|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy显示文摘anti-CTLA-4 抗体由阻止 B7-CTLA-4 相互作用接近否定发信号引起肿瘤拒绝,这被假定。在比临床上有效的 dosing 完成的血浆层次更加高的集中,令人惊讶地, anti-CTLA-4 抗体 Ipilimumab 不由 CTLA-4 也不 CTLA-4 绑定堵住任何一 B7 trans-endocytosis 到使不能调动或联系房间的 B7。因而, Ipilimumab 不从人性化的任何一个 CTLA4 基因在树枝状的房间(DC ) 上增加 B7 (Ctla4 h/h ) 或人的 CD34 + 茎重新组成房间的 NSG 老鼠。在 Ctla4 高效地表示人和老鼠 CTLA4 基因,绑在人的 anti-CTLA-4 抗体然而并非老鼠 CTLA-4 的 h/m 老鼠导致 Treg 弄空和 Fc 受体依赖者肿瘤拒绝。堵住的抗体 L3D10 比得上在引起肿瘤拒绝的非阻塞的 Ipilimumab。显著地,输在人类化期间堵住活动的 L3D10 子孙在导致 Treg 弄空和肿瘤拒绝仍然保持充分能干。有效地在淋巴的器官堵住 CD4 T 细胞激活和 de novo CD8 T 细胞 priming 的 Anti-B7 抗体否定地不影响 Ipilimumab 的 immunotherapeutic 效果。因此,临床上有效的 anti-CTLA-4 mAb 由独立于检查点封锁的机制引起肿瘤拒绝但是依赖于主人 Fc 受体。我们为 CTLA-4 检查点的一个重评价的数据电话封锁假设并且为安全、有效的 anti-CTLA-4 mAbs 的下一代提供新卓见。 | Xuexiang Du Fei Tang Mingyue Liu Juanjuan Su Yan Zhang Wei Wu Martin Devenport Christopher A Lazarski Peng Zhang Xu Wang Peiying Ye Changyu Wang Eugene Hwang Tinghui Zhu Ting Xu Pan Zheng Yang Liu | 2018 | Cell Research2018，28，4： | 25 |
| 2 | Angiogenesis in hepatocellular carcinoma:mechanisms and anti-angiogenic therapies显示文摘Hepatocellular carcinoma(HCC)is the fourth leading cause of cancer-associated death worldwide.Angiogenesis,the process of formation of new blood vessels,is required for cancer cells to obtain nutrients and oxygen.HCC is a typical hypervascular solid tumor with an aberrant vascular network and angiogenesis that contribute to its growth,progression,invasion,and metastasis.Current anti-angiogenic therapies target mainly tyrosine kinases,vascular endothelial growth factor receptor(VEGFR),and plateletderived growth factor receptor(PDGFR),and are considered effective strategies for HCC,particularly advanced HCC.However,because the survival benefits conferred by these anti-angiogenic therapies are modest,new anti-angiogenic targets must be identified.Several recent studies have determined the underlying molecular mechanisms,including pro-angiogenic factors secreted by HCC cells,the tumor microenvironment,and cancer stem cells.In this review,we summarize the roles of pro-angiogenic factors;the involvement of endothelial cells,hepatic stellate cells,tumor-associated macrophages,and tumor-associated neutrophils present in the tumor microenvironment;and the regulatory influence of cancer stem cells on angiogenesis in HCC.Furthermore,we discuss some of the clinically approved anti-angiogenic therapies and potential novel therapeutic targets for angiogenesis in HCC.A better understanding of the mechanisms underlying angiogenesis may lead to the development of more optimized anti-angiogenic treatment modalities for HCC. | Changyu Yao Shilun Wu Jian Kong Yiwen Sun Yannan Bai Ruhang Zhu Zhuxin Li Wenbing Sun Lemin Zheng | 2023 | Cancer Biology & Medicine2023，20，1： | 3 |
| 3 | Diversity of oligotrich ciliates(Ciliophora, Spirotrichea) in the northern coast of South China Sea as revealed in LSU rDNA sequences显示文摘Although the taxonomy of oligotrich ciliates has been widely investigated,yet the species diversity remains poorly known.We newly designed a pair of oligotrich-specific LSU rDNA primers covering the 600-bp D1/D2 region,and it was effective for detecting oligotrich species.Using the primers,we constructed the cloning libraries to investigate the species diversity of oligotrichs in the northern coastal waters of the South China Sea.In total,165 oligotrich sequences were obtained from five widely separated sampling sites.Sixty operational taxonomic units(OTUs)were obtained at 99%similarity threshold,and low-abundance OTUs with no more than two sequences contributed most of these(about 78%).Our findings are consistent with previous morphological studies,Strombidium was found the most abundant and widely distributed genus in this area.In addition,the BLAST search in the NCBI database resulted in 95%OTUs matching with named oligotrich species in similarity below 99%.Therefore,oligotrich morphospecies diversity has been underestimated as low-abundance species,and the LSU rDNA oligotrich sequence database needs to be better promoted. | LU Kaihui LIU Weiwei Alan WARREN XU Yusen ZHU Changyu ZHAO Yan YI Zhenzhen | 2020 | Journal of Oceanology and Limnology2020，38，1： | 1 |
| 4 | Food Selection of Apodemus peninsulae under Artificial Rearing Condition显示文摘[Objective]The paper aimed to screen the poison bait and lure suitable for controlling Apodemus peninsulae. [Method]A. peninsulae was reared individually in a single cage,to observe its feeding conditions. [Result] A. peninsulae preferred carrot and cucumber,followed by peanut,and rat diet was the last choice. [Conclusion] Carrot and cucumber could be used to prepare poisoning bait for controlling A. peninsulae,in order to improve rat capture efficiency. | Fu Dahang Jin Zhimin Yang Changyu Zhu Xianbing | 2015 | Animal Husbandry and Feed Science2015，7，5： | 0 |
| 5 | Comparison of Oxygen Consumption between Clethrionomys rufocanus and Apodemus agrarius显示文摘[Objective] The paper was to find out the difference in oxygen consumption between Clethrionomys rufocanus and Apodemus agrarius. [Method] The oxygen consumption value of C. rufocanus and A. agrarius was measured using improved closed pressure breathing apparatus,and the oxygen consumption rate was calculated. [Result] The oxygen consumption of C. rufocanus and A. agrarius increased with the increasing body weight,while the increase amplitude of A. agrarius was relatively smaller. The oxygen consumption rate decreased with the increasing body weight. [Conclusion]The result provides a biological basis for breeding and research of experimental rats. | Jin Zhimin Yang Changyu Xin Di Fu Dahang Zhu Xianbing | 2015 | Animal Husbandry and Feed Science2015，7，5： | 0 |
| 6 | Neuroprotective effects of repetitive transcranial magnetic stimulation on Alzheimer's disease: Undetermined therapeutic protocols and mechanisms显示文摘Alzheimer's disease(AD)is a prevalent neurodegenerative disorder characterized by gradual deterioration of cognitive functions,for which an effective treatment is currently unavailable.Repetitive transcranial magnetic stimulation(rTMS),a well-established noninvasive brain stimulation method,is utilized in clinical settings to address various neuropsychiatric conditions,such as depression,neuropathic pain,and poststroke dys-function.Increasing evidence suggests that rTMs may enhance cognitive abilities in individuals with AD.However,its optimal therapeutic protocols and precise mechanisms are currently unknown,impeding its clinical implementation.In the present review,we aimed to summarize and discuss the efficacy-related parameters in rTMs treatment,encompassing stimulus frequency,stimulus pattern,stimulus intensity,and the configuration of the stimulus coil.Furthermore,we reviewed promising rTMS therapeutic protocols involving various combinations of these factors,that were examined in clinical studies.Based on our analysis,we propose that a multisite high-frequency rTMS(HF-rTMS)regimen has value in AD therapy,and that promising single-site protocols,such as HF-rTMS,applied over the left dorsolateral prefrontal cortex,precuneus,or cerebellum are required to be validated in larger clinical studies.Lastly,we provide a comprehensive review of the potential mechanisms underlying the neuroprotective effects of rTMS on cognition in AD in terms of brain network modulation as well as cellular and molecular reactions.In conclusion,the interaction of diverse mechanisms may be responsible for the total therapeutic effect of rTMS on AD.This review provides theoretical and practical evidence for the future clinical application and scientific research of rTMS in AD. | Yang Zhu Lingyi Liao Shihao Gao Yong Tao Hao Huang Xiangqin Fang Changyan Yuan Changyue Gao | 2024 | Neuroprotection2024，2，1： | 0 |
| 7 | Polymer composites designed with 3D fibrous CNT“tracks”achieving excellent thermal conductivity and electromagnetic interference shielding efficiency显示文摘The rapid improvement in the running speed,transmission efficiency,and power density of miniaturized devices means that multifunctional flexible composites with excellent thermal management capability and high electromagnetic interference(EMI)shielding performance are urgently required.Here,inspired by the fibrous pathways of the human nervous system,a“core–sheath”fibers structured strategy was proposed to prepare thermoplastic polyurethane/polydopamine/carbon nanotube(TPU/PDA/CNT)composites film with thermal management capability and EMI shielding performance.Firstly,TPU@PDA@CNT fibers with CNT shell were prepared by a facile polydopamine-assisted coating on electrospun TPU fibers.Subsequently,TPU/PDA/CNT composites with three-dimensional(3D)fibrous CNT“tracks”are obtained by a hot-pressing process,where CNTs distributed on adjacent fibers are compactly contacted.The fabricated TPU/PDA/CNT composites exhibit a high in-plane thermal conductivity(TC)of 9.6 W/(m·K)at low CNT loading of 7.6 wt.%.In addition,it also presents excellent mechanical properties and excellent EMI shielding effectiveness of 48.3 dB as well as multi-source driven thermal management capabilities.Hence,this study provides a simple yet scalable technique to prepare composites with advanced thermal management and EMI shielding performance to develop new-generation wireless communication technologies and portable intelligent electronic devices. | Gui Yang Liangchun Zhou Mingjie Wang Tiantian Xiang Duo Pan Jingzhan Zhu Fengmei Su Youxin Ji Chuntai Liu Changyu Shen | 2023 | Nano Research2023，16，8： | 0 |
| 8 | P7C3-A20 treats traumatic brain injury in rats by inhibiting excessive autophagy and apoptosis显示文摘Traumatic brain injury is a severe health problem leading to autophagy and apoptosis in the brain.3,6-Dibromo-beta-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine(P7C3-A20)can be neuroprotective in various diseases,including ischemic stroke and neurodegenerative diseases.However,whether P7C3-A20 has a therapeutic effect on traumatic brain injury and its possible molecular mechanisms are unclear.Therefore,in the present study,we investigated the therapeutic effects of P7C3-A20 on traumatic brain injury and explored the putative underlying molecular mechanisms.We established a traumatic brain injury rat model using a modified weight drop method.P7C3-A20 or vehicle was injected intraperitoneally after traumatic brain injury.Severe neurological deficits were found in rats after traumatic brain injury,with deterioration in balance,walking function,and learning memory.Furthermore,hematoxylin and eosin staining showed significant neuronal cell damage,while terminal deoxynucleotidyl transferase mediated dUTP nick end labeling staining indicated a high rate of apoptosis.The presence of autolysosomes was observed using transmission electron microscope.P7C3-A20 treatment reversed these pathological features.Western blotting showed that P7C3-A20 treatment reduced microtubule-associated protein 1 light chain 3-Ⅱ(LC3-Ⅱ)autophagy protein,apoptosis-related proteins(namely,Bcl-2/adenovirus E1B 19-kDa-interacting protein 3[BNIP3],and Bcl-2 associated x protein[Bax]),and elevated ubiquitin-binding protein p62(p62)autophagy protein expression.Thus,P7C3-A20 can treat traumatic brain injury in rats by inhibiting excessive autophagy and apoptosis. | Zhiqing Yang Zhenchao Wang Xiaoqi Deng Lingxin Zhu Zhaomeng Song Changyu Cao Xinran Li | 2024 | Neural Regeneration Research2024，19，5： | 0 |
| 9 | Synthesis and evaluation of poly(N-vinyl caprolactam)-co-tert-butyl acrylate as kinetic hydrate inhibitor显示文摘Low dosage kinetic hydrate inhibitors(KHIs)are a kind of alternative chemical additives to high dosage thermodynamic inhibitors for preventing gas hydrate formation in oil&gas production wells and transportation pipelines.In this paper,a new KHI,poly(N-vinyl caprolactam)-co-tert-butyl acrylate(PVCapco-TBA),was successfully synthesized with N-vinyl caprolactam(NVCap)and tert-butyl acrylate.The kinetic inhibition performances of PVCap-co-TBA on the formations of both structureⅠmethane hydrate and structureⅡnatural gas hydrate were investigated by measuring the onset times of hydrate formation under different conditions and compared with commercial KHIs such as PVP,PVCap and inhibex 501.The results indicated that PVCap-co-TBA outperformed these widely applied inhibitors for both structureⅠand structureⅡhydrates.At the same dosage of KHI,the maximum tolerable degree of subcooling under which the onset time of hydrate formation exceeded 24 hours for structureⅠhydrate was much lower than that for structureⅡhydrate.The inhibition strength increased with the increasing dosage of PVCap-co-TBA;The maximum tolerable degree of subcooling for the natural gas hydrate is more than10 K when the dosage was higher than 0.5%(mass)while it achieved 12 K when that dosage rose to0.75%(mass).Additionally,we found polypropylene glycol could be used as synergist at the dosage of 1.0%(mass)or so,under which the kinetic inhibition performance of PVCap-co-TBA could be improved significantly.All evaluation results demonstrated that PVCap-co-TBA was a very promising KHI and a competitive alternative to the existing commercial KHIs. | Xing Huang Ran Zhu Liwei Cheng Yijian Zhu Peng Xiao Xiaohui Wang Bei Liu Changyu Sun Weixin Pang Qingping Li Guangjin Chen Xinjing Xu Jinfeng Ji | 2022 | Chinese Journal of Chemical Engineering2022，，10： | 0 |
| 10 | Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer:a randomized,non-inferiority,multicenter trial显示文摘We conducted a prospective study to assess the non-inferiority of adjuvant chemotherapy alone versus adjuvant concurrent chemoradiotherapy (CCRT) as an alternative strategy for patients with early-stage (FIGO 2009 stage IB–IIA) cervical cancer having risk factors after surgery. The condition was assessed in terms of prognosis, adverse effects, and quality of life. This randomized trial involved nine centers across China. Eligible patients were randomized to receive adjuvant chemotherapy or CCRT after surgery. The primary end-point was progression-free survival (PFS). From December 2012 to December 2014, 337 patients were subjected to randomization. Final analysis included 329 patients, including 165 in the adjuvant chemotherapy group and 164 in the adjuvant CCRT group. The median follow-up was 72.1 months. The three-year PFS rates were both 91.9%, and the five-year OS was 90.6% versus 90.0% in adjuvant chemotherapy and CCRT groups, respectively. No significant differences were observed in the PFS or OS between groups. The adjusted HR for PFS was 0.854 (95% confidence interval 0.415–1.757;P = 0.667) favoring adjuvant chemotherapy, excluding the predefined non-inferiority boundary of 1.9. The chemotherapy group showed a tendency toward good quality of life. In comparison with post-operative adjuvant CCRT, adjuvant chemotherapy treatment showed non-inferior efficacy in patients with early-stage cervical cancer having pathological risk factors. Adjuvant chemotherapy alone is a favorable alternative post-operative treatment. | Danhui Weng Huihua Xiong Changkun Zhu Xiaoyun Wan Yaxia Chen Xinyu Wang Youzhong Zhang Jie Jiang Xi Zhang Qinglei Gao Gang Chen Hui Xing Changyu Wang Kezhen Li Yaheng Chen Yuyan Mao Dongxiao Hu Zimin Pan Qingqin Chen Baoxia Cui Kun Song Cunjian Yi Guangcai Peng Xiaobing Han Ruifang An Liangsheng Fan Wei Wang Tingchuan Xiong Yile Chen Zhenzi Tang Lin Li Xingsheng Yang Xiaodong Cheng Weiguo Lu Hui Wang Beihua Kong Xing Xie Ding Ma | 2023 | Frontiers of Medicine2023，17，1： | 0 |
| 11 | Determination on Blood Physiological Parameters of Apodemus agrarius显示文摘The study was conducted to investigate the characteristics of blood physiological parameters of Apodemus agrarius( A. agrarius). Blood physiological parameters of 10 A. agrarius( half male and half female) were determined by automated hematology analyzer. Results showed that difference of A. agrarius hematokrit( HCT) between male and female was significant( P <0. 05),and differences of all the other blood physiological parameters between male and female were not significant( P > 0. 05). In the study,blood physiological reference value of A. agrarius was set up,which provided a basis for the bio-research and prophylaxis and treatment of A. agrarius. | Zhu Xianbing Jin Zhimin Yang Changyu | 2016 | Animal Husbandry and Feed Science2016，8，1： | 0 |
| 12 | Deep learning of DEM image texture for landform classification in the Shandong area,China显示文摘Landforms are an important element of natural geographical environment,and textures are the research basis for the spatial differentiation,evolution features,and analysis rules of the landform.Using the regional difference of texture to describe the spatial distribution pattern of macro landform features is helpful to the landform classification and identification.Digital elevation model(DEM)image texture,which gives full expression to texture difference,is key data source to reflect the surface features and landform classification.Following the texture analysis,landform features analysis is assistant to different landforms classification,even in landform boundary.With the increasing accuracy requirement of landform information acquisition in geomorphic thematic mapping,hierarchical landform classification has become the focus and difficulty in research.Recently,the pattern recognition represented by Convolutional Neural Network has made great achievements in landform research,whose multichannel feature fusion structure satisfies the network structure of different landform classification.In this paper,DEM image texture was taken as the data source,and gray level co-occurrence matrix was applied to extract texture measures.Owing to the similarity of similar landform and the difference of different landform in a certain scale,a comprehensive texture factor reflecting landform features was proposed,and the spatial distribution pattern of landform features was systematically analyzed.On this basis,the coupling relationship between texture and landform type was explored.Thus,the deep learning method of Convolutional Neural Network is used to train the texture features,and the second-class landform classification is carried out through softmax.The classification results in small relief and mid-relief low mountains,overall accuracy are 84.35%and 69.95%respectively,while kappa coefficient are 0.72 and 0.40 respectively,were compared to that of traditional unsupervised landform classification results,and the superiority of Convolutional Neural Network classification was verified,it approximately improved 6%in overall accuracy and 0.4 in kappa coefficient. | Yuexue XU Hongchun ZHU Changyu HU Haiying LIU Yu CHENG | 2022 | Frontiers of Earth Science2022，16，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员