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| 1 | Migration and accumulation of natural gas in Kela-2 gas field显示文摘With the guidance of petroleum system theory,the dynamic filling history of natural gas in the Kela-2 gasfield is analyzed by using a large suite of oil and gas geo-chemistry evidence in combination with the tectonic evolu-tion history and reservoir evolution history. It concludes thatthe Kela-2 gas field was formed by capturing the gas gener-ated during the main gas generation period, while the latekerogen cracking gas contributed a little to the gas field. Itsuggests that the gas generated during the main gas genera-tion accumulated in the early-formed wide-gentle anticline,which is the necessary condition for natural gas to re-migrateand enrich late to form the large-scale gas reservoir. Thenewest research shows that the filling history of gas in theDabei-1, Yinan-2, Tuziluoke and Dina-2 gas fields was re-lated with the natural gas accumulation in the early wide-gentle anticline as well as late re-migration and enrichmentof natural gas. | WANG Zhaoming WANG Tingdong XIAO Zhongyao XU Zhiming LI Mei LIN Feng | 2002 | Chinese Science Bulletin2002，47，S1： | 16 |
| 2 | Targets and molecular mechanisms of triptolide in cancer therapy显示文摘Triptolide(TPL/TL) is a natural drug with novel anticancer effects. Preclinical studies indicated that TPL inhibits cell proliferation, induces cell apoptosis, inhibits tumor metastasis and enhances the effect of other therapeutic methods in various cancer cell lines. Multiple molecules and signaling pathways, such as caspases, heat-shock proteins, NF-κB, and deoxyribonucleic acid(DNA) repair-associated factors, are associated with the anti-cancer effect. TPL also improves chemoradiosensitivity in cancer therapy. Phase I trials indicate the potential clinical value of TPL use. However, further trials with larger sample sizes are needed to confirm these results. | Cuicui Meng Hongcheng Zhu Hongmei Song Zhongming Wang Guanhong Huang Defan Li Zhaoming Ma Jianhua Ma Qin Qin Xinchen Sun Jianxin Ma | 2014 | Chinese Journal of Cancer Research2014，26，5： | 16 |
| 3 | Identification of the novel recessive gene pi55(t) conferring resistance to Magnaporthe oryzae显示文摘The elite rice cultivar Yuejingsimiao 2 (YJ2) is characterized by a high level of grain quality and yield, and resistance against Magnaporthe oryzae. YJ2 showed 100% resistance to four fungal populations collected from Guangdong, Sichuan, Liaoning, and Heilongjiang Provinces, which is a higher frequency than that shown by the well-known resistance (R) gene donor cultivars such as Sanhuangzhan 2 and 28zhan. Segregation analysis for resistance with F 2 and F 4 populations indicated the resistance of YJ2 was controlled by multiple genes that are dominant or recessive. The putative R genes of YJ2 were roughly tagged by SSR markers, located on chromosomes 2, 6, 8, and 12, in a bulked-segregant analysis using genome-wide selected SSR markers with F 4 lines that segregated into 3 resistant (R):1 susceptible (S) or 1R:3S. The recessive R gene on chromosome 8 was further mapped to an interval 1.9 cM/152 kb in length by linkage analysis with genomic position-ready markers in the mapping population derived from an F 4 line that segregated into 1R:3S. Given that no major R gene was mapped to this interval, the novel R gene was designated as pi55(t). Out of 26 candidate genes predicted in the region based on the reference genomic sequence of the cultivar Nipponbare, two genes that encode a leucine-rich repeat-containing protein and heavy-metalassociated domain-containing protein, respectively, were suggested as the most likely candidates for pi55(t). | HE XiuYing LIU XinQiong WANG Li WANGLing LIN Fei CHENG YongSheng CHEN ZhaoMing LIAO YaoPing PAN QingHua | 2012 | Science China(Life Sciences)2012，55，2： | 15 |
| 4 | Effect of minor Sc addition on microstructure and stress corrosion cracking behavior of medium strength Al–Zn–Mg alloy显示文摘Influence of Sc content on microstructure and stress corrosion cracking behavior of medium strength Al–Zn–Mg alloy have been investigated by optical microscopy, scanning electron microscopy, electron backscatter diffraction, transmission electron microscopy and slow strain rate test. The results indicate that the addition of Sc results in the formation of the quaternary coherent Al_3(Sc, Zr, Ti) dispersoids during homogenization treatment, which will inhibit the dynamic recrystallization behavior. The number density of Al_3(Sc, Zr, Ti) particles increases with the increase of Sc content, and thus the recrystallization fraction of hot-extruded alloy is reduced and the peak strength in two-stage artificial aging sample is enhanced. At the same time, the wide of precipitation free zone is reduced, and the content of Zn and Mg in grain boundary particles and precipitation free zone is increased with the increase of Sc content. In peak-aged state, the 0.06 wt% Sc added alloy shows the better stress corrosion cracking resistance than the Sc-free alloy because of the reduction of recrystallization fraction and the interrupted distribution of grain boundary precipitates along grain boundary. However, the further addition of Sc to 0.11 wt% will result in the deterioration of stress corrosion cracking resistance due to the increase of electrochemical activity of grain boundary particles and precipitation free zone as well as hydrogen embrittlement. | Zhaoming Li Haichang Jiang Yunli Wang Duo Zhang Desheng Yan Lijian Rong | 2018 | Journal of Materials Science & Technology2018，34，7： | 14 |
| 5 | Oil cracking to gases: Kinetic modeling and geological significance显示文摘从 Tarim 盆的 LN14 的一件三叠纪的油样品是用在在 50 MPa 的恒压下面的 200-620 deg C 的封上的金试管的 pyrolyzed。气体并且剩余可溶的烃被分析。结果证明到气体的石油的裂化能被划分成二个不同阶段:从液体油的全部的 C1-5 气体的主要产生由 C2-5 烃和 secondary 或到甲烷的 C2-5 气体的进一步的裂开的优势描绘了导致气体的进步的干的 andcarbon 富有的事。基于试验性的数据,运动参数为主要产生和第二等的石油的裂化裂化气被决定并且外推到地质的条件预言热稳定性和原油的裂开的程度。最后,为原油的热破坏的一个进化模型被建议,它到油裂化气的迁居和累积的含意被讨论。 | TIAN Hui 1,2 WANG Zhaoming XIAO Zhongyao LI Xianqing XIAO Xianming | 2006 | Chinese Science Bulletin2006，51，22： | 13 |
| 6 | Species-dependent neuropathology in transgenic SOD' aigs显示文摘 | Huaqiang Yang Guohao Wang Haitao Sun Runzhe Shu Tao Liu Chuan-En Wang Zhaoming Liu Yu Zhao Bentian Zhao Zhen Ouyang Dongshan Yang Jiao Huang Yueling Zhou Shihua Li Xiaodan Jiang Zhicheng Xiao Xiao-Jiang Li Liangxue Lai | 2014 | Cell Research2014，24，4： | 13 |
| 7 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 8 | Inhibiting autophagy enhances sulforaphane-induced apoptosis via targeting NRF2 in esophageal squamous cell carcinoma显示文摘Sulforaphane(SFN), a natural anti-tumor compound from cruciferous vegetables, has been reported to induce protective autophagy to cancer cells, which might impair the anti-tumor efficiency of SFN. However, the accurate function and mechanism of SFN inducing autophagy in cancers are still obscure, especially in esophageal squamous cell carcinoma(ESCC), one of malignancies with high incidence in North China. Here, we mainly explored the potential function of autophagy upon SFN treatment in ESCC and molecular mechanism. We demonstrated that SFN could inhibit cell proliferation and induce apoptosis by activating caspase pathway. Moreover, we found activation of NRF2 pathway by SFN was responsible for the induction of autophagy and also a disadvantage element to the anti-tumor effects of SFN on ESCC, indicating that SFN might induce protective autophagy in ESCC. We, therefore,investigated effects of autophagy inhibition on sensitivity of ESCC cells to SFN and found that chloroquine(CQ) could neutralize the activation of SFN on NRF2 and enhance the activation of SFN on caspase pathway, thus improved the anti-tumor efficiency of SFN on ESCC in vitro and in vivo. Our study provides a preclinical rationale for development of SFN and its analogs to the future treatment of ESCC. | Zhaoming Lu Yandan Ren Li Yang Ang Jia Yi Hu Yu Zhao Wuduo Zhao Bin Yu Wen Zhao Jianying Zhang Guiqin Hou | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 8 |
| 9 | The nitritation performance of biofilm reactor for treating domestic wastewater under high dissolved oxygen显示文摘The objective of this study was to investigate the nitritation performance in a biofilm reactor for treating domestic wastewater.The reactor was operated in continuous feed mode from phases 1 to 3.The dissolved oxygen(DO)was controlled at 3.5–7 mg/L throughout the experiment.The biofilm reactor showed excellent nitritation performance after the inoculation of nitrifying sludge,with the hydraulic retention time being reduced from 24 to 7 hr.Above 90%nitrite accumulation ratio(NAR)was maintained in phase 1.Afterwards,nitratation occurred with the low NH_4^+–N concentration in the reactor.The improvement of NH_4^+–N concentration to 20–35 mg/L had a limited effect on the recovery of nitritation.However,nitritation recovered rapidly when sequencing batch feed mode was adopted in phase 4,with the effluent NH_4^+-N concentration above 7 mg/L.The improvement of ammonia oxidizing bacteria(AOB)activity and the combined inhibition effect of free ammonia(FA)and free nitrous acid(FNA)on the nitrite oxidizing bacteria(NOB)were two key factors for the rapid recovery of nitritation.Sludge activity was obtained in batch tests.The results of batch tests had a good relationship with the long term operation performance of the biofilm reactor. | Zhaoming Zheng Zebing Li Jing Ma Jia Du Guanghui Chen Wei Bian Jun Li Baihang Zhao | 2016 | Journal of Environmental Sciences2016，28，4： | 7 |
| 10 | Quaternary pyrite-structured nickel/cobalt phosphosulfide nanowires on carbon cloth as efficient and robust electrodes for water electrolysis显示文摘元素替换的策略是在催化剂调节活跃地点的电子结构的一个有效方法,从而在催化活动和稳定性导致改进。此处,我们设计并且综合黄铁矿类型镍 / 磷共同做碳布(NiCoPS/CC ) 上的公司 2 nanowires 为水电解的同样有效、持久的电极。镍和磷的介绍由于催化剂的活跃地点的电子结构的规定在氢进化反应生产了电极的表演的逐步、出色的改进并且在一个宽 pH 范围(014 ) 上加速了费用转移。也交付的 NiCoPS/CC 电极一将近 undecayed 10 | Jiayuan Li Zhaoming Xia Xuemei Zhou Yuanbin Qin Yuanyuan Ma Yongquan Qu | 2017 | Nano Research2017，10，3： | 7 |
| 11 | Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering显示文摘Dear Editor,Type1diabetes(T1D)isa lifelong(chronic)disease and a major health problem throughout the world.This disease can be treatedby either insulin injection or islet transplantation.Islet transplantation is considered as a better treatment for T1D patients,because islets can produce and release insulin at the appropriate time,resulting in tight blood glucose control. | Yi Yang Kepin Wang Han Wu Qin Jin Degong Ruan Zhen Ouyang Bentian Zhao Zhaoming Liu Yu Zhao Quanjun Zhang Nana Fan Qishuai Liu Shimei Guo Lei Bu Yong Fan Xiaofang Sun Xiaoping Li Liangxue Lai | 2016 | Journal of Molecular Cell Biology2016，8，2： | 6 |
| 12 | Protection strategy for improved catalytic stability of silicon photoanodes for water oxidation显示文摘Silicon-based electrodes have attracted great attention in the artificial photosynthetic systems that mimic natural photosynthesis and directly convert the solar energy into chemical energy. Despite significant efforts to date,catalytic stability of the silicon photoelectrodes is limited by their poor electrochemical stability. The formation of passivation or protective layers provides a feasible strategy to improve the photocatalytic stability of silicon photoelectrodes. Many candidates including metals, metal oxides, metal silicides and polymers have been explored as the protection layers for silicon photoelectrodes. The present review gives a concise overview of the protected silicon photoanodes for water oxidation with a focus on the relationship between the structural architecture of silicon photoanodes and their photocatalytic activity and stability. | Zhaoming Xia Xuemei Zhou Jing Li Yongquan Qu | 2015 | Science Bulletin2015，60，16： | 5 |
| 13 | Inhibition factors and Kinetic model for ammonium inhibition on the anammox process of the SNAD biofilm显示文摘The aim of the present work was to evaluate the anaerobic ammonium oxidation(anammox) activity of simultaneous partial nitrification, anammox and denitrification(SNAD) biofilm with different substrate concentrations and p H values. Kaldnes rings taken from the SNAD biofilm reactor were incubated in batch tests to determine the anammox activity. Haldane model was applied to investigate the ammonium inhibition on anammox process. As for nitrite inhibition, the NH_(4^-)^+N removal rate of anammox process remained 87.4% of the maximum rate with the NO_(2^-)^-N concentration of 100 mg/L. Based on the results of Haldane model, no obvious difference in kinetic coefficients was observed under high or low free ammonia(FA) conditions, indicating that ammonium rather than FA was the true inhibitor for anammox process of SNAD biofilm. With the p H value of 7.0, the r max, Ks and K_I of ammonium were 0.209 kg NO_(2^-)^-N/kg VSS/day, 9.5 mg/L and 422 mg/L, respectively. The suitable p H ranges for anammox process were 5.0 to 9.0. These results indicate that the SNAD biofilm performs excellent tolerance to adverse conditions. | Zhaoming Zheng Jun Li Jing Ma Jia Du Fan Wang Wei Bian Yanzhuo Zhang Baihang Zhao | 2017 | Journal of Environmental Sciences2017，29，3： | 5 |
| 14 | Characteristics,genesis and accumulation history of natural gas in Hetianhe gasfield,Tarim Basin,China显示文摘Hetianhe gasfield in Bachu region of the Tarim Basin is mainly composed of three reservoir-caprock assembly,namely regional caprock of upper mudstone,middle mudstone and lower mudstone of the Carboniferous and reservoir of Bachu bioclastic limestone,glutenite and the Ordovician carbonate buried hill.Natural gas in Hetianhe gasfield sourced from the Cambrian source rock.It is thought that gases in Ma4 well block in the east of Hetianhe gasfield are mainly crude-oil cracked gases,while those in Ma3 and Ma8 well blocks in the west are the mixture gases of kerogen cracked gases and crude-oil cracked gases.Natural gas is rich in H2S and accumulated in multiply stages as the result of TSR.The accumulation history is divided into three stages,namely accumulation and breakage in the late Caledonian-early Hercynian,migration and dissipation in the late Hercynian and accumulation in Himalayan. The main accumulation of reformed gas reservoir is in Himalayan. | WANG ZhaoMing 1 ,WANG QingHua 1 ,ZHAO MengJun 2 ,LI Yong 1 &XU ZhiMing 3 1 Tarim Oilfield Company,PetroChina,Kuerle 841000,China 2 Research Institute of Petroleum Exploration&Development,PetroChina,Beijing 100083,China 3 Southwest Petroleum Institute,Nanchong 637001,China | 2008 | Science China Earth Sciences2008，51，S1： | 4 |
| 15 | Magnetism in Mn and Co doped ZnO bulk samples显示文摘Bulk samples with nominal composition Zn0.95Co0.05O and Zn0.92Co0.05Mn0.03O were fabricated by a solid-state reaction method at 600℃.X-ray diffraction experiment showed that the peaks of secondary phase Co3O4 with a cubic structure were visible in both samples,besides the main peaks of wurtzite structure as ZnO.Magnetization measurement indicated that doping Co alone can induce ferromag- netism in ZnO itself,while the introduction of Mn significantly enhances ferromagnetism.However, both samples showed different magnetic behavior at temperatures below 50 K.It was also noted that ferromagnetic coupling interaction was weakened due to the presence of antiferromagnetic Co3O4. | WANG YongQiang YUAN SongLiu SONG YunXing LIU Li TIAN ZhaoMing LI Pai ZHOU YuanMing LI YunLong YIN ShiYan | 2007 | Chinese Science Bulletin2007，52，8： | 4 |
| 16 | Enhanced production of seed oil with improved fatty acid composition by overexpressing NAD^(+)-dependent glycerol-3-phosphate dehydrogenase in soybean显示文摘There is growing interest in expanding the production of soybean oils(mainly triacylglycerol, or TAG) to meet rising feed demand and address global energy concerns. We report that a plastidlocalized glycerol-3-phosphate dehydrogenase(GPDH), encoded by GmGPDHp1 gene, catalyzes the formation of glycerol-3-phosphate(G3 P), an obligate substrate required for TAG biosynthesis.Overexpression of GmGPDHp1 increases soybean seed oil content with high levels of unsaturated fatty acids(FAs), especially oleic acid(C18:1), without detectably affecting growth or seed protein content or seed weight. Based on the lipidomic analyses, we found that the increase in G3 P content led to an elevated diacylglycerol(DAG) pool, in which the Kennedy pathwayderived DAG was mostly increased, followed by PC-derived DAG, thereby promoting the synthesis of TAG containing relatively high proportion of C18:1. The increased G3 P levels induced several transcriptional alterations of genes involved in the glycerolipid pathways. In particular, genes encoding the enzymes responsible for de novo glycerolipid synthesis were largely upregulated in the transgenic lines, in-line with the identified biochemical phenotype. These results reveal a key role for GmGPDHp1-mediated G3 P metabolism in enhancing TAG synthesis and demonstrate a strategy to modify the FA compositions of soybean oils for improved nutrition and biofuel. | Ying Zhao Pan Cao Yifan Cui Dongxu Liu Jiapeng Li Yabin Zhao Siqi Yang Bo Zhang Runnan Zhou Minghao Sun Xuetian Guo Mingliang Yang Dawei Xin Zhanguo Zhang Xin Li Chen Lv Chunyan Liu Zhaoming Qi Jingyu Xu Xiaoxia Wu Qingshan Chen | 2021 | Journal of Integrative Plant Biology2021，63，6： | 4 |
| 17 | Petroleum geological characteristics of Kela-2 gas field显示文摘The Kela-2 gas field is located in the center ofKelasu structural belt in Kuqa Depression. This trap is oneof a series of traps in the folded belts which are distributed ina string of pearls in the dual structure. The primary gas-bearing layers are sandstone of Lower Cretaceous K1bswhile the secondary layers are dolomite member and gluten-ite member of Lower Tertiary E1-2km and sandstone ofLower Cretaceous K1b. The main component of natural gasis methane whose content is higher than 97%. It is charac-terized by dry gas whose source rock is Jurassic coal meas-ure. The Kela-2 structural trap was formed during the Xiyuperiod and then became a reservoir in the late time. The res-ervoir formed late and the thick seal rock of Lower Tertiarygipsmantle are the avail reason why the giant Kela-2 gasfield has been well kept. The abnormal high pressure of theKela-2 gas field results from the strong structural compres-sion in the northern part during the Xiyu period. | JIA Chengzao ZHOU Xinyuan WANG Zhaoming LI Qiming PI Xuejun CAI Zhenzhong HU Xiaoyong | 2002 | Chinese Science Bulletin2002，47，S1： | 4 |
| 18 | An Integrated Map of Soybean Physical Map and Genetic Map显示文摘Soybean is a major crop in the world, and it is a main source of plant proteins and oil. A lot of soybean genetic maps and physical maps have been constructed, but there are no integrated map between soybean physical map and genetic map. In this study, soybean genome sequence data, released by JGI (US Department of Energy's Joint Genome Institute), had been downloaded. With the software Blast 2.2.16, a total of 161 super sequences were mapped on the soybean public genetic map to construct an integrated map. The length of these super sequences accounted for 73.08% of all the genome sequence. This integrated map could be used for gene cloning, gene mining, and comparative genome of legume. | QI Zhaoming LI Hui WU Qiong SUN Yanan LIU Chunyan HU Guohua CHEN Qingshan | 2009 | Journal of Northeast Agricultural University(English Edition)2009，16，2： | 3 |
| 19 | Hexagonally arranged arrays of urchin-like Ag hemispheres decorated with Ag nanoparticles for surface-enhanced Raman scattering substrates显示文摘The surface topography of noble metal particles is a significant factor in tailoring surface-enhanced Raman scattering (SERS) properties. Here, we present a simple fabrication route to hexagonally arranged arrays of surface-roughened urchin- like Ag hemispheres (Ag-HSs) decorated with Ag nanoparticles (Ag-NPs) for highly active and reproducible SERS substrates. The urchin-like Ag-HS arrays are achieved by sputtering Ag onto the top surface of a highly ordered porous anodic aluminum oxide (AAO) template to form ordered arrays of smooth Ag-HSs and then by electrodepositing Ag-NPs onto the surface of each Ag-HS. Owing to the ordered arrangement of the Ag-HSs and the improved surface roughness, the urchin-like hierarchical Ag-HS arrays can provide sufficient and uniform "hot spots" for reproducible and highly active SERS effects. Using the urchin-like Ag-HS arrays as SERS substrates, 10-7 M dibutyl phthalate (a member of plasticizers family) and 1.5 × 10-5 M PCB-77 (one congener of polychlorinated biphenyl, a notorious class of pollutants) are identified, showing promising potential for these substrates in the rapid recognition of organic pollutants. | Haibin Tang Guowen Meng Zhongbo Li Chuhong Zhu Zhulin Huang Zhaoming Wang Fadi Li | 2015 | Nano Research2015，8，7： | 3 |
| 20 | Synthesis,photophysical properties and TD-DFT calculation of four two-photon absorbing triphenylamine derivatives显示文摘In this study,linear absorption,single-photon excited fluorescence,fluorescence quantum yields,fluorescence lifetime and two-photon excited fluorescence of a series of triphenylamine derivatives (L1,L2,L3 and L4) have been measured.L1 and L3 are D--A type dyes,while L2 and L4 are D--D--A type dyes (D=donor,A=acceptor).The investigated compounds consist of triphenylamine-bearing donor-substituted and/or systematically extended-conjugated length,which are designed to gain insight into the effect of the ethoxyl unit and-linkage length on the linear and nonlinear optical properties.The influence of solvent polarity on the photophysical properties was investigated.Employing time-dependent density functional theory (TD-DFT) calculations,the structure-property relationships are discussed. | KONG Lin YANG JiaXiang ZHOU HongPing LI ShengLi HAO FuYing ZHANG Qiong TU YuLong WU JieYing XUE ZhaoMing TIAN YuPeng | 2013 | Science China Chemistry2013，56，1： | 3 |
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