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| 1 | Functionalization of small black phosphorus nanoparticles for targeted imaging and photothermal therapy of cancer显示文摘Black phosphorus(BP) nanomaterials have attracted extensive attention due to their unique physical,chemical, and biological properties. In this study, small BP nanoparticles were synthesized and modified with dextran and poly(ethyleneimine) for functionalization with folic acid and cyanine 7. The functionalized BP nanoparticles exhibit excellent biocompatibility, stability, and near infrared optical properties for targeted imaging of tumors through photoacoustic imaging and near-infrared fluorescence imaging.They also display high photothermal conversion efficiency for photothermal therapy of cancer. This work demonstrates the potential of functionalized small BP nanoparticles as an emerging nanotheranostic agent for the diagnosis and treatment of cancer. | Lijuan Deng Yifan Xu Caixia Sun Baofeng Yun Qiao Sun Chongjun Zhao Zhen Li | 2018 | Science Bulletin2018，63，14： | 12 |
| 2 | Zebrafish model for assessing induced organ toxicity by Strychnos nux-vomica显示文摘OBJECTIVE:To assess the acute organ toxicity of Strychnos nux-vomica with zebrafish model visually.METHODS:To assess acute toxicity,we initially determined the lethal concentration after Strychnos nux-vomica treatment for 24 h.Zebrafish was treated with five concentrations Strychnos nux-≦vo LC10 for 24 h,and the effects ofmica on morphology,function of heart,central nervous system,liver,kidney and organ-specific cell death were assessed.Next,we assessed the reversibility of toxic effect.RESULTS:Strychnos nux-vomica has an effect on the different organs of zebrafish,including heart,central nervous system,liver,and kidney,and cadiotoxicity induced by Strychnos nux-vomica was reversible to some extent.CONCLUSION:Zebrafish model is suitable for confirming the toxic target organs for Chinese traditional medicine. | Zhao Chongjun Tian Jinghuan Wang Jinfeng Feng Yaru Ni Yuanyuan Fan Jiaojiao Wang Chunmei Cao Dan Zou Qinwen Ma Zhiqiang Lin Ruichao | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 9 |
| 3 | Parallel algorithm for real-time contouring from grid DEM on modern GPUs显示文摘A real-time algorithm for constructing contour maps from grid DEM data is pre-sented.It runs completely within the programmable 3D visualization pipeline.The interpolation is paralleled by rasterizer units in the graphics card,and contour line extraction is paralleled by pixel shader.During each frame of the rendering,we first make an elevation gradient map out of original terrain vertex data,then figure out the final contour lines with image-space processing,and directly blend the results on the original scene to obtain a final scene with contour map using alpha-blending.We implement this method in our global 3D-digitalearth system with Direct3D?9.0c API and tested on some consumer level PC platforms.For arbitrary scene with certain LOD level,the process takes less than 10 ms,giving topologically correct,anti-aliased contour lines. | CHEN Zhuo,SHEN Lei,ZHAO YanQing & YANG ChongJun State Key Laboratory of Remote Sensing Science,Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University,Beijing 100101,China | 2010 | Science China(Technological Sciences)2010，53，S1： | 3 |
| 4 | The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway显示文摘Polyphyllin I(PPI)and polyphyllin II(PII)are the main active substances in the Paris polyphylla.However,liver toxicity of these compounds has impeded their clinical application and the potential hepatotoxicity mechanisms remain to be elucidated.In this work,we found that PPI and PII exposure could induce significant hepatotoxicity in human liver cell line L-02 and zebrafish in a dose-dependent manner.The results of the proteomic analysis in L-02 cells and transcriptome in zebrafish indicated that the hepatotoxicity of PPI and PII was associated with the cholesterol biosynthetic pathway disorders,which were alleviated by the cholesterol biosynthesis inhibitor lovastatin.Additionally,3-hydroxy-3-methy-lglutaryl CoA reductase(HMGCR)and squalene epoxidase(SQLE),the two rate-limiting enzymes in the cholesterol synthesis,selected as the potential targets,were confirmed by the molecular docking,the overexpression,and knockdown of HMGCR or SQLE with siRNA.Finally,the pull-down and surface plasmon resonance technology revealed that PPI could directly bind with SQLE but not with HMGCR.Collectively,these data demonstrated that PPI-induced hepatotoxicity resulted from the direct binding with SQLE protein and impaired the sterol-regulatory element binding protein 2/HMGCR/SQLE/lanosterol synthase pathways,thus disturbing the cholesterol biosynthesis pathway.The findings of this research can contribute to a better understanding of the key role of SQLE as a potential target in drug-induced hepatotoxicity and provide a therapeutic strategy for the prevention of drug toxic effects with similar structures in the future. | Zhiqi Li Qiqi Fan Meilin Chen Ying Dong Farong Li Mingshuang Wang Yulin Gu Simin Guo Xianwen Ye Jiarui Wu Shengyun Dai Ruichao Lin Chongjun Zhao | 2023 | Journal of Pharmaceutical Analysis2023，13，1： | 2 |
| 5 | Metal nanopartiele precipitation in periodic arrays in Au20-doped glass by two interfered femtosecond laser pulses 显示文摘 | Qu Shiliang QIU Jianrong ZHAO Chongjun | 2004 | Appl Phys Lett2004，84，12： | 1 |
| 6 | Preparation and Optical Properties of Ag/PPy Composite Colloids显示文摘 | Chongjun Zhao Qitao Zhao Quanzhong Zhao | 2007 | Journal of Photochemistry and Photobiology A:Chemistry2007，187，23： | 1 |
| 7 | Synthesis of nano-sized Li4Ti5 O12/C composite anode material with excellent high-rate performance显示文摘 | Shaowei Zheng Yunlong Xu Chongjun Zhao | | 0，，： | 1 |
| 8 | Synthesis and formation mechanism of silver nanowires by a templateless and seedless method显示文摘 | Qitao Zhao Jianrong Qiu Chongjun Zhao | 2005 | Chemistry Letters2005，34，1： | 1 |
| 9 | A Study of Nano Materials and Their Reactions in Liquid Using in situ Wet Cell TEM Technology显示文摘几个 nano 材料和反应系统在监视,一个电气化学的 TEM 湿房间建立了的 situ。在 1 个 g/L 裂片粒子水的答案,粒子被观察是 ca。10 nm 缩放,在分离粒子和 nano 簇形式。银粒子被附在湿房间的 50 扇 nm 厚的 Si3N4 窗户并且不能自由地搬到液体。与在湿房间装载的 SiCl4 液体,硅 nano 材料 controllably 借助于一根液体阶段电子横梁在湿房间窗户上被种导致的免职(EBID ) 方法。扔的 nano 点是漂亮地塑造回合的,并且在一个木头木头阴谋在横梁暴露时间表明了幂定律生长相关性。在一个 NiCl2 solution/Ni 系统,当使用电的偏爱在上时,镍 nano 电影的电气化学的免职和溶解被观察到在湿房间的镍电极。而不是存在晶体上的 extensional 生长,有趣地,新镍 nano 粒子首先在存在电影前面外面成长,这更通常被观察然后合并了进这部电影。建立的湿房间被表明是为 nano 液体系统研究的一个万用的工具。 | Chen Xin Zhou Lihui Wang Ping Zhao Chongjun Miao Xiaoli | 2012 | Chinese Journal of Chemistry2012，30，12： | 1 |
| 10 | One-pot hydrothermal synthesis of reduced graphene oxide/Ni(OH) 2 films on nickel foam for high performance supercapacitors显示文摘 | Shudi Min Chongjun Zhao Guorong Chen Xiuzhen Qian | 2014 | Electrochimica Acta2014，，： | 1 |
| 11 | Direct synthesis of RGO/Cu 2 O composite films on Cu foil for supercapacitors显示文摘 | Xiangmao Dong Kun Wang Chongjun Zhao Xiuzhen Qian Shi Chen Zhen Li Huakun Liu Shixue Dou | 2014 | Journal of Alloys and Compounds2014，，： | 1 |
| 12 | Mechanism of Magnetoresistance Ratio enhancement in MgO/NiFe/MgO Heterostructure by Rapid Thermal Annealing显示文摘 | Zhao Chongjun Liu Yang Zhang Jingyan | 2012 | Appl Phys Lett2012，101，07： | 1 |
| 13 | One-pot Hydrothermal Synthesis of 3D Flower-like RGO/Co 3 O 4 /Ni(OH) 2 Composite Film on Nickel Foam for High-performance Supercapacitors显示文摘 | Shudi Min Chongjun Zhao Guorong Chen Zhuomin Zhang Xiuzhen Qian | 2014 | Electrochimica Acta2014，，： | 1 |
| 14 | Comparative transcriptomics provide new insights into the mechanisms by which foliar silicon alleviates the effects of cadmium exposure in rice显示文摘Silicon(Si)has been shown to alleviate Cd stress in rice.Here,we investigated the beneficial effects of foliar Si in an indica rice Huanghuazhan(HHZ).Our results showed that foliar Si in-creases the dry weight and decreases Cd translocation in Cd-exposed rice at the grain-filling stage only,implying that the filling stage is critical for foliar Si to reduce Cd accumulation.We also investigated the transcriptomics in flag leaves(FLs),spikelets(SPs),and node Is(NIs)of Cd-exposed HHZ after foliar Si application at the filling stage.Importantly,the gene expression profiles associated with the Si-mediated alleviation of Cd stress were tissue spe-cific,while shared pathways were mediated by Si in Cd-exposed rice tissues.Furthermore,after the Si treatment of Cd-exposed rice,the ATP-binding cassette(ABC)-transporters were mostly upregulated in FL and SP,while the bivalent cation transporters were mostly down-regulated in FL and NI,possibly helping to reduce Cd accumulation.The genes associated with essential nutrient transporters,carbohydrate and secondary metabolite biosynthesis,and cytochrome oxidase activity were mostly upregulated in Cd-exposed FL and SP,which may help to alleviate oxidative stress and improve plant growth under Cd exposure.Inter-estingly,genes responsible for signal transduction were negatively regulated in FL,but pos-itively regulated in SP,by foliar Si.Our results provide transcriptomic evidence that foliar Si plays an active role in alleviating the effects of Cd exposure in rice.In particular,foliar Si may alter the expression pattern of genes associated with transport,biosynthesis and metabolism,and oxidation reduction. | Chongjun Sun Xiaoyu Liang Xiaomei Gong Huamei Chen Xiulian Liu Shuchang Zhang Fangbai Li Junliang Zhao Jicai Yi | 2022 | Journal of Environmental Sciences2022，34，5： | 0 |
| 15 | Comparative physiological and transcriptomic analyses illuminate common mechanisms by which silicon alleviates cadmium and arsenic toxicity in rice seedlings显示文摘The inessential heavy metal/loids cadmium(Cd)and arsenic(As),which often co-occur in polluted paddy soils,are toxic to rice.Silicon(Si)treatment is known to reduce Cd and As toxicity in rice plants.To better understand the shared mechanisms by which Si alleviates Cd and As stress,rice seedlings were hydroponically exposed to Cd or As,then treated with Si.The addition of Si significantly ameliorated the inhibitory effects of Cd and As on rice seedling growth.Si supplementation decreased Cd and As translocation from roots to shoots,and significantly reduced Cd-and As-induced reactive oxygen species generation in rice seedlings.Transcriptomics analyses were conducted to elucidate molecular mechanisms underlying the Si-mediated response to Cd or As stress in rice.The expression patterns of the differentially expressed genes in Cd-or As-stressed rice roots with and without Si application were compared.The transcriptomes of the Cd-and As-stressed rice roots were similarly and profoundly reshaped by Si application,suggesting that Si may play a fundamental,active role in plant defense against heavy metal/loid stresses by modulating whole genome expression.We also identified two novel genes,0s01g0524500 and 0s06g0514800,encoding a myeloblastosis(MYB)transcription factor and a thionin,respectively,which may be candidate targets for Si to alleviate Cd and As stress in rice,as well as for the generation of Cd-and/or As-resistant plants.This study provides valuable resources for further clarification of the shared molecular mechanisms underlying the Si-mediated alleviation of Cd and As toxicity in rice. | Huiqiong Chen Xiaoyu Liang Xiaomei Gong John R.Reinfelder Huamei Chen Chongjun Sun Xiulian Liu Shuchang Zhang Fangbai Li Chuanping Liu Junliang Zhao Jicai Yi | 2021 | Journal of Environmental Sciences2021，33，11： | 0 |
| 16 | How China's Belt and Road Initiative Promises to Bring Harmonious Development to the World显示文摘With the economic rise of China,Chairman Xi Jinping has been backing the ambitious'Belt and Road Initiative'( BRI) to connect China with the world via land and maritime networks,strengthening the role of China as an effective global power spreading investment and prosperity. The BRI was unveiled under the banner — 'harmonious development',however,many viewed the expansion of Chinese influence as a threat to the US hegemony better known as'Washington Consensus'. This paper focused on the economic and political opportunities arising from the BRI plan,and moreover,interpreted howthe'Beijing Consensus'promised to promote world develpment. | Zhao Chongjun Huang Yongliang | 2018 | 学术界2018，，12： | 0 |
| 17 | Preparation and Nonlinearity properties of Pd Nanoparticles显示文摘Pd nanoparticles less than 8 nm were photoinduced by a near-IR femtosecond laser. The sign of the refraction nonlinearity is negative for the Pd nanoparticles with TiO2, while it is positive for those without TiO2. | Chongjun Zhao, Shiliang Qu, Jianrong Qiu, Congshan Zhu(Photon Craft Project, Shanghai Institute of Optics & Fine Mechanics, Chinese Academy of Sciences and Japan Science and Technology Corporation, Shanghai, 201800, P.R. China, Tel: 86-21-59911897, Fax: 86-21-59929373, E-mail:chongjunzhao@mail.siom.ac.cn) | 2003 | 光学学报2003，23，S1： | 0 |
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