering.Furthermore,the mechanical properties of Yb single-filled CoSb_(3) skutterudite are improved by manipulation of the microstructure through cryogenic grinding.These findings highlight the realistic prospect of producing high-performance thermoelectric materials with reduced compositional complexity. | Zhenxing Zhou Matthias T.Agne Qihao Zhang Shun Wan Qingfeng Song Qing Xu Xiaofang Lu Shijia Gu Yuchi Fan Wan Jiang Gerald Jeffrey Snyder Lianjun Wang | 2019 | Journal of Materiomics2019，5，4： | 4 |
| 10 | The establishment and evaluation of near infrared universal model to determinate the effective ingredient content in pesticide rapidly显示文摘一个近红外线的通用定量分析模型被建立到确定在杀虫剂 EC (hikernalisation ) 由的有效成分内容请(部分最少的广场) 算法,模型预兆的能力被外部检查方法评估。模型在从五个不同公司,和模型决心系数 R2 和 RMSECV (生气确认的根均方差)包含一样的活跃成分的样品之中被建立分别地,是 0.9997 和 0.0223 在预言的价值和严峻的集合样品的化学价值之间的相对错误在2.71%和3.36%之间,它显示方法到确定在由确定的通用模型的杀虫剂 EC 的有效成分内容能遇见 | Yan Mei Xiong Xiang Zhong Song Chang Zhou Chen Hong Ping Lin Guo Tang Yue Huang Jia Duan Shun Geng Min | 2012 | Chinese Chemical Letters2012，23，9： | 3 |
| 11 | Enhanced Damping Capacities of Mg–Ce Alloy by the Special Microstructure with Parallel Second Phase显示文摘Microstructure evolution and damping capacities of Mg–Ce binary alloys with three different Ce contents(0.5, 1, or 2 wt%) have been systematically investigated in this work. Numerous fine parallel second phases in Mg–2Ce alloy are obtained, as well as a large number of dislocations around them, but few dislocations appear around the reticular second phase in the Mg–1Ce alloy. Among the three alloys, two internal friction peaks(P_1 and P_2) are detected at about 78 and 167?C in both the Mg–0.5Ce and Mg–1Ce alloys.In addition, the alloy with special parallel second phase structure exhibits excellent damping capacity in both strain amplitude and temperature-dependent regions. These results may be ascribed to the stress concentration and the formation of abundant parallel and uniform dislocation configurations in the ?-Mg matrix without the influence of crystal orientation. The obtained results may provide a novel idea to prepare high-damping magnesium alloys by tailoring their microstructure. | Zhongshan Wu Jingfeng Wang Haibo Wang She Ma Song Huang Shun Li Fusheng Pan | 2017 | Journal of Materials Science & Technology2017，33，9： | 3 |
| 12 | Effect of Jiaji electroacupuncture in transected rat spinal cord显示文摘We evaluated the effect of Jiaji electroacupuncture on cell proliferation and the expression of markers of endogenous neural stem cell activation after complete spinal cord transection. Female Wistar rats were assigned to 4 groups (n = 24 each): a sham-operated group, a control group, a Jiaji electroacupuncture group, and a Jiaji electroacupuncture preconditioning group. Motor function was significantly improved in the acupuncture groups compared to the control group at 7 and 14 d. Numbers of bromodeoxyuridine (BrdU)-, nestin-, and glial fibrillary acidic protein (GFAP)-positive cells were significantly greater in the acupuncture groups than in the controls at each time point. Expression of nestin and GFAP mRNA was significantly higher in the acupuncture groups than in the controls at each time point. Thus, Jiaji electroacupuncture and preconditioning may promote the proliferation of endogenous neural stem cells after spinal cord transection. | XiuYing Teng DeSheng Wang XiaoMei Zhang ZengJiao Lai HaiXia Jiang JianLi Wu Huan Qi Qian Yu Shun Yao WenBo Song et al. | 2012 | Chinese Science Bulletin2012，57，7： | 2 |
| 13 | Efficient and mild cyclization procedures for the synthesis of novel 2-amino-4H-pyran derivatives with potential antitumor activity显示文摘A series of novel 2-amino-4H-pyran derivatives have been synthesized via a three-component reaction of a, b-unsaturated ketone derivatives, malononitrile, aldehydes in excellent yields, using DBU as a catalyst and ethanol as a cheap, safe, and environmentally benign solvent under mild conditions. Their antitumor activity was evaluated in three human tumor cell lines, including human colon cancer(HCT116), human cervical cancer(Hela), and non-small cell lung cancer(H1975). | Dao-Cai Wang Yong-Mei Xie Chen Fan Shun Yao Hang Song | 2014 | Chinese Chemical Letters2014，25，7： | 2 |
| 14 | A thermal actuated switchable dry adhesive with high reversibility for transfer printing显示文摘Transfer printing based on switchable adhesive that heterogeneously integrates materials is essential to develop novel electronic systems,such as flexible electronics and micro LED displays.Here,we report a robust design of a thermal actuated switchable dry adhesive,which features a stiff sphere embedded in a thermally responsive shape memory polymer(SMP)substrate and encapsulated by an elastomeric membrane.This construct bypasses the unfavorable micro-and nano-fabrication processes and yields an adhesion switchability of over1000 by combining the peel-rate dependent effect of the elastomeric membrane and the thermal actuation of the sub-surface embedded stiff sphere.Experimental and numerical studies reveal the underlying thermal actuated mechanism and provide insights into the design and operation of the switchable adhesive.Demonstrations of this concept in stamps for transfer printing of fragile objects,such as silicon wafers,silicon chips,and inorganic micro-LED chips,onto challenging non-adhesive surfaces illustrate its potential in heterogeneous material integration applications,such as flexible electronics manufacturing and deterministic assembly. | Shun Zhang Hongyu Luo Suhao Wang Zhou Chen Shuang Nie Changying Liu Jizhou Song | 2021 | International Journal of Extreme Manufacturing2021，3，3： | 2 |
| 15 | A hybrid real-parameter genetic algorithm for function optimization 显示文摘 | Hwang Shun Fa He Rong Song | 2006 | Advanced Engineering Informatics (S1474-0346)2006，20，1： | 1 |
| 16 | Flame Retardation and Char Formation Mechanism of Intumescent Flame Retarded Polypropylene Composites Containing Melamine Phosphate and Pentaerythritol Phosphate 显示文摘 | Zhou Shun Song Lei Wang Zhengzhou | 2008 | Polymer Degradation and Stability2008，93，： | 1 |
| 17 | Promoting Exports: The Role of Inward FDI in China 显示文摘 | Kevin Honglin Zhang Shun Feng- Song | 2000 | China Economic Review2000，11，： | 1 |
| 18 | Flame retardation and char formation mechanism of intumescentame Retarded polypropylene composites containing melamine phosphate and Pentaerythritol phosphate显示文摘 | Shun Zhou Lei Song Zhengzhou Wang | 2008 | Polymer Degradation and Stability2008，93，7： | 1 |
| 19 | 'A Study of the China Model and Its Sustainability'显示文摘 | Yuhua Song Shun Huang | 2005 | China & World Economy2005，，： | 1 |
| 20 | Stearic-caprie acid eu- tectic/activated-attapulgiate composite as form-stable phase change material for thermal energy storage 显示文摘 | Shaokun Song Lijie Dong Shun Chen | 2014 | Energy Conversion and Management2014，81，： | 1 |
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