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| 1 | PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130显示文摘Golgi 仪器(GA ) 的维护结构和功能取决于 Golgi 矩阵蛋白质。象 golgin 和掌握家庭的成员的 phosphorylation 那样的 Golgi 蛋白质的 posttranslational 修正为决定 Golgi 建筑学是重要的。包括 golgin-84 的一些 Golgi 蛋白质也被知道是 methylated,但是 golgin methylation 的功能仍然保持不清楚。这里,我们证明蛋白质精氨酸 methyltransferase (PRMT5 ) 5 本地化到 GA 和形式建筑群,几个部件在拴住的 GA 带子形成和泡包含了。PRMT5 在 Golgi 带子形成与 PRMT5 原因缺点的 golgin GM130,和弄空交往。而且,在 GM130 的 PRMT5 甲醇化物 N 终端精氨酸,和如此的精氨酸 methylation 为 GA 显得批评带子形成。我们的调查结果揭示 GM130 的 PRMT5 依赖的精氨酸 methylation 由控制 GA 建筑学的维护的分子的机制。 | Zhongwei Zhou Xiaotian Sun Zhenhua Zou Litao Sun Tao Zhang Shaoshi Guo Ya Wen Lin Liu Yi Wang Jun Qin Lei Li Weimin Gong Shilai Bao | 2010 | Cell Research2010，20，9： | 16 |
| 2 | Labeling of cynomolgus monkey bone marrow-derived mesenchymal stem cells for cell tracking by multimodality imaging显示文摘Recently,transplantation of allogeneic and autologous cells has been used for regenerative medicine.A critical issue is monitoring migration and homing of transplanted cells,as well as engraftment efficiency and functional capability in vivo.Monitoring of superparamagnetic iron oxide(SPIO) particles by magnetic resonance imaging(MRI) has been used in animal models and clinical settings to track labeled cells.A major limitation of MRI is that the signals do not show biological characteristics of transplanted cells in vivo.Bone marrow mesenchymal stem cells(MSCs) have been extensively investigated for their various therapeutic properties,and exhibit the potential to differentiate into cells of diverse lineages.In this study,cynomolgus monkey MSCs(cMSCs) were labeled with Molday ION Rhodamine-BTM(MIRB),a new SPIO agent,to investigate and characterize the biophysical and MRI properties of labeled cMSCs in vitro and in vivo.The results indicate that MIRB is biocompatible and useful for cMSCs labeling and cell tracking by multimodality imaging.Our method is helpful for detection of transplanted stem cells in vivo,which is required for understanding mechanisms of cell therapy. | REN ZhenHua WANG JiaYin ZOU ChunLin GUAN YunQian ZHANG Yu Alex | 2011 | Science China(Life Sciences)2011，54，11： | 9 |
| 3 | A naturally occurring CD8^+CD122^+ T-cell subset as a memory-like Treg family显示文摘尽管有 CD4 + CD25 + 规章的 T 房间(Tregs ) 在过去的十年期间,在他们的临床的翻译以后的进步仍然保持停滞。增长证据建议那自然地发生的 CD8 + CD122 + T 房间也是有能力的 Tregs 禁止 T 房间回答并且象 alloimmunity 一样压制 autoimmunity。事实上,他们是像记忆的 Tregs 类似于一个中央记忆 T 房间(T 厘米 ) 显型。位于他们的抑制下面的机制仍然不好被理解,尽管他们可以包括 IL-10 生产。我们最近证明了那个规划 death-1 (PD-1 ) 表达式区分在之间规章并且存储器 CD8 + CD122 + T 房间和那 CD8 + CD122 + Tregs 经历更快的 homeostatic 增长并且比常规 CD4 + CD25 + Tregs。这些调查结果可以为在诊所加速有效 Treg 治疗打开调查的一根新线。在这评论,我们在 CD8 + CD122 + Treg 在诊所研究并且讨论他们的显型,在 autoimmunity 和 alloimmunity 的镇压角色,功能的要求,行动的机制和潜在的应用。 | Shanshan Li Qingfeng Xie Yuqun Zeng Chuan Zou Xusheng Liu Shouhai Wu Haixia Deng Yang Xu Xian C Li Zhenhua Dai | 2014 | Cellular & Molecular Immunology2014，11，4： | 6 |
| 4 | Discrimination of False Negative Results in RT-PCR Detection of SARS-CoV-2 RNAs in Clinical Specimens by Using an Internal Reference显示文摘Reverse transcription-polymerase chain reaction(RT-PCR)is an essential method for specific diagnosis of SARS-CoV-2 infection.Unfortunately,false negative test results are often reported.In this study,we attempted to determine the principal causes leading to false negative results of RT-PCR detection of SARS-CoV-2 RNAs in respiratory tract specimens.Multiple sputum and throat swab specimens from 161 confirmed COVID-19 patients were tested with a commercialfluorescent RT-PCR kit targeting the ORF1 ab and N regions of SARS-CoV-2 genome.The RNA level of a cellular housekeeping gene ribonuclease P/MRP subunit p30(RPP30)in these specimens was also assessed by RT-PCR.Data for a total of 1052 samples were retrospectively re-analyzed and a strong association between positive results in SARS-CoV-2 RNA tests and high level of RPP30 RNA in respiratory tract specimens was revealed.By using the ROC-AUC analysis,we identified Ct cutoff values for RPP30 RT-PCR which predicted false negative results for SARS-CoV-2 RT-PCR with high sensitivity(95.03%–95.26%)and specificity(83.72%–98.55%)for respective combination of specimen type and ampli-fication reaction.Using these Ct cutoff values,false negative results could be reliably identified.Therefore,the presence of cellular materials,likely infected host cells,are essential for correct SARS-CoV-2 RNA detection by RT-PCR in patient specimens.RPP30 could serve as an indicator for cellular content,or a surrogate indicator for specimen quality.In addition,our results demonstrated that false negativity accounted for a vast majority of contradicting results in SARS-CoV-2 RNA test by RT-PCR. | Yafei Zhang Changtai Wang Mingfeng Han Jun Ye Yong Gao Zhongping Liu Tengfei He Tuantuan Li Mengyuan Xu Luping Zhou Guizhou Zou Mengji Lu Zhenhua Zhang | 2020 | Virologica Sinica2020，35，6： | 5 |
| 5 | Characterizing the induction of diabetes in juvenile cynomolgus monkeys with different doses of streptozotocin显示文摘Juvenile(2-3 years old) cynomolgus monkeys are frequently used as recipients in non-human primate islet transplantation studies.The aim of this study was to examine the effects of different doses of streptozotocin(STZ),and find the optimal dose for inducing diabetes in these monkeys.Fifteen juvenile(2-3 years old) cynomolgus monkeys were separated into three groups and administered with different doses of STZ(100,68 or 60 mg kg-1).Basal and glucose-stimulated blood glucose,insulin,and C-peptide levels,as well as body weights were monitored.Hepatic and renal function tests and pancreatic immunohistochemistry were performed before and after STZ treatment.Monkeys treated with both 100 and 68 mg kg-1 of STZ exhibited continuous hyperglycemia,which coincided with a nearly complete loss of islet--cells.Two monkeys received 60 mg kg-1 of STZ,but only one became completely diabetic.During the first week following STZ treatment,hepatic and renal function slightly increased in these three groups.However,24 hours post-STZ,serum total bile acid levels were significantly increased in monkeys treated with 100 mg kg-1 than those treated with 68 mg kg-1 of STZ(P<0.05).These data suggest that 100 mg kg-1 and 68 mg kg-1 of STZ can safely induce diabetes in cynomolgus monkeys aged 2-3 years,but 68 mg kg-1 of STZ,rather than 100 mg kg-1 of STZ,may be more appropriate for inducing diabetes in these monkeys.Furthermore,body surface area,rather than body weight,was a more reliable determinant of dosage,where 700 mg m-2 of STZ should be the lower limit for inducing diabetes in juvenile monkeys. | ZOU ChunLin WANG JiaYin WANG ShuYan HUANG Fen REN ZhenHua CHEN ZhiGuo ZHANG YU | 2012 | Science China(Life Sciences)2012，55，3： | 3 |
| 6 | Highly efficient catalytic performances of nitro compounds via hierarchical PdNPs-loaded MXene/polymer nanocomposites synthesized through electrospinning strategy for wastewater treatment显示文摘The problem of water pollution has become increasingly serious,and it has already threatened the survival of mankind and has become an obstacle to the healthy development of human health.Here,we prepared a novel polyvinyl alcohol(PVA)/polyacrylic acid(PAA)/MXene fiber membrane by electrospinning.After heat treatment of film and subsequent modification with Pd nanoparticles,PVA/PAA/MXene@PdNPs composite nanofiber membrane with high specific surface area and excellent catalytic performance was finally prepared.The uniform distribution of MXene sheets in the composite fiber membrane not only solves the problem that the MXene sheet is not easy to be monolayerized,but also can grow the self-reduced Pd nanoparticles on the MXene sheets.In addition,the composite nanofiber membrane exhibits excellent catalytic ability and cycle stability for 4-nitrophenol(4-NP)and 2-nitrophenol(2-NA),providing new strategy for the study of catalytic composite materials related to degradation of wastewater. | Juanjuan Yin Fangke Zhan Tifeng Jiao Huizhen Deng Guodong Zou Zhenhua Bai Qingrui Zhang Qiuming Peng | 2020 | Chinese Chemical Letters2020，31，4： | 3 |
| 7 | Sinorhizobium meliloti nifA gene exerts a pleiotropic effect on nodulation through the enhanced plant defense response显示文摘Sinorhizobium meliloti nifA gene is required for the expression of a bunch of nif and fix genes. Here, we report its pleiotropic effects on the nodule formation. Compared with wild type strain, nifA mutant sig- nificantly reduced nodule suppression rate in split-root system. The plants inoculated with mutant strain produced lower amount of daidzein and less necrotic cells on their roots. In addition, the defense genes failed to be evoked by nifA mutant at the early nodulation stage. These findings indicated that host defense response was one of the mechanisms mediated by nifA gene to regulate nodule formation during symbiosis. Even though nifA mutant could increase the number of nodules in host plant, it synthesized lower Nod factors than wild type. This suggested that nifA gene mediated multiple and diverse instances in nodulation formation. | CHEN XiaoTao ZOU HuaSong YAO ZhenHua CHENG HaiPing DAI XiaoMi ZHU JiaBi YU GuanQiao | 2007 | Chinese Science Bulletin2007，52，21： | 2 |
| 8 | Complementation analyses of Sinorhizobium meliloti nifA mutant with different originated nifA genes显示文摘推断的一个以前的工作 Enterobacter 下水道的 nifA 基因没恢复 Sinorhizobium meliloti nifA 的共生显型变异。在现在的学习, Bra-dyrhizobium 的 twonifA 基因日本嗯并且 Mesorhizobium huakuii 也没恢复 S 的共生显型。meliloti nifA 异种。在微数组试验的整个 genomic, 238 基因被发现是在 S 以后表示的差别。meliloti nifA 组成地在它的 nifAmutant 被表示了。相反,当表示 B.japonium 时,仅仅 20, 7 和 9 基因改变了他们的 transcriptional 层次, M。在 Sm nifA 异种的 huakuii 和 Enterobacter 下水道 nifA 基因独立。这些基因包括房子保留,精力和中央中间代谢被分类进几官能基,运输系统和共生。有趣地, nifHoperons,显示出的高表示面对任何一个 B 铺平的基因。japonium 或 M。huakuii NifA,它被随后的紫胶 Z 熔化实验证实。 | YAO Zhenhua TIAN Zhexian DAI Xiaomi BECKER Anke LI Jian YAN Haiqin XIAO Yan ZHU Jiabi YU Guanqiao RUVERG Silvia WANG Yiping ZOU Huasong | 2006 | Chinese Science Bulletin2006，51，22： | 2 |
| 9 | Chemically - modified activated carbon with ethylenediamine for selective solid -phase extraction and preconcentration of metal ions显示文摘 | LI Zhenhua CHANG Xijun ZOU Xiaojun ZHU Xiangbing NIE Rong HU Zheng LIRuijun | 2009 | Anal Chim Acta2009，632，2： | 1 |
| 10 | Carbon Price Volatility: Evi- dence from EU ETS显示文摘 | ZhenHua Feng LeLe Zou YiMing Wei | 2011 | Applied Energy2011，，88： | 1 |
| 11 | The time process of post‐earthquake recovery: the Yao’an earthquake in China显示文摘 | Ying Wang Juan Li Hao Chen Zhenhua Zou | 2014 | Disasters2014，，4： | 1 |
| 12 | Chemically-modified activated carbon with ethylenediamine for selective solid-phase extraction and preconcentration of metal ions显示文摘 | Zhenhua Li Xijun Chang Xiaojun Zou Xiangbing Zhu Rong Nie Zheng Hu Ruijun Li | 2008 | Analytica Chimica Acta2008，，2： | 1 |
| 13 | Impacts of human activities on the flow regime of the Yangtze River显示文摘 | LI QIONGFANG ZOU ZHENHUA XIA ZIQIANG | 2007 | IAHS Redbook2007，315，： | 1 |
| 14 | Identification of sweet spots in shale-type and siltstone-type“shale oil systems”:A case study of the Chang 7 Member in Ordos Basin显示文摘Mid-high maturity shale oil is the most realistic field for the scale breakthrough of terrestrial shale oil production in China.Generally,three deficiencies hinder shale oil development in China:heavy oil density,small sweet spot areas,and poor distribution continuity.Thus,identifying the“sweet spots”in shale oil reservoirs is critical for the efficient exploration and development of terrestrial shale oil.This study targets the siltstone type(Class-Ⅱshale oil)and pure shale type(Class-Ⅲshale oil)of the Chang 7 Member in the Ordos Basin,and identifies three stratigraphic units,namely the hydrocarbon accumulation unit,hydrocarbon generation unit,and hydrocarbon retention unit,which together constitute the in-source“shale oil system”.The hydrocarbon accumulation unit is mainly siltstone,where the hydrocarbons are migrated from shales.It has favorable porethroat network connectivity with a pore connectivity ratio of 32–57%,being the siltstone-type sweet spots.The hydrocarbon generation unit is mainly composed of high-TOC mudstone/shale and is the main contributor to in-source hydrocarbon generation and expulsion.This unit has high three-dimensional connectivity(28–30%),as shown by the pore-throat network model,associated with vertical paths for hydrocarbon expulsion.The hydrocarbon retention unit is mainly composed of low-TOC mudstone/shale retaining self-generated and migrated hydrocarbons.The pore connectivity rate is 17–42%,and the pore-throat network connectivity direction is uneven.Light and low-carbon-number hydrocarbons are preferentially trapped or even sealed in small pores of the retention unit,forming the typical mudstone/shale-type sweet spots.In the process called shale oil intrasource migration,the oil migrates in source rocks causing component fractionation,which allows more shale oil to enrich in the hydrocarbon accumulation and retention units to form sweet spots,compared with the hydrocarbon generation unit.The migration paths include the one from mudstone/shale to siltstone interlayers and that from the high-TOC mudstone/shale intervals to the low-TOC intervals.The in-source accumulation of shale oil shows the differentiated enrichment model featuring“high-TOC mudstone/shale generating hydrocarbons,low-TOC mudstone/shale retaining hydrocarbons,siltstone accumulating hydrocarbons and multiple intra-source migration paths”.In the Ordos Basin,the organic-lean(TOC 1–3%)mudstone/shale intervals appear to be the sweet spots of shale oil,where there are abundant medium-short-chain hydrocarbons retained with high flowability.After fracturing stimulation,their production conditions may be even superior to those of siltstones.This proposed idea changes the previous strategy to look for sweet spots in high-TOC intervals derived from the shale gas industry. | Songqi PAN Qiulei GUO Caineng ZOU Zhenhua JING Ming YUAN Ying HE He ZHENG Ying MU Zhi YANG Shixiang LI Xinping ZHOU Songtao WU Hanlin LIU Feng YANG Yuanjia HAN | 2023 | Science China Earth Sciences2023，66，7： | 1 |
| 15 | Magneticfluid core optical fiber显示文摘 | Yun Zou Kun Liu Zhenhua Shen | | 0，，10： | 1 |
| 16 | Optofluidic microring dye laser embedded in polydimenthylsiloxane with reduced threshold显示文摘We demonstrate an integrated optofluidic microring dye laser with a relatively low threshold on a polydimenthylsiloxane(PDMS) chip.The chip was fabricated through conventional soft lithography.It consists of a liquid waveguide with microring structure providing the feedback.A reduced threshold is realized due to the unique design of the bus waveguide across the center of the microring structure,which results in a great reduction in the cavity losses.Laser dye rhodamine 6G(R6G) dissolved in benzyl alcohol was injected into the microfluidic channel as the gain medium.When the dye laser was pumped with a pulsed laser at 532 nm,the dye laser oscillation was achieved with a threshold of only 4?5 μJ mm-2.The convenience in fabrication and operation makes the optofluidic microring dye laser a promising underlying photonic component in the integrated optofluidic systems. | SHEN ZhenHua ZOU Yun CHEN XianFeng | 2013 | Chinese Science Bulletin2013，58，7： | 1 |
| 17 | Chemically-modified activated carbon with ethylenediamine for selective solid-phase extraction and preconcentration of metal ions显示文摘 | Zhenhua Li Xijun Chang Xiaojun Zou | 2009 | Analytica Chimica Acta2009，632，2： | 1 |
| 18 | Chemically-modified activated carbon with ethylenediamine for selective solid-phase extraction and preconcentration of metal ions显示文摘 | LI Zhenhua CHANG Xijun ZOU Xiaojun ZHU Xiangbing NIE Rong HU Zheng LI Ruijun | 2009 | Anal Chim Acta2009，632，2： | 1 |
| 19 | Accurate Assessment and Tracking the Process of Liver-Specific Injury by the Residual Tissue Activity of Carboxylesterase 1 and Dipeptidyl Peptidase 4显示文摘Accurately assessing and tracking the progression of liver-specific injury remains a major challenge in the field of biomarker research.Here,we took a retrospective validation approach built on the mutuality between serum and tissue biomarkers to characterize the liver-specific damage of bile duct cells caused by a-naphthyl isothiocyanate(ANIT).We found that carboxylesterase 1(CES1),as an intrahepatic marker,and dipeptidyl peptidase 4(DPP-IV),as an extrahepatic marker,can reflect the different pathophysiologies of liver injury.Levels of CES1 and DPP-IV can be used to identify liver damage itself and the inflammatory state,respectively.While the levels of the conventional serological biomarkers alkaline phosphatase(ALP),alanine aminotransferase(ALT),and aspartate aminotransferase(AST)were all concomitantly elevated in serum and tissues after ANIT-induced injury,the levels of bile acids decreased in bile,increased in serum,and ascended in intrahepatic tissue.Although the level of γ-glutamyl transpeptidase(γ-GT)changed in an opposite direction,the duration was much shorter than that of CES1 and was quickly restored to normal levels.Therefore,among the abovementioned biomarkers,only CES1 made it possible to specifically determine whether the liver cells were destroyed or damaged without interference from inflammation.CES1 also enabled accurate assessment of the anti-cholestasis effects of ursodeoxycholic acid(UDCA;single component)and Qing Fei Pai Du Decoction(QFPDD;multicomponent).We found that both QFPDD and UDCA attenuated ANIT-induced liver damage.UDCA was more potent in promoting bile excretion but showed relatively weaker anti-injury and antiinflammatory effects than QFPDD,whereas QFPDD was more effective in blocking liver inflammation and repairing liver damage.Our data highlights the potential of the combined use of CES1(as an intrahepatic marker of liver damage)and DPP-IV(as an extrahepatic marker of inflammation)for the accurate evaluation and tracking of liver-specific injury—an application that allows for the differentiation of liver damage and inflammatory liver injury. | Qiusha Pan Peifang Song Zhenhua Ni Xingkai Qian Anqi Wang Liwei Zou Yong Liu Ping Wang Weidong Zhang Hong Ma Ling Yang | 2022 | Engineering2022，，12： | 0 |
| 20 | Major biological events and fossil energy formation: On the development of energy science under the earth system framework显示文摘In geological history, one major life explosion and five mass extinction events occurred. These major biological and environmental events affected the evolution of the Earth ecosystem and controlled the formation of organic-rich strata. The life explosion occurred in Cambrian and the five mass extinction events happened at the end of Ordovician, Late Devonian, end of Permian, end of Triassic, and end of Cretaceous, respectively. They are corresponded to the formation of multiple suites of organic-rich strata globally, which are crucial to the formation, evolution and distribution of the fossil energy on Earth. China’s energy is characterized by 'unlimited new energy, rich in coal but insufficient in oil and gas ', and it is determined to rely on new energy sources to achieve ' energy independence ' and carbon neutrality. From the perspective of the Earth system evolution, we investigate the multiple relationships between energy and Earth, energy and environment, as well as energy and human beings, and carry out comprehensive research on energy. Energy science refers to the science of studying the various energy sources formation and distribution, evaluation and selection, production and utilization, orderly replacement, development prospects, etc. in temporal and spatial scales based on the evolution of the Earth system. The connotation of energy science includes three core contents:(1) The relationship between the Earth and energy, including the formation of energy in the Earth system and the feedback of energy consumption to the Earth’s climate and environment;(2) The relationship between the Earth environment and the human beings, including the Earth environment breeding human beings and human activities transforming the earth environment;(3) The relationship between the energy and the human beings, including the development of energy technology by human beings and the progress of human society driven by energy utilization. The energy science focuses on the formation and development of fossil energy, development and orderly replacement of new energy, exploration and utilization of energy in deep earth and deep space, and energy development strategy and planning. The proposal of energy science is of great significance for improving the discipline system, promoting energy development, clarifying the development direction of energy transition, driving the carbon neutral geology research and constructing a habitable Earth. | PAN Songqi ZOU Caineng LI Yong JING Zhenhua LIU Entao YUAN Ming ZHANG Guosheng YANG Zhi WU Songtao QIU Zhen LIU Hanlin | 2021 | Petroleum Exploration and Development2021，48，3： | 0 |
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