|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Manipulation of autophagy by HCMV infection is involved in mTOR and influences the replication of virus显示文摘 | Jun Zhao Zeng Li Mingli Wang Zhaoxuan Zhang Hongyu Ma Jun Chang Dongmei Gao Shiping Wang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，11： | 7 |
| 2 | Doping bioactive elements into a collagen scaffold based on synchronous self-assembly/mineralization for bone tissue engineering显示文摘Pure collagen is biocompatible but lacks inherent osteoinductive,osteoimmunomodulatory and antibacterial activities.To obtain collagen with these characteristics,we developed a novel methodology of doping bioactive elements into collagen through the synchronous self-assembly/mineralization(SSM)of collagen.In the SSM model,amorphous mineral nanoparticles(AMN)(amorphous SrCO3,amorphous Ag3PO4,etc.)stabilized by the polyampholyte,carboxymethyl chitosan(CMC),and collagen molecules were the primary components under acidic conditions.As the pH gradually increased,intrafibrillar mineralization occurred via the self-adaptive interaction between the AMNs and the collagen microfibrils,which were self-assembling;the AMNs wrapped around the microfibrils became situated in the gap zones of collagen and finally transformed into crystals.Srdoped collagen scaffolds(Sr-CS)promoted in vitro cell proliferation and osteogenic differentiation of rat bone marrow mesenchymal stromal cells(rBMSCs)and synergistically improved osteogenesis of rBMSCs by altering the macrophage response.Ag-doped collagen scaffolds(Ag-CS)exhibited in vitro antibacterial effects on S.aureus,as well as cell/tissue compatibility.Moreover,Sr-CS implanted into the calvarial defect of a rat resulted in improved bone regeneration.Therefore,the SSM model is a de novo synthetic strategy for doping bioactive elements into collagen,and can be used to fabricate multifunctional collagen scaffolds to meet the clinical challenges of encouraging osteogenesis,boosting the immune response and fighting severe infection in bone defects. | Huanhuan Liu Mingli Lin Xue Liu Ye Zhang Yuyu Luo Yanyun Pang Haitao Chen Dongwang Zhu Xue Zhong Shiqing Ma Yanhong Zhao Qiang Yang Xu Zhang | 2020 | Bioactive Materials2020，5，4： | 6 |
| 3 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 4 | Carbazole-endcapped Spiro[fluorene-9,9'-xanthene] with Large Steric Hindrance as Hole-transporting Host for Heavily-doped and High Performance OLEDs显示文摘 | Xianghua Zhao Yukun Wu Nannan Shi Xiaoyu Li Yi Zhao Mingli Sun Dongxue Ding Hui Xu Linghai Xie | 2015 | Chinese Journal of Chemistry2015，33，8： | 3 |
| 5 | Rett syndrome-causing mutations compromise MeCP2- mediated liquid—liquid phase separation of chromatin显示文摘Rett syndrome(RTT),a severe postnatal neurodevelopmental disorder,is caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2(MeCP2).MeCP2 is a chromatin organizer regulating gene expression.RTT-causing mutations have been shown to affect this function.However,the mechanism by which MeCP2 organizes chromatin is unclear.In this study,we found that MeCP2 can induce compaction and liquid-liquid phase separation of nudeosomal arrays in vitro,and DNA methylation further enhances formation of chromatin condensates by MeCP2.Interestingly,RTT-causing mutations compromise MeCP2-mediated chromatin phase separation,while benign variants have little effect on this process.Moreover,MeCP2 competes with linker histone H1 to form mutually exclusive chromatin condensates in vitro and distinct heterochromatin foci in vivo.RTT-causing mutations reduce or even abolish the ability of MeCP2 to compete with histone H1 and to form chromatin condensates.Together,our results identify a novel mechanism by which phase separation underlies MeCP2-mediated heterochromatin formation and reveal the potential link between this process and the pathology of RTT. | Liang Wang Mingli Hu Mei-Qing Zuo Jicheng Zhao Di Wu Li Huang Yongxin Wen Yunfan Li Ping Chen Xinhua Bao Meng-Qiu Dong Guohong Li Pilong Li | 2020 | Cell Research2020，30，5： | 3 |
| 6 | Selective Introduction of Carbazole and Diphenylamine into Spirofluorenexanthene Core for Different Phosphorescent Hosts显示文摘Built on the spiro[fluorene-9,9'-xanthene] (SFX) core and two frequently-used hole-transporting groups such ascarbazole and diphenylamine, two SFX derivatives, namely SFXCz and SFXDPA, have been synthesized byone-step reaction for red, green and blue phosphorescent organic light-emitting devices (PHOLEDs). Though theproperties of these two groups are very similar, the devices based on SFXCz and SFXDPA exhibit distinct perfor-mances. In blue PHOLEDs, the device based on SFXCz exhibited much better performances than that based onSFXDPA. However, the latter was superior to the former in green and red PHOLEDs. And the red PHOLED basedon SFXDPA exhibited maximum current efficiency (CE) of 27.1 cdoA^-l, power efficiency (PE) of 25.01m·W^-1, andexternal quantum efficiency (EQE) of 15.0%. The results show that the introduction of diphenylamine group issuitable for constructing green and red host materials, whereas the introduction of carbazole group is suitable forconstructing blue host materials. | Mingli Sun Shouzhen Yue Hongtao Cao Changjin Ou Yan Qian Ting Wang Ligang Chen Yi Zhao Wei Huang | 2016 | Chinese Journal of Chemistry2016，34，8： | 3 |
| 7 | Research on surfaceroughness and micro-topography of Nano-ZrO2 plate intwo-dimensional ultrasonic grinding显示文摘 | Bo Zhao Mingli Zhao Guofu Gao | 2008 | Advanced Mate-rials Research2008，5354，： | 1 |
| 8 | Genetic analysis of the VP1 region of enterovirus 71 reveals the emergence of genotype A in central China in 2008显示文摘 | Haiyang Yu Wei Chen Hongwei Chang Renshu Tang Jun Zhao Lin Gan Boyu Liu Jason Chen Mingli Wang | 2010 | Virus Genes2010，，1： | 1 |
| 9 | Response of ^(210)Pb_(ex) inventory to changes in soil erosion rates on uncultivated land显示文摘This analysis studies changes in the variation 210Pbex inventory in soil in response to soil erosion on uncultivated land.A model was created to fit the response of 210 Pb ex inventory to variations in soil erosion rates on uncultivated land using the principle of mass balance.By numerical simulation of the variation in the soil erosion rate in soil of uncultivated land,we prove:(1) past use of what has long been considered the best method of determining 210 Pb ex levels over the past 100 to 200 years is not scientifically accurate;(2) the model shows that variation in 210 Pb ex inventory as a function of time varies according to the index law after variation of soil erosion rates in uncultivated land is considered;and(3) the time needed for the variation in 210 Pb ex inventory to reach a steady-state is affected by changes in the rate of soil erosion and the quality and depth of relaxation in soil of uncultivated land.The results of this research can guide efforts to measure soil erosion rates. | SUN Wei YANG Hao ZHAO QiGuo ZHANG MingLi XU LiangJiang | 2013 | Chinese Science Bulletin2013，58，15： | 1 |
| 10 | Effects of initialchlorobenzene concentration,air flow rate and temperature on masstransfer of chlorobenzene by air stripping显示文摘 | Lin Mingli Zhao Zhiwei Cui Fuyi | 2012 | Desalination and WaterTreatment2012，40，： | 1 |
| 11 | Research on surface roughness and micro-topography of nano-ZrO2 plate in two-dimension ultrasonic grinding 显示文摘 | Zhao Bo Zhao Mingli Gao Guofu | 2008 | Advanced Materials Research2008，53，： | 1 |
| 12 | Research on surface roughness and micro-topography of nano-ZrO2 pPlate in two-dimensional ultrasonic grinding显示文摘 | ZHAO Bo ZHAO Mingli GAO Guofu | | 0，，： | 1 |
| 13 | High efficient mechanism of material removal in two- dimensional ultrasonic grinding from the locus per- spective 显示文摘 | ZHAO MINGLI ZHAO BO WANG YUQING | 2009 | Key Engineering Materials2009，416，1： | 1 |
| 14 | Clinical implications of ERβ methylation on sporadic breast cancers in Chinese women显示文摘 | Lin Zhao Zhaojin Yu Yunan Li Xiaoyan Wen Wenfeng Ma Lin Wang Jie Ren Caigang Liu Miao He Xuefeng Bai Mingli Sun Zhihong Zheng Xiaoyi Mi Enhua Wang Olufunmilayo I. Olopade Feng Jin Minjie Wei | 2012 | Medical Oncology2012，，3： | 1 |
| 15 | Controlling Ebola: what we can learn from China’s 1911 battle against the pneumonic plague in Manchuria显示文摘 | He Liu Mingli Jiao Siqi Zhao Kai Xing Ye Li Ning Ning Libo Liang Qunhong Wu Yanhua Hao | 2015 | International Journal of Infectious Diseases2015，，： | 1 |
| 16 | A Simple Way of Calculating the Change in the Gibbs' Free Energy of Ion Adsorption Reactions显示文摘 | Wu Xiaofu Zhao Fang Chen Mingli | 2009 | Adsorption Science & Technology2009，27，1： | 1 |
| 17 | Factors Affecting the Adsorption of Zn2 and Cd2+ Ions from Aqueous Solution onto Vermiculite显示文摘 | Wu Xiaofu Zhao Fang Chen Mingli | 2008 | Adsorpiton Science & Technology2008，26，3： | 1 |
| 18 | Mixed Rare‐Earth Complexes of Eu(III) and Y(III) with Pyridine‐2,4,6‐tricarboxylic Acid and Their Photoluminescent Properties显示文摘 | Hongsheng Wang Xiaoqing Zhao Mingli Liu Wei Shi Peng Cheng | 2012 | Chem2012，，9： | 1 |
| 19 | Genetic analysis of the VP1 region of enterovirus 71 reveals the emergence of genotype A in central China in 2008显示文摘 | Haiyang Yu Wei Chen Hongwei Chang Renshu Tang Jun Zhao Lin Gan Boyu Liu Jason Chen Mingli Wang | 2010 | Virus Genes2010，，1： | 1 |
| 20 | Prognostic value of K-RAS mutations in patients with non-small cell lung cancer: A systematic review with meta-analysis显示文摘 | Daquan Meng Mingli Yuan Xiaojuan Li Lijun Chen Jie Yang Xin Zhao Wanli Ma Jianbao Xin | 2013 | Lung Cancer2013，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员