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| 1 | GaN-based substrates and optoelectronic materials and devices显示文摘In order to solve the problems of GaN heteroepitaxy on sapphire substrate,some techniques were explored.Freestanding GaN substrates have been made by hydride vapor phase epitaxy(HVPE),laser lift-off(LLO),and chemical mechanical polishing techniques.Wafer bending and cracking in the HVPE growth were partly settled by pulsed flow modulation method.High-crystal quality was established for 1.2 mm thick GaN substrate by X-ray diffraction measurement,in which the full width of half maximum values were 72,110 arcsec for(102),(002)peaks.A novel micro-size patterned sapphire substrate(PSS)and a nano PSS were also fabricated.High-power vertical structure light emitting diodes(VSLEDs)have been developed by Au–Sn eutectic wafer bonding,homemade micro-area LLO,and light extraction structure preparation.The high-injection-level active region with low temperature GaN sandwiched layers was used for lowefficiency droop.The light output power of VSLED was achieved as 400 mW driven at 350 mA,and the dominant wavelength is about 460 nm.The structures and properties of strain modulated superlattices(SLs)and quantum wells as well as advanced simulation of carriers transport across the electron blocking layer were investigated in laser diodes.The hole concentration was achieved as high as1.6 9 1018cm-3in AlGaN/GaN SLs:Mg by inserting an AlN layer.High-quality AlGaN epilayers and structures were grown by MOCVD.Some device structures of UV LEDs and detectors were demonstrated.The emission wavelength of 262 nm UV LED has been successfully fabricated.At last,high-quality InN and InGaN materials for solar cell were grown by boundary-temperature-controlled epitaxy and growth-temperature-controlled epitaxy.Hall-effect measurement showed a recorded electron mobility of 3,280 cm2/(V s)and a residual electron concentration of 1.47 9 1017cm-3at 300 K. | Guoyi Zhang Bo Shen Zhizhong Chen Xiaodong Hu Zhixin Qin Xinqiang Wang Jiejun Wu Tongjun Yu Xiangning Kang Xingxing Fu Wei Yang Zhijian Yang Zhizhao Gan | 2014 | Chinese Science Bulletin2014，59，12： | 4 |
| 2 | Effect of Cooling Water Flow Path on the Flow and Heat Transfer in a 660 MW Power Plant Condenser显示文摘The effect of the cooling water flow path on the flow and heat transfer in a double tube-pass condenser for a 660 MW power plant unit was numerically investigated based on a porous medium model. The results were used to analyze the streamline, velocity, air mass fraction and heat transfer coefficient distributions. The simulations indicate that the cooling water flow path is important in large condensers. For the original tube arrangement, the heat transfer with the lower-upper cooling water flow path is better than that with the upper-lower cooling water flow path. The reason is that the steam cannot flow into the internal of upper tube bundle and the air fractions are higher in the upper tube bundle with the upper-lower cooling water flow path. An improvement tube arrangement was developed for the upper-lower cooling water flow path which reduced the back pressure by 0.47 kPa compared to the original scheme. Thus, the results show that the tube arrangements should differ for different cooling water flow paths and the condenser heat transfer can be improved for the upper-lower cooling water flow path by modifying the tube arrangement. | ZHONG Dawen MENG Ji'an QIN Peng QIU Xiaolong JIANG Ping LI Zhixin YUAN Fang | 2019 | Journal of Thermal Science2019，28，2： | 3 |
| 3 | Curcumin enhances the radiosensitivity in nasopharyngeal carcinoma cellsinvolving the reversal of differentially expressed long non-coding RNAs显示文摘 | Qirui Wang Haoning Fan Ying Liu Zhixin Yin Hongbing Cai Jie Liu Zhiyuan Wang Meng Shao Xuegang Sun Jianxin Diao Yuanliang Liu Li Tong Qin Fan | 2014 | International Journal of Oncology2014，，3： | 1 |
| 4 | Sub-nanometer ultrathin epitaxy of AlGaN and its application in efficient doping显示文摘Solving the doping asymmetry issue in wide gap semiconductors is a key dificulty and long-standing challenge for device applications.Here,a desorption-tailoring strategy is proposed to juggle the carrier concentration and transport.Specific to the p-doping issue in Al-rich AlGaN,self-assembled p-AlGaN superlattices with an average Al composition of over 50%are prepared by adopting this approach.The hole concentration as high as 8.1×10^(18)cm^(-3)is thus realized at room temperature,which is attributed to the signifcant reduction of effective Mg activation energy to 17.5 meV through modulating the activating path,as well as the highlighted Mg surface-incorporation by an intentional interruption for desorption.More importantly,benefting from the constant ultrathin barrier thickness of only three monolayers via this approach,vertical miniband transport of holes is verifed in the p-AlGaN superlattices,greatly satisfying the demand of hole injection in device application.280 nm deep-ultraviolet light emitting diodes are then fabricated as a demo with the desorption-tailored Al-rich p-AlGaN superlattices,which exhibit a great improvement of the carrier injection efficiency and light extraction efficiency,thus leading to a 55.7%increase of the light output power.This study provides a solution for p-type doping of Al-rich AlGaN,and also sheds light on solving the doping asymmetry issue in general for wide-gap semiconductors. | Jiaming Wang Mingxing Wang Fujun Xu Baiyin Liu Jing Lang Na Zhang Xiangning Kang Zhixin Qin Xuelin Yang Xinqiang Wang Weikun Ge Bo Shen | 2022 | Light(Science & Applications)2022，11，4： | 1 |
| 5 | One-step electrodeposition process to fabricate superhydrophobic surface with improved anticorrosion property on magnesium alloy显示文摘 | Qin Liu Zhixin Kang | 2014 | Materials Letters2014，，： | 1 |
| 6 | One Single Amino Acid for Estimation the Content of Total Free Amino Acids in Qingkailing Injection Using High-Performance Liquid Chromatography-Diode Array Detection显示文摘 | Li Zhang Xue Wang Jiankun Su Haiyu Liu Zhixin Zhang Lingling Qin Cheng He Long Peng Mingxing Guo Xiaoyan Gao Shuang-Qing Zhang | 2014 | Journal of Analytical Methods in Chemistry2014，，： | 1 |
| 7 | X-ray diffraction reciprocal space and pole figure characterization of cubic GaN epitaxial layers grown on (0 0 1) GaAs by molecular beam epitaxy显示文摘 | Zhixin Qin Masakazu Kobayashi Akihiko Yoshikawa | 1999 | Journal of Materials Science: Materials in Electronics1999，，3： | 1 |
| 8 | IL-13/IL-13RA2 signaling promotes colorectal cancer stem cell tumorigenesis by inducing ubiquitinated degradation of p53显示文摘Cancer stem cells(CSCs)are considered tumor-initiating cells and the main drivers of disease progression.Targeting these rare cancer cells,however,remains challenging with respect to therapeutic benefit.Here,we report the up-regulation of IL-13RA2 expression in colorectal cancer(CRC)tissues and spheroid cells.The expression of IL-13RA2 was positively correlated with canonical stemness markers in CRC.We further demonstrated that the level of IL-13 was up-regulated in the serum of CRC patients.Biologically,recombinant IL-13(rIL13)stimulation promoted the sphere formation,proliferation,and migration of CRC cells in vitro and enhanced tumorigenesis in vivo.This phenotype could be reversed by knocking down IL-13RA2.Mechanistically,IL-13 activated autophagy by inducing LC3I/LC3II transformation in CRC-CSCs,which was crucial for the biological functions of IL-13.We further demonstrated that IL-13RA2 acted as a modular link of the E3 ligase UBE3C and the substrate p53 protein,enhancing the interaction of UBE3C and p53,thereby inducing the K48-linked ubiquitination of p53.In conclusion,the IL-13/IL-13RA2 signaling cascade promotes CRC-CSC self-renewal and tumorigenesis by inducing p53 ubiquitination,adding an important layer to the connection between IL-13 and p53,which can be translated into novel targeted therapies. | Baoyu He Jing Liang Qianqian Qin Yuqin Zhang Shuo Shi Jinghe Cao Zhixin Zhang Qingli Bie Rou Zhao Li Wei Baogui Zhang Bin Zhang | 2024 | Genes & Diseases2024，11，1： | 0 |
| 9 | Fabrication of dodecagonal pyramid on nitrogen face GaN and its effect on the light extraction显示文摘Wet etching has been widely used in defect evaluation for Ga-face GaN and surface roughness for N-face GaN dodecagonal pyramids has been fabricated on laser-lift-off N-face GaN by hot phosphor acid etching.The dodecagonal pyramid shows twelve facets including six{20-2-3}and six{22-4-5}planes.From cross-sectional TEM image,it is shown that the pyramid corresponds to the top of the edge dislocation.Compared with hexagonal pyramid-surface light emitting diodes(LEDs)etched by commonly used photoelectrochemical(PEC)process in KOH aqueous,the dodecagonal pyramid-surface LEDs show improved light extraction efficiency because of more facets,which effectively reduces the total internal reflection. | QI ShengLi,CHEN ZhiZhong,SUN YongJian,FANG Hao,TAO YueBin,SANG LiWen,TIAN PengFei,DENG JunJing,ZHAO LuBing,YU TongJun,QIN ZhiXin&ZHANG GuoYi State Key Laboratory for Artificial Microstructure and Mesoscopic Physics,School of Physics,Peking University,Beijing 100871,China | 2010 | Science China(Technological Sciences)2010，53，3： | 0 |
| 10 | Using radium isotopes to evaluate the uncertainty of submarine groundwater discharge in the northeast and entirety of Daya Bay显示文摘Submarine groundwater discharge(SGD),which can be traced using naturally occurring radium isotopes,has been recognized as a significant nutrient source and land-ocean interaction passage for the coastal waters of the Daya Bay,China.However,uncertainties in assessing SGD fluxes must still be discussed in detail.In this study,we attempted to utilize the Monte Carlo method to evaluate the uncertainties of radium-derived SGD flux in the northeast and entirety of the Daya Bay.The results show that the uncertainties of the SGD estimate in the northeast bay are very sensitive to variations in excess radium inventories as well as radium inputs from bottom sediments,while the uncertainties of the SGD estimate for the entire bay are strongly affected by fluctuations in radium inputs from bottom sediments and radium end-members of SGD.This study will help to distinguish the key factors controlling the accuracy of SGD estimates in similar coastal waters. | Hequan Gu Feng Zhao Zhixin Ni Meigui Wu Li Zhao Aicui Dang Dongmei Li Minxia Zhang Qin Hu | 2023 | Acta Oceanologica Sinica2023，42，8： | 0 |
| 11 | Progress in efficient doping of Al-rich AlGaN显示文摘The development of semiconductors is always accompanied by the progress in controllable doping techniques.Taking AlGaN-based ultraviolet(UV)emitters as an example,despite a peak wall-plug efficiency of 15.3%at the wavelength of 275 nm,there is still a huge gap in comparison with GaN-based visible light-emitting diodes(LEDs),mainly attributed to the inefficient doping of AlGaN with increase of the Al composition.First,p-doping of Al-rich AlGaN is a long-standing challenge and the low hole concentration seriously restricts the carrier injection efficiency.Although p-GaN cladding layers are widely adopted as a compromise,the high injection barrier of holes as well as the inevitable loss of light extraction cannot be neglected.While in terms of n-doping the main issue is the degradation of the electrical property when the Al composition exceeds 80%,resulting in a low electrical efficiency in sub-250 nm UV-LEDs.This review summarizes the recent advances and outlines the major challenges in the efficient doping of Al-rich AlGaN,meanwhile the corresponding approaches pursued to overcome the doping issues are discussed in detail. | Jiaming Wang Fujun Xu Lisheng Zhang Jing Lang Xuzhou Fang Ziyao Zhang Xueqi Guo Chen Ji Chengzhi Ji Fuyun Tan Xuelin Yang Xiangning Kang Zhixin Qin Ning Tang Xinqiang Wang Weikun Ge Bo Shen | 2024 | Journal of Semiconductors2024，45，2： | 0 |
| 12 | The glycosylation in SARS-CoV-2 and its receptor ACE2显示文摘Coronavirus disease 2019(COVID-19),a highly infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARSCoV-2),has infected more than 235 million individuals and led to more than 4.8 million deaths worldwide as of October 52021.Cryo-electron microscopy and topology show that the SARS-CoV-2 genome encodes lots of highly glycosylated proteins,such as spike(S),envelope(E),membrane(M),and ORF3a proteins,which are responsible for host recognition,penetration,binding,recycling and pathogenesis.Here we reviewed the detections,substrates,biological functions of the glycosylation in SARS-CoV-2 proteins as well as the human receptor ACE2,and also summarized the approved and undergoing SARS-CoV-2 therapeutics associated with glycosylation.This review may not only broad the understanding of viral glycobiology,but also provide key clues for the development of new preventive and therapeutic methodologies against SARS-CoV-2 and its variants. | Yanqiu Gong Suideng Qin Lunzhi Dai Zhixin Tian | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 0 |
| 13 | Synergistic effect of CuO coupled with MoS_(2) for enhanced photodegradation of organic dyes under visible light显示文摘A series of MoS_(2)-modified CuO(CuO/MoS_(2))heterostructures were successfully fabricated.The photodegradation properties of organic dyes were explored in detail under visible light.The photocatalytic results demonstrate that the CuO/MoS_(2)-3 heterostructure delivers superior degradation rates towards methyl violet dye(MV)and rhodamine B(RhB),reaching 99.8%and 95.3%within 30 min,respectively.The decent photodegradation activity is due to improved visible light adsorption and faster transfer of electron-hole pairs.The radical trapping experiments show that superoxide radicals(O_(2)^(-))and holes(h+)are the main active species in the removal of MV.Furthermore,the CuO/MoS_(2)-3 composite possesses the prominent stability and recyclability.This work offers a highly sustainable technique for designing a high-efficiency photocatalyst to remove environmental pollutants. | Umsalama Abuelgasim Abubakr Yasin Zhixin Jia Ziwen Qin Tianyu Guo Ruihua Zhao Jianping Du | 2023 | Chinese Journal of Chemical Engineering2023，64，12： | 0 |
| 14 | Simulation of tin penetration process in the surface layer of soda-lime-silica float glass显示文摘Based on the analysis of tin penetration mechanism in the float glass process, the oxidation model of stannous ion is constructed considering the oxygen activity and the redox reaction in the glass surface layer. The calculation of stannous ion's oxidation rate makes it possible to predict both stannous and stannic ion's concentrations independently. And it is also the necessary precondition for the numerical verification of tin penetration mechanism. Coupled diffusion simulation method is established to simulate the penetration process of both stannous and stannic ions simultaneously. The result shows that when the green glass is formed in the reducing atmosphere in tin bath, the stannic ion is accumulated at the position where oxygen activity changes sharply. Satellite peak (internal local concentration maximum) occurs in the tin concentration profile of green glass, which is quite different from that in low iron glass. Compared with gradually cooling temperature regulation, the tin penetrated shifts to greater depth and the depth and magnitude of the satellite peak also increase when reheating temperature regulation is applied. In order to reduce the amount of penetrated tin, the residual time in the high temperature region should be shortened. | ZHANG Qin CHEN ZeJing LI ZhiXin | 2011 | Science China(Technological Sciences)2011，54，3： | 0 |
| 15 | Multi-ratio optical thermometry and energy storage characteristics of Yb^(3+)/Er^(3+)/Tm^(3+)doped BaNb_(2)O_(6)transparent glass-ceramics显示文摘In order to meet the needs of new materials gradually developing towards miniaturization,integration,and light weight,multifunctional BaNb_(2)O_(6):Yb^(3+)/Er^(3+)/Tm^(3+)transparent glass-ceramics were success-fully prepared by melt quenching and controllable crystallization.Its structure,luminescence,and en-ergy transmission were studied.Using the opposite temperature dependence of the Tm^(3+)emission band and the corresponding large energy level gap,a maximum relative sensitivity of 2.3%K^(-1)based on thermal coupling levels(TCLs)is obtained in a wide temperature range(298-673 K).The multi-ratio optical thermometry based on TCLs and non-TCLs is successfully realized by using the different emission bands of double emission centers,which makes it possible for self-reference optical temperature measurement modes.In addition,the transparent glass-ceramic exhibits excellent electrical properties under 700 kV cm^(-1)electric field:high discharge energy density(W_(d)=0.99 J cm^(-3)),huge instantaneous power density(225.3 MW cm^(-3)),and ultra-fast discharge rate(T_(0.9)≤15.8 ns).The prepared glass-ceramic is expected to be a new type of lead-free multifunctional photoelectric material for temperature sensors and transparent electronic devices. | Junhao Xing Feng Luo Yaoyi Qin Xiaolu Chen Yingying Liang Zhixin Gao Fei Shang Huarui Xu Guohua Chen | 2023 | Journal of Materials Science & Technology2023，，7： | 0 |
| 16 | Individually resolved luminescence from closely stacked GaN/AlN quantum wells显示文摘Investigating closely stacked GaN/AlN multiple quantum wells(MQWs)by means of cathodoluminescence spectroscopy directly performed in a scanning transmission electron microscope,we have reached an ultimate spatial resolution ofσCL=1.8 nm.The pseudomorphically grown MQWs with high interface quality emit in the deep ultraviolet spectral range.Demonstrating the capability of resolving the 10.8 nm separated,ultra-thin quantum wells,a cathodoluminescence profile was taken across individual ones.Applying a diffusion model of excitons generated by a Gaussian-broadened electron probe,the spatial resolution of cathodoluminescence down to the free exciton Bohr radius scale has been determined. | BOWEN SHENG GORDON SCHMIDT FRANK BERTRAM PETER VEIT YIXIN WANG TAO WANG XIN RONG ZHAOYING CHEN PING WANG JüRGEN BLASING HIDETO MIYAKE HONGWEI LI SHIPING GUO ZHIXIN QIN ANDRéSTRITTMATTER BO SHEN JüRGEN CHRISTEN XINQIANG WANG | 2020 | Photonics Research2020，8，4： | 0 |
| 17 | Phase reaction of Au/Sn solder bonding for GaN-based vertical structure light emitting diodes显示文摘Au/Sn solder bonding on Si substrates was used to fabricate the GaN-based vertical structure light emitting diodes (VSLEDs). The phase reaction of Au/Sn solder under different bonding conditions was investigated by the measurement of electron back scattering diffraction (EBSD), and the characteristics of VSLED were analyzed by scanning acoustic microscope (SAM), Raman scattering, current-voltage (I-V) and light output-current (L-I) curves. After the bonding process, horizontal stripes of Au/Sn phase (δ phase) and Au5Sn phase (ζ phase) were redirected to vertical stripes, and δ phase tended to move to the solder joint. Sn interstitial diffusion led to the distribution of δ phase and voids in Au/Sn solder, which could be seen in SAM and SEM images. Vertical distribution of the δ phase and ζ phase with proper voids in the Au/Sn bonding layer showed the best bonding quality. Good bonding quality led to little shift of the E2-high mode of Raman spectra peak in GaN after laser lift off (LLO). It also caused more light extraction and forward bias reduction to 2.9 V at 20 mA. | TIAN PengFei, SUN YongJian, CHEN ZhiZhong, QI ShengLi, DENG JunJing, YU TongJun, QIN ZhiXin & ZHANG GuoYi State Key Laboratory for Artificial Microstructure and Mesoscopic Physics, School of Physics, Peking University, Beijing 100871, China | 2010 | Science China(Technological Sciences)2010，53，2： | 0 |
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