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| 1 | Trends of foodborne diseases in China: lessons from laboratory- based surveillance since 2011显示文摘Foodborne 疾病是世界范围的最重要的公共健康问题之一。中国在食物链的所有方面面对各种各样、崭新的挑战。从从 2013 ~ 2016 的基于实验室的 foodborne 疾病监视系统的数据,以及不同区域和年龄,能在与多样的特征检测的病原体的模式与差别一起被发现。Vibrio parahaemolyticus 是在中国的传染腹泻的领先的原因,特别在在沿海的区域的成年人之中。沙门氏菌是为实质的社会经济的负担负责的严肃、广泛地分布式的病原体。Shigella 主要在 5 年下面在孩子之中与开发更少的区域在西北中国和内陆省(河南省) 被识别。从从 2011 ~ 2016 报导系统的 foodborne 疾病爆发的数据证明有毒的动物和为大多数死亡负责的植物因素在在西南区域的遥远的区域是有毒的蘑菇(54.7%) 。引起了报导的大多数案例(42.3%) 的生物危险被归因于 V。parahaemolyticus, foodborne 爆发的领先的原因。在这评论,我们在中国总结最近的监视途径到 foodborne 疾病并且在发达国家把结果与那些作比较。 | Jikai Liu Li Bai Weiwei Li Haihong Han Ping Fu Xiaochen Ma Zhenwang Bi Xiaorong Yang Xiuli Zhang Shiqi Zhen Xiaoling Deng Xiumei Liu Yunchang Guo | 2018 | Frontiers of Medicine2018，12，1： | 55 |
| 2 | Correlation of N-myc downstream-regulated gene 1 overexpression with progressive growth of colorectal neoplasm显示文摘AIM:To study the function of N-myc downstream-regulated gene 1 (NDRG1) in colorectal carcinogenesis and its correlation with tumor lymph node metastasis,METHODS:NDRG1 was detected at its protein level by immunohistochemistry (IHC) and image analysis (IA), and NDRG1 mRNA was detected by in situ hybridization (ISH) in formalin-fixed and paraffin-embedded sections with a total of 190 specimens including 38 normal colorectal mucosae, 31 colorectal adenomas, 45 non-metastatic colorectal carcinomas (CRCs), 38 metastatic primary CRC and subsequently regional lymph nodes respectively. At the same time, the correlations of NDRG1 with sex, age of patients and histological types of colorectal carcinomas were observed.RESULTS: NDRG1 proteins were gradually increased in colorectal carcinogenesis (P<0.05 or P<0.01). There was a significant difference in the expression of NDRG1 between non-metastatic and metastatic CRCs (P<0.05), and the correlation was positive (P<0.01, rs=0.329). However, there was no obvious difference in the expression of NDRG1 between the primary sites of CRCs and that in the metastatic sites of corresponding regional lymph nodes, nor was there an apparent difference in sex, age, and histological types.The expression of NDRG1 mRNA was generally in concordance with that of NDRG1 protein.CONCLUSION: NDRG1 gene may play an important role in colorectal carcinogenesis.In addition, NDRG1 may be a putative tumor metastasis promoter gene and is regarded as one of the molecular biological markers that can forecast early metastasis of CRCs. NDRG1 gene in the metastatic sites of regional lymph nodes may preserve its expression characteristics in the primary sites of CRCs to some extent.The expression of NDRG1 is not affected by sex, age and histological types. The role of NDRG1 in tumor metastatic process can be demonstrated by in vivo and in vitro. | ZhenWang FangWang wei-QiWang QianGao Wan-LiWei YunYang Guo-YingWang | 2004 | World Journal of Gastroenterology2004，10，4： | 33 |
| 3 | Conserved Functions of Arabidopsis and Rice CC-Type Glutaredoxins in Flower Development and Pathogen Response显示文摘Glutaredoxins (GRX ) 是无所不在的 oxidoreductases 由在各种各样的有机体减少二硫化物响应氧化应力起一个关键作用。在 planta,三个不同 GRX 班根据他们的活跃地点主题被识别了。CPYC 和 CGFS 班在所有有机体被发现,而 CC 类型班为更高的陆地植物是特定的。最近,二 Arabidopsis CC 类型 GRX, ROXY1 和 ROXY2,被显示在花瓣和花药开始和区别施加关键功能。在远地相关的 monocots 分析 CC 类型 GRX 的功能,我们孤立并且描绘 ROXY1 的 OsROXY1 和 OsROXY2two 米饭相当或相同的事物。两基因在植物、繁殖的阶段被表示。尽管米饭花形态学从 eudicots 是不同的, OsROXY1/2 花的表示模式类似于他们的 Arabidopsis 对应物 ROXY1/2。互补实验证明 OsROXY1 和 OsROXY2 罐头充分救 roxy1 花的变异的显型。在 Arabidopsis 的 OsROXY1, OsROXY2,和 ROXY1 的 Overexpression 引起类似的植物、繁殖的植物发展缺点。ROXY1 和它的米饭相当或相同的事物因此在 eudicot 和 monocot 花开发期间施加一个保存函数。惊人地,这些 CC 类型 GRX 的 overexpression 也从 necrotrophic 病原体 Botrytis cinerea 导致氢过氧化物层次和超的增加的累积到感染,揭示在花机关开发和病原体防卫的平衡氧化还原作用过程的重要性。 | ZhenWang Shuping Xing Rainer R Birkenbihl Sabine Zachgo | 2009 | Molecular Plant2009，2，2： | 13 |
| 4 | G protein-coupled receptors: bridging the gap from the extracellular signals to the Hippo pathway显示文摘河马小径在机关尺寸控制是关键的,而它的 dysregulation 贡献机关退化或 tumorigenesis。MST1/2 和 LATS1/2 和联合抄写激活剂 YAP/TAZ 的 kinase 串联代表河马小径的核心部件。广泛的研究识别了河马小径的很多个在上游的管理者,包括房间极性和房间连接的接触抑制,技工压力,细胞外的矩阵僵硬,细胞骨架重新整理,和一些分子。然而,弥漫的细胞外的信号怎么调整河马小径,很长时间难倒研究人员。出人意料地,最近的漂亮研究表明了一些 G 联合蛋白质的受体(GPCR ) 的那刺激,例如由支持肌动朊细胞骨架的激活的受体 PAR1,原因有势力 YAP/TAZ dephosphorylation 和激活装配的 lysophosphatidic 酸受体, sphingosine-1-phosphate 受体,和朊酶。在这评论,我们简短在癌症房间由 GPCR 和 G 蛋白质关于河马小径的规定描述最近的进步上的河马小径和焦点的部件。另外,我们也讨论在人的癌症指向河马小径的潜在的治疗学的角色。 | Xin Zhou ZhenWang Wei Huang Qun-Ying Lei | 2015 | Acta Biochimica et Biophysica Sinica2015，47，1： | 7 |
| 5 | Effects of AGEs on Oxidation Stress and Antioxidation Abilities in Cultured Astrocytes显示文摘Objective To investigate whether two kinds of in vitro prepared advanced glycation end products (AGEs), Glu-BSA and Gal-BSA, could change oxidation stress and anti-oxidation abilities in astrocytes, and thus might contribute to brain injury. Methods Changes of GSH, MDA, SOD,MAO-B, nitric oxide were measured after AGEs treatment. Results Both 0.1 g/L Glu-BSA and Gal-BSA could slightly decrease GSH level, while 1 g/L of them significantly decreased GSH level by 35% and 43% respectively. The MDA levels of both 1 g/L AGEs treated groups (306±13 and 346±22) were higher than that of the normal group (189±18), which could be inhibited by free radical scavenger NAC. The SOD activities of both 1 g/L AGEs treated groups (67.0±5.2 and 74.0±11.0)were lower than that of the normal group (85.2±8.0). Both 0.1 g/L AGEs could slightly increase the activity of MAO-B, while 1 g/L of them could increase MAO-B activity by 1.5 and 1.7 folds respectively. Both AGEs stimulation could produce NO level by 1.7 and 2 folds respectively.Conclusion Enhanced levels of astrocytic oxidation stress and decrease of antioxidation abilities may contribute to, at least partially, the detrimental effects of AGEs in neuronal disorders and aging brain. | JIAN-MINGJIANG ZHENWANG DIAN-DONGLI | 2004 | Biomedical and Environmental Sciences2004，17，1： | 7 |
| 6 | Apelin-13 inhibits lipoprotein lipase expression via the APJ/PKCα/miR-361-5p signaling pathway in THP-1 macrophage-derived foam cells显示文摘动脉粥样硬化患者损害被丰富的类脂化合物和长期的发炎的累积描绘。以前的研究显示了导出巨噬细胞的脂蛋白脂肪分解酵素(LPL ) 由加速类脂化合物累积和支持 inflammatory cytokine 分泌物支持动脉粥样硬化前进。尽管 apelin-13 被认为是一个 atheroprotective 因素,它是否能调整 LPL 的表示,仍然保持不清楚。这研究的目的是在 THP-1 导出巨噬细胞的泡沫房间在 LPL 和内在的机制的表示上探索 apelin-13 的效果。Apelin-13 显著地减少了在 10 和 100 nM 的集中的全部的胆固醇,免费胆固醇,和胆固醇酉旨的细胞的层次。ELISA 分析证实有 apelin-13 的处理减少了支持 inflammatory cytokine 分泌物,例如 interleukin-6 (IL-6 ) , interleukin-1 (IL-1 ) 和肿瘤坏死 factor-alpha (TNF-) 。apelin-13 禁止了由西方的污点和即时 PCR 分析揭示了的 LPL 的表示,这也被发现。生物信息学分析和双酶的记者试金直接显示了那 miR-361-5p downregulated 由指向 LPL 的 3UTR 的 LPL 的表示。另外, apelin-13 + miR-361-5p 显著地模仿 downregulated 在房间的 LPL 的表示。最后,我们表明了那 apelin-13 downregulated 通过激活 PKC 的活动的 LPL 的表示。一起拿,我们的结果显示出那 apelin-13 downregulated 经由激活在 THP-1 导出巨噬细胞的泡沫房间表明小径的 APJ/PKC/miR-361-5p 的 LPL 的表示,导致类脂化合物累积和支持 inflammatory cytokine 分泌物的抑制。因此,我们的研究由 apelin-13 提供重要新卓见进类脂化合物累积和支持 inflammatory cytokine 分泌物的抑制,并且在动脉粥样硬化作为一个有希望的治疗学的目标加亮 apelin-13。 | Xin Zhang Qiong Ye Duo Gong Yuan Lv Haipeng Cheng Chong Huang Lingyan Chen Zhenwang Zhao Liang Li Xie Wei Min Zhang Xiaodan Xia Xiaohua Yu Xilong Zheng Shuzhi Wang Zongbao Wang Chaoke Tang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，6： | 6 |
| 7 | Interleukin-5 promotes ATP-binding cassette transporter A1 expression through miR-211/JAK2/STAT3 pathways in THP-1-dervied macrophages显示文摘Interleukin-5 (IL-5) is manifested as its involvement in the process of atherosclerosis, but the mechanism is still unknown. In this study, we explored the effect of IL-5 on lipid metabolism and its underlying mechanisms in THP-1-derived macrophages. The quantitative polymerase chain reaction (qPCR) and western blot analysis results showed that IL-5 significantly up-regulated ATP-binding cassette transporter A1 (ABCA1) expression in a dose-dependent and time-dependent manner. [3H]-labeled cholesterol was used to assess the levels of cholesterol efflux, and the results showed that IL-5 increased ABCA1-mediated cholesterol efflux. A high-performance liquid chromatography assay indicated that cellular cholesterol content was decreased by IL-5 treatment in THP-1-derived macrophages. The selective inhibitor and small interfering RNA were used to block the Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) pathway. The results of the qPCR and western blot analysis showed that IL-5 activated JAK2/STAT3 pathway to up-regulate ABCA1 expression. Meanwhile, IL-5 reduced the expression level of miR-211. Furthermore, we found that JAK2 is a target gene of miR-211 and miR-211 mimic inhibited the expression of JAK2 and reduced the levels of p-STAT3 and ABCA1 as revealed by luciferase reporter assay, qPCR and western blot analysis. In summary, these findings indicated that IL-5 promotes ABCA1 expression and cholesterol efflux through the miR-211/JAK2/STAT3 signaling pathway in THP-1-derived macrophages. | Kong Chen Zhenwang Zhao Gang Wang Jin Zou Xiaohua Yu Dawei Zhang Gaofeng Zeng Chaoke Tang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 3 |
| 8 | Patient-Specific Design and Biomechanical Evaluation of a Novel Bipolar Femoral Hemi-Knee Prosthesis显示文摘 | Qin Lian Dichen Li Zhongmin Jin ZhenWang Yuhan Sun | 2014 | Journal of Bionic Engineering2014，11，2： | 3 |
| 9 | Myristica fragrans promotes ABCA1 expression and cholesterol efflux in THP-1-derived macrophages显示文摘Myristica fragrans is a traditional herbal medicine and has been shown to alleviate the development of atherosclerosis.However,the anti-atherogenic mechanisms of M.fragrans are still to be addressed.In this study,we explored the effect of M.fragrans on lipid metabolism and inflammation and its mechanisms in THP-1-derived macrophages.The quantitative polymerase chain reaction and western blot analysis results showed that M.fragrans promotes cholesterol efflux from THP-1-derived macrophages and reduces intracellular total cholesterol,cholesterol ester,and free cholesterol contents in a dose-and a time-dependent manner.Further study found that liver X receptor alpha(LXRα)antagonist GGPP significantly blocked the upregulation of ABCA1 expression with M.fragrans treatment.In addition,chromatin immunoprecipitation assay confirmed that GATA binding protein 3(GATA3)can bind to the LXRαpromoter,and inhibition of GATA3 led to the downregulation of LXRαand ATP-binding cassette subfamily A member 1 expression.Furthermore,M.fragrans reduced lipid accumulation,followed by decreasing tumor necrosis factor-α,interleukin(IL)-6,and IL-1βand increasing IL-10 produced by THP-1-derived macrophages.Therefore,M.fragrans is identified as a valuable therapeutic medicine for atherosclerotic cardiovascular disease. | Shangming Liu Jiahui Gao Linhao He Zhenwang Zhao Gang Wang Jin Zou Li Zhou Xiangjun Wan Shilin Tang Chaoke Tang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，1： | 2 |
| 10 | Atmospheric oxidizing capacity in autumn Beijing:Analysis of the O_(3) and PM_(2.5) episodes based on observation-based model显示文摘Atmospheric oxidizing capacity(AOC)is the fundamental driving factors of chemistry process(e.g.,the formation of ozone(O_(3))and secondary organic aerosols(SOA))in the troposphere.However,accurate quantification of AOC still remains uncertainty.In this study,a comprehensive field campaign was conducted during autumn 2019 in downtown of Beijing,where O_(3) and PM_(2.5) episodes had been experienced successively.The observation-based model(OBM)is used to quantify the AOC at O_(3) and PM_(2.5) episodes.The strong intensity of AOC is found at O_(3) and PM2.5 episodes,and hydroxyl radical(OH)is the dominating daytime oxidant for both episodes.The photolysis of O_(3) is main source of OH at O_(3) episode;the photolysis of nitrous acid(HONO)and formaldehyde(HCHO)plays important role in OH formation at PM_(2.5) episode.The radicals loss routines vary according to precursor pollutants,resulting in different types of air pollution.O_(3) budgets and sensitivity analysis indicates that O_(3) production is transition regime(both VOC and NOx-limited)at O3 episode.The heterogeneous reaction of hydroperoxy radicals(HO_(2))on aerosol surfaces has significant influence on OH and O_(3) production rates.The HO_(2) uptake coefficient(γHO_(2))is the determining factor and required accurate measurement in real atmospheric environment.Our findings could provide the important bases for coordinated control of PM_(2.5) and O_(3) pollution. | Chenhui Jia Shengrui Tong Xinran Zhang Fangjie Li Wenqian Zhang Weiran Li ZhenWang Gen Zhang Guiqian Tang Zirui Liu Maofa Ge | 2023 | Journal of Environmental Sciences2023，，2： | 2 |
| 11 | Role of insulin/insulin-like growth factor 1 signaling pathway in longevity显示文摘The insulin/insulin-like growth factor 1 (IGF-1) signaling pathway is evolutionary conserved in diverse speciesincluding C.elegans, saccharomyces cerevisiae, Drosophila melanogaster, rodents and humans, which is involved in many interrelated functions that are necessary for metabolism, growth and reproduction. Interestingly, more and more research has revealed that insulin/IGF-1 signaling pathway plays a pivotal role in the regulation of longevity. Generally, disruption of the power of this pathway will extend longevity in species ranging from C.elegansto humans. The role of insulin/IGF-1 in longevit yis probably related to stress resistance. Although the underlying mechanisms of longevity are not fully understood, the Insulin/IGF-1 signaling pathway has attracted substantial attention and it will be a novel target to prevent or postpone age-related diseases and extend life span. In this review, we mainly focus on the similar constitution and role of insulin/IGF-1 signaling pathway in C.elegans, saccharomyces cerevisiae, rodents and humans. | Chun-LeiCheng Tian-QinGao ZhenWang Dian-DongLi | 2005 | World Journal of Gastroenterology2005，11，13： | 2 |
| 12 | Mathematical Model of Small Water-plane Area Twin-hull and Application in Marine Simulator显示文摘小水飞机区域成双壳(一行) 由于它的好经得起海上风浪的能力引起了许多研究人员的注意。在这份报纸,分离的 MMG 想法被用来执行一行运动建模和模拟;分别地,一行的力量和时刻被划分成赤裸的壳,推进器,在液体水动力学的 rudder,等等。在还原剂插入了相互的干扰在壳之中强迫的系数,和 rudder 的推进器和推进器弄醒系数,为一行的计算,都被考虑。集成的第四顺序的 Runge-Kutta 方法被解决微分方程使用,以便得到一行运动状态。作为一个例子,在全速和海鸥手艺的完整的右舷 rudder 的转弯的测试被显示出。模拟结果显示出一行常规模式和运动的趋势。它验证转弯的运动的数学模型的正确性。一行数学模型被用于海洋的模拟器以便训练飞行员或 seamen,或为海洋工程的安全评价投射。最后,模仿系统(FMNSS ) 的完整的使命航行决心是航行模拟的域里的一件成功的虚拟现实技术应用程序样品。 | XiufengZhang Zhenwang Lyu Yong Yin Yicheng Jin | 2013 | Journal of Marine Science and Application2013，12，3： | 2 |
| 13 | Path planning with general end effector constraints显示文摘 | YAO Zhenwang KAMAL G | 2007 | Robotics and Autonomous Systems2007，55，4： | 1 |
| 14 | Non-catalytic roles for TET1 protein negatively regulating neuronal differentiation through srGAP3 in neuroblastoma cells显示文摘methylcytosine dioxygenases TET 蛋白质(TET1, TET2,和 TET3 ) 在神经功能起重要规章的作用。在这研究,我们作为一个模型用 Neuro2a 房间在 neuronal 区别调查了 TET 蛋白质的角色。我们观察了那支持的 TET1, TET2 或 TET3 击倒 Neuro2a 房间的 neuronal 区别,和他们的 overexpression 禁止了导致的 VPA (valproic 酸) neuronal 区别,建议所有三 TET 蛋白质否定地调整 Neuro2a 房间的 neuronal 区别。有趣地, TET 蛋白质的导致的活动独立于它的酶的活动。我们的以前的研究证明了 srGAP3 能否定地调整 Neuro2a 房间的 neuronal 区别。而且,我们表明 TET1 能断然调整它的催化活动的 srGAP3 表示独立人士,并且 srGAP3 为 Neuro2a 房间的调停 TET 的 neuronal 区别被要求。这里介绍的结果可以在 neuronal 区别便于 TET 蛋白质的角色的更好的理解,并且为 neuroblastoma 提供一个可能的治疗目标。 | Jie Gao Yue Ma Hua-Lin Fu Qian Luo ZhenWang Yu-Huan Xiao Hao Yang Da-Xiang Cui Wei-Lin Jin | 2016 | Protein & Cell2016，7，5： | 1 |
| 15 | SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin显示文摘 | Huifeng Pi Shangcheng Xu Russel J Reiter Pan Guo Lei Zhang Yuming Li Min Li Zhenwang Cao Li Tian Jia Xie Ruiqi Zhang Mindi He Yonghui Lu Chuan Liu Weixia Duan Zhengping Yu Zhou Zhou | 2015 | Autophagy2015，，7： | 1 |
| 16 | Effect and safety of anaprazole in the treatment of duodenal ulcers:a randomized,rabeprazole-controlled,phase Ⅲ non-inferiority study显示文摘Background:The pharmacokinetic and clinical behaviors of many proton pump inhibitors(PPIs)in peptic ulcer treatment are altered by CYP2C19 genetic polymorphisms.This non-inferiority study evaluated the efficacy and safety of the novel PPI anaprazole compared with rabeprazole.We also explored the influence of Helicobacter pylori(H.pylori)infection status and CYP2C19 polymorphism on anaprazole.Methods:In this multicenter,randomized,double-blind,double-dummy,positive-drug parallel-controlled,phase Ⅲ study,Chinese patients with duodenal ulcers were randomized 1:1 to receive rabeprazole 10 mg+anaprazole placebo or rabeprazole placebo+anaprazole 20 mg once daily for 4 weeks.The primary efficacy endpoint was the 4-week ulcer healing rate assessed by blinded independent review.Secondary endpoints were the proportion of patients with improved overall and individual duodenal ulcer symptoms at 4 weeks.Furthermore,exploratory subgroup analysis of the primary endpoint by H.pylori status and CYP2C19 polymorphism was conducted.Adverse events were monitored for safety.Non-inferiority analysis was conducted for the primary endpoint.Results:The study enrolled 448 patients(anaprazole,n=225;rabeprazole,n=223).The 4-week healing rates were 90.9%and 93.7%for anaprazole and rabeprazole,respectively(difference,-2.8%[95%confidence interval,-7.7%,2.2%]),demonstrating non-inferiority of anaprazole to rabeprazole.Overall duodenal ulcer symptoms improved in 90.9%and 92.5%of patients,respectively.Improvement rates of individual symptoms were similar between the groups.Healing rates did not significantly differ by H.pylori status or CYP2C19 genotype for either treatment group.The incidence of treatment-emergent adverse events was similar for anaprazole(72/220,32.7%)and rabeprazole(84/219,38.4%).Conclusions:The efficacy of anaprazole is non-inferior to that of rabeprazole in Chinese patients with duodenal ulcers.Registration:ClinicalTrials.gov,NCT04215653. | Huiyun Zhu Xue Pan Li Zhang Hongxin Sun Huizhen Fan Zhongwei Pan Caibin Huang Zhenwang Shi Jin Ding Qi Wang Yiqi Du Nonghua Lyu Zhaoshen Li | 2022 | Chinese Medical Journal2022，135，24： | 1 |
| 17 | IQGAP3 promotes the progression of glioma as an immune and prognostic marker显示文摘Background:IQGAP3 plays a crucial role in regulating cell proliferation,division,and cytoskeletal organization.Abnormal expression of IQGAP3 has been linked to various tumors,but its function in glioma is not well understood.Methods:Various methods,including genetic differential analysis,single-cell analysis,ROC curve analysis,Cox regression,Kaplan-Meier analysis,and enrichment analysis,were employed to analyze the expression patterns,diagnostic potential,prognostic implications,and biological processes involving IQGAP3 in normal and tumor tissues.The impact of IQGAP3 on immune infiltration and the immune microenvironment in gliomas was evaluated using immunofluorescence.Additionally,the cBioPortal database was used to analyze copy number variations and mutation sites of IQGAP3.Experimental validation was also performed to assess the effects of IQGAP3 on glioma cells and explore underlying mechanisms.Results:High IQGAP3 expression in gliomas is associated with an unfavorable prognosis,particularly in wild-type IDH and 1p/19q non-codeleted gliomas.Enrichment analysis revealed that IQGAP3 is involved in regulating the cell cycle,PI3K/AKT signaling,p53 signaling,and PLK1-related pathways.Furthermore,IQGAP3 expression may be closely related to the immunosuppressive microenvironment of glioblastoma.BRD-K88742110 and LY-303511 are potential drugs for targeting IQGAP3 in anti-glioma therapy.In vitro experiments showed that downregulation of IQGAP3 inhibits the proliferation and migration of glioma cells,with the PLK1/PI3K/AKT pathway potentially playing a crucial role in IQGAP3-mediated glioma progression.Conclusion:IQGAP3 shows promise as a valuable biomarker for diagnosis,prognosis,and immunotherapeutic strategies in gliomas. | XIAOFENG GAO JUANJUAN GE XUZHENG GAO NA MEI YANTING SU SHIGANG SHAN WENBIN QIAN JIANGHENG GUAN ZHENWANG ZHANG LONG WANG | 2024 | Oncology Research2024，32，4： | 0 |
| 18 | cGAS-STING-mediated inflammation and neurodegeneration as a strategy for the treatment of neurodegenerative diseases显示文摘Aging poses a significant global health challenge due to its association with various diseases,including cancers,cardiovascular diseases,diabetes,and particularly neurodegenerative diseases.Extensive evidence has suggested cellular senescence plays a critical role in the initiation and progression of ageing-associated diseases.Under pathological conditions,senescent cells exhibit intrinsic disorders and secrete various bioactive molecules,referred to as senescence-associated secretory phenotype(SAsP),which results in chronic inflammation and impaired tissue function.Aging is commonly accompanied with systemic low-grade inflammation(named inflammaging),contributing to organ damage and ageingrelated impairment and diseases.Hence,alleviating inflammaging could serve as a potential strategy for anti-aging and anti-ageingrelated diseases. | Yongjia Luo Zhenwang Zhao Xiaobo Hu | 2024 | Acta Biochimica et Biophysica Sinica2024，56，1： | 0 |
| 19 | STUDY ON THE DIGESTION PROCESS OF ASF-AQ WHEAT STRAW PULP显示文摘A study on alkaline sulfite anthraquinone pulping of wheat straw indicated that the addition of formaldehyde could improve fine pulp yield effectively, enhance brightness of unbleached pulp, and decrease kappa number. Finally, the optimum conditions of this process were formed. | JianWang HuaiyuZhan ZhenWang | 2004 | 天津科技大学学报2004，19，A01： | 0 |
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