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| 1 | Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine显示文摘Gegen Qinlian Decoction(GQD),a traditional Chinese medicine(TCM)formula,has long been used for the treatment of common metabolic diseases,including type 2 diabetes mellitus.However,the main limitation of its wider application is ingredient complexity of this formula.Thus,it is critically important to identify the major active ingredients of GQD and to illustrate mechanisms underlying its action.Here,we compared the effects of GQD and berberine,a hypothetical key active pharmaceutical ingredient of GQD,on a diabetic rat model by comprehensive analyses of gut microbiota,short-chain fatty acids,proinflammatory cytokines,and ileum transcriptomics.Our results show that berberine and GQD had similar effects on lowering blood glucose levels,modulating gut microbiota,inducing ileal gene expression,as well as relieving systemic and local inflammation.As expected,both berberine and GQD treatment significantly altered the overall gut microbiota structure and enriched many butyrate-producing bacteria,including Faecalibacterium and Roseburia,thereby attenuating intestinal inflammation and lowering glucose.Levels of short-chain fatty acids in rat feces were also significantly elevated after treatment with berberine or GQD.Moreover,concentration of serum proinflammatory cytokines and expression of immune-related genes,including Nfkb1,Stat1,and Ifnrg1,in pancreatic islets were significantly reduced after treatment.Our study demonstrates that the main effects of GQD can be attributed to berberine via modulating gut microbiota.The strategy employed would facilitate further standardization and widespread application of TCM in many diseases. | Xizhan Xu Zezheng Gao Fuquan Yang Yingying Yang Liang Chen Lin Han Na Zhao Jiayue Xu Xinmiao Wang Yue Ma Lian Shu Xiaoxi Hu Na Lyu Yuanlong Pan Baoli Zhu Linhua Zhao Xiaolin Tong Jun Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 29 |
| 2 | An-2 Encodes a Cytokinin Synthesis Enzyme that Regulates Awn Length and Grain Production in Rice显示文摘大量词法、生理的特点在驯服下面在栽培米饭 Oryza sativa 和野米饭 Oryza rufipogon 之间变化了。这里,我们报导 An-2 基因克隆,编码象蛋白质 6 一样的孤独的盖伊(OsLOGL6 ) ,它在 O 催化细胞激动素合成的最后的步。rufipogon。在 theawnless indica Guangluai 4 的基因背景怀有 An-2 的野等位基因的 near-isogenic 线证明 An-2 由由每植物每圆锥花序和 tillers 减少谷物提高房间分割,而是减少谷物生产支持芒延伸。我们表明在 An-2 地点的一个基因变化在减少芒长度并且在驯养的米饭增加 tiller 和谷物数字上有大影响。基因 expressionpatterns 的分析建议 An-1 调整芒的形成初发,并且 An-2 支持芒延伸。在栽培米饭的 theAn-2 地点的核苷酸差异被发现显著地与野米饭的相比被减少,建议 An-2 地点受到人工的选择。我们因此在 An-2 的基因变化的选择由于减少的芒长度并且增加的 proposethat 在栽培米饭的谷物产量。 | Benguo Gu Taoying Zhou Jianghong Luo Hui Liu Yongchun Wang Yingying Shangguan Jingjie Zhu Yan Li Tao Sang Zixuan Wang Bin Han | 2015 | Molecular Plant2015，8，11： | 22 |
| 3 | Scene text detection and recognition: recent advances and future trends显示文摘 | Yingying ZHU Cong YAO Xiang BAI | 2016 | Frontiers of Computer Science2016，10，1： | 20 |
| 4 | Nutritional composition and antioxidant activity of twenty mung bean cultivars in China显示文摘Interest in mung bean(Vigna radiata L.) as a functional food is growing; however, studies on the nutritional composition of major mung bean cultivars planted in China are limited.Twenty Chinese mung bean cultivars were collected and their nutritional compositions including starch, fat, protein, and phytochemicals were analyzed. The cultivars were found to have a high amount of resistant starch, accounting for 16.1%–22.3% of total starch, and balanced amino acid constitutions. Palmitic acid and linoleic acid were the two dominant fatty acids, accounting for respectively 32.4% and 36.1% of all of the assayed fatty acids. Four bound phenolic acids(syringic, caffeic, p-coumaric, and ferulic acids) and two free phenolic acids(caffeic and ferulic acids) were identified by HPLC. The antioxidant activity of 70%ethanol extracts from the 20 mung bean cultivars was evaluated. Their DPPH and ABTS+free-radical-scavenging capacity ranged from 28.13 ± 2.24 to 35.68 ± 0.71 μmol g-1and from3.82 ± 0.25 to 13.44 ± 1.76 μmol g-1, respectively. Significant positive correlations of ABTS+free-radical-scavenging capacity with total phenolic acids and total flavonoid contents were observed. These results suggest that Chinese mung bean cultivars are rich in balanced nutrients and that their phytochemicals should be considered as potential sources of natural antioxidants. | Zhenxing Shi Yang Yao Yingying Zhu Guixing Ren | 2016 | The Crop Journal2016，4，5： | 16 |
| 5 | PtrHB7, a class III HD-Zip Gene, Plays a Critical Role in Regulation of Vascular Cambium Differentiation in Populus显示文摘在树的第二等的生长的一个关键问题是脉管的形成层房间的区别怎么被指导到 concurrentlyform 二不同纸巾:木部或韧皮部。类 III homeodomain 白氨酸拉链(HD 压缩 III ) 基因被知道在主要、第二等的 growth.However 的进程在脉管的系统的开始, patterning,和区别玩 criticalroles,这些基因怎么控制第二等的脉管的区别的机制是未知的。这里,我们显示出那 Populus 类 III HD 压缩基因, PtrHB7,优先地在 cambial 被表示地区。压制 PtrHB7 的植物在木部与减小在脉管的纸巾显示了重要变化但是韧皮部的增加。Transcriptionalanalysis 表明调整木部区别的基因是下面调整的,而基因调整韧皮部 differentiationwere 起来调整。相应地, PtrHB7 overexpression 向木部房间提高了 cambial 房间的区别,但是禁止了韧皮部区别。cambial 房间区别上的 PtrHB7 规定与它的抄本丰富被联系。一起,结果 demonstratedthat PtrHB7 在在剂量依赖者 manner.Key 在 processof Populus 第二等的生长控制在第二等的木部和韧皮部纸巾之间的平衡区别起一个关键作用词: | Yingying Zhu Dongliang Song Jiayan Sun Xingfen Wang Laigeng Li | 2013 | Molecular Plant2013，6，4： | 13 |
| 6 | Gibberellin homeostasis and plant height control by EUI and a role for gibberellin in root gravity responses in rice显示文摘米饭 Eui (伸长最高节间) 基因编码撤销的细胞色素 P450 monooxygenase 简历活跃赤霉素(气体) 。在这研究,我们在植物开发调查了 Eui 基因和它的角色的控制表示。我们发现 Eui 是外长的气体导致的差别并且 Eui 倡导者在维管束举办了最高的活动。eui 异种在在根冠的淀粉小粒开发是有缺点的,在表达式上的 Eui 提高了淀粉小粒产生和严肃回答,揭示为在根淀粉小粒开发和严肃回答的 GA 的一个角色。使用胚胎更少一半种子的实验揭示了那 RAmy1A, GAmyb 是高度起来当外长的 GA 不在时在 eui 糊粉房间调整了。另外, GA 生合成基因 GA3ox1 和 GA20ox2 是调整的 down, GA2ox1 起来在 eui 调整了幼苗。这些结果显示 EUI 涉及 GA 动态平衡,不是在仅仅内部在出发阶段的节点,而且在苗期,根和种子。扰乱 GA 动态平衡影响了表明基因 GID1 (赤霉素感觉迟钝的矮子 1 ) 的 GA 的表示, GID2 和 SLR1。有效地增加的 Eui 基因的转基因的 RNA 干扰种高度和改进标题性能。由对比,在米饭 GA 生合成基因 GA3ox2 和 GA20ox2 的倡导者下面的 Eui 的宫外的表示显著地减少了植物高度。这些结果证明 Eui 表示的细微增加能戏剧性地改变米饭形态学,显示在米饭的 Eui 基因的实际申请为一个高产潜力的分子的繁殖。 | Yingying Zhang Yongyou Zhu Yu Peng Dawei Yan Qun Li Jianjun Wang Linyou Wang Zuhua He | 2008 | Cell Research2008，18，3： | 10 |
| 7 | Efficient visible light photo-Fenton-like degradation of organic pollutants using in situ surface-modified BiFeO_3 as a catalyst显示文摘The visible light photo-Fenton-like catalytic performance of BiFeO3 nanoparticles was investigated using Methyl Violet(MV),Rhodamine B(RhB) and phenol as probes.Under optimum conditions,the pseudo first-order rate constant(k) was determined to be 2.21 × 102,5.56 × 102 and 2.01 × 102 min 1 for the degradation of MV(30 μmol/L),RhB(10 μmol/L) and phenol(3 mmol/L),respectively,in the BiFeO3-H2O2-visible light(Vis) system.The introduction of visible light irradiation increased the k values of MV,RhB and phenol degradation 3.47,1.95 and 2.07 times in comparison with those in dark.Generally,the k values in the BiFeO3H2O2-Vis system were accelerated by increasing BiFeO3 load and H2O2 concentration,but decreased with increasing initial pollutant concentration.To further enhance the degradation of pollutants at high concentrations,BiFeO3 was modified with the addition of surface modifiers.The addition of ethylenediamineteraacetic acid(EDTA,0.4 mmol/L) increased the k value of MV degradation(60 μmol/L) from 1.01 × 102 min-1 in the BiFeO 3-H2O2-Vis system to 1.30 min-1 in the EDTA-BiFeO3-H2O2-Vis system by a factor of 128.This suggests that in situ surface modification can enable BiFeO3 nano-particles to be a promising visible light photo-Fenton-like catalyst for the degradation of organic pollutants. | Junjian An Lihua Zhu Yingying Zhang Heqing Tang | 2013 | Journal of Environmental Sciences2013，25，6： | 10 |
| 8 | Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients显示文摘Dear Editor,In 2019,a zoonotic coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was identified as the causative agent of Coronavirus Disease 2019(COVID-19).As of 8 June 2020,the World Health Organization(WHO)has reported 6,912,751 globally confirmed cases with 400,469 deaths.Although generally causes mild disease,SARS-CoV-2 infection can result in serious outcomes,including acute lung injury(ALI)and acute respiratory distress syndrome(ARDS),the leading cause of mortality in patients with comorbidities.Recent autopsy studies of COVID-19 patients revealed mononuclear infiltration and excessive production of mucus in the infected lung,especially in the damaged small airways and alveoli(Bian and Team,2020;Liu et al.,2020). | Jiangping He Shuijiang Cai Huijian Feng Baomei Cai Lihui Lin Yuanbang Mai Yinqiang Fan Airu Zhu Huang Huang Junjie Shi Dingxin Li' Yuanjie Wei Yueping Li Yingying Zhao’ Yuejun Pan He Liu Xiaoneng Mo Xi He Shangtao Cao FengYu Hu Jincun Zhao Jie Wang Nanshan Zhong Xinwen Chen Xilong Deng Jiekai Chen | 2020 | Protein & Cell2020，11，9： | 7 |
| 9 | Roles of polyacrylate dispersant in the synthesis of well-dispersed BaSO_4 nanoparticles by simple precipitation显示文摘Well-dispersed BaSO_4 nanoparticles were synthesized in the presence of sodium polyacrylate(PAAS) by a simple precipitation method,with BaCl_2 and(NH_4)_2SO_4 as reactants.The different roles performed by PAAS in the synthesis of BaSO_4 nanoparticles were investigated using X-ray diffractometry,Fourier transform infrared spectroscopy,and transmission electron microscopy.The results indicate that the assynthesized BaSO_4 nanoparticles were spheres with an average diameter of 30 nm and that their surfaces were affected by the PAAS.Under a typical procedure employed,PAAS reacted with BaCl_2 to yield an intermediate,serving as a control releasing agent and separating the nucleation and crystal growth processes of the BaSO_4 nuclei.During formation of the BaSO_4 nanospheres,the intermediate slowly dissolved and released barium and polyacrylate ions,inhibiting the growth and aggregation of newly formed BaSO_4seeds and resulting in particles of narrow diameter distribution and improved dispersibility.Moreover,these polyacrylate ions further modified the surfaces of the BaSO_4 nanoparticles. | Yingying Sun Feng Zhang Daxiong Wu Haitao Zhu | 2014 | Particuology2014，12，3： | 7 |
| 10 | Application of Stable Isotope Tracing Technologies in Identification of Transformation among Waters in Sanjiang Plain,Northeast China显示文摘In order to investigate the transformation among the precipitation,groundwater,and surface water in the Sanjiang Plain,Northeast China,precipitation and groundwater samples which were collected at the meteorological station of the Sanjiang Mire Wetland Experimental Station,Chinese Academy of Sciences and the surface water which collected from the Wolulan River were used to identify the transformation of three types of water.The isotope composition of different kinds of water sources were analyzed via stable isotope(deuterium and oxygen-18) investigation of natural water.The results show a clear seasonal difference in the stable isotopes in precipitation.During the cold half-year,the mean stable isotope in precipitation in the Sanjiang Plain reaches its minimum with the minimum temperature.The δ18O and δD values are high in the rainy season.In the Wolulan River,the evaporation is the highest in August and September.The volume of evaporation and the replenishment to the river is mostly same.The groundwater is recharged more by the direct infiltration of precipitation than by the river flow.The results of this study indicate that the water bodies in the Sanjiang Plain have close hydrologic relationships,and that the transformation among each water system frequently occurs. | XU Yingying YAN Baixing LUAN Zhaoqing ZHU Hui WANG Lixia | 2013 | Chinese Geographical Science2013，23，4： | 6 |
| 11 | microRNA-21a-5p/PDCD4 axis regulates mesenchymal stem cell-induced neuroprotection in acute glaucoma显示文摘间充质的干细胞(MSC ) 被表明了为许多神经病学的疾病有有希望的治疗学的好处;然而,内在的机制糟糕被理解。这里,我们显示出 MSC 的那 intravitreal 注入在尖锐绿内障的一个老鼠模型的支持的网膜的中心细胞(RGC ) 幸存与 microglial 激活的重要抑制, TNF- , IL-1,和反应的氧种类的生产,以及 caspase-8 和 caspase-3 激活。在 vitro, MSC 禁止了两 caspase-8-mediated RGC apoptosis 和 microglial 激活,部分经由 stanniocalcin 的行动 1 (STC1 ) 。而且,我们发现了那 microRNA-21a-5p (miR-21 ) 和它的目标, PDCD4,为 STC1 生产和在 vitro 并且在 vivo 的 MSC 的 neuroprotective 性质是必要的。重要地, miR-21 overexpression 或 PDCD4 尖锐绿内障上的击倒的扩充调停 MSC 的 neuroprotective 效果。miR-21/PDCD4 轴由导致 MSC 分泌施加 neuroprotective 的 STC1 和另外的因素的以前未被认出的 neuroprotective 机制完成的这些数据热点。因此, modulating miR-21/PDCD4 轴可能是为尖锐绿内障和另外的神经病学的疾病的临床的处理的有希望的策略。 | Wenru Su Zuohong Li Yu Jia Yingting Zhu Wenjia Cai Peixing Wan Yingying Zhang Song Guo Zheng Yehong Zhuo | 2017 | Journal of Molecular Cell Biology2017，9，4： | 5 |
| 12 | Preparation and performances of bulk porous Al foams impregnated with phase-change-materials for thermal storage | Jinghua Jiang Yingying Zhu Aibin Ma Donghui Yang Fumin Lu Jianqing Chen Jun Shi Dan Song | 2012 | Progress in Natural Science:Materials International2012，22，5： | 5 |
| 13 | Physical sensors for skin-inspired electronics显示文摘Skin,the largest organ in the human body,is sensitive to external stimuli.In recent years,an increasing number of skin-inspired electronics,including wearable electronics,implantable electronics,and electronic skin,have been developed because of their broad applications in healthcare and robotics.Physical sensors are one of the key building blocks of skin-inspired electronics.Typical physical sensors include mechanical sensors,temperature sensors,humidity sensors,electrophysiological sensors,and so on.In this review,we systematically review the latest advances of skin-inspired mechanical sensors,temperature sensors,and humidity sensors.The working mechanisms,key materials,device structures,and performance of various physical sensors are summarized and discussed in detail.Their applications in health monitoring,human disease diagnosis and treatment,and intelligent robots are reviewed.In addition,several novel properties of skin-inspired physical sensors such as versatility,self-healability,and implantability are introduced.Finally,the existing challenges and future perspectives of physical sensors for practical applications are discussed and proposed. | Shuo Li Yong Zhang Yiliang Wang Kailun Xia Zhe Yin Huimin Wang Mingchao Zhang Xiaoping Liang Haojie Lu Mengjia Zhu Haomin Wang Xinyi Shen Yingying Zhang | 2020 | InfoMat2020，2，1： | 5 |
| 14 | Shaped Pt-Ni nanocrystals with an ultrathin Pt-enriched shell derived from one-pot hydrothermal synthesis as active electrocatalysts for oxygen reduction显示文摘有 3d 转变金属的磅的合金 nanocrystals (NC ) ,特别 Ni,是为氧减小反应(ORR ) 的优秀催化剂。在这个工作,第一次,我们表明了水阶段 Pt-M (M = Ni,公司和 Fe ) 的胶体的合成有通过一个灵巧的热水的方法的悦耳的作文和形态学的合金 NC。Pt-Ni 合金 NC 综合了,这个方法更好介绍了 ORR 活动比商业 Pt/C 催化剂。X 光检查精力印射技术的散系列(版本) 表明充实磅的壳在同样综合的 Pt-Ni 合金 NC 上存在。厚分层的充实磅的壳在磅上形成了的大约二个原子 < 潜水艇 class= “ a-plus-plus ” > 50 Ni < 潜水艇 class= “ a-plus-plus ” > 当 Ni 内容增加了, 50 NC 和充实磅的壳的厚度增加了。而且, X 光检查光电子光谱学分析表明 Pt-Ni 合金 NC 上的表面磅原子的氧化水平与一金属的磅 NC 相比减少了,暗示在表面磅原子的 oxophilicity 的减少。有表面磅原子的更低的 oxophilicity 的 Pt-Ni 合金 NC 给更高的 ORR 活动。最活跃的合金样品显示出高 13 倍的特定的活动和高六倍的质量在 0.9 V 对一个可逆的氢电极的活动什么时候与商业 Pt/C 相比。Pt-Ni 合金 NC 也在长期的 ORR 测试比商业 Pt/C 显示出更好的耐久性。 | Jun Gu Guangxu Lan Yingying Jiang Yanshuang Xu Wei Zhu Chuanhong Jin Yawen Zhang | 2015 | Nano Research2015，8，5： | 5 |
| 15 | Catalytic oxidation of CO on mesoporous codoped ceria catalysts:Insights into correlation of physicochemical property and catalytic activity显示文摘Codoping approach is an appealing strategy to further improve the catalytic activity of Ce-based catalysts.In the present study,Mn and/or Cu doped ceria solid solutions MnxCuyCe1-x-yO2,CuxCe1-xO2,MnxCe1-xO2 and pure CeO2 were prepared by CTAB-assisted hydrothermal method for CO oxidation.XRD,SEM,EDS,BET,Raman,H2-TPR,XPS and in situ DRIFTS techniques were carried out to study the physicochemical properties and to correlate them to the activity.The doped samples maintain the cubic fluorite structure of CeO2 with high crystallinity and small crystallite size,forming Ce-based solid solutions.The obtained catalysts have large mesoporous structure with average pore size of 10-14 nm.The doped transition metal enhances the oxygen vacancies and improves reducibility of the solids.The synergistic interaction of Mn and Cu codoping induces mo re oxygen vacancies,pro moting the increase of surface adsorbed oxygen and the transfer of bulk oxygen of catalyst,thereby enhancing the catalytic activity for CO oxidation.Besides,the decomposition rate of the carbonate species which is derived from in situ DRIFTS for each catalyst can provide a measure to evaluate its catalytic activity of CO oxidation. | Hongjian Zhu Yingying Chen Yibo Gao Wenxu Liu Zhongpeng Wang Chenchen Cui Wei Liu Liguo Wang | 2019 | Journal of Rare Earths2019，37，9： | 5 |
| 16 | DBU-based CO2 absorption-mineralization system: Reaction process,feasibility and process intensification显示文摘Amine-based carbon dioxide(CO2)capture is still limited by high desorption energy consumption.Fixing CO2 into carbonate is a safer and more permanent method.In this work,calcium oxide(CaO)is introduced to perform chemical desorption instead of thermal desorption on 1,8-diazabicyclo[5.4.0]undec-7-ene(DBU)aqueous solution after CO2 absorption.The X-ray diffraction(XRD)patterns of solid products show the formation of calcite calcium carbonate(CaCO3),which prove the feasibility of this method.The effects of reaction temperature,reaction time and Ca2+/CO32-molar ratios on the related reactions in CO2 absorption-mineralization process and CaCO3 precipitation are discussed,and purer CaCO3 is obtained by ultrasonic treatment.The CaCO3 content can be increased to 95.8%and the CO2 desorption ratio can achieve 80%by 30 min ultrasonic dispersion treatment under the conditions(40℃,180 min,Ca2+/CO32-molar ratio=1.0).After five cycles,DBU aqueous solution shows stable CO2 absorption and mineralization ability.Fourier transform infrared spectroscopy(FT-IR)spectra of the reaction process also indicate the regeneration of the solvent.Compared with thermal desorption,this process is exothermic,almost without no additional heat. | Cong Luo Kejing Wu Hairong Yue Yingying Liu Yingming Zhu Wei Jiang Houfang Lu Bin Liang | 2020 | Chinese Journal of Chemical Engineering2020，28，4： | 4 |
| 17 | Fabrication of metal-organic framework-based nanofibrous separator via one-pot electrospinning strategy显示文摘Metal-organic framework(MOF)/polymer composites have attracted extensive attention in the recent years.However,it still remains challenging to efficiently and effectively fabricate these composite materials.In this study,we propose a facile one-pot electrospinning strategy for preparation of HKUST-1/polyacrylonitrile(PAN)nanofibrous membranes from a homogeneous stock solution containing HKUST-1 precursors and PAN.MOF crystallization and polymer solidification occur simultaneously during the electrospinning process,thus avoiding the issues of aggregation and troublesome multistep fabrication of the conventional approach.The obtained HKUST-1/PAN electrospun membranes show uniform MOF distribution throughout the nanofibers and yield good mechanical properties.The membranes are used as separators in Li-metal full batteries under harsh testing conditions,using an ultrathin Li-metal anode,a high mass loading cathode,and the HKUST-1/PAN nanofibrous separator.The results demonstrate significantly improved cycling performance(capacity retention of 83.1%after 200 cycles)under a low negative to positive capacity ratio(N/P ratio of 1.86).The improvement can be attributed to an enhanced wettability of the separator towards electrolyte stemmed from the nanofibrous structure,and a uniform lithium ion flux stabilized by the open metal sites of uniformly distributed HKUST-1 particles in the membrane during cycling. | Congcong Chen Weidong Zhang He Zhu Bo-Geng Li Yingying Lu Shiping Zhu | 2021 | Nano Research2021，14，5： | 4 |
| 18 | High energy batteries based on sulfur cathode显示文摘Lithium-ion batteries(LIBs)have become an indispensable part of our daily life,however,the energy and power capability that LIBs can deliver are lagging far behind the ever-increasing demands of portable electronics and electric vehicles.Metal-sulfur batteries as one of the most promising alternatives to LIBs are receiving rapidly growing research interests due to the extremely high energy density and abundant resources of sulfur.In this short review,we will discuss the state-of-art development of high energy density battery technologies based on sulfur cathode in combination with different metal anodes,with focus on sodium,magnesium and aluminum anodes.We leave lithium-sulfur batteries out of discussion since there are already a large number of nicely organized review papers available.The operation mechanism of various anode materials and the variety of electrolytes used in sulfur batteries will be reviewed.Some perspectives on improving the performances and overcoming the remaining issues in sulfur batteries will be discussed.It is expected that this review will draw more attention to sulfur batteries from both the academic and industrial communities. | Jian Zhu Jianli Zou Hua Cheng Yingying Gu Zhouguang Lu | 2019 | Green Energy & Environment2019，4，4： | 4 |
| 19 | Lysine enhances the effect of amphotericin B against Candida albicans in vitro显示文摘Amphotericin B (AmB ) 是 Streptomyces nodosus 生产的多烯抗菌素并且被用于 > 在急性全身的真菌的感染的处理的 50 年。在现在的学习,我们表明了那离氨酸,必要氨基酸,能在 vitro 对 Candida albicans 提高 AmB 的效果,尽管离氨酸本身没施加杀菌剂效果。另外,有离氨酸的 AmB 的联合能独自与 AmB 相比对 Candida parapsilosis 和 Cryptococcus neoformans 提供一个提高的行动。离氨酸能也提高 caspofungin 或制霉菌素的抗真菌的效果。有 AmB 的离氨酸的联合的提高的效果为 biofilm 和 hypha 形成的预防被观察。而且,我们的结果证明那调停离氨酸的氧化损坏例如内长的反应的氧种类的产生,可以是在 AmB 上位于离氨酸的提高的效果下面的机制。我们的结果也证明那 CaMCA1 基因在增加 C 的敏感起一个重要作用。在 AmB 处理之上的 albicans 房间。和离氨酸使用 AmB 可以是为传播 candidiasis 的治疗的有希望的策略。 | Liuya Zhao Jingchen Jiang Zhenyu Zhu Zebin Liao Xiangwen Yao Yu Yang Yingying Cao Yuanying Jiang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，2： | 4 |
| 20 | Exhumation history of the Huangshan granite pluton,southern Anhui Province:New insights from fission-track analysis显示文摘The dating of the uplift onset of the Huangshan pluton in the southern part of Anhui Province associated with the collision between paleo-Pacific Block and the Eurasian Block is a fundamental issue to better understand the uplift mechanisms and the regional tectonic evolution.χ2 values of seven zircon fission track(ZFT) samples collected from the south part of the Huangshan pluton were all<5%.Based on the grain ages of four typical ZFT samples,three thermal overprints ranging in 113-123,72-95 and 49-66 Ma were distinguished respectively using the binomial peak-fitting method in accordance with the tectonic thermal events after south China shifted into circum-Pacific tectonic region.Apatite fission track(AFT) study of the Huangshan pluton shows ages lie between 15±3 and 56±6 Ma with allχ2 values>5%,and all are significantly younger than their host rock formation ages,indicating that the samples have experienced post-formation thermal history.Based on the AFT results and topography characteristics in the Huangshan pluton,three zones with different denudation intensities caused by the differential uplift of the fault blocks were recognized in this paper,indicating that denudation was driven by the increase in elevation significantly.Modeling of the AFT data shows that the earlier cooling phase took place in the early Cenozoic and involved 3.3,3.8 and 6.0°C/Ma of cooling rates equivalent to the exhumation rates of 90,104 and 167 m/Ma in different fault blocks.The last phase of cooling took place from~10 Ma with average cooling rate of~5.6°C/Ma,equivalent to average denudation rates of~156 m/Ma.The fission track results imply that the regional compression field plays an important role for the differential exhumation between individual fault blocks of the Huangshan pluton. | ZHENG Yong YU XinQi YUAN WanMing WANG De'En JIANG GongBing ZHU DeLai WANG Cheng JIA YingYing | 2011 | Science China Earth Sciences2011，54，4： | 3 |
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