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| 1 | Severe human infection with a novel avian-origin influenza A(H7N4) virus显示文摘Human infections with influenza H7 subtypes, such as H7N9, have raised concerns worldwide. Here, we report a human infection with a novel influenza A(H7N4) virus. A 68 years-old woman with cardiovascular and cholecystic comorbidities developed rapidly progressed pneumonia with influenza-like-illness as initial symptom, recovered after 23 days-hospitalization including 8 days in ICU. Laboratory indicators for liver and blood coagulation dysfunction were observed. Oseltamivir phosphate, glucocorticoids and antibiotics were jointly implemented, with nasal catheterization of oxygen inhalation for this patient.We obtained the medical records and collected serial respiratory and blood specimens from her. We collected throat, cloacal and/or feces samples of poultry and wild birds from the patient's backyard, neighborhood, local live poultry markets(LPMs) and the nearest lake. All close contacts of the patient were followed up and sampled with throat swabs and sera. Influenza viruses and other respiratory pathogens were tested by real-time RT-PCR, viral culturing and/or sequencing for human respiratory and bird samples. Micro-neutralizing assay was performed for sera. A novel reassortant wild bird-origin H7N4 virus is identified from the patient and her backyard poultry(chickens and ducks) by sequencing, which is distinct from previously-reported avian H7N4 and H7N9 viruses. At least four folds increase of neutralizing antibodies to H7N4 was detected in her convalescent sera. No samples from close contacts, wild birds or other poultry were tested positive for H7N4 by real-time RT-PCR. | Xiang Huo Lun-biao Cui Cong Chen Dayan Wang Xian Qi Ming-hao Zhou Xiling Guo Fengming Wang William J. Liu Weirong Kong Daxin Ni Ying Chi Yiyue Ge Haodi Huang Feifei Hu Chao Li Xiang Zhao Ruiqi Ren Chang-jun Bao George F. Gao Feng-Cai Zhu | 2018 | Science Bulletin2018，63，16： | 4 |
| 2 | Flow imaging method of electromagnetic measurement in well logging显示文摘Multiphase flow in an oil well is a dynamic phenomenon of inhomogeneous medium,which should be studied in a nonlinear way. This paper presents an electromagnetic measurement method based on the electrical property differences between oil,gas and water to scan,inverse and show the distribution and condition of multiphase flow. Both numerical simulation and physical experiments have proved that clear images could be obtained by this way. | WU XiLing,WANG XiaoXing,ZHAO YanWei & YANG Mei School of Resource and Information Technology,China University of Petroleum,Beijing 102249,China | 2008 | Science China Earth Sciences2008，51，S2： | 3 |
| 3 | Image restoration with shifting reflective boundary conditions显示文摘In signal and image processing,we want to recover a faithful representation of an original scene from blurred,noisy image data.This process can be transformed mathematically into solving a linear system with a blurring matrix.Particularly,the blurring matrix is determined from not only a point spread function(PSF),which defines how each pixel is blurred,but also boundary conditions(BCs),which specify our assumptions on the data outside the domain of consideration.In this paper,we first propose shifting reflective BCs which preserve the continuity at the boundaries and,therefore,reduce ringing effects in the restored image.A Kronecker product approximation of the corresponding blurring matrix is then provided,regardless of symmetry requirement of the PSF.Finally,we demonstrate the efficiency of our approximation in an SVD-based regularization method by several numerical examples. | HUANG Jie HUANG TingZhu ZHAO XiLe XU ZongBen | 2013 | Science China(Information Sciences)2013，56，6： | 2 |
| 4 | Relationship between full-thickness macular hole and retinal break/lattice degeneration显示文摘Background: The purpose is to investigate the relationship between full-thickness macular hole(MH) and retinal break(RB) and/or lattice degeneration.Methods: Patients diagnosed as full-thickness MH and referred to Dr. Lin Lu from January 2009 to December 2013 were evaluated. All patients underwent general ophthalmologic examinations, fundus examination and optical coherence tomography(OCT). The RB and/or lattice degeneration were recorded.Results: Totally 183 eyes of 167 patients were included. The sex ratio of men to women was 1:2.88. A total of 17 eyes were pseudophakic and 166 eyes were phakic. RB and/or lattice degeneration were found in 62 eyes(33.88%). The prevalence of RB and/or lattice degeneration was similar between men and women(P=0.344>0.05). There was no statistical difference between the pseudophakic eyes and phakic eyes(P=0.138>0.05). All of the RB and/or lattice degeneration were located near or anterior to the equator. The inferior quadrants and the vertical meridian were af ected more often than the superior quadrants and the horizontal meridian.Conclusions: We identified a high incidence of RB/lattice degeneration in cases of full-thickness MH. Carefully examination of the peripheral retina and prophylactic treatment of RB and/or lattice degeneration are critical. | Jinglin Zhang Yonghao Li Xiujuan Zhao Yu Cai Xiling Yu Lin Lu | 2015 | Eye Science2015，30，4： | 2 |
| 5 | Simulation Experiments in Electromagnetic Tomography Well Logging in Two-phase Flow显示文摘Electromagnetic Computer Tomography (ECT) is a method to probe the interior of an inhomogeneous medium via surface measurement in a non-linear way. Due to the great differences in conductivity and permittivity between oil and water in the well, Electromagnetic Tomography Well Logging (ETWL), a new flow imaging measurement system, is proposed to describe the distribution and movement of oil/water two-phase flow in the well by scanning the detected region and applying a suitable data processing algorithm. The results of the numerical simulation and physical modeling show that the system could provide a clear image of the flow profile. | Wu Xiling Zhao Yanwei | 2006 | Petroleum Science2006，3，3： | 2 |
| 6 | Chromosome-level Genomes Reveal the Genetic Basis of Descending Dysploidy and Sex Determination in Morus Plants显示文摘Multiple plant lineages have independently evolved sex chromosomes and variable karyotypes to maintain their sessile lifestyles through constant biological innovation.Morus notabilis,a dioecious mulberry species,has the fewest chromosomes among Morus spp.,but the genetic basis of sex determination and karyotype evolution in this species has not been identified.In this study,three high-quality genome assemblies were generated for Morus spp.[including dioecious M.notabilis(male and female)and Morus yunnanensis(female)]with genome sizes of 301–329 Mb and were grouped into six pseudochromosomes.Using a combination of genomic approaches,we found that the putative ancestral karyotype of Morus species was close to 14 protochromosomes,and that several chromosome fusion events resulted in descending dysploidy(2n=2x=12).We also characterized a~6.2-Mb sex-determining region on chromosome 3.Four potential male-specific genes,a partially duplicated DNA helicase gene(named MSDH)and three Ty3_Gypsy long terminal repeat retrotransposons(named MSTG1/2/3),were identified in the Y-linked area and considered to be strong candidate genes for sex determination or differentiation.Population genomic analysis showed that Guangdong accessions in China were genetically similar to Japanese accessions of mulberry.In addition,genomic areas containing selective sweeps that distinguish domesticated mulberry from wild populations in terms of flowering and disease resistance were identified.Our study provides an important genetic resource for sex identification research and molecular breeding in mulberry. | Zhongqiang Xia Xuelei Dai Wei Fan Changying Liu Meirong Zhang Peipei Bian Yuping Zhou Liang Li Baozhong Zhu Shuman Liu Zhengang Li Xiling Wang Maode Yu Zhonghuai Xiang Yu Jiang Aichun Zhao | 2022 | Genomics, Proteomics & Bioinformatics2022，20，6： | 1 |
| 7 | A new type of district heating method with co-generation based on absorption heat exchange (co-ah cycle)显示文摘 | Yan Li Lin Fu Shigang Zhang Yi Jiang Zhao Xiling | 2010 | Energy Conversion and Management2010，，2： | 1 |
| 8 | Distributional characteristics of grain sizes of surface sediments in the Zhujiang River Estuary显示文摘Distributions of the parameters of sedimentary grain sizes and their correlations were studied to trace the sources of silts and their movement trends in the Zhujiang River Estuary based on the analyses of grain sizes from more than 1 080 sedimentary samples. The distributions of the median diameter, public value, quartile deviation, and skewness of sediments were complex in the Zhujiang River Estuary mainly because of the impact of the matter source regions, distances from the source regions, and hydrodynamic conditions, such as waves, tidal currents, and coastal currents. Analyses of the parameters of the grain sizes for the various types of sediments showed that the distributions of the surface sediments in the Zhujiang River Estuary were controlled by many factors. Their matter sources were mainly the sediments discharged from the runoffs and ebb tidal currents, and from the open sea. The sediments mainly moved by suspension movement. The silts formed a large area of sediments with suspended fine silts in the Zhujiang River Estuary by internal adjustment transportation in the area, and moved toward the western coast of the Zhujiang River Estuary under the effect of Coriolis forces and coastal currents. | JIANG Siyi XU Fangjian LI Yan LIU Xiling ZHAO Yongfang XU Wei | 2014 | Acta Oceanologica Sinica2014，33，4： | 1 |
| 9 | Deblurring and sparse unmixing for hyperspectral images显示文摘 | Zhao Xile Wang Fan Huang Tingzhu | 2013 | IEEE Transactions on Geoscience and Remote Sensing2013，51，7： | 1 |
| 10 | The performance research of high efficiency prime motor DIR-SOFC for decentralized energy system显示文摘 | Zhao Xiling Zhang Xingmei Duan Changgui | 2007 | Journal of Harbin Institute of Technology(New Series)2007，14，： | 1 |
| 11 | The performance research of high efficiency prime motor DIR-SOFC for decentralized energy system显示文摘 | Zhao Xiling Zhang Xingmei Duan Changgui | 2007 | Joumal of Harbin Institute of Technology (New Series)2007，，14： | 1 |
| 12 | Discrete-time variable structure control of seismically excited building structures 显示文摘 | Lu Xiling Zhao Bin | 2001 | Earthquake Engineering and Structure Dynamic2001，30，6： | 1 |
| 13 | Licochalcone A inhibiting proliferation of bladder cancer T24 cells by inducing reactive oxygen species production显示文摘 | Feng Liu Ali Goodarzi Haifeng Wang Joanna Stasiak Jianbo Sun Yu Zhou Jiangtao Jiang Xuan Yuan Hong Zhao Xinyan Yan Xiling Sun Qiusheng Zheng | 2014 | Bio-Medical Materials and Engineering2014，，1： | 1 |
| 14 | Waveletbased two-level methods for image restoration显示文摘 | Deng Liangjian Huang Tingzhu Zhao Xile | 2012 | Communications in Nonlinear Science and Numerical Simulation2012，17，12： | 1 |
| 15 | Development of phosphonate-terminated magnetic mesoporous silica nanoparticles for pH-controlled release of doxorubicin and improved tumor accumulation显示文摘In this study,phosphonate-terminated magnetic mesoporous nanoparticles(pMMSNs)was designed by incorporation of MNPs in the center of mesoporous silica nanoparticles(MSNs)and followed by grafting phosphonate group on to the surface of MMSNs.The carrier exhibited a typical superparamagnetic feature and the saturation magnetization was 4.89 emu/g measured by vibrating sample magnetometer(VSM).pMMSNs had a spherical morphology and a pore size of 2.2 nm.FromN2 adsorption-desorption analysis,pMMSNs had a surface area of 613.4 m^(2)/g and a pore volume of 0.78 cm^(3)/g.Phosphonate modification improved the colloidal stability of MMSNs,and the hydrodynamic diameter of pMMSNs was around 175 nm.The hydrophilic phosphonate group significantly enhanced the negative surface charge of MMSNs from -19.3 mV to -28.8 mV pMMSNs with more negative surface charge had a 2.3-fold higher drug loading capacity than that of MMSNs.In addition,the rate and amount of release of doxorubicin(DOX)from DOX/pMMSNs was pH-dependent and increased with the decrease of pH.At pH 7.4,the release amount was quite low and only approximately 17wt%ofDOXwasreleasedin48h.AtpH5.0and3.0,the release rate increased significantly and the release amount achieved 31 wt%and 60 wt%in 48 h,respectively.To evaluate the magnetic targeting performance ofpMMSNs,FITC labeledpMMSNswas injected into mice bearing S180 solid tumor.FITC labeledpMMSNscontrolled by an external magnetic field showed higher tumor accumulation and lower normal tissue distribution. | Erxi Che Long Wan Ying Zhang Qinfu Zhao Xiling Han Jia Li Jia Liu Siling Wang | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，6： | 0 |
| 16 | An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19显示文摘The global spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019(COVID-19).In this study,we developed an integrative drug repositioning framework,which fully takes advantage of machine learning and statistical analysis approaches to systematically integrate and mine large-scale knowledge graph,literature and transcriptome data to discover the potential drug candidates against SARS-CoV-2.Our in silico screening followed by wet-lab validation indicated that a poly-ADP-ribose polymerase 1(PARP1)inhibitor,CVL218,currently in Phase I clinical trial,may be repurposed to treat COVID-19.Our in vitro assays revealed that CVL218 can exhibit effective inhibitory activity against SARS-CoV-2 replication without obvious cytopathic effect.In addition,we showed that CVL218 can interact with the nucleocapsid(N)protein of SARS-CoV-2 and is able to suppress the LPS-induced production of several inflammatory cytokines that are highly relevant to the prevention of immunopathology induced by SARS-CoV-2 infection. | Yiyue Ge Tingzhong Tian Suling Huang Fangping Wan Jingxin Li Shuya Li Xiaoting Wang Hui Yang Lixiang Hong Nian Wu Enming Yuan Yunan Luo Lili Cheng Chengliang Hu Yipin Lei Hantao Shu Xiaolong Feng Ziyuan Jiang Yunfu Wu Ying Chi Xiling Guo Lunbiao Cui Liang Xiao Zeng Li Chunhao Yang Zehong Miao Ligong Chen Haitao Li Hainian Zeng Dan Zhao Fengcai Zhu Xiaokun Shen Jianyang Zeng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 17 | Genome transfer for the prevention of female infertility caused by maternal gene mutation显示文摘Poor oocyte quality is associated with early embryo developmental arrest and infertility.Maternal gene plays crucial roles in the regulation of oocyte maturation,and its mutation is a common cause of female infertility.However,how to improve oocyte quality and develop effective therapy for maternal gene mutation remains elusive.Here,we use Zar1 as an example to assess the feasibility of genome transfer to cure maternal gene mutationecaused female infertility.We first discover that cytoplasmic deficiency primarily leads to Zar1-null embryo developmental arrest by disturbing maternal transcript degradation and minor zygotic genome activation(ZGA)during the maternal-zygotic transition.We next perform genome transfer at the oocyte(spindle transfer or polar body transfer)and zygote(early pronuclear transfer or late pronuclear transfer)stages to validate the feasibility of preventing Zar1 mutationecaused infertility.We finally demonstrate that genome transfer either at the oocyte or at the early pronuclear stage can support normal preimplantation embryo development and produce live offspring.Moreover,those pups grow to adulthood and show normal fertility.Therefore,our findings provide an effective basis of therapies for the treatment of female infertility caused by maternal gene mutation. | Dandan Bai Jin Sun Yanping Jia Jiqing Yin Yalin Zhang Yanhe Li Rui Gao Xiling Du Kunming Li Jiaming Lin Zhifen Tu Yu Wang Jiaping Pan Shanshan Liang Yi Guo Jingling Ruan Xiaochen Kou Yanhong Zhao Hong Wang Cizhong Jiang Fengchao Wang Xiaoming Teng Wenqiang Liu Shaorong Gao | 2020 | Journal of Genetics and Genomics2020，47，6： | 0 |
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