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| 1 | Mechanism underlying treatment of ischemic stroke using acupuncture:transmission and regulation显示文摘The inflammatory response after cerebral ischemia/reperfusion is an important cause of neurological damage and repair.After cerebral ischemia/reperfusion,microglia are activated,and a large number of circulating inflammatory cells infiltrate the affected area.This leads to the secretion of inflammatory mediators and an inflammatory cascade that eventually causes secondary brain damage,including neuron necrosis,blood-brain barrier destruction,cerebral edema,and an oxidative stress response.Activation of inflammatory signaling pathways plays a key role in the pathological process of ischemic stroke.Increasing evidence suggests that acupuncture can reduce the inflammatory response after cerebral ischemia/reperfusion and promote repair of the injured nervous system.Acupuncture can not only inhibit the activation and infiltration of inflammatory cells,but can also regulate the expression of inflammation-related cytokines,balance the effects of pro-inflammatory and anti-inflammatory factors,and interfere with inflammatory signaling pathways.Therefore,it is important to study the transmission and regulatory mechanism of inflammatory signaling pathways after acupuncture treatment for cerebral ischemia/reperfusion injury to provide a theoretical basis for clinical treatment of this type of injury using acupuncture.Our review summarizes the overall conditions of inflammatory cells,mediators,and pathways after cerebral ischemia/reperfusion,and discusses the possible synergistic intervention of acupuncture in the inflammatory signaling pathway network to provide a foundation to explore the multiple molecular mechanisms by which acupuncture promotes nerve function restoration. | Bing-Qian Cao Feng Tan Jie Zhan Peng-Hui Lai | 2021 | Neural Regeneration Research2021，16，5： | 43 |
| 2 | Buyang Huanwu decoction increases angiopoietin-1 expression and promotes angiogenesis and functional outcome after focal cerebral ischemia显示文摘 | Jian SHEN Yu ZHU Hai YU Zuo-xu FAN Feng XIAO Pan WU Qi-hui ZHANG Xiao-xing XIONG Jian-wei PAN Ren-ya ZHAN | 2014 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2014，15，3： | 36 |
| 3 | clusterProfiler 4.0:A universal enrichment tool for interpreting omics data显示文摘Functional enrichment analysis is pivotal for interpreting highthroughput omics data in life science.It is crucial for this type of tool to use the latest annotation databases for as many organisms as possible.To meet these requirements,we present here an updated version of our popular Bioconductor package,clusterProfiler 4.0.This package has been enhanced considerably compared with its original version published 9 years ago.The new version provides a universal interface for functional enrichment analysis in thousands of organisms based on internally supported ontologies and pathways as well as annotation data provided by users or derived from online databases.It also extends the dplyr and ggplot2 packages to offer tidy interfaces for data operation and visualization.Other new features include gene set enrichment analysis and comparison of enrichment results from multiple gene lists.We anticipate that clusterProfiler 4.0 will be applied to a wide range of scenarios across diverse organisms. | Tianzhi Wu Erqiang Hu Shuangbin Xu Meijun Chen Pingfan Guo Zehan Dai Tingze Feng Lang Zhou Wenli Tang Li Zhan Xiaocong Fu Shanshan Liu Xiaochen Bo Guangchuang Yu | 2021 | The Innovation2021，2，3： | 40 |
| 4 | Magnetic resonance susceptibility weighted imaging in detecting intracranial calcification and hemorrhage显示文摘背景计算断层摄影术(CT ) 在检测 intracranial 石灰化比平淡的磁性的回声成像(MRI ) 好。试图估计在 intracranial 石灰化和 hemorrhage.Methods 的察觉和区别的加权的成像(SWI ) 在这研究注册了的先生危险性的价值的这研究是包括 CT 表明的石灰化的 13 个盒子和 intracerebral 出血的 22 个盒子的 35 个病人。在所有这些题目使用的先生序列包括了轴的 T1WI, T2WI 和 SWI。SWI 上的石灰化和出血的阶段移动(PS ) 被计算,他们的信号在改正的阶段图象上展示被比较。在检测 intracranial 石灰化和出血的 T1WI, T2WI 和 SWI 的敏感是为头部的石灰化的 SWI 的察觉率是的分析 statistically.Results 98.2% ,比 T1 Wl 和 T2WI 的显著地高。它不与 CT 的显著地不同(P > 0.05 ) 。在不同阶段有 49 出血性的损害检测 n SWI, 30 在 T2WI 上并且 18 在 T1WI 上。石灰化和出血的平均 PS 是在检测的 +0.734han 常规 MRI 微出血, SWI 可以在区分与石灰化或出血联系的服的疾病起一个重要作用。 | ZHU Wen-zhen QI Jian-pin ZHAN Chuan-jia SHU Hong-ge ZHANG Lin WANG Cheng-yuan XIA Li-ming HU Jun-wu FENG Ding-yi | 2008 | Chinese Medical Journal2008，，20： | 26 |
| 5 | A high-quality genome assembly of quinoa provides insights into the molecular basis of salt bladder-based salinity tolerance and the exceptional nutritional value显示文摘 | Changsong Zou Aojun Chen Lihong Xiao Heike M Muller Peter Ache Georg Haberer Meiling Zhang Wei Jia Ping Deng Ru Huang Daniel Lang Feng Li Dongliang Zhan Xiangyun Wu Hui Zhang Jennifer Bohm Renyi Liu Sergey Shabala Rainer Hedrich Jian-Kang Zhu Heng Zhang | 2017 | Cell Research2017，27，11： | 22 |
| 6 | The electromagnetic wave experiment for CSES mission: Search coil magnetometer显示文摘The seismic activities on the Earth can produce a disturbance of the electromagnetic field and particles in the ionosphere. The search coil magnetometer(SCM) mounted on China Seismo-Electromagnetic satellite(CSES) is designed to measure the magnetic field fluctuation of low frequency electromagnetic waves in the frequency range of 10 Hz–20 k Hz. The SCM comprises a three-axis search coil sensor mounted on a 4.5 m boom and an electronic box inside satellite module. The sampling rate of the SCM is 51.2 k Hz and the time resolution of the power spectrum density(PSD) is 2 s. The frequency resolution is 12.5 Hz.There are three operation modes: survey, detailed survey and calibration. In the survey mode, the SCM can provide a PSD in the whole frequency range of 10 Hz–20 k Hz and wave forms in the low frequency range below 2 k Hz while in the detailed survey mode the SCM can provide both PSD and wave forms in the whole frequency range of 10 Hz–20 k Hz. The sensitivity of the SCM instrument is 5.0×10^(-4) n T Hz^(-1/2) at 10 Hz, 5.0×10^(–5) n T Hz^(-1/2) at 200 Hz, 3.4×10^(-5) n T Hz^(-1/2) at 2 k Hz and 1.1×10^(-4) n T Hz^(-1/2) at 20 k Hz. The telemetry rate is ~0.85 Mbps in the survey mode and ~3.0 Mbps in the detailed survey mode. The phase difference between three axes can be made generally with a precision of less than 1.0°. The dynamic range of the SCM instrument is over 100 d B. The orthogonality of three mechanical axes of search coil senor is better than 0.13°. The performance of SCM can satisfy the requirement of scientific objectives of CSES mission. | CAO JinBin ZENG Li ZHAN Feng WANG ZuoGui WANG Yan CHEN Yu MENG QingChun JI ZhanQiang WANG PengFei LIU ZhongWei MA LingYu | 2018 | Science China(Technological Sciences)2018，61，5： | 13 |
| 7 | Electroacupuncture exerts neuroprotective effects on ischemia/reperfusion injury in JNK knockout mice:the underlying mechanism显示文摘Simple regulation of c-Jun N-terminal kinase(JNK) or p38 mitogen-activated protein kinase(MAPK) pathways is not enough to trigger cell apoptosis.However,activation of the stress activated pathway(JNK/p38 MAPK) together with inhibition of the growth factor activated extracellular signal-regulated kinase(ERK) pathway can promote cell apoptosis.We hypothesized that inhibition of the JNK or p38 pro-apoptotic pathway and activating the ERK pathway could be the mechanism of anti-apoptosis following cerebral ischemia/reperfusion injury.To investigate the mechanism of the protective effect of electroacupuncture on cerebral ischemia/reperfusion injury in JNK knockout mice,mouse models of cerebral ischemia/reperfusion injury were established by Longa's method.Electroacupuncture was conducted at acupoints Chize(LU5),Hegu(LI4),Sanyinjiao(SP6) and Zusanli(ST36) 1.5 hours after ischemia/reperfusion injury for 20 minutes,once a day.The neurological function was evaluated using neurological deficit scores.The expression of phospho-extracellular signal-regulated kinase(p-ERK) and phospho-p38(p-p38) in JNK knockout mice was detected using double-labeling immunofluorescence and western blot assay.The m RNA expression of ERK and p38 was measured by quantitative real-time polymerase chain reaction.Electroacupuncture improved neurological function,increased the immunoreactivity and relative expression of p-ERK and reduced that of p-p38 in the cerebral cortex and hippocampus on the injured side.Electroacupuncture increased m RNA expression of ERK,but decreased that of p38 in the cerebral cortex and hippocampus on the injured side.In conclusion,electroacupuncture upregulated the protective ERK pathway and inhibited the pro-apoptotic p38 pathway,thereby exerting a neuroprotective effect and improving the neurological function in JNK knockout mice. | Chun-Xiao Wu Yi-Hui Feng Lu Yang Zhu-Lian Zhan Xiu-Hong Xu Xiao-Ying Hu Zhi-Hua Zhu Guo-Ping Zhou | 2018 | Neural Regeneration Research2018，13，9： | 11 |
| 8 | Research progress in ZnO single-crystal:growth, scientific understanding, and device applications显示文摘Zinc oxide,a wide band-gap semiconductor,has shown extensive potential applications in high-efficiency semiconductor photoelectronic devices,semiconductor photocatalysis,and diluted magnetic semiconductors.Due to the undisputed lattice integrity,ZnO single crystals are essential for the fabrication of high-quality ZnO-based photoelectronic devices,and also believed to be ideal research subjects for understanding the underlying mechanisms of semiconductor photocatalysis and diluted magnetic semiconductors.This review,which is organized in two main parts,introduces the recent progress in growth,basic characterization,and device development of ZnO single crystals,and some related works in our group.The first part begins from the growth of ZnO single crystal,and summarizes the fundamental and applied investigations based on ZnO single crystals.These works are composed of the fabrication of homoepitaxial ZnO-based photoelectronic devices,the research on the photocatalysis mechanism,and dilute magnetic mechanism.The second part describes the fabrication of highly thermostable n-type ZnO with high mobility and high electron concentration through intentional doping.More importantly,in this part,a conceptual approach for fabricating highly thermostable p-type ZnO materials with high mobility through an integrated three-step treatment is proposed on the basis of the preliminary research. | Feng Huang Zhang Lin Wenwen Lin Jiye Zhang Kai Ding Yonghao Wang Qinghong Zheng Zhibing Zhan Fengbo Yan Dagui Chen Peiwen Lv Xian Wang | 2014 | Chinese Science Bulletin2014，59，12： | 11 |
| 9 | Paeoniflorin Attenuates Myocardial Fibrosis in Isoprenaline-induced Chronic Heart F ailure Rats via Inhibiting P38 MA PK Pathway显示文摘Paconiflorin(Pae)is a monoterpenoid glycoside compound and has many biological activitics,such as immunosuppression,anti-inflammation and anti-cell proliferation.However,the effects and mechanisms of Pae on chronic heart failure(CHF)remain unclear.This study was conducted to assess the effects and mechanisms of Pae on myocardial fibrosis in isoprenaline(Iso)-induced CHF rats.Pae(20 mgkg)was intragastrically administrated to CHF rats for 6 weeks.Cardiac structure and function were assessed.The protein and mRNA levels of transforming growth factorβ1(TGF-β1)and p38 were detected.C ompared to Iso group,Pae could alleviate myocardial fbrosis and improve cardiac function in CHF rats.The levels of collagen volume fraction(13.75%+3.77%vs.30.97%+4.22%,P<0.001)and perivascular collagen volume area(14.32%+2.50%v8.28.31%+3.16%,P<0.001)were significantly reduced in Pae group as compared with those in Iso group.The expression of TGF-BI protein(0.30+0.07 vs.0.66+0.07,P<0.05)and mRNA(3.51+0.44 vs.7.58+0.58,P<0.05)decreased significantly in Pac group as compared with that in Iso group.The expression of p38 protein(0.36+0.12 vs.0.81+0.38,P<0.05)and mRNA(3.84+0.05 vs.4.40+0.17,P<0.05)also decreased markedly in Pae group as compared with that in Iso group.Pae could attenuate myocardial fibrosis and improve cardiac function in CHF rats by down-regulating the p38 MAPK signaling pathway. | Mao LIU Jie FENG Qian DU Jiao AI Zhan LV | 2020 | Current Medical Science2020，40，2： | 11 |
| 10 | Comparison of Long-term Outcomes in Patients with Premature Triple-vessel Coronary Disease Undergoing Three Different Treatment Strategies: A Prospective Cohort Study显示文摘 | Jing-Jing Xu Yin Zhang Lin Jiang Jian Tian Lei Song Zhan Gao Xin-Xing Feng Xue-Yan Zhao Yan-Yan Zhao Dong Wang Kai Sun Lian-Jun Xu Ru Liu Run-Lin Gao Bo Xu Lei Song Jin-Qing Yuan | 2018 | Chinese Medical Journal2018，，1： | 10 |
| 11 | Construction and stability of an extra-large section chamber in solid backfill mining显示文摘In solid backfill mining without gangue removal, the gangue is separated directly underground and backfilled into goaf. This necessitates the underground construction of an extra-large section chamber for separation equipments. For the construction of an extra-large section chamber in the Tangshan mine, we proposed an active support through a combination of bolting, anchor cables, lining, and a reinforced chamber floor by inverted arch pouring. ABAQUS software was used to analyze the surrounding rock deformation and the plastic zone development of the chamber under different excavation schemes.The best excavation scheme was determined, and the effectiveness of the combined supports was verified. In practice, the engineering installation showed good overall control of the movement of the surrounding rock, with roof-to-floor and side-to-side convergences of 154.6 and 77.5 mm, respectively,which meets the requirements for underground coal gangue separation. | Ju Feng Li Meng Zhang Jixiong Miao Xiexing Liu Zhan | 2014 | International Journal of Mining Science and Technology2014，24，6： | 10 |
| 12 | Effects of elevated ozone on growth and yield of field-grown rice in Yangtze River Delta,China显示文摘与在 Yangtze 三角洲的快速的工业化和都市化,中国,球的臭氧集中增加了到导致的层次的对流收割收获损失。瑞斯,在中国的广泛地成年的庄稼,在建立地的、开顶的房间被调查。四个处理被使用:过滤炭的空气(CF ) , non-charcoal-filtered 空气(NF ) ,和有另外的臭氧(O3-1 和 O3-2 ) 的二个层次的过滤炭的空气。AOT40s (在 40 ppbv 上面的积累的时时吝啬的臭氧集中) 分别地是为 CF, NF, O3-1,和 O3-2 的处理的 0, 0.91, 23.24,和 39.28 ppmv · h。米饭高度和生物资源在提高的臭氧集中被减少。显著地在提高的臭氧下面划分到根的更少的有机物减少了米饭根活动。收获损失分别地在 O3-1 和 O3-2 暴露下面是 14.3% 和 20.2% 。这被减小大部分每圆锥花序在粒重引起。 | CHEN Zhan WANG Xiaoke FENG Zhaozhong ZHENG Feixiang DUAN Xiaonan YANG Wenrui | 2008 | Journal of Environmental Sciences2008，20，3： | 10 |
| 13 | Aging Precipitation Behavior of 18Cr-16Mn-2Mo-1.1N High Nitrogen Austenitic Stainless Steel and Its Influences on Mechanical Properties显示文摘The solution-treated (ST) condition and aging precipitation behavior of 18Cr-16Mn-2Mo-1.1N high nitrogen austenitic stainless steel (HNS) were investigated by optical microscope (OM), scanning electron microscope (SEM), and transmission electron microscope (TEM). The results show that the ST condition of 18Cr-16Mn-2Mo-1.1N HNS with wN above 1% is identified as 1 100 ℃ for 90 min, followed by water quenching to make sure the secondary phases completely dissolve into austenitic matrix and prevent the grains coarsening too much. Initial time-temperature-precipitation (TTP) curve of aged 18Cr-16Mn-2Mo-1.1N HNS which starts with precipitation of 0.05% in volume fraction is defined and the 'nose' temperature of precipitation is found to be 850 ℃ with an incubation period of 1 min. Hexagonal intergranular and cellular Cr2N with a=0.478 nm and c=0.444 nm precipitates gradually increase in the isothermal aging treatment. The matrix nitrogen depletion due to the intergranular and a few cellular Cr2N precipitates induces the decay of Vickers hardness, and the increment of cellular Cr2N causes the increase in the values. Impact toughness presents a monotonic decrease and SEM morphologies show the leading brittle intergranular fracture. The ultimate tensile strength (UTS), yield strength (YS) and elongation (El) deteriorate obviously. Stress concentration occurs when the matrix dislocations pile up at the interfaces of precipitation and matrix, and the interfacial dislocations may become precursors to the misfit dislocations, which can form small cleavage facets and accelerate the formation of cracks. | LI Hua-bing, JIANG Zhou-hua, FENG Hao, MA Qi-feng, ZHAN Dong-ping (School of Materials and Metallurgy, Northeastern University, Shenyang 110819, Liaoning, China) | 2012 | Journal of Iron and Steel Research(International)2012，19，8： | 10 |
| 14 | Traditional Chinese medicine “Qing Yi Tang” alleviates oxygen free radical injury in acute necrotizing pancreatitis显示文摘TraditionalChinesemedicine“QingYiTang”aleviatesoxygenfreeradicalinjuryinacutenecrotizingpancreatitisLIZhanLiang1,WUChengTan... | LI ZhanLiang1, WU ChengTang2, LU LianRong, ZHU XiaoFeng and XIONG DeXinKeywords pancreatitis/therapy Qing Yi Tang free radicals superoxide dismutase/analysis malonyldiadehyde/analysis | 1998 | World Journal of Gastroenterology1998，4，4： | 8 |
| 15 | Dissecting the Genetic Basis of Grain Shape and Chalkiness Traits in Hybrid Rice Using Multiple Collaborative Populations显示文摘 | Junyi Gong Jiashun Miao Yan Zhao Qiang Zhao Qi Feng Qilin Zhan Benyi Cheng Junhui Xia Xuehui Huang Shihua Yang Bin Han | 2017 | Molecular Plant2017，10，10： | 8 |
| 16 | Effect of Static Load on the Nucleus Pulposus of Rabbit Intervertebral Disc Motion Segment in Ex vivo Organ Culture显示文摘 | Li-Guo Zhu Min-Shan Feng Jia-Wen Zhan Ping Zhang Jie Yu | 2016 | Chinese Medical Journal2016，，19： | 7 |
| 17 | Newborn screening with targeted sequencing:a multicenter investigation and a pilot clinical study in China显示文摘Different newborn screening(NBS) programs have been practiced in many countries since the 1960 s. It is of considerable interest whether next-generation sequencing is applicable in NBS. We have developed a panel of 465 causative genes for 596 early-onset, relatively high incidence, and potentially actionable severe inherited diseases in our Newborn Screening with Targeted Sequencing(NESTS) program to screen 11,484 babies in 8 Women and Children’s hospitals nationwide in China retrospectively. The positive rate from preliminary screening of NESTS was 7.85%(902/11,484). With 45.89%(414/902) follow-up of preliminary positive cases, the overall clinically confirmative diagnosis rate of monogenic disorders was 12.07%(50/414), estimating an average of 0.95%(7.85% × 12.07%) clinical diagnosis rate, suggesting that monogenic disorders account for a considerable proportion of birth defects. The disease/gene spectrum varied in different regions of China. NESTS was implemented in a hospital by screening 3923 newborns to evaluate its clinical application. The turn-around time of a primary report, including the sequencing period of < 7 days, was within 11 days by our automatic interpretation pipeline. Our results suggest that NESTS is feasible and cost-effective as a first-tier NBS program, which will change the status of current clinical practice of NBS in China. | Chanjuan Hao Ruolan Guo Xuyun Hu Zhan Qi Qi Guo Xuanshi Liu Yuanhu Liu Yanhua Sun Xiaofen Zhang Feng Jin Xiujie Wu Ren Cai Dingyuan Zeng Xijiang Hu Xiaohua Wang Xiaoping Ji Wenjie Li Quansheng Xing Lanfang Mu Xiulian Jiang Xue Yang Weimin Yang Yan Zhang Qianli Yin Xin Ni Wei Li | 2022 | Journal of Genetics and Genomics2022，49，1： | 7 |
| 18 | Paleotopographic controls on facies development in various types of braid-delta depositional systems in lacustrine basins in China显示文摘Braid-delta depositional systems are widely developed in most continental basins in China.Research indicates that,for different types of braid delta,the facies sequence and association,which are critical to the prediction of the distribution of reservoirs,differ greatly.This study illustrates the differences in braid-delta depositional systems in terms of sedimentary characteristics,associated systems and reservoir distributions using three typical paleodeltas in western China:the Zhenbei delta of the upper Triassic Yanchang Formation in the Ordos Basin,the Yuanba delta of the upper Triassic Xujiahe Formation in the Sichuan Basin and the Jimsar delta of the upper Permian Wutonggou Formation in the Junggar Basin.A stratigraphic framework was established using seismic data,logs and cores by choosing stable mud sections as regional correlation markers and,topographies of these deltas were reconstructed based on the decompaction and paleobathymetric corrections.Based on both the paleotopography of these deltas and the differences of their sedimentary facies,these braided deltas can be classified into two systems:steep-gradient braid-delta-turbidite system and low-gradient braid-delta-lacustrine system.Moreover,the low-gradient braid-delta-lacustrine system can be further divided into interfingered and sharp contact sub-types according to the contact relation between the delta sands and lacustrine muds.This study shows that the paleotopography of basin margins strongly controls the accommodation as braid deltas prograde into lacustrine basins and,influences the location of the shoreline in response to changes in the lake level.Furthermore,paleotopography plays a significant role in facies and reservoir distribution which is important for petroleum exploration and development. | Dong Feng Hongwen Deng Zhan Zhou Xiaopeng Gao Longtao Cui | 2015 | Geoscience Frontiers2015，6，4： | 7 |
| 19 | Amino-functionalized magnetic bacterial cellulose/activated carbon composite for Pb^2+ and methyl orange sorption from aqueous solution显示文摘A new nanostructured amino-functionalized magnetic bacterial cellulose/activated carbon(BC/AC)composite bioadsorbent(AMBCAC)was prepared for removal of Pb^(2+)and methyl orange(MO)from aqueous solution.The results demonstrated that the equilibrium adsorption capacity(q_e)for Pb^(2+)obviously increases by 2.14 times after introduction of amino groups,the optimum p H for Pb^(2+)and MO adsorption was 5.0 and 3.0,respectively,and the q_eof AMBCAC was 161.78 mg g^(-1)for Pb^(2+)and 83.26 mg g^(-1)for MO under the optimal conditions in this investigation.The kinetics and adsorption isotherm data of the sorption process were well fitted by pseudo-second-order kinetic model and Langmuir isotherm respectively.The thermodynamic results(the Gibbs free energy change G<0,the enthalpy change H>0,the entropy change S>0)implied that the adsorption process of Pb^(2+)and MO was feasible,endothermic and spontaneous in nature.These results support that the AMBCAC composite developed in this work can provide a cheap and efficient way for easy removal of both Pb^(2+)and MO as a promising adsorbent candidate for wastewater treatment. | Xiaogui Huang Xiaozhang Zhan Cuilian Wen Feng Xu Lijin Luo | 2018 | Journal of Materials Science & Technology2018，34，5： | 7 |
| 20 | Study of differential polymerase chain reaction of C-erbB-2 oncogene amplification in gastric cancer显示文摘METHODSCerbB2oncogeneamplificationwasexaminedbyusingdiferentialpolymerasechainreaction(dPCR)insurgicalandendoscopicspecimen... | JI Feng, PENG Qing Bi, ZHAN Jing Biao and LI You Ming | 1999 | World Journal of Gastroenterology1999，5，2： | 7 |
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