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| 1 | Washed microbiota transplantation vs.manual fecal microbiota transplantation:clinical findings,animal studies and in vitro screening显示文摘Fecal microbiota transplantation(FMT)by manual preparation has been applied to treat diseases for thousands of years.However,this method still endures safety risks and challenges the psychological endurance and acceptance of doctors,patients and donors.Population evidence showed the washed microbiota preparation with microfiltration based on an automatic purification system followed by repeated centrifugation plus suspension for three times significantly reduced FMT-related adverse events.This washing preparation makes delivering a precise dose of the enriched microbiota feasible,instead of using the weight of stool.Intraperitoneal injection in mice with the fecal microbiota supernatant obtained after repeated centrifugation plus suspension for three times induced less toxic reaction than that by the first centrifugation following the microfiltration.The toxic reactions that include death,the change in the level of peripheral white blood cells,and the proliferation of germinal center in secondary lymphoid follicles in spleen were noted.The metagenomic next-generation sequencing(NGS)indicated the increasing types and amount of viruses could be washed out during the washing process.Metabolomics analysis indicated metabolites with pro-inflammatory effects in the fecal microbiota supernatant such as leukotriene B4,corticosterone,and prostaglandin G2 could be removed by repeated washing.Near-infrared absorption spectroscopy could be served as a rapid detection method to control the quality of the washingprocess.In conclusion,this study for the first time provides evidence linking clinical findings and animal experiments to support that washed microbiota transplantation(WMT)is safer,more precise and more quality-controllable than the crude FMT by manual. | Ting Zhang Gaochen Lu Zhe Zhao Yafei Liu Quan Shen Pan Li Yaoyao Chen Haoran Yin Huiquan Wang Cicilia Marcella Bota Cui Lei Cheng Guozhong Ji Faming Zhang | 2020 | Protein & Cell2020，11，4： | 44 |
| 2 | Effect of Boschniakia rossica on expression of GSTP,p53 and p21^(ras)proteins in early stage of chemical hepatocarcinogenesis and its anti-inflammatory activities in rats显示文摘AIM To investigate the effect of Boschniakiarossica(BR)extract on expression of GST-P,p53 and p21rasproteins in early stage of chemicalhepatocarcinogenesis in rats and its anti-inflammatory activities.METHODS The expression of tumor marker-placental form glutathione S-transferase(GST-P),p53 and p21rasproteins were investigated byimmunohistochemical techniques and ABCmethod.Anti-inflammatory activities of BR werestudied by xylene and croton oil-induced mouseear edema,carrageenin,histamine and hotscald-induced rat pow edema,adjuvant-inducedrat arthritis and cotton pellet-induced mousegranuloma formation methods.RESULTS The 500 mg/kg of BR-H2O extractfractionated from BR-Methanol extract hadinhibitory effect on the formation of DEN-inducedGST-P-positive foci in rat liver(GST-P stainingwas 78% positive in DEN+AAF group vs 20%positive in DEN+AAF+BR group,P<0.05)andthe expression of mutant p53 and p21rasproteinwas lower than that of hepatic preneoplasticlesions(33% and 22% positive respectively inDEN+AAF group vs negative in DEN+AAF+BRgroup).Both CH2Cl2 and H2O extracts from BRhad anti-inflamatory effect in xylene and crotonoil-induced mouse ear edema(inhibitory rateswere 26%-29% and 35%-59%,respectively). BR-H2O extract exhibited inhibitory effect incarrageenin,histamine and hot scald-inducedhind paw edema and adjuvant-induced arthritis inrats and cotton pellet-induced granulomaformation in mice.CONCLUSION BR extract exhibited inhibitory effect on formation of preneoplastic hepatic foci in early stage of rat chemical hepato-carcinogenesis. Both CH2CI2 and H2O extracts from BR exerted anti-inflammatory effect in rats and mice. | Zong Zhu Yin Hai Ling Jin Xue Zhe Yin Tian Zhu Li Ji Shu Quan Zeng Nan Jin Institute for Cancer Research,Yanbian University College of Medicine,Yanji 133000,Jilin Province,China | 2000 | World Journal of Gastroenterology2000，6，6： | 33 |
| 3 | Signal transducers and activators of transcription 3 mediates up-regulation of angiotensin ll-induced tissue inhibitor of metalloproteinase-1 expression in cultured human senescent fibroblasts显示文摘Backgroud 血管收缩素Ⅱ(Ang Ⅱ) , renin-angiotensinsystem (地岬) 的一个主要受动器并且在老化纸巾增加了,能经由 theG-protein-coupled Ang Ⅱ受体类型Ⅰ(AT1 ) 刺激 JAK/STAT 小径并且导致信号变换器的原子 translocation 和抄写(STAT ) 的使活跃之物。为了推进,在老化探索 Ang Ⅱ的角色,我们在人的 replicative 上检验了 Ang Ⅱ的效果衰老的双成纤维细胞 WI-38 房间。方法人的衰老的 WI-38 房间与 Ang Ⅱ,受体对手 PD123319, valsartan, STAT3 感觉原生质标志,或 STAT3 反感觉原生质被孵化标志。方法被使用 includingelectrophoretic 活动性移动试金(EMSA ) ,西方的污点, transfection,并且激光扫描共焦的显微镜学。有教养的人的衰老的 WI-38 房间组成地表示了 metalloproteinase-1 (TIMP-1 ) 的织物禁止者,这被发现的结果,和 Ang Ⅱ在时间依赖者和剂量依赖者礼貌导致了 TIMP-1 蛋白质表示。Ang Ⅱ在两时间也导致了 STAT-DNA 有约束力的活动 -- 并且剂量依赖者礼貌。并且超级移动试金证明导致 sis 因素(SIF ) 乐队包含了 STAT3 蛋白质。STAT3 反感觉 oligonucleotides 能禁止两项 Ang Ⅱ - inducedSTAT3-DNA 绑定活动以及 TIMP-1 表示。结论 Ang Ⅱ通过激活 STAT3 的起来调整 TIMP-1expression 能在人的衰老的房间表明小径,显示那条 Ang Ⅱ - STAT3-TIMP-1 小径可以在老化纸巾涉及硬化的机制。 | WANG Xiao-dan CHEN Xiang-mei WANG Jian-zhong HONG Quan FENG Zhe FU Bo ZHOU Feng WANG Feng-yang FAN Dai-ming | 2006 | Chinese Medical Journal2006，，13： | 7 |
| 4 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
| 5 | Integrating morphological spatial pattern analysis and the minimal cumulative resistance model to optimize urban ecological networks: a case study in Shenzhen City, China显示文摘Background:With the increasing fragmentation of landscape induced by rapid urbanization,the construction of ecological networks is of great signifcance to alleviate the degradation of urban habitats and protect natural envi‑ronments.However,there is considerable uncertainty when constructing ecological networks,especially the difer‑ent approaches to selecting ecological sources.We used the southern Chinese city of Shenzhen as a study area to construct and optimize ecological networks using a coupling approach.Ecological source areas were extracted using morphological spatial pattern analysis(MSPA)and the landscape index method.Ecological networks were con‑structed using the minimal cumulative resistance(MCR)model and the gravity model.Stepping stones and ecological fault points were added in corridors to optimize the ecological network.Results:Ten core areas with maximum importance patch values were extracted by the landscape index method as ecological source areas according to MSPA,after which corridors between ecological sources were constructed based on the MCR model.The constructed ecological networks were optimized using 35 stepping stones and 17 ecologi‑cal fault points.The optimized ecological networks included 11 important corridors,34 general corridors,and seven potential corridors.The results of corridor landscape-type analysis showed that a suitable ecological corridor is 60 to 200 m wide.Conclusions:Overall,our results imply that ecological source areas can be identifed virtually,and that ecological networks can be signifcantly optimized by combining MSPA and MCR models.These results provide a methodologi‑cal reference for constructing ecological networks,and they will be useful for urban planning and biodiversity protec‑tion in Shenzhen and other similar regions around the world. | Yang‑Yang Li Yu‑Zhe Zhang Zhi‑Yun Jiang Cheng‑Xuan Guo Ming‑Yue Zhao Zhi‑Guang Yang Ming‑Yan Guo Bing‑Yue Wu Quan‑Ling Chen | 2021 | Ecological Processes2021，10，1： | 3 |
| 6 | Design,synthesis characterization and in vitro biological activity of a series of 3-aryl-6-(bromoarylmethyl)-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives as the novel acetylcholinesterase inhibitors显示文摘Bromination 被用作策略在药用的化学改进生物活动。以便在与 7H-thiazolo 的新奇 acetylcholinesterase 禁止者的 structureactivity 关系上学习[ 3,2-b ]-1, 2 , 4-triazin-7-one 支架基于我们的以前的工作并且分子的建模,一系列新奇3-aryl-6-( bromoarylmethyl )-7H-thiazolo[3,2-b]-1, 2 , 4-triazin-7-one 衍生物被分子的停靠设计,由集体系列,红外线的系列,质子 NMR 和元素的分析综合了并且描绘。疼痛的学习禁止的活动与 huperzine 用 Ellman 比色的试金被执行 -- 是的 A 积极控制。大多数所有目标混合物在 10 mol/L 展出了超过 45% 抑制。初步的 structureactivity 关系在在父母原子核的 C6 位置的苯基戒指是溴原子和氢氧根组在目标混合物的疼痛禁止的活动的起的重要角色。 | He Nan Xu Zhe Jin Si Jie Liu Hong Min Liu Shuo Li Huang Quan Lin David Chicheong Wan Chun Hu | 2012 | Chinese Chemical Letters2012，23，7： | 3 |
| 7 | Interpretation and compensation of backlash error data in machine centers for intelligent predictive maintenance using ANNs显示文摘It is especially significant for a manufacturing company to select a proper maintenance policy because maintenance impacts not only on economy,reliability and availability but also on personnel safety.This article reports on research in the backlash error data interpretation and compensation for intelligent predictive maintenance in machine centers based on artificial neural networks(ANNs).The backlash error,measurement system and prediction methods are analyzed in detail.The result indicates that it is possible to predict and compensate for the backlash error in both forward and backward directions in machine centers. | Ke-Sheng Wang Zhe Li JФrgen Braaten Quan Yu | 2015 | Advances in Manufacturing2015，3，2： | 2 |
| 8 | Erratum to Percutaneous transluminal septal myocardial ablation for hypertrophic obstructive cardiomyopathy显示文摘 | Zhan Quan Li Tsung O. Cheng Wei Wei Zhang Shu Bin Qiao Lin Yang Zhao Yuan Zhe Jin Ru Ming Guan Li Liu | 2003 | International Journal of Cardiology2003，，2： | 1 |
| 9 | Ultra-small nanodots coated with oligopeptides providing highly negative charges to enhance osteogenic differentiation of hBMSCs better than osteogenic induction medium显示文摘For bone regenerative engineering,it is a promising method to form skeletal tissues differentiating from human bone morrow mesenchyme stem cells(hBMSCs).However,it is still a critical challenge to efficiently control ostogenesis and clearly reveal the influence factor.To this end,the fluorescent gold nanodots(Au NDs) with highly negative charges as osteogenic induction reagent are successfully synthesized,which display better than commercial osteogenic induction medium through the investigations of ALP activity(2.5 folds) and cytoskeleton staining(1.5 folds).Two kinds of oligopeptides with different bio-structures(cysteine,Cys and glutathione,GSH) are selected for providing surficial charges on Au NDs.It is revealed that Au-Cys with more negative charges(-51 mV) play better role than Au-GSH(-19 mV) in osteogenic differentiation,when both of them have same size(~2 nm),sphere shape and show similar cell uptake amount.To explore deeply,osteogenesis related signaling pathways are monitored,revealing that the enhancement of osteogenic differentiation was through autophagy signaling pathway triggered by Au-Cys.And the promotion of highly negative charges in osteogenic diffe rentiation was further proved via sliver nanodots(Ag NDs,Ag-Cys and Ag-GSH) and carbon nanodots(CDs,Cys-CDs and GSH-CDs).This work indicates part of insights during hBMSCs differentiation and provides a novel strategy in osteogenic differentiation process. | Yueqi Zhao Lin Meng Kai Zhang Yuanqing Sun Yue Zhao Zhe Yang Yangliu Lin Xinrui Liu Hongchen Sun Bai Yang Quan Lin | 2021 | Chinese Chemical Letters2021，32，1： | 1 |
| 10 | Analysis of clinical characteristics and treatment of pancreatic cystic tumors显示文摘Objective: To summarize experience in the diagnosis and treatment of pancreatic cystic neoplasms.Methods: This is a retrospective study of 207 patients who were diagnosed with pancreatic cystic tumors at Peking Union Medical College Hospital between Jan 2009 and Mar 2014.Clinical data, such as clinical manifestations, radiological and pathological images and surgical recordings, were collected.Results: Of the 207 included patients, females accounted for 76.81%, and the mean patient age was 52.04 years.Malignancy was more common in older patients who presented with marasmus and jaundice.Other risk factors included solid components in the tumor, a large tumor size, and elevated levels of tumor markers.Surgical treatment was required when a malignant tumor was suspected.The operation approach was selected based on the location, size and characteristics of the tumor.The position of the tumor relative to the pancreatic duct also played a significant role.Conclusions: No specific symptoms were observed for the patients with pancreatic cystic tumors.Imaging played an important role in making a differential diagnosis.Furthermore, surgical treatment should be proposed for patients with significant symptoms and potentially malignant tumors.The tumor resection rate is high, suggestive of good prognosis. | Lei You Jianchun Xiao Zhe Cao Wanying Zhang Quan Liao Menghua Dai Taiping Zhang Yupei Zhao | 2016 | Chinese Journal of Cancer Research2016，28，5： | 1 |
| 11 | In situ synthesis of metallophthalocyanines in inorganic matrix显示文摘 | Zhan Hong - bing Wang Min -quan Chen Wen - zhe | 2002 | Materiais Letters2002，55，： | 1 |
| 12 | Screening method for substrates of multidrug resistance-associated protein显示文摘 | Zhe Quan Takeaki Ozawa | 2000 | Anal Chim Acta2000，423，2： | 1 |
| 13 | Effect of IFN on caspase-3, Bcl-2 and Bax expression, and apoptosis in rabbit placenta 显示文摘 | Zhe L Quan H Ying Y | 2003 | Cytokine2003，24，： | 1 |
| 14 | Efficacy of Extracorporeal Shockwave Therapy for Knee Osteoarthritis: A Randomized Controlled Trial显示文摘 | Zhe Zhao Rufang Jing Zhan Shi Bing Zhao Quan Ai Gengyan Xing | 2013 | Journal of Surgical Research2013，，： | 1 |
| 15 | Evaluation of a sequential extraction procedure for the fractionation of amorphous iron and manganese oxides a nd organic matter in soils显示文摘 | Tu Qiang Shan Xiao quan Ni Zhe ming | 1994 | Total Environ1994，151，： | 1 |
| 16 | Effect of IFN-γ on caspase-3,Bcl-2 and Bax expression,and apoptosis in rabbit placenta显示文摘 | Zhe Liu Quan Hong Sun Ying Yang | 2003 | Cytokine2003，24，： | 1 |
| 17 | Efficacy of extracorporeal shockwave therapy for knee osteoarthritis: a randomized controlled trial显示文摘 | Zhe Zhao Rufang Jing Zhan Shi Bin Zhao Quan Ai Gengyan Xing | 2013 | Journal of Surgical Research2013，，2： | 1 |
| 18 | Efficacy of Extracorporeal Shockwave Therapy for Knee Osteoarthritis: A Randomized Controlled Trial显示文摘 | Zhe Zhao Rufang Jing Zhan Shi Bing Zhao Quan Ai Gengyan Xing | 2013 | Journal of Surgical Research2013，，： | 1 |
| 19 | Enhancing capillary liquid chromatography/tandem mass spectrometry of biogenic amines by pre-column derivatization with 7-fuloro-4-nitrobenzoxadiazole 显示文摘 | Yaru Song Zhe Quan Joseph L Evans | 2004 | Rapid Commun Mass Spectrum2004，18，： | 1 |
| 20 | Correlations between serum levels of 25-hydroxyvitamin D and carotid atherosclerosis in patients with type 2 diabetes in Shanghai显示文摘 | Rui-hua Chen Xiao-zhen Jiang Quan Jiang Zhe Gu Pei-li Gu Bin Zhou Zhen-hong Zhu Lin-yan Xu Yu-feng Zou | 2014 | Annales d’Endocrinologie2014，，4： | 1 |
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