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| 1 | Research progress in ZnO single-crystal:growth, scientific understanding, and device applications显示文摘Zinc oxide,a wide band-gap semiconductor,has shown extensive potential applications in high-efficiency semiconductor photoelectronic devices,semiconductor photocatalysis,and diluted magnetic semiconductors.Due to the undisputed lattice integrity,ZnO single crystals are essential for the fabrication of high-quality ZnO-based photoelectronic devices,and also believed to be ideal research subjects for understanding the underlying mechanisms of semiconductor photocatalysis and diluted magnetic semiconductors.This review,which is organized in two main parts,introduces the recent progress in growth,basic characterization,and device development of ZnO single crystals,and some related works in our group.The first part begins from the growth of ZnO single crystal,and summarizes the fundamental and applied investigations based on ZnO single crystals.These works are composed of the fabrication of homoepitaxial ZnO-based photoelectronic devices,the research on the photocatalysis mechanism,and dilute magnetic mechanism.The second part describes the fabrication of highly thermostable n-type ZnO with high mobility and high electron concentration through intentional doping.More importantly,in this part,a conceptual approach for fabricating highly thermostable p-type ZnO materials with high mobility through an integrated three-step treatment is proposed on the basis of the preliminary research. | Feng Huang Zhang Lin Wenwen Lin Jiye Zhang Kai Ding Yonghao Wang Qinghong Zheng Zhibing Zhan Fengbo Yan Dagui Chen Peiwen Lv Xian Wang | 2014 | Chinese Science Bulletin2014，59，12： | 11 |
| 2 | Two soybean bHLH factors regulate response to iron deficiency显示文摘Iron is an indispensable micronutrient for plant growth and development. Limited bioavailability of Fe in the soil leads to iron deficiency chlorosis in plants and yield loss. In this study, two soybean basic helix-loophelix transcription factors, Gmb HLH57 and Gmb HLH300,were identified in response to Fe-deficiency. Both transcription factors are expressed in roots and nodules,and are induced by Fe deficiency; these patterns were confirmed in transgenic hairy roots expressing constructs of the endogenous promoters fused to a GUS reporter gene. Bimolecular fluorescence complementation, yeast two-hybrid and coimmunoprecipitation(co-IP) assays indicated a physical interaction between Gmb HLH57 and Gmb HLH300. Studies on transgenic soybeans Reseoverexpressing Gmb HLH57 and Gmb HLH300 revealed that overexpression of each transcription factor, alone,results in no change of the responses to Fe deficiency,whereas overexpression of both transcription factors upregulated the downstream Fe uptake genes and increased the Fe content in these transgenic plants.Compared to wild type, these double overexpression transgenic plants were more tolerant to Fe deficiency.Taken together, our findings establish that Gmb HLH57 and Gmb HLH300 are important transcription factors involved in Fe homeostasis in soybean. | Lin Li Wenwen Gao Qi Peng Bin Zhou Qihui Kong Yinghui Ying Huixia Shou | 2018 | Journal of Integrative Plant Biology2018，60，7： | 10 |
| 3 | MiR156 regulates anthocyanin biosynthesis through SPL targets and other microRNAs in poplar显示文摘Anthocyanins biosynthesized from the flavonoid pathway are types of pigments that are involved in the protection of poplar from biotic and abiotic stresses.Previous researchers studying anthocyanin-related transcription factors and structural genes in poplar have made significant discoveries.However,little is known about the regulatory role of microRNAs in anthocyanin biosynthesis in poplar.Here,we overexpressed miR156 in poplar to study the comprehensive effects of the miR156-SPL module on the biosynthesis of anthocyanins.Small RNA sequencing analysis revealed 228 microRNAs differentially expressed in transgenic poplar plants with dramatically increased miR156 levels.Furthermore,integrated microRNAomic and transcriptomic analysis suggested that two microRNAs,miR160h,and miR858,have the potential to affect anthocyanin accumulation in poplar by regulating auxin response factors and MYB transcription factors,respectively.Additionally,the accumulation of miR160h and miR858 displayed a positive correlation with miR156 levels,suggesting a possible interaction between the miR156-SPL module and these microRNAs in poplar.Last,metabolomics analysis revealed that the levels of anthocyanins,flavones,and flavonols were substantially elevated in transgenic poplar plants overexpressing miR156 compared with the wild type,whereas the total lignin content was reduced in the transgenic plants.Taken together,our results indicate that miR156 can fine tune the anthocyanin biosynthetic pathway via multiple factors,including microRNAs,transcription factors,and the levels of structural genes,in poplar.This provides additional clues for understanding the complex regulatory network of anthocyanin biosynthesis in woody plants. | Yamei Wang Wenwen Liu Xinwei Wang Ruijuan Yang Zhenying Wu HanWang LeiWang Zhubing Hu Siyi Guo Hailing Zhang Jinxing Lin Chunxiang Fu | 2020 | Horticulture Research2020，7，1： | 9 |
| 4 | BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules显示文摘Error-free mitosis depends on accurate chromosome attachment to spindle microtubules, powered congression of those chromosomes, their segregation in anaphase, and assembly of a spindle midzone at mitotic exit. The centromere-associated kinesin motor CENP-E, whose binding partner is BubR1, has been implicated in congression of misaligned chromosomes and the transition from lateral kinetochore-microtubule association to end-on capture. Although previously proposed to be a pseudokinase, here we report the structure of the kinase domain of Drosophila melanogaster BubR1, revealing its folding into a conformation predicted to be catalytically active. BubR1 is shown to be a bona fide kinase whose phosphorylation of CENP-E switches it from a laterally attached microtubule motor to a plus-end microtubule tip tracker. Computational modeling is used to identify bubristatin as a selective BubR1 kinase antagonist that targets the αN1 helix of N-terminal extension and αC helix of the BubR1 kinase domain. Inhibition of CENP-E phosphorylation is shown to prevent proper microtubule capture at kinetochores and, surprisingly, proper assembly of the central spindle at mitotic exit. Thus, BubR1-mediated CENP-E phosphorylation produces a temporal switch that enables transition from lateral to end-on microtubule capture and organization of microtubules into stable midzone arrays. | Yuejia Huang Lin Lin Xing Liu Sheng Ye Phil Y. Yao Wenwen Wang Fengrui Yang Xinjiao Gao Junying Li Yin Zhang Jiancun Zhang Zhihong Yang Xu Liu Zhenye Yang Jianye Zang Maikun Teng Zhiyong Wang Ke Ruan Xia Ding Lin Li Don W. Cleveland Rongguang Zhang Xuebiao Yao | 2019 | Cell Research2019，29，7： | 8 |
| 5 | DYNAMIC PRICING UNDER TEMPERATURE CONTROL FOR PERISHABLE FOODS显示文摘Consumers pay more and more attention to the quality of perishable foods,which is mainly affected by storage temperature.This paper presents a dynamic pricing model for perishable foods under temperature control.To maximize the total profit,the optimal price and storage temperature are obtained using Pontryagin's maximum principle.A static pricing model is provided to compare with the dynamic one.It is shown by a numerical example that the dynamic policy can make more revenue than the static one.Moreover,the managerial implications are analyzed and the effectiveness of the proposed method is demonstrated. | Wenwen Liu Wansheng Tang Lin Feng Jianxiong Zhang | 2014 | Journal of Systems Science and Systems Engineering2014，23，3： | 3 |
| 6 | Proteomics provides individualized options of precision medicine for patients with gastric cancer显示文摘While precision medicine driven by genome sequencing has revolutionized cancer care,such as lung cancer,its impact on gastric cancer(GC)has been minimal.GC patients are routinely treated with chemotherapy,but only a fraction of them receive the clinical benefit.There is an urgent need to develop biomarkers or algorithms to select chemo-sensitive patients or apply targeted therapy.Here,we carried out retrospective analyses of 1,020 formalin-fixed,paraffin-embedded GC surgical resection samples from 5 hospitals and developed a mass spectrometry-based workflow for proteomic subtyping of GC.We identified two proteomic subtypes:the chemo-sensitive group(CSG)and the chemo-insensitive group(CIG)in the discovery set.The 5-year overall survival of CSG was significantly improved in patients who had received adjuvant chemotherapy after surgery compared with those who received surgery only(64.2%vs.49.6%;Cox P-value=0.002),whereas no such improvement was observed in CIG(50.0%vs.58.6%;Cox P-value=0.495).We validated these results in an independent validation set.Further,differential proteome analysis uncovered 9 FDA-approved drugs that may be applicable for targeted therapy of GC.A prospective study is warranted to test these findings for future GC patient care. | Wenwen Huang Dongdong Zhan Yazhuo Li Nairen Zheng Xin Wei Bin Bai Kecheng Zhang Mingwei Liu Xuefei Zhao Xiaotian Ni Xia Xia Jinwen Shi Cheng Zhang Zhihao Lu Jiafu Ji Juan Wang Shiqi Wang Gang Ji Jipeng Li Yongzhan Nie Wenquan Liang Xiaosong Wu Jianxin Cui Yongsheng Meng Feilin Cao Tieliu Shi Weimin Zhu Yi Wang Lin Chen Qingchuan Zhao Hongwei Wang Lin Shen Jun Qin | 2021 | Science China(Life Sciences)2021，64，8： | 3 |
| 7 | Choroidal thickness and choriocapillaris vascular density in myopic anisometropia显示文摘Background:This study aims to examine interocular differences in the choroidal thickness and vascular density of the choriocapillaris in anisometropic myopes and to further explore the relationship between choroidal blood flow and myopia.Methods:The sample comprised 44 participants with anisometropic myopia,aged 9 to 18 years,with normal bestcorrected visual acuity.All participants underwent a series of examinations,including spherical equivalent refraction(SER)and axial length(AL),measured by a Lenstar optical biometer and optical coherence tomography angiography(OCTA)scanner.OCT measured the choroidal thickness,vascular density,and flow voids of the choriocapillaris,and a customized algorithm was implemented in MATLAB R2017a with the post-correction of AL.The choroidal thickness was measured at the fovea and 0.5,1.0,1.5,2.0,2.5,and 3.0 mm nasally,temporally,inferiorly,and superiorly to the fovea.The vascular density and the flow voids of the choriocapillaris were measured at a 0.6-mm-diameter central circle,and the 0.6-2.5 mm diameter circle in the nasal,temporal,inferior,and superior regions.Repeated-measured ANOVAs were used to analyze the interocular differences.Partial correlations with the K value and age adjustments were used to study the relationships between the choroidal thickness,the choriocapillaris vascular density and flow voids,the SER and AL.Results:The choroidal thickness of the more myopic eyes was significantly thinner than less myopic eyes(P≤0.001),and the flow voids in the more myopic eyes were more than less myopic eyes(P=0.002).There was no significant difference in the vascular density of the choriocapillaris between the more and less myopic eyes(P=0.525).However,when anisometropia was more than 1.50 D,the vascular density of choriocapillaris in the more myopic eyes was significantly less than the less myopic eyes(P=0.026).The interocular difference of the choroidal thickness was significantly correlated with the interocular difference in SER and AL in the center,superior,and inferior regions but not in the nasal or temporal regions.The interocular differences of the vascular density and the flow voids of the choriocapillaris were not correlated with the interocular difference of SER and AL.Conclusions:The choroidal thickness is thinner in the more myopic eyes.The flow void is increased,and the vascular density of the choriocapillaris is reduced in the more myopic eyes of children with anisometropia exceeding 1.50 D. | Xinting Liu Zhiyi Lin Feifu Wang Xiaoyi Peng Wenwen He Dan Chen Meixiao Shen Fan Lu Jun Jiang | 2021 | Eye and Vision2021，8，1： | 3 |
| 8 | Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy——lysosomal pathway显示文摘Nonalcoholic fatty liver disease(NAFLD) is characterized by hepatic steatosis and insulin resistance and there are currently no approved drugs for its treatment.Hyperactivation of mTOR complex1(mTORCl) and subsequent impairment of the transcription factor EB(TFEB)-mediated autophagy-lysosomal pathway(ALP) are implicated in the development of NAFLD.Accordingly,agents that augment hepatic TFEB transcriptional activity may have therapeutic potential against NAFLD.The objective of this study was to investigate the effects of nuciferine,a major active component from lotus leaf,on NAFLD and its underlying mechanism of action.Here we show that nuciferine activated ALP and alleviated steatosis,insulin resistance in the livers of NAFLD mice and palmitic acid-challenged hepatocytes in a TFEB-dependent manner.Mechanistic investigation revealed that nuciferine interacts with the Ragulator subunit hepatitis B X-interacting protein and impairs the interaction of the Ragulator complex with Rag GTPases,thereby suppressing lysosomal localization and activity of mTORC1,which activates TFEB-mediated ALP and further ameliorates hepatic steatosis and insulin resistance.Our present results indicate that nuciferine may be a potential agent for treating NAFLD and that regulation of the mTORCl-TFEB-ALP axis could represent a novel pharmacological strategy to combat NAFLD. | Xiliang Du Chiara Di Malta Zhiyuan Fang Taiyu Shen Xiaodi Niu Meng Chen Bo Jin Hao Yu Lin Lei Wenwen Gao Yuxiang Song Zhe Wang Chuang Xu Zhijun Cao Guowen Liu Xinwei Li | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 2 |
| 9 | Enhanced coalescence separation of oil-in-water emulsions using electrospun PVDF nanofibers显示文摘A novel and high-efficiency coalescence membrane enhanced by nano-sized polyvinylidene fluoride(PVDF)nanofibers based on polyester(PET)substrate was fabricated using electrospinning method.The properties of the electrospun nanofibers such as roughness and surface morphology greatly affected the oil droplet interception efficiency and surface wettability of the membrane.A series of coalescence units were prepared with different layers of nanofibrous membrane and the separation efficiencies at different initial concentrations,flow rates,and oil types were tested.It is very interesting that the obtained nanofibrous membrane exhibited superoleophilicity in air but poor oleophilicity under water,which was beneficial to the coalescence process.The coalescence unit with four membrane layers had excellent performances under different initial concentrations and flow rates.The separation efficiency of the 4-layers unit remained above 98.2%when the initial concentration reached up to 2000 mg·L-1.Furthermore,the unit also exhibited good performance with the increasing oil density and viscosity,which is promising for large-scale oil wastewater treatment. | Yujie Yang Lei Li Qian Zhang Wenwen Chen Song Lin Zaiqian Wang Wangliang Li | 2021 | Chinese Journal of Chemical Engineering2021，34，10： | 2 |
| 10 | HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5-WDR5-dependent transcriptional program显示文摘Background:Lymphatic metastasis has been associated with poor prognosis in bladder cancer patients with limited therapeutic options.Emerging evidence shows that heat shock factor 1(HSF1)drives diversified transcriptome to promote tumor growth and serves as a promising therapeutic target.However,the roles of HSF1 in lymphatic metastasis remain largely unknown.Herein,we aimed to illustrate the clinical roles and mechanisms of HSF1 in the lymphatic metastasis of bladder cancer and explore its therapeutic potential.Methods:We screened the most relevant gene to lymphatic metastasis among overexpressed heat shock factors(HSFs)and heat shock proteins(HSPs),and analyzed its clinical relevance in three cohorts.Functional in vitro and in vivo assays were performed in HSF1-silenced and-regained models.We also used Coimmunoprecipitation to identify the binding proteins of HSF1 and chromatin immunoprecipitation and dual-luciferase reporter assays to investigate the transcriptional program directed by HSF1.The pharmacological inhibitor of HSF1,KRIBB11,was evaluated in popliteal lymph node metastasis models and patientderived xenograft models of bladder cancer.Results:HSF1 expression was positively associated with lymphatic metastasis status,tumor stage,advanced grade,and poor prognosis of bladder cancer.Importantly,HSF1 enhanced the epithelial-mesenchymal transition(EMT)of cancer cells in primary tumor to initiate metastasis,proliferation of cancer cells in lymph nodes,and macrophages infiltration to facilitate multistep lymphatic metastasis.Mechanistically,HSF1 interacted with protein arginine methyltransferase 5(PRMT5)and jointly induced the monomethylation of histone H3 at arginine 2(H3R2me1)and symmetric dimethylation of histone H3 at arginine 2(H3R2me2s).This recruited the WD repeat domain 5(WDR5)/mixed-lineage leukemia(MLL)complex to increase the trimethylation of histone H3 at lysine 4(H3K4me3);resulting in upregulation of lymphoid enhancer-binding factor 1(LEF1),matrix metallopeptidase 9(MMP9),C-C motif chemokine ligand 20(CCL20),and E2F transcription factor 2(E2F2).Application of KRIBB11 significantly inhibited the lymphatic metastasis of bladder cancer with no significant toxicity.Conclusion:Our findings reveal a novel transcriptional program directed by the HSF1-PRMT5-WDR5 axis during the multistep process of lymphatic metastasis in bladder cancer.Targeting HSF1 could be a multipotent and promising therapeutic strategy for bladder cancer patients with lymphatic metastasis. | Ming Huang Wen Dong Ruihui Xie Jilin Wu Qiao Su Wuguo Li Kai Yao Yuelong Chen Qianghua Zhou Qiang Zhang Wenwen Li Liang Cheng Shengmeng Peng Siting Chen Jian Huang Xu Chen Tianxin Lin | 2022 | Cancer Communications2022，42，5： | 2 |
| 11 | FXYD3 enhances IL-17A signaling to promote psoriasis by competitively binding TRAF3 in keratinocytes显示文摘Psoriasis is a common chronic inflammatory skin disease characterized by inflammatory cell infiltration and epidermal hyperplasia.However,the regulatory complexity of cytokine and cellular networks still needs to be investigated.Here,we show that the expression of FXYD3,a member of the FXYD domain-containing regulators of Na+/K+ATPases family,is significantly increased in the lesional skin of psoriasis patients and mice with imiquimod(IMQ)-induced psoriasis.IL-17A,a cytokine important for the development of psoriatic lesions,contributes to FXYD3 expression in human primary keratinocytes.FXYD3 deletion in keratinocytes attenuated the psoriasis-like phenotype and inflammation in an IMQ-induced psoriasis model.Importantly,FXYD3 promotes the formation of the IL-17R-ACT1 complex by competing with IL-17R for binding to TRAF3 and then enhances IL-17A signaling in keratinocytes.This promotes the activation of the NF-κB and MAPK signaling pathways and leads to the expression of proinflammatory factors.Our results clarify the mechanism by which FXYD3 serves as a mediator of IL-17A signaling in keratinocytes to form a positive regulatory loop to promote psoriasis exacerbation.Targeting FXYD3 may serve as a potential therapeutic approach in the treatment of psoriasis. | Wenjuan Yang Rukun He Hao Qu Wenwen Lian Yue Xue Tao Wang Wenlong Lin Peishuo Zhu Meng Xia Lihua Lai Qingqing Wang | 2023 | Cellular & Molecular Immunology2023，20，3： | 2 |
| 12 | Postharvest behavior and endogenous ethylene pattern of Paeonia suffruticosa cut flowers 显示文摘 | Jia Peiyi Zhou Lin Guo Wenwen | 2008 | Acta Horticulture2008，768，： | 1 |
| 13 | Modeling of COVID-19 disease disparity in gastric organoids reveals the spatiotemporal dynamics of SARS-CoV-2 infectivity显示文摘Dear Editor,The promptness and continuous expansion of the coronavirus disease 2019(COVID-19)pandemic,elicited by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants,has presented an unprecedented impact on human health(WHO Coronavirus(COVID-19)Dashboard,2021).Although vaccination has attenuated the severe symptoms,there is no specific antiviral medication available for preventing the viral spread(Drayman et al.,2021). | Wenwen Wang Fengrui Yang Jie Lin Saravanakumar Muthusamy Shihao Du McKay Mullen Fatima Garba Wanjuan Wang Xu Liu Tao Li Zhihong Yang Xia Ding Felix Aikhionbare Xinjiao Gao Zhikai Wang Xing Liu Xuebiao Yao | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 14 | Study on the Frame-work of e - Government services capability : An empirical investiga-tion显示文摘 | Hu Guangwei Pan Wenwen Lin Hui | 2014 | Social Science Computer Review2014，32，1： | 1 |
| 15 | The E3 ubiquitin ligase NEDD4-1 protects against acetaminophen-induced liver injury by targeting VDAC1 for degradation显示文摘Acetaminophen(APAP)overdose is a major cause of liver injury.Neural precursor cell expressed developmentally downregulated 4—1(NEDD4-1)is an E3 ubiquitin ligase that has been implicated in the pathogenesis of numerous liver diseases;however,its role in APAP-induced liver injury(AILI)is unclear.Thus,this study aimed to investigate the role of NEDD4-1 in the pathogenesis of AILI.We found that NEDD4-1 was dramatically downregulated in response to APAP treatment in mouse livers and isolated mouse hepatocytes.Hepatocyte-specific NEDD4-1 knockout exacerbated APAP-induced mitochondrial damage and the resultant hepatocyte necrosis and liver injury,while hepatocyte-specific NEDD4-1 overexpression mitigated these pathological events both in vivo and in vitro.Additionally,hepatocyte NEDD4-1 deficiency led to marked accumulation of voltage-dependent anion channel 1(VDAC1)and increased VDAC1 oligomerization.Furthermore,VDAC1 knockdown alleviated AILI and weakened the exacerbation of AILI caused by hepatocyte NEDD4-1 deficiency.Mechanistically,NEDD4-1 was found to interact with the PPTY motif of VDAC1 through its WW domain and regulate K48-linked ubiquitination and degradation of VDAC1.Our present study indicates that NEDD4-1 is a suppressor of AILI and functions by regulating the degradation of VDAC1. | Yiwei Zhu Lin Lei Xinghui Wang Linfang Chen Wei Li Jinxia Li Chenchen Zhao Xiliang Du Yuxiang Song Wenwen Gao Guowen Liu Xinwei Li | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 1 |
| 16 | Modelling the effects of soil water potential on growth and quality of cut chrysanthemum ( Chrysanthemum morifolium )显示文摘 | Lu Lin Wenwen Li Jingqing Shao Weihong Luo Jianfeng Dai Xinyou Yin Yanbao Zhou Chunjiang Zhao | 2011 | Scientia Horticulturae2011，，1： | 1 |
| 17 | An overview of the sheet metal CNC incremental forming toolpath generation 显示文摘 | Zhu Hu Lin Wenwen Bai Jin|an | 2012 | Advanced Mate- rials Research2012，，： | 1 |
| 18 | Genome Assembly of Alfalfa Cultivar Zhongmu-4 and Identification of SNPs Associated with Agronomic Traits显示文摘Alfalfa(Medicago sativa L.)is the most important legume forage crop worldwide with high nutritional value and yield.For a long time,the breeding of alfalfa was hampered by lacking reliable information on the autotetraploid genome and molecular markers linked to important agronomic traits.We herein reported the de novo assembly of the allele-aware chromosome-level genome of Zhongmu-4,a cultivar widely cultivated in China,and a comprehensive database of genomic variations based on resequencing of 220 germplasms.Approximate 2.74 Gb contigs(N50 of 2.06 Mb),accounting for 88.39%of the estimated genome,were assembled,and 2.56 Gb contigs were anchored to 32 pseudo-chromosomes.A total of 34,922 allelic genes were identified from the allele-aware genome.We observed the expansion of gene families,especially those related to the nitrogen metabolism,and the increase of repetitive elements including transposable elements,which probably resulted in the increase of Zhongmu-4 genome compared with Medicago truncatula.Population structure analysis revealed that the accessions from Asia and South America had relatively lower genetic diversity than those from Europe,suggesting that geography may influence alfalfa genetic divergence during local adaption.Genome-wide association studies identified 101 single nucleotide polymorphisms(SNPs)associated with 27 agronomic traits.Two candidate genes were predicted to be correlated with fall dormancy and salt response.We believe that the alleleaware chromosome-level genome sequence of Zhongmu-4 combined with the resequencing data of the diverse alfalfa germplasms will facilitate genetic research and genomics-assisted breeding in variety improvement of alfalfa. | Ruicai Long Fan Zhang Zhiwu Zhang Mingna Li Lin Chen Xue Wang Wenwen Liu Tiejun Zhang Long-Xi Yu Fei He Xueqian Jiang Xijiang Yang Changfu Yang Zhen Wang Junmei Kang Qingchuan Yang | 2022 | Genomics, Proteomics & Bioinformatics2022，20，1： | 1 |
| 19 | The transport mechanisms of polymer nanoparticles in Caco-2 epithelial cells显示文摘 | Bing He Ping Lin Zengrong Jia Wenwen Du Wei Qu Lan Yuan Wenbing Dai Hua Zhang Xueqing Wang Jiancheng Wang Xuan Zhang Qiang Zhang | 2013 | Biomaterials2013，，25： | 1 |
| 20 | Beliefs towards the COVID-19 pandemic among patients with emotional disorders in China显示文摘Background The novel coronavirus disease 2019(COVID-19)pandemic has given rise to fear and panic in the public.Although hospitals in China reduced outpatient visits and restricted inpatient admission to lower the risk of transmission of COVID-19,this has significantly affected patients in need of medical attention,for example,patients with emotional disorders.Aims This study aimed to compare the beliefs towards COVID-19 among outpatients with emotional disorders(ie,anxiety or depression)with those offamily caregivers and the general public and examine factors that shape the beliefs towards COVID-19 among outpatients with emotional disorders.Methods Survey data from 570 outpatients with anxiety or depression disorders,449 family caregivers and 470 general public subjects were collected.Multiple stepwise regression analyses were used to describe participants'level of concern,prevention atitude and positive expectations towards the COVID-19 outbreak.Results About 70.9%of outpatients had to postpone their mental health treatment;43.2%of patients admitted that their mental health was adversely affected by the COVID-19 outbreak--these patients tended to be older,male and less educated.After controlling for age and education level,outpatients with emotional disorders had significantly lower levels of concerns but more negative expectations towards COVID-19,compared with family caregivers and the public.Multivariate linear stepwise regression analysis showed that age,education and the perception of the impact of COVID-19 on one's existing mental ilness were significantly associated with outpatients'beliefs about the epidemic.Conclusion Outpatients with anxiety or depression disorders were relatively less focused on the COVID-19 outbreak,but the impact of the infection was found to be independently associated with their beliefs towards COVID-19.In addition,outpatients who were older and of low educational levels particularly held more negative beliefs about the epidemic,which may place them at a higher risk for poor mental health. | Yining Gao Fei Sun Wenwen Jiang Yuan Fang Ling Yue Xiang Lin Xia Li | 2020 | General Psychiatry2020，33，3： | 1 |
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