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| 1 | Molecular Typing of Brucella Suis Collected from 1960s to 2010s in China by MLVA and PFGE显示文摘Brucellosis is a bacterial anthropozoonosis usually caused by Brucella abortus, Brucella melitensis, Brucella suis and Brucella canis. Brucella suis, the causative agent of swine brucellosis, is classified into five biovars and preferentially infects different animal hosts [1] . | LI Zhen Jun CUI Bu Yun CHEN Hai CHEN Jing Diao ZHAO Hong Yan PIAO Dong Ri JIANG Hai ZHANG Li TANG Xu KE Chang Wen YAO zhen TIAN Guo Zhong | 2013 | Biomedical and Environmental Sciences2013，26，6： | 13 |
| 2 | Novel adaptive neural control of flexible air-breathing hypersonic vehicles based on sliding mode differentiator显示文摘A novel adaptive neural control strategy is exploited for the longitudinal dynamics of a generic flexible air-breathing hypersonic vehicle(FAHV).By utilizing functional decomposition method, the dynamics of FAHV is decomposed into the velocity subsystem and the altitude subsystem.For each subsystem, only one neural network is employed for the unknown function approximation.To further reduce the computational burden, minimal-learning parameter(MLP)technology is used to estimate the norm of ideal weight vectors rather than their elements.By introducing sliding mode differentiator(SMD) to estimate the newly defined variables, there is no need for the strict-feedback form and virtual controller.Hence the developed control law is considerably simpler than the ones derived from back-stepping scheme.Finally, simulation studies are made to illustrate the effectiveness of the proposed control approach in spite of the flexible effects, system uncertainties and varying disturbances. | Bu Xiangwei Wu Xiaoyan Ma Zhen Zhang Rui | 2015 | Chinese Journal of Aeronautics2015，28，4： | 11 |
| 3 | Upconversion nano-photosensitizer targeting into mitochondria for cancer apoptosis induction and cyt c fluorescence monitoring显示文摘反应的氧种类(mitoROS ) 玩的 mitochondrial 的混乱在癌症房间 apoptosis 的一个主要角色。这里,我们设计了 core/shell-structured 有由 photosensitizer (PS ) 涂的核心合并了的做 lanthanide 的 upconversion nanoparticle (UCNP ) 的指向线粒体的基于 upconversion 的使 nano 具有感光性(TPP-UC (PS )) 稠密的硅石壳。有外部在红外线附近的激光(NIR ) 的后面的照耀,在引起为激活的基于 upconversion 的光力学的治疗(UC 太平洋夏季时间) 胀大的严肃的 mitochondrial 矩阵的线粒体的 TPP-UC (PS ) ,和细胞色素 c (cyt c ) 的动员响应增加的 mitoROS 被放大。明确地,这包含 heme cyt c 能被改变 TPP-UC (PS ) s upconversion 光信号(UCL ) 监视,它可以便于在里面为 apoptosis 研究的 cyt c 的 situ 察觉。作为概念的一个证明,我们的设计 TPP-UC (PS ) 可以为在 NIR 刺激下面控制癌症房间 apoptosis 并且为用动态 UCL 学习 apoptosis 提供重要机会,它被本地 cyt c 影响。 | Yanyan Liu Jiawen Zhang Changjing Zuo Zhen Zhang Dalong Ni Chen Zhang Jing Wang Hui Zhang Zhenwei Yao Wenbo Bu | 2016 | Nano Research2016，9，11： | 8 |
| 4 | Efficacy and safety of Yunxiangjing derived from Chinese herbal medicine administered as an enema in the management of acute radiation-induced proctitis in patients with pelvic malignancy显示文摘OBJECTIVE: To assess the efficacy and safety of Yunxiangjing(YXJ), derived from Chinese herbal medicine, in the management of acute radiation-induced proctitis(ARIP) in patients with pelvic malignancy.METHODS: Forty-eight patients with grade 2 ARIP were administered YXJ as an enema(1∶30 dilution)for 2 weeks and followed up for 2 years. All were assessed for response and ARIP grade. Quality of life(QOL) was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30.RESULTS: Of the 48 patients, six(12.5%) achieved complete remission of ARIP and 28(58.3%) showed a decrease from grade 2 to grade 1 ARIP. No patient experienced a grade ≥3 toxicity. At the end of radiotherapy, patients showed significant improvements in QOL(P < 0.05). Two years after treatment, 46 patients showed no late toxicity, with only two experiencing grade 1 late toxicity.CONCLUSION: YXJ can be used as an enema to manage acute radiation-induced proctitis in cancer patients undergoing radiotherapy. These findings suggest that YXJ enema may be an alternative treatment of ARIP. | Tang Huaying Huang Yinchun Mo Xingneng Yi Guisheng Wen Hui Guo Zhen Feng Kaihua Liu Yin Bu Qing Jiang Wei | 2016 | Journal of Traditional Chinese Medicine2016，36，1： | 7 |
| 5 | Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering显示文摘Dear Editor,Type1diabetes(T1D)isa lifelong(chronic)disease and a major health problem throughout the world.This disease can be treatedby either insulin injection or islet transplantation.Islet transplantation is considered as a better treatment for T1D patients,because islets can produce and release insulin at the appropriate time,resulting in tight blood glucose control. | Yi Yang Kepin Wang Han Wu Qin Jin Degong Ruan Zhen Ouyang Bentian Zhao Zhaoming Liu Yu Zhao Quanjun Zhang Nana Fan Qishuai Liu Shimei Guo Lei Bu Yong Fan Xiaofang Sun Xiaoping Li Liangxue Lai | 2016 | Journal of Molecular Cell Biology2016，8，2： | 6 |
| 6 | PTEN-L promotes type I interferon responses and antiviral immunity显示文摘Phosphatase and tensin homolog deleted on chromosome ten(PTEN)is a well-known tumor suppressor that acts as a dual-specificity phosphatase and is frequently mutated in human cancer.Our previous work has demonstrated that PTEN also plays a vital role in type I interferon responses and antiviral innate immunity.Recently,a translational variant of PTEN with a long N-terminal extension(PTEN-L)has been discovered that is secreted into the extracellular environment and enters recipient cells,where it exerts a phosphatase function antagonistic to PI3K/Akt signaling and tumorigenesis.In this study,we demonstrate that PTEN-L promotes type I interferon responses and antiviral innate immunity during viral infection in a phosphatase activity-dependent manner.Compared with canonical PTEN,PTEN-L also exerts its antiviral function when it is applied exogenously in protein form.This finding was confirmed in cell cultures and mouse infection models.Furthermore,PTEN-L enhances the responses of both type I interferon and proinflammatory cytokines,thus suggesting that PTEN-L might possess additional functions compared with those of PTEN.Thus,the antiviral function of PTEN-L may open an avenue for the use of PTEN-L in antiviral therapy,particularly in patients with PTEN-deficient tumors. | Yuanyuan Cao Hongyun Wang Liu Yang Zhen Zhang Chenlin Li Xu Yuan Lang Bu Lang Chen Yu Chen Chun-Mei Li Deyin Guo | 2018 | Cellular & Molecular Immunology2018，15，1： | 3 |
| 7 | Prognosis of patients with gastric cancer and solitary lymph node metastasis显示文摘AIM:To investigate the relationship of solitary lymph node metastasis(SLNM)and age with patient survival in gastric cancer(GC).METHODS:The medical records databases of China’s Beijing Cancer Hospital at the Peking University School of Oncology and Shanghai Tenth People’s Hospital affiliated to Tongji University were searched retrospectively to identify patients with histologically proven GC and SLNM who underwent surgical resection between October 2003 and December 2012.Patients with distant metastasis or gastric stump carcinoma following resection for benign disease were excluded from the analysis.In total,936 patients with GC+SLNM were selected for analysis and the recorded parameters of clinicopathological disease and follow-up(range:13-2925 d)were collected.The Kaplan-Meier method was used to stratify patients by age(≤50 years-old,n=198;50-64 years-old,n=321;≥65 years-old,n=446)and by metastatic lymph node ratio[MLR<0.04(1/25),n=180;0.04-0.06(1/25-1/15),n=687;≥0.06(1/15),n=98]for 5-year survival analysis.The significance of intergroup differences between the survival curves was assessed by a log-rank test. RESULTS:The 5-year survival rate of the entire GC+SLNM patient population was 49.9%.Stratification analysis showed significant differences in survival time(post-operative days)according to age:≤50 yearsold:950.7±79.0 vs 50-64 years-old:1697.8±65.9 vs≥65 years-old:1996.2±57.6,all P<0.05.In addition,younger age(≤50 years-old)correlated significantly with mean survival time(r=0.367,P<0.001).Stratification analysis also indicated an inverse relationship between increasing MLR and shorter survival time:<0.04:52.8%and 0.04-0.06:51.1%vs≥0.06:40.5%,P<0.05.The patients with the shortest survival times and rates were younger and had a high MLR(≥0.06):≤50 years-old:496.4±133.0 and 0.0%vs 50-65 years-old:1180.9±201.8 and 21.4%vs≥65 years-old:1538.4±72.4 and 37.3%,all P<0.05.The same significant trend in shorter survival times and rates for younger patients was seen with the mid-range MLR group(0.04-0.06),but the difference between the two older groups was not significant.No significant differences were found between the age groups of patients with MLR<0.04.Assessment of clinicopathological parameters identified age group,Borrmann type,histological type and tumor depth as the most important predictors of the survival rates and times observed for this study population.CONCLUSION:GC patients below 51 years of age with MLR of SLNM above 0.06 have shorter life expectancy than their older counterparts. | Chun-Qiu Chen Xiao-Jiang Wu Zhen Yu Zhao-De Bu Ke-Qiang Zuo Zi-Yu Li Jia-Fu Ji | 2013 | World Journal of Gastroenterology2013，19，46： | 3 |
| 8 | Association of Polygenic Risk Score with Age at Onset and Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease in a Chinese Cohort显示文摘To evaluate whether the polygenic profile modifies the development of sporadic Alzheimer’s disease(sAD)and pathological biomarkers in cerebrospinal fluid(CSF),462 sAD patients and 463 age-matched cognitively normal(CN)controls were genotyped for 35 singlenucleotide polymorphisms(SNPs)that are significantly associated with sAD.Then,the alleles found to be associated with sAD were used to build polygenic risk score(PRS)models to represent the genetic risk.Receiver operating characteristic(ROC)analyses and the Cox proportional hazards model were used to evaluate the predictive value of PRS for the sAD risk and age at onset.We measured the CSF levels of Aβ42,Aβ42/Aβ40,total tau(T-tau),and phosphorylated tau(P-tau)in a subgroup(60 sAD and 200 CN participants),and analyzed their relationships with the PRSs.We found that 14 SNPs,including SNPs in the APOE,BIN1,CD33,EPHA1,SORL1,and TOMM40 genes,were associated with sAD risk in our cohort.The PRS models built with these SNPs showed potential for discriminating sAD patients from CN controls,and were able to predict the incidence rate of sAD and age at onset.Furthermore,the PRSs were correlated with the CSF levels of Aβ42,Aβ42/Aβ40,T-tau,and P-tau.Our study suggests that PRS models hold promise for assessing the genetic risk and development of AD.As genetic risk profiles vary among populations,large-scale genome-wide sequencing studies are urgently needed to identify the genetic risk loci of sAD in Chinese populations to build accurate PRS models for clinical practice. | Wei-Wei Li Zhen Wang Dong-Yu Fan Ying-Ying Shen Dong-Wan Chen Hui-Yun Li Ling Li Heng Yang Yu-Hui Liu Xian-Le Bu Wang-Sheng Jin Fan Zeng Zhi-Qiang Xu Jin-Tai Yu Li-Yong Chen Yan-Jiang Wang | 2020 | Neuroscience Bulletin2020，36，7： | 3 |
| 9 | Phase Chemistry Study of the Zabuye Salt Lake Brine:Isothermal Evaporation at 15℃ and 25℃显示文摘Zabuye Salt Lake in Tibet,China is a carbonate-type salt lake,which has some unique characteristics that make it different from other types of salt lakes.The lake is at the latter period in its evolution and contains liquid and solid resources.Its brine is rich in Li,B,K and other useful minor elements that are of great economic value.We studied the concentration behavior of these elements and the crystallization paths of salts during isothermal evaporation of brine at 15℃and 25℃.The crystallization sequence of the primary salts from the brine at 25℃is halite(NaCl)→aphthitalite (3K_2SO_4·Na_2SO_4)→zabuyelite(Li_2CO_3)→trona(Na_2CO_3·NaHCO_3·2H_2O)→thermonatrite (Na_2CO_3·H_2O)→sylvite(KCl),while the sequence is halite(NaCl)→sylvite(KCl)→trona (Na_2CO_3·NaHCO_3·2H_2O)→zabuyelite(Li_2CO_3)→thermonatrite(Na_2CO_3·H_2O)→aphthitalite (3K_2SO_4·Na_2SO_4) at 15℃.They are in accordance with the metastable phase diagram of the Na^+,K^+-Cl^-, CO_3^(2-),SO_4^(2-)-H_2O quinary system at 25℃,except for Na_2CO_3·7H_2O which is replaced by trona and thermonatrite.In the 25℃experiment,zabuyelite(Li_2CO_3) was precipitated in the early stage because Li_2CO_3 is supersaturated in the brine at 25℃,in contrast with that at 15℃,it precipitated in the later stage.Potash was precipitated in the middle and late stages in both experiments,while boron was concentrated in the early and middle stages and precipitated in the late stage. | NIE Zhen BU Lingzhong ZHENG Mianping ZHANG Yongsheng | 2010 | Acta Geologica Sinica(English Edition)2010，84，6： | 2 |
| 10 | Physicochemical Properties of Bi-containing Ionic Liquid Analogs Based on Choline Chloride显示文摘 | BU Luxia LIU Daying WEI Zhen MA Zhanlin | 2017 | Chemical Research in Chinese Universities2017，33，6： | 2 |
| 11 | Identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma and stratification by integrative multi-omics analysis显示文摘 | Ruoyu Miao Haitao Luo Huandi Zhou Guangbing Li Dechao Bu Xiaobo Yang Xue Zhao Haohai Zhang Song Liu Ying Zhong Zhen Zou Yan Zhao Kuntao Yu Lian He Xinting Sang Shouxian Zhong Jiefu Huang Yan Wu Rebecca A. Miksad Simon C. Robson Chengyu Jiang Yi Zhao Haita | 2014 | Journal of Hepatology2014，，： | 2 |
| 12 | Expression of the simian virus 40 large tumor antigen (Tag) and formation of Tag-p53 and Tag-pRb complexes in human brain tumors 显示文摘 | Zhen HN Zhang X Bu XY | 1999 | Cancer1999，86，10： | 1 |
| 13 | Expression and localization of urokinase-type plasminogen activator gene in gliomas显示文摘 | Zhang Z Bu XY Zhen HN | 2000 | J Clin Neurosci2000，7，2： | 1 |
| 14 | Prognostic significance of tumor grading and staging in mammary carcinomas with neuroendocrine differentiation显示文摘 | Zhen Tian Bing Wei Feng Tang Wei Wei Michael Z. Gilcrease Lei Huo Constance T. Albarracin Erika Resetkova Lavinia Middleton Aysegul Sahin Yan Xing Kelly K. Hunt Jieqing Chen Hong Bu Asif Rashid Susan C. Abraham Yun Wu | 2011 | Human Pathology2011，，8： | 1 |
| 15 | Wind tunnel experiments on wind-induced natural ventilation rate in residential basements with areaway space显示文摘 | BU Zhen Kato S Takahashi T | 2010 | Building and Environment2010，45，10： | 1 |
| 16 | New criteria for assessing local wind environment at pedestrian level based on exceedance probability anal ysis显示文摘 | Zhen Bu Kato S Ishida Y | 2009 | Building and Environment2009，44，7： | 1 |
| 17 | New criteria for assessing local wind environment at pedestrian level based on exceedance probability analysis显示文摘 | Zhen Bu Shinsuke Kato Yoshihiro Ishida | 2009 | Building and Environment2009，44，7： | 1 |
| 18 | Prognostic significance of tumor grading and staging in mammary carcinomas with neuroendocrine differentiation显示文摘 | Zhen Tian Bing Wei Feng Tang Wei Wei Michael Z. Gilcrease Lei Huo Constance T. Albarracin Erika Resetkova Lavinia Middleton Aysegul Sahin Yan Xing Kelly K. Hunt Jieqing Chen Hong Bu Asif Rashid Susan C. Abraham Yun Wu | 2011 | Human Pathology2011，，8： | 1 |
| 19 | ABCB6 mutations cause ocular coloboma 显示文摘 | WANG L HE F BU J ZHEN Y L1U X DU W | 2012 | Am J Hum Genet2012，90，1： | 1 |
| 20 | Experimental study of natural brine solar ponds in Tibet显示文摘 | NIE Zhen BU Ling-zhong ZHENG Mian-ping HUANG Wei-nong | 2011 | Solar Energy2011，85，7： | 1 |
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