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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Suppression of P-gp induced multiple drug resistance in a drug resistant gastric cancer cell line by overexpression of Fas显示文摘AIM To observe the drug sensitizing effect andrelated mechanisms of fas gene transduction onhuman drug-resistant gastric cancer cellSGC7901/VCR(resistant to Vincristine).METHODS The cell cycle alteration wasobserved by FACS.The sensitivity of gastriccancer cells to apoptosis was determined by invitro apoptosis assay.The drug sensitization ofcells to several anti-tumor drugs was observedby MTT assay.Immunochemical method wasused to show expression of P-gp and Topo Ⅱ ingastric cancer cells.RESULTS Comparing to SGC7901 and pBK-SGC7901/VCR,fas-SGC7901/VCR showeddecreasing G2 cells and increasing S cells,theG2 phase fraction of pBK-SGC7901/VCR wasabout 3.0 times that of fas-SGC7901/VCR,but Sphase fraction of fas-SGC7901/VCR was about1.9 times that of pBK-SGC7901/VCR,indicatingS phase arrest of fas-SGC7901/VCR.FACS alsosuggested apoptosis of fas-SGC7901/VCR,fas-SGC7901/VCR was more sensitive to apoptosisinducing agent VM-26 than pBK-SGC7901/VCR.MTT assay showed increased sensitization offas-SGC7901/VCR to DDP,MMC and 5-FU,butsame sensitization to VCR according to pBK-SGC7901/VCR.SGC7901,pBK-SGC7901/ VCRand fas-SGC7901/VCR had positively stainedTopo Ⅱ equally.P-gp staining in pBK- SGC7901/VCR was stronger than in SG07901,but there was little staining of P-gp in fas.SGC7901/VCR.CONCLUSION fas gene transduction couldreverse the MDR of human drug-resistant gastriccancer cell SGC7901/VCR to a degree,possiblybecause of higher sensitization to apoptosis anddecreased expression of P-gp. | Yin F Shi YQ Zhao WP Xiao B Miao JY Fan DM | 2000 | World Journal of Gastroenterology2000，6，5： | 24 |
| 3 | Modeling of chemical mechanical polishing with soft pads显示文摘 | Shi F G Zhao B | 1998 | Applied Physics A1998，67，： | 2 |
| 4 | Improved cell growth and total flavonoids of Saussurea medusa on solid culture medium supplemented with rare earth elements 显示文摘 | Yuan X F Wang Q Zhao B | 2002 | Biotechnol Lett2002，24，： | 2 |
| 5 | AAV9-mediated erythropoie-tin gene delivery into the brain protects nigral dopaminergic neurons in a rat model of Parkinson's disease显示文摘 | Xue Y Q Ma B F Zhao L R | 2009 | Gene Therapy2009，17，1： | 1 |
| 6 | Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 angstrom pores显示文摘 | ZHAO D FENG J HUO Q MELOSH N FREDRICKSON G H CHMELKA B F STUCKY G D | 1998 | Science1998，279，5350： | 1 |
| 7 | Modeling of chemical mechanical polishing with soft pads显示文摘 | Shi F G Zhao B | 1998 | Applied Physics A1998，67，： | 1 |
| 8 | HIF-1αbinding to VHL is gulated bystimulus-sensitive praline hydroxylation显示文摘 | YU F WHITE S B ZHAO Q | 2001 | Proc Nail Acad Sci USA2001，98，： | 1 |
| 9 | Leaching of heavy metals from contaminated soils using EDTA 显示文摘 | Sun B Zhao F J Lombi E | 2001 | Environ Pollut2001，113，： | 1 |
| 10 | Usefulness of enhanced power Doppler imaging in monitoring acral microcirculation in type 2 diabetes mellitus and its complications 显示文摘 | Ma F Zhao B Zhang H | 2011 | Cell Biochem Biophys2011，61，2： | 1 |
| 11 | Soft semirings显示文摘 | Feng F Jun Y B Zhao X Z | 2008 | Computers and Mathematics with Applications2008，56，10： | 1 |
| 12 | Particle stick- ing behavior near the throat of a low-NOx Lxial-swirl coal burner 显示文摘 | Li Z Q Zeng L Y Zhao G B Shen S P Zhang F C | 2011 | Applied Energy2011，88，： | 1 |
| 13 | Investigation on properties of a novel ceria-zireonia-praseodymia solid solution and its appli- cation in Pd-only three-way catalyst for gasoline engine emis- sion control显示文摘 | Wang Q Y Li G F Zhao B | 2011 | Fuel2011，90，10： | 1 |
| 14 | Contrasting zircon Hf and O isotopes in the two episodes of Neoproterozoic granitoids in South China:Implications for growth and reworking of continental crust显示文摘 | Zheng Y F Zhang S B Zhao Z F | 2007 | Lithos2007，96，： | 1 |
| 15 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 16 | Development of soft sensor by incorporating the delayed infrequent and irregular measurements显示文摘 | GUO Y F ZHAO Y HUANG B | 2014 | Journal of Process Control2014，24，11： | 1 |
| 17 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 18 | Brookite TiO2 nanoflowers 显示文摘 | Zhao B Chen F Huang Q W | 2009 | Chem Commun2009，34，： | 1 |
| 19 | *-λ-semiring and*-μ-semiring显示文摘 | Feng F Zhao X Z Jun Y B | 2005 | Theoretical Compute Science2005，，347： | 1 |
| 20 | Preparation of highly ordered cubic NaA zeolite from halloysite mineral for adsorption of ammonium ions 显示文摘 | Zhao Y F Zhang B Zhang X | 2010 | Journal of Hazardous Materials2010，178，13： | 1 |
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