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| 1 | Characterization of Arabidopsis MYB transcription factor gene AtMYB17 and its possible regulation by LEAFY and AGL15显示文摘MYB transcription factors compose one of the largest transcription factor families in Arabidopsis, which play important roles in various developmental processes as well as defense responses against environmental stresses.In this study, we report the characterization of AtMYB17 gene, a putative R2R3 type MYB gene family member in Arabidopsis.AtMYB17 was found exclusively localized in nuclear, with an activation domain at its C-terminus.AtMYB17 was highly expressed in inflorescences and siliques, especially at early flower developmental stages.The level of AtMYB17 transcripts was also found to increase after imbibition during seed germination and gradually concentrate to the shoot apex.Bioinformatics analysis identified several binding sites of LEAFY(LFY) and AGL15 in the promoter re-gion of AtMYB17.Promoter-GUS fusion analysis showed that the LFY binding sites were important in fine-tuning regulation of the spatio-temporal expression of AtMYB17 in transgenic plants.Moreover, AtMYB17 was up-regulated in 35S::AGL15 plants.Taken together, our data suggest that LFY may be involved in the regulation of AtMYB17, possibly together with AGL15, and thereafter in early inflorescence development and seed germination. | Yunfei Zhang Guangyu Cao Li-Jia Qu Hongya Gu | 2009 | Journal of Genetics and Genomics2009，36，2： | 24 |
| 2 | Catalyst-Free Growth of Nanographene Films on Various Substrates显示文摘我们开发了一个新方法在各种各样的底层上直接种一致 graphene 电影,例如绝缘体,半导体,甚至金属,没有使用任何催化剂。生长用遥远的血浆改进化学药品蒸汽免职(r-PECVD ) 被执行在相对低的温度的系统,启用 graphene 电影的免职直到 4 英寸的晶片规模。扫描通道显微镜学(STM ) 证实电影由在侧面的尺寸的十纳米的 nanocrystalline graphene 粒子组成。为 nanographene 的生长机制为 PECVD 方法种的钻石类似于那,尽管有在 graphene 的情况中被形成的 sp2 碳原子而非象在钻石的 sp3 碳原子。这条生长途径简单、便宜、可伸缩,并且可能在象薄电影电阻器,煤气的传感器,电极材料,和透明传导性的电影那样的域里有潜在的应用程序。 | Lianchang Zhang Zhiwen Shi Yi Wang Rong Yang Dongxia Shi Guangyu Zhang | 2011 | Nano Research2011，4，3： | 12 |
| 3 | NEW NONSTANDARD JOB SHOP SCHEDULING ALGORITHM显示文摘Considering the complex constraint between operations in nonstandard job shop scheduling problem (NJSSP), critical path of job manufacturing tree is determined according to priority scheduling function constructed. Operations are divided into dependent operations and independent operations with the idea of subsection, and corresponding scheduling strategy is put forward according to operation characteristic in the segment and the complementarities of identical function machines. Forward greedy rule is adopted mainly for dependent operations to make operations arranged in the right position of machine selected, then each operation can be processed as early as possible, and the total processing time of job can be shortened as much as possible. For independent operations optimum scheduling rule is adopted mainly, the inserting position of operations will be determined according to the gap that the processing time of operations is subtracted from idle time of machine, and the operation will be inserted in the position with minimal gap. Experiments show, under the same conditions, the result that operations are scheduled according to the object function constructed, and the scheduling strategy adopted is better than the result that operations are scheduled according to efficiency scheduling algorithm. | XIE Zhiqiang YE Guangjie ZHANG Dali TAN Guangyu | 2008 | Chinese Journal of Mechanical Engineering2008，21，4： | 10 |
| 4 | Two-photon-excited near-infrared emissive carbon dotsas multifunctional agents for fluorescence imaging andphotothermal therapy显示文摘C dots (CDs) have shown great potential in bioimaging and phototherapy.However, it is challenging to manipulate their fluorescent properties andtherapeutic efficacy to satisfy the requirements for clinic applications. In thisstudy, we prepared S, Se-codoped CDs via a hydrothermal method anddemonstrated that the doping resulted in excitation wavelength-independentnear-infrared (NIR) emissions of the CDs, with peaks at 731 and 820 nm.Significantly, the CDs exhibited a photothermal conversion efficiency of -58.2%,which is the highest reported value for C nanostructures and is comparable tothat of Au nanostructures. Moreover, the CDs had a large two-photon absorptioncross section (-30,045 GM), which allowed NIR emissions and the photothermalconversion of the CDs through the two-photon excitation (TPE) mechanism. Invitro and in vivo tests suggested that CDs can function as new multi functionalphototheranostic agents for the TPE fluorescence imaging and photothermaltheraov of cancer cells. | Minhuan Lan Shaojing Zhao Zhenyu Zhang Li Yan Liang Guo Guangle Niu Jinfeng Zhang Junfang Zhao Hongyan Zhang Pengfei Wang Guangyu Zhu Chun-Sing Lee Wenjun Zhang | 2017 | Nano Research2017，10，9： | 9 |
| 5 | Positioning error compensation of an industrial robot using neural networks and experimental study显示文摘Due to the characteristics of high efficiency,wide working range,and high flexibility,industrial robots are being increasingly used in the industries of automotive,machining,electrical and electronic,rubber and plastics,aerospace,food,etc.Whereas the low positioning accuracy,resulted from the serial configuration of industrial robots,has limited their further developments and applications in the field of high requirements for machining accuracy,e.g.,aircraft assembly.In this paper,a neural-network-based approach is proposed to improve the robots’positioning accuracy.Firstly,the neural network,optimized by a genetic particle swarm algorithm,is constructed to model and predict the positioning errors of an industrial robot.Next,the predicted errors are utilized to realize the compensation of the target points at the robot’s workspace.Finally,a series of experiments of the KUKA KR 500–3 industrial robot with no-load and drilling scenarios are implemented to validate the proposed method.The experimental results show that the positioning errors of the robot are reduced from 1.529 mm to 0.344 mm and from 1.879 mm to 0.227 mm for the no-load and drilling conditions,respectively,which means that the position accuracy of the robot is increased by 77.6%and 87.9%for the two experimental conditions,respectively. | Bo LI Wei TIAN Chufan ZHANG Fangfang HUA Guangyu CUI Yufei LI | 2022 | Chinese Journal of Aeronautics2022，35，2： | 9 |
| 6 | Advanced EMS and its trial operation in Shanghai power system显示文摘To meet the demand of high stability,high quality,and low losses of power systems,the advanced energy management system (AEMS) is established and revealed in this bulletin,which has been put into trial operation in Shanghai power system for almost half a year. The AEMS is novel from all aspects covering idea,theory,method,software,and engineering. The essence of AEMS is exercising the hybrid automatic control theory and technology to realize multi-objective optimal closed-loop control of power systems. Based on an 'event-driven' strategy,the AEMS transforms multi-objective optimal control problems into event identification and elimination by defining the unsatisfactory states of a power system as events. This bulletin concisely presents the theory and main advantages of AEMS,as well as its implementation in Shanghai power system. | LU Qiang HE GuangYu MEI ShengWei SUN YingYun RUAN QianTu WANG Wei ZHANG WangJun YU XuFeng | 2008 | Science China(Technological Sciences)2008，51，2： | 9 |
| 7 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 8 | Research on the Effect Evaluation of Protected Space Driving New Technologies Industrialization from the Perspective of ST显示文摘Based on the perspective of sustainability transitions(ST)theory,the paper dissects the opera-tional mechanisms of protected space driving emerging technology industrialization from an external system perspective,which is on the basis of defining essential characteristics and func-tional attributes of protected space.Meanwhile,it structures a three-dimensional evaluation model of protected space from the perspective of internal mechanism by introducing the policy mixes method.Finally,taking the Chinese New Energy Vehicle(NEV)industry as the example and using the system dynamics modeling method,the paper designs different simulation schemes from three dimensions of horizontal evolution trend,three types of policy instrument change and policy mixes of protected space,to predict and analyze the operation effect of protected space.The results show that the Chinese NEV industry is in the stage of market niche entry,and corresponding measures should be taken to increase the market scale,form effective demand and scale effect,and promote the diffusion of market niche;the effect of policy mixes is better than that of the single policy instrument;specific policy mixes should be adopted to develop simultaneously from both the supply and demand sides to improve the industrialization level of NEV. | LIU Yixin OU Chunyao ZHANG Guangyu LIANG Xiao | 2020 | Journal of Systems Science & Complexity2020，33，2： | 8 |
| 9 | YB-1, a new biomarker of glioma progression, is associated with the prognosis of glioma patients显示文摘(YB-1 ) Y 盒子蛋白质 1 是在各种各样的癌症表示的多功能的细胞的蛋白质,并且是在癌症治疗的一个潜在的目标。尽管有证据出现,那 YB-1 在人的癌症起一个作用,在 glioma 的 YB-1 表示的临床的意义没被建立。在现在的学习,我们在 glioma 肿瘤调查了 YB-1 水平并且分析了在 YB-1 水平和恶意的 glioma 的等级之间的关系,与提供为在临床、基本的研究背景的 gliomas 的诊断和治疗的新想法的目的。108 个病人的一个总数,与等级的 gliomas 包括 14, 31, 30,和 33 分别地,我, II, III,和 IV 在这研究被包括。YB-1 的 mRNA 和蛋白质层次被发现在等级 IV 和降低等级的肿瘤之间显著地不同。在脑髓的液体的 YB-1 层次比在等级在等级 III 和 IV glioma 病人是显著地更高的我和 II 病人。染色的 Immunofluorescence 被用来在细胞质和原子核检测 YB-1 的层次,并且结果显示细胞内部的分发显著地与 glioma 的病理学的等级被联系。YB-1 的高水平与弄短的幸存被联系,建议 YB-1 起在人的 glioma 的前进的一个作用。 | Jin Zheng Jiangwei Zhang Guangyue Li Huilin Gong | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 8 |
| 10 | A review on ignition mechanisms and characteristics of magnesium alloys显示文摘Magnesium alloys have become more attractive because of their low density and electromagnetic shielding effectiveness in the aerospace industry.However,some unpredictable situation may lead to the ignition of magnesium alloys.In this review,the thermodynamic conditions and transfer processes of magnesium alloys ignition are analyzed from the point of mechanisms.The criteria of ignition are emphasized.In addition,ignitability and flammability test systems are compared.And a more suitable method to assess the potential ignition and flammability risks of magnesium alloys in extreme environments is recommended.Furthermore,the ignition characteristics of magnesium alloys are discussed in detail.It was found that the ignition of magnesium alloys is a complex process determined by internal properties such as thermo-physical properties,oxide film properties,chemical compositions and geometrical parameters,as well as the external environment such as gas species,oxygen concentration and oxygen pressure.Ignition temperature is not physical constants of materials.It is not simply assumed that ignition may occur when the temperature of Mg alloys reaches a certain ignition point.Finally,the unsolved issues in the ignition of magnesium alloys are pointed out and the future investigation are suggested for improving the safety and reliability of magnesium alloys in the aerospace applications. | Dong Han Jin Zhang Jinfeng Huang Yong Lian Guangyu He | 2020 | Journal of Magnesium and Alloys2020，8，2： | 7 |
| 11 | Stable isotope labelled mass spectrometry for quantification of the relative abundances for expressed proteins induced by PeaT1显示文摘The protein elicitor from the mycelium of Alternaria tenuissima has been isolated.The elicitor triggered resistance to the tobacco mosaic virus in tobacco by inducing relative oxygen species,but without causing hypersensitive necrosis.The elicitor is reported to impart resistance against Verticillium dahliae and to increase yield in cotton,but its mechanism is not yet clear.In this study,the stable isotope labelled mass spectrometry method was used to quantify the relative abundances of protein expression induced by PeaT1 in Arabidopsis.A significant difference in the relative abundances for the expression of different proteins related to metabolism,modification,regulatory,defense,stress and antioxidation was found in Arabidopsis. | LI GuangYue,YANG XiuFen,ZENG HongMei,MAO JianJun,LIU Hua,ZHANG YunHua & QIU DeWen* Key Laboratory for Biological Control of the Ministry of Agriculture,Institute of Plant Protection,Chinese Academy of Agricultural Sciences,Beijing 100081,China | 2010 | Science China(Life Sciences)2010，53，12： | 7 |
| 12 | Losses of Ecosystem Service Values in the Taihu Lake Basin from 1979 to 2010显示文摘 | Hui ZHANG Qiao WANG Guangyu LI Hanpei ZHANG Jue ZHANG | 2017 | Frontiers of Earth Science2017，11，2： | 7 |
| 13 | Significant isostatic imbalance near the seismic gap between the M8.0 Wenchuan and M7.0 Lushan earthquakes显示文摘A gravity network with 302 observation points has been established in the western Sichuan Foreland Basin(SFB) to explore Bouguer gravity anomalies(BGAs). Our observational results reveal that the BGAs are negative as a whole, with a maximum value of-220 m Gal(10-5m s-2)at the northwest region of the study area. The real Moho depths beneath the SFB revealed by BGA data change smoothly from 39.5 km in the southeast to 43.7 km in the northwest of the monitoring region. However, the isostatic ones deduced from Airy isostatic model and topographical data vary approximately 39.5–42.0 km. The maximum differences of 2.7 km between the real and isostatic Moho depths are found near the seismic gap between the M8.0Wenchuan and M7.0 Lushan earthquakes, where the crust is in the greatest isostatic imbalance of the monitoring region. Analysis of the isostatic state indicates that the deep dynamic environment near the seismic gap between these two earthquakes indicates an M C 7.0 earthquake in the future. This study indicates that we can use isostasy as a potential approach to study the dynamic process of crustalmaterial movement and to analyze regional potential seismic risks. | Guangyu Fu Guoqing Zhang | 2014 | Chinese Science Bulletin2014，59，34： | 7 |
| 14 | Application of Improved Multi-Objective Ant Colony Optimization Algorithm in Ship Weather Routing显示文摘This paper presents a novel intelligent and effective method based on an improved ant colony optimization(ACO)algorithm to solve the multi-objective ship weather routing optimization problem,considering the navigation safety,fuel consumption,and sailing time.Here the improvement of the ACO algorithm is mainly reflected in two aspects.First,to make the classical ACO algorithm more suitable for long-distance ship weather routing and plan a smoother route,the basic parameters of the algorithm are improved,and new control factors are introduced.Second,to improve the situation of too few Pareto non-dominated solutions generated by the algorithm for solving multi-objective problems,the related operations of crossover,recombination,and mutation in the genetic algorithm are introduced in the improved ACO algorithm.The final simulation results prove the effectiveness of the improved algorithm in solving multi-objective weather routing optimization problems.In addition,the black-box model method was used to study the ship fuel consumption during a voyage;the model was constructed based on an artificial neural network.The parameters of the neural network model were refined repeatedly through the historical navigation data of the test ship,and then the trained black-box model was used to predict the future fuel consumption of the test ship.Compared with other fuel consumption calculation methods,the black-box model method showed higher accuracy and applicability. | ZHANG Guangyu WANG Hongbo ZHAO Wei GUAN Zhiying LI Pengfei | 2021 | Journal of Ocean University of China2021，20，1： | 7 |
| 15 | Graphene: Nanostructure engineering and applications显示文摘 | Tingting Zhang Shuang Wu Rong Yang Guangyu Zhang | 2017 | Frontiers of physics2017，12，1： | 6 |
| 16 | THE IMPACT OF RELATIVE HUMIDITY ON THE RADIATIVE PROPERTY AND RADIATIVE FORCING OF SULFATE AEROSOL显示文摘With the data of complex refractive index of sulfate aerosol, the radiative properties of the aerosol under 8 relative humidity conditions are calculated in this paper. By using the concentration distribution from two CTM models and LASG GOALS/AGCM, the radiative forcing due to hygroscopic sulfate aerosol is simulated. The results show that: (1) With the increase of relative humidity, the mass extinction coefficiency factor decreases in the shortwave spectrum: single scattering albedo keeps unchanged except for a little increase in longwave spectrum, and asymmetry factor increases in whole spectrum. (2) Larger differences occur in radiative forcing simulated by using two CTM data, and the global mean forcing is -0. 268 and -0. 816 W/m2,respectively. (3) When the impact of relative humidity on radiative property is taken into account,the distribution pattern of radiative forcing due to the wet particles is very similar to that of dry sulfate, but the forcing value decreases by 6%. | ZHANG Lisheng(张立盛) SHI Guangyu(石广玉) | 2001 | Acta meteorologica Sinica2001，15，4： | 6 |
| 17 | Exosomal LINC00355 derived from cancer-associated fibroblasts promotes bladder cancer cell resistance to cisplatin by regulating miR-34b-5p/ABCB1 axis显示文摘Cisplatin resistance is a major challenge for bladder cancer(BC).Evidence indicates that exosome derived from cancer-associated fibroblasts(CAF-Exo)can promote chemotherapy resistance in various human tumors by delivering bioactive molecules.We have previously demonstrated that CAF-derived exosomal LINC00355 promotes BC cell proliferation and invasion.However,the underlying mechanisms are still unclear.In this study,we aimed to investigate the role and mechanisms of CAF-derived exosomal LINC00355 in BC cell resistance to cisplatin.Exosomes were isolated from normal fibroblasts(NFs)and BC tumor-derived CAFs,namely,NF-Exo and CAF-Exo.CAFs were transfected with si-Ctrl or si-LINC00355 and then different exosomes were isolated,namely,CAF^(si-Ctrl)-Exo and CAF^(si-LINC00355)-Exo.The human BC cell lines(T24 and 5367)were incubated with NF-Exo,CAF-Exo,CAF^(si-Ctrl)-Exo,and CAF^(si-LINC00355)-Exo in the presence of cisplatin.MTT proliferation assay and flow cytometric analysis showed that CAF-Exo promoted BC cell resistance to cisplatin and upregulated ABCB1 expression in BC cells by transferring LINC00355 to BC cells.Luciferase activity assay confirmed the interaction between miR-34b-5p and LINC00355 or ABCB1.qRT-PCR and western blot analysis further showed that LINC00355 sponged miR-34b-5p to upregulate ABCB1 expression.However,the promoting effects of CAF-Exo on BC cell resistance to cisplatin were abolished by miR-34b-5p overexpression and ABCB1 silencing.In conclusion,exosomal LINC00355 derived from CAFs promotes BC cell resistance to cisplatin by regulating the miR-34b-5p/ABCB1 axis. | Guangyue Luo Yangyang Zhang Zhonghui Wu Ligang Zhang Chaozhao Liang Xianguo Chen | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 6 |
| 18 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 19 | Enhanced antibacterial behavior of a novel Cu-bearing high-entropy alloy显示文摘Contact infection of bacteria and viruses has been a critical threat to human health. The worldwideoutbreak of COVID-19 put forward urgent requirements for the research and development of the selfantibacterial materials, especially the antibacterial alloys. Based on the concept of high-entropy alloys, thepresent work designed and prepared a novel Co_(0.4)FeCr_(0.9)Cu_(0.3) antibacterial high-entropy alloy with superior antibacterial properties without intricate or rigorous annealing processes, which outperform the antibacterial stainless steels. The antibacterial tests presented a 99.97% antibacterial rate against Escherichiacoli and a 99.96% antibacterial rate against Staphylococcus aureus after 24 h. In contrast, the classic antibacterial copper-bearing stainless steel only performed the 71.50% and 80.84% antibacterial rate, respectively. The results of the reactive oxygen species analysis indicated that the copper ion release and theimmediate contact with copper-rich phase had a synergistic effect in enhancing antibacterial properties.Moreover, this alloy exhibited excellent corrosion resistance when compared with the classic antibacterialstainless steels, and the compression test indicated the yield strength of the alloy was 1015 MPa. Thesefindings generate fresh insights into guiding the designs of structure-function-integrated antibacterial alloys. | Guangyu Ren Lili Huang Kunling Hu Tianxin Li Yiping Lu Dongxu Qiao Haitao Zhang Dake Xu Tongmin Wang Tingju Li Peter K.Liaw | 2022 | Journal of Materials Science & Technology2022，，22： | 6 |
| 20 | Multiple locus genealogies and phenotypic characters reappraise the causal agents of apple ring rot in China显示文摘Apple ring rot inflicts severe economic losses in the main apple producing areas of East Asia.The causal agent of the disease has been variously identified as Macrophoma kuwatsukai,Physalospora piricola and Botryosphaeria berengeriana f.sp.piricola,although B.dothidea is currently the most widely accepted pathogen name.The taxonomic uncertainty has delayed research that is needed to manage effectively this destructive disease.In the present study,genealogical concordance phylogenetic species recognition(GCPSR)was applied to pathogenic fungal isolates from apple and pear from several locations in China,along with several reference isolates.Phylogenetic results based on sequences of four nuclear loci(ITS,EF-1α,HIS and HSP)revealed the existence of two species within the examined isolates.One includes an ex-epitype isolate of B.dothidea and the other includes an isolate that was previously designated as B.berengeriana f.sp.piricola.Morphologically,the latter taxon presented an appressed mycelial mat on PDA whereas B.dothidea displayed columns of aerial mycelia reaching the lids,and conidia of the latter species were longer than B.dothidea.Botryosphaeria dothidea had a faster growth rate than the latter taxon under relatively high temperatures.Pathogenicity tests showed that on pear stems the latter taxon caused large-scale cankers along with blisters whereas B.dothidea was non-pathogenic,but on apple shoots the two fungi induced large and small wart-like prominences,respectively.Overall,this cryptic species demonstrated sufficient genetic variations and biological differences from B.dothidea.As a result of taxonomic study,we described here the latter taxon in a new combination,Botryosphaeria kuwatsukai and designate an epitype.Both B.kuwatsukai and B.dothidea are considered to be the main causal agents for apple ring rot in China and Japan. | Chao Xu Chunsheng Wang Liangliang Ju Rong Zhang Alan R.Biggs Eiji Tanaka Bingzhi Li Guangyu Sun | 2015 | Fungal Diversity2015，，2： | 6 |
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