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| 1 | Management of cytokine release syndrome related to CAR-T cell therapy显示文摘Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening toxicities. This syndrome is a systemic immune storm that involves the mass cytokines releasing by activated immune cells. This phenomenon causes multisystem damages and sometimes even death. In this study, we reported the management of a patient with recurrent and refractory multiple myeloma and three patients with acute lymphocytic leukemia who suffered CRS during CAR-T treatment. The early application of tocilizumab, an anti-IL-6 receptor antibody, according to toxicity grading and clinical manifestation is recommended especially for patients who suffer continuous hyperpyrexia, hypotensive shock, acute respiratory failure, and whose CRS toxicities deteriorated rapidly. Moreover, low doses of dexamethasone (5-10 mg/day) were used for refractory CRS not responding to tocilizumab. The effective management of the toxicities associated with CRS will bring additional survival opportunities and improve the quality of life for patients with cancer. | Hongli Chen Fangxia Wang Pengyu Zhang Yilin Zhang Yinxia Chen Xiaohu Fan Xingmei Cao Jie Liu Yun Yang Baiyan Wang Bo Lei Liufang Gu Ju Bai Lili Wei Ruili Zhang Qiuchuan Zhuang Wanggang Zhang Wanhong Zhao Aili He | 2019 | Frontiers of Medicine2019，13，5： | 21 |
| 2 | Therapeutic effect of artemisinin on lupus nephritis mice and its mechanisms显示文摘在这研究,我们由比较豺狼座肾炎(行) 之间的差别在豺狼座肾炎老鼠和它的机制上调查了 artemisinin (艺术) 的治疗学的效果在分子的生物学, immunohistochemistry,和组织病理学说给艺术和控制老鼠的老鼠。结果证明艺术能显著地减轻症状,减少尿 protein/24 h 的水平,并且减轻病理学的肾的损害。在在 NF-Bp65 蛋白质的表示的四个组之中的差别,原子 factor-B ( NF-B )活动,并且在肾的织物转变生长 factor-1 ( TGF-1 ) mRNA 的表达式建议那个艺术罐头降低肿瘤坏死因素的浆液层次--(TNF-)并且 interleukin-6 ( IL-6 )并且在行鼠标的肾的纸巾禁止 NF-Bp65 蛋白质和 NF-B 和 TGF-1 mRNA 的表达式。这些结果证明使用艺术对待行老鼠可靠、有效,并且它的治疗学的机制应该仔细与艺术能显然减少的事实有关是 TNF-6 和 IL-6 和下面调整的浆液层次在肾的纸巾的 NF-Bp65 蛋白质和 NF-B 和 TGF-1 mRNA 的表示。 | Xili Wu Wanggang Zhang Xingmin Shi Peng An Wansen Sun Zhu Wang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，12： | 17 |
| 3 | Effects of emodin on the proliferation of the glomerular mesangial cell and correlative cytokines in rats显示文摘客观: 在老鼠在房间增长和 glomerular mesangial 的关联词 cytokines 分泌物上调查 emodin (EMD ) 的效果。方法: 房间增长和 IL-6 上的 EMD 的效果, TGF- β在老鼠的 glomerular mesangial 的 1 分泌物被观察。房间增长被 MTT 方法测量。IL-6 和 TGF- β 1 分泌物与 ELISA 被检测。结果: EMD 能禁止房间增长和下面调整 IL-6 和 TGF- β glomerular mesangial 的 1 分泌物,作为与在老鼠的模型组相比(P < 0.05 ) 。结论: EMD 能显著地禁止房间增长,并且减少细胞外的矩阵(ECM ) 的创造,这显示它能在 glomerular 的缓和和预防起一个重要作用硬化。机制可以是 EMD 能减少 IL-6 和 TGF- β在老鼠的 glomerular mesangial 房间的 1 分泌物。 | Xili Wu Wanggang Zhang Wansen Sun Chenglin Qiao | 2007 | Journal of Nanjing Medical University2007，21，5： | 5 |
| 4 | Preparation of monoclonal antibody against human KIAA0100 protein and Northern blot analysis of human KIAA0100 gene显示文摘Monoclonal antibodies(MAbs) are important tools for the study of proteins′ function and structure. But there has been no report on the preparation of MAbs against human KIAA0100 protein up to date. Here, first, we generated the mouse MAb against human KIAA0100 protein using purified recombinant 6×Histidinc(6×His)-tagged human KIAA0100 protein segment(1557–2234) as an antigen; then, the m RNA expression of human KIAA0100 gene was detected in U937 cells using Northern blot analysis. The results showed that the mouse MAb against human KIAA0100 protein could sensitively recognize the human KIAA0100 protein using Western blot analysis and immunocytochemistry analysis. Besides, Western blot analysis revealed that human KIAA0100 gene possibly encoded two different protein products(254 k Da and < 250 k Da) in U937 cells. Moreover,Northern blot analysis confirmed that human KIAA0100 gene might produced two different m RNA products(6000–10000 bp and 5000–6000 bp) in U937 cells. The results provide a basis for large-scale production of the MAb against human KIAA0100 protein, which will be useful for the study of human KIAA0100 protein′s function/structure and MAb-targeted drugs in the future. | He Cui Xi Lan Shemin Lu Fujun Zhang Wanggang Zhang | 2017 | Journal of Pharmaceutical Analysis2017，7，3： | 4 |
| 5 | An effective rolling process of magnesium alloys for suppressing edge cracks: Width-limited rolling显示文摘To suppress the edge crack of the magnesium alloy sheet during the ordinary rolling process, a new rolling process named width-limited rolling was proposed in this paper. Width-limited rolling is a rolling method in which the width of the alloy sheet is limited by modifying the shape of the rollers, allowing a compressive stress field to form at the edge portion of the alloy sheet during rolling, resulting in the reduction of edge cracks. At present work, magnesium alloy sheets were separately subjected to ordinary rolling and width-limited rolling. The microstructure evolution and mechanical properties of the rolled sheets were investigated by EBSD, TEM, and XRD. The results exhibited that under the same rolling conditions, the sheet after ordinary rolling exhibited obvious edge cracks while no crack was found at the edge of the sheet after width-limited rolling. The edge crack suppressing effect was attributed to the reduction of the tensile stress along rolling direction during WLR, promoting the synchronous extension of the edge and center regions to suppress edge crack tendency. Microstructure observation showed that the compressive twins formed in the sheet after ordinary rolling usually exhibited as thin plates and cannot continue to fully develop due to the premature generation of the edge cracks. However, the compressive twins developed maturely in some of which double twins formed and various slip systems with different dislocation Burgers vectors occurred in the rolled sheet after WLR. More twin intersections and shear bands, providing more potential recrystallization nucleation sites, which are beneficial to weaken basal texture. With the cooperation of twinning and dislocation slip, the texture of the sheet after the width-limited rolling is weakened and the mechanical properties are improved. | Jing Tian Huihu Lu Wanggang Zhang Huihui Nie Quanxin Shi Jiafei Deng Wei Liang Lifei Wang | 2022 | Journal of Magnesium and Alloys2022，10，8： | 2 |
| 6 | Theexpression and functional characterization associated withcell apoptosis and proteomic analysis of the novel geneMLAA-34 in U937 cells显示文摘 | Zhang Wenjuan Zhang Wanggang Zhang Pengyu | 2013 | Oncol Rep2013，29，2： | 1 |
| 7 | Quantitativeassessment of MLAA-34 expression in diagnosis and progno-sis of acute monocytic leukemia 显示文摘 | Zhao Jianqiang He Aili Zhang Wanggang | 2011 | Cancer Immunol Immu-nother2011，60，4： | 1 |
| 8 | Effects of Annealing Temperature on the Properties of Copper Films Prepared by Magnetron Sputtering显示文摘Copper oxide thin films were prepared by a direct-current magnetron sputtering method followed by a thermal annealing treatment at 100-500 °C. The obtained films were characterized by X-ray diffraction, UV–vis absorption spectroscopy, scanning electron microscopy, Raman spectroscopy, and X-ray photoelectron spectroscopy. With the increase of the annealing temperature, it was found that the films transformed sequentially from amorphous to single-phase Cu(100 ℃), mixed-phase of Cu and Cu2O(150 ℃), single-phase Cu2O(200 ℃), then to mixed-phase of Cu2 O and Cu O(300 ℃), and finally to single-phase Cu O(400- 500 ℃). Further analyses indicated that the Cu/Cu2 O thin films and the Cu2 O thin films presented no further oxidation even on the surface in air atmosphere. Additionally, the visible-light photocatalytic behavior of the copper oxide thin films on the degradation of methylene blue(MB) was also investigated, indicating that the films with pure Cu2 O phase or Cu/Cu2 O mixed phases have excellent photocatalytic efficiencies. | 刘一鸣 ZHANG Jianjun ZHANG Wanggang 梁伟 YU Bin XUE Jinbo | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，1： | 1 |
| 9 | Studies on the EBV, B7 and active immunotherapy of multiple myeloma patients 显示文摘 | Zhang Wanggang Cao Xingmei Wang Xiangling | 1998 | Bri J Haematol1998，102，： | 1 |
| 10 | Bioinformatic prediction and functional characterization of human KIAA0100 gene显示文摘Our previous study demonstrated that human KIAA0100 gene is a novel acute monocytic leukemia-associated antigen(MLAA) gene. But the functional characterization of human KIAA0100 gene has remained unknown to date. Here, firstly, bioinformatic prediction of human KIAA0100 gene was carried out using online software;Secondly, human KIAA0100 gene expression was downregulated by the clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated(Cas) 9 system in U937 cells. Cell proliferation and apoptosis were next evaluated in KIAA0100-knockdown U937 cells. The bioinformatic prediction showed that human KIAA0100 gene was located on 17q11.2, and human KIAA0100 protein was located in the secretory pathway. Besides, human KIAA0100 protein contained a signal peptide, a transmembrane region, three types of secondary structures(alpha helix, extended strand, and random coil), and four domains from mitochondrial protein 27(FMP27). The observation on functional characterization of human KIAA0100 gene revealed that its downregulation inhibited cell proliferation, and promoted cell apoptosis in U937 cells. To summarize, these results suggest human KIAA0100 gene possibly comes within mitochondrial genome; moreover, it is a novel anti-apoptotic factor related to carcinogenesis or progression in acute monocytic leukemia, and may be a potential target for immunotherapy against acute monocytic leukemia. | He Cui Xi Lan Shemin Lu Fujun Zhang Wanggang Zhang | 2017 | Journal of Pharmaceutical Analysis2017，7，1： | 1 |
| 11 | mRNA expression of the XAGE-1 gene in human acute leukemia显示文摘 | Yuqiang Ji Wanggang Zhang Jin Wang Liufang Gu | 2010 | International Journal of Hematology2010，，2： | 1 |
| 12 | Se- rological identification of immunogenic antigensin acute monocytic leukemia 显示文摘 | Gang Chen Wanggang Zhang Xingmei Cao | 2005 | Leukemia Research2005，，： | 1 |
| 13 | A phase-Ⅰ clinical trial of active immunotherapy for acute leukemia using inactivated autologous leukemia cells mixed with IL-2,GM-CSF,and IL-6显示文摘 | Zhang Wanggang Liu Suhu Cao Xinmei | | 0，，01： | 1 |
| 14 | The novel active immunotherapy of leukemia 显示文摘 | Zhang Wanggang Wang Yili Cao Xingmei | 1998 | Br J Hematol1998，102，1： | 1 |
| 15 | STUDIES ON THE RELATIONSHIP BETWEEN EPSTEIN BARR VIRUS (EBV) AND PATHOGENESIS OF MULTIPLE MYELOMA显示文摘In order to explore the relationship between Epstein Barr virus (EBV) and pathogenesis of multiple myeloma (MM), the presence of EBV DNA in mononuclear cells of bone marrow (BMMC) and peripheral blood (PBMC) taken from 23 multiple myeloma patients who were neither posttransplanted nor HIV positive were examined by polymerase chain reaction (PCR). Meanwhile the presence of EBV EBERs in bioptic bone marrow’s specimens of 4 MM patients were examined by in situ hybridization (ISH). Acute leukemia, aplastic anemia and malnourished anemia patients were taken as control. It showed EBV DNA detective rate in BMMC (69 6%) and in PBMC (39 1%) of MM patients were higher significantly than control groups (P<0 05). The positive signals of EBERs were located in BMMC and the EBV positive samples detected by ISH were consistent with those by PCR. The results indicate that EBV is closely correlated to pathogenesis of MM. | Wang Jianli,Zhang Wanggang,Wang Xiangling, Cao Xingmei,Chen YinxiaDepartment of Hematology, Second Affiliated Hospital, of Xi′an Medical University Xi′an 710004 | 1999 | Journal of Pharmaceutical Analysis1999，13，2： | 1 |
| 16 | Detection of serum tumor markers in multiple myeloma using the CLINPROT system显示文摘 | Aili He Ju Bai Chen Huang Juan Yang Wanggang Zhang Jianli Wang Yun Yang Pengyu Zhang Fuling Zhou | 2012 | International Journal of Hematology2012，，6： | 1 |
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