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| 1 | Progress in China's Unconventional Oil & Gas Exploration and Development and Theoretical Technologies显示文摘The new century has witnessed a strategic breakthrough in unconventional oil & gas.Hydrocarbon accumulated in micro-/nano-scale pore throat shale systems has become an important domain that could replace current oil & gas resources.Unconventional oil & gas plays an increasingly important role in our energy demand.Tight gas,CBM,heavy oil and asphaltic sand have served as a key domain of exploration & development,with tight oil becoming a 'bright spot' domain and shale gas becoming a 'hotspot' domain.China has made great breakthroughs in unconventional oil & gas resources,such as tight gas,shale gas,tight oil and CBM,and great progress in oil shale,gas hydrate,heavy oil and oil sand.China has an estimated(223-263)×10~8t of unconventional oil resources and(890-1260)×l0^(12)m^3 of gas resources.China has made a breakthrough for progress in unconventional oil & gas study.New progress achieved in fine-grained sedimentary studies related to continental open lacustrine basin large-scale shallow-water delta sand bodies,lacustrine basin central sandy clastic flow sediments and marine-continental fine-grained sediments provide a theoretical basis for the formation and distribution of basin central reservoir bodies.Great breakthroughs have been made in unconventional reservoir geology in respect of research methodology & technology,multi-scale data merging and physical simulation of formation conditions.Overall characterization of unconventional reservoirs via multi-method and multi-scale becomes increasingly popular and facilitates the rapid development of unconventional oil & gas geological theory,method and technology.The formation of innovative,continuous hydrocarbon accumulation theory,the establishment of the framework of the unconventional oil & gas geological theory system,and the determination of the implications,geological feature,formation mechanism,distribution rule and core technology of unconventional oil& gas geological study lays a theoretical foundation for extensive unconventional oil & gas exploration and development.Theories and technologies of unconventional oil & gas exploration and development developed rapidly,including some key evaluation techniques such as 'sweet spot zone' integrated evaluation and a six-property evaluation technique that uses hydrocarbon source,lithology,physical property,brittleness,hydrocarbon potential and stress anisotropy,and some key development &engineering technologies including micro-seismic monitoring,horizontal drilling & completion and 'factory-like' operation pattern, 'man-made reservoir' development,which have facilitated the innovative development of unconventional oil & gas.These breakthroughs define a new understanding in four aspects:①theoretical innovation;② key technologies;③ complete market mechanism and national policy support;and ④ well-developed ground infrastructure,which are significant for prolonging the life cycle of petroleum industry,accelerating the upgrade and development of theories and technologies and altering the global traditional energy structure. | ZOU Caineng YANG Zhi ZHU Rukai ZHANG Guosheng HOU Lianhua WU Songtao TAO Shizhen YUAN Xuanjun DONG Dazhong WANG Yuman WANG Lan HUANG Jinliang WANG Shufang | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 27 |
| 2 | Characteristics and Origin of Tight Oil Accumulations in the Upper Triassic Yanchang Formation of the Ordos Basin,North-Central China显示文摘The Upper Triassic oil accumulations in the Ordos Basin is the most successful tight oil play in China,with average porosity values of less than 10% and permeability values below 1.0 mD.This study investigated the geological characteristics and origin of the tight oil accumulations in the Chang 6 member of the Upper Triassic Yanchang Formation in the Shanbei area based on over 50,000 petrological,source-rock analysis,well logging and production data.The tight oil accumulation of the Chang 6 member is distributed continuously in the basin slope and the centre of the basin.The oilwater relationships are complex.Laumontite dissolution pores are the most important storage spaces,constituting 30%-60% of total porosity and showing a strong positive relationship with oil production.The pore-throat diameter is less than 1 μm,and the calculated critical height of the oil column is much larger than the tight sand thickness,suggesting that the buoyancy was probably of limited importance for oil migration.The pressure difference between the source rocks and sandstone reservoirs is inferred to have provided driving force for hydrocarbon migration.Two factors of source-reservoir configuration and laumontite dissolution contributed to the formation of the Chang 6 tight oil accumulations.Intense hydrocarbon generation and continuous sand bodies close to the hydrocarbon kitchen are the foundation for the large-scale oil distribution.Dissolution of feldspar-laumontite during the process of organic matter evolution generated abundant secondary pores and improved the reservoir quality. | WU Songtao ZOU Caineng ZHU Rukai YAO Jingli TAO Shizhen YANG Zhi ZHAI Xiufen CUI Jingwei LIN Senhu | 2016 | Acta Geologica Sinica(English Edition)2016，90，5： | 13 |
| 3 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 4 | Methods for Shale Gas Play Assessment: A Comparison between Silurian Longmaxi Shale and Mississippian Barnett Shale显示文摘Based on field work, organic geochemical analyses and experimental testing, a six-property assessment method for shale gas is proposed. These six properties include organic matter properies, lithofacies, petrophysical properties, gas content, brittleness and local stress field. Due to the features of continuous distribution over a large area and low resource abundance in shale plays, a sweet spot should have these following properties:(a) TOC>2%;(b) brittle minerals content(>40%) and clay minerals(<30%);(c) Ro(>1.1%);(d) porosity(>2%) and permeability(>0.000 1 m D), and(e) effective thickness(30–50 m). Applying these criteria in the Sichuan Basin, the Silurian Longmaxi shale consists of four prospecting sweet spots, including blocks of Changning, Weiyuan, Zhaotong and Fushun-Yongchuan. Although these four blocks have some similarities, different features were usually observed. After comprehensive analyses using the six-property assessment method, the Fushun-Yongan Block ranks the most favorable sweet spot, followed by the Weiyuan Block. For the other two blocks, the Changning Block is better than the Zhaotong Block. By comparing with the Mississippian Barnett shale, characteristics that are crucial for a high-yielding in the Sichuan Basin include a high content of organic matter(TOC>2.5%), a moderate thermal maturity(Ro=0.4%–2%), a high content of brittle minerals(quartz: 30%–45%), a high gas content(>2.5 m3?t-1), and types I and II1 kerogen. | Songqi Pan Caineng Zou Zhi Yang Dazhong Dong Yuman Wang Shufang Wang Songtao Wu Jinliang Huang Qun Liu Dule Wang Ziyuan Wang | 2015 | Journal of Earth Science2015，26，2： | 10 |
| 5 | The Effects of Arbuscular Mycorrhizal Fungi on Reactive Oxyradical Scavenging System of Tomato Under Salt Tolerance显示文摘The effects of arbuscular mycorrhizal fungi(AMF),Glomus mosseae,on oxygen radical scavenging system of tomato under salt stress were studied in potted culture experiments.The response of tomato(Lycopersicon esculentum L.) cultivar Zhongza 9 seedlings with AMF inoculation and control to salt stress(0,0.5 and 1.0% NaCl solution,respectively) was investigated.The results showed that the salt stress significantly reduced the dry matter content of roots,stems and leaves,and also the leaf area as compared with the control treatment.However,arbuscular mycorrhizal-inoculated(AM) significantly improved the dry matter and the leaf area in the salt-stressed plants.The effect of AMF on dry matter was more pronounced in aerial biomass than in root biomass which might be due to AM colonization.The activities of SOD,POD,ASA-POD,and CAT in leaves and roots of mycorrhizal and non-mycorrhizal treatment of tomato plants were increased and had different rules under different NaCl concentrations(solution of 0,0.5 and 1% NaCl),but all enzymes had a rise in the beginning of treatment under salt stress conditions.The AMF did not change the rule of tomato itself under salt stress,but AMF increased these enzyme activities in different levels.The AMF treatment significantly increased SOD,POD and ASA-POD activities in leaves and roots,whereas it had little effects on CAT in root.O2 production rate and MDA content in leaves increased continuously,which showed a positive line correlation with salt stress concentration.O2 production rate and MDA content in tomato plants significantly decreased by AM treatment compared with nonmycorrhizal treatment.In conclusion,AM could alleviate the growth limitations imposed by saline conditions,and thereby play a very important role in promoting plant growth under salt stress in tomato. | HUANG Zhi HE Chao-xing HE Zhong-qun ZOU Zhi-rong ZHANG Zhi-bin | 2010 | Agricultural Sciences in China2010，9，8： | 9 |
| 6 | Shale Gas Formation and Occurrence in China: An Overview of the Current Status and Future Potential显示文摘Shale gas is one of the most promising unconventional resources both in China and abroad. It is known as a form of self-contained source-reservoir system with large and continuous dimensions. Through years of considerable exploration efforts, China has identified three large shale gas fields in the Fuling, Changning and Weiyuan areas of the Sichuan Basin, and has announced more than 540 billion m^3 of proven shale gas reserves in marine shale systems. The geological theories for shale gas development have progressed rapidly in China as well. For example, the new depositional patterns have been introduced for deciphering the paleogeography and sedimentary systems of the Wufeng shale and Longmaxi shale in the Sichuan Basin. The shale gas storage mechanism has been widely accepted as differing from conventional natural gas in that it is adsorbed on organic matter or a mineral surface or occurs as free gas trapped in pores and fractures of the shale. Significant advances in the techniques of microstructural characterization have provided new insights on how gas molecules are stored in micro- and nano-scale porous shales. Furthermore, newly-developed concepts and practices in the petroleum industry, such as hydraulic fracturing, microseismic monitoring and multiwell horizontal drilling, have made the production of this unevenly distributed but promising unconventional natural gas a reality. China has 10–36 trillion m^3 of promising shale gas among the world's whole predicted technically recoverable reserves of 206.6 trillion m^3. China is on the way to achieving its goal of an annual yield of 30–50 billion m^3 by launching more trials within shale gas projects. | ZOU Caineng YANG Zhi PAN Songqi CHEN Yanyan LIN Senhu HUANG Jinliang WU Songtao DONG Dazhong WANG Shufang LIANG Feng SUN Shasha HUANG Yong WENG Dingwei | 2016 | Acta Geologica Sinica(English Edition)2016，90，4： | 9 |
| 7 | Synthesis and thermal stability of a novel phosphorus-nitrogen containing intumescent flame retardant显示文摘包含膨胀火焰的新奇的磷氮延迟蚂蚁(P N IFR ) 与 N-methylaniline 经由 dichloropentate 的反应被准备。产品的结构被 1H NMR, 31P NMR, MS 和红外证实。TGA 分析证明它有有效热稳定性。 | Zhi Yu Ju Yong Ye Ru Yi Zou Xin Cheng Liao Yu Fen Zhao | 2008 | Chinese Chemical Letters2008，19，3： | 7 |
| 8 | Two new phenylethanoid glycosides and a new secoiridoid glycoside from the roots of Picrorhiza scrophulariiflora显示文摘二新 phenylethanoid glycosides,命名 scroside H (1 ) , scroside 我(2 ) ,并且新 secoiridoid glycoside,命名 picrogentioside 我(3 ) ,从地下被孤立 Picrorhiza scrophulariiflora 的部分。他们的结构根据分光镜的证据被阐明。 | Lian Chun Zou Zhi Hui Yan Tong Fei Zhu Hua Xiang Da Cheng Wang Xu Ming Deng | 2010 | Chinese Chemical Letters2010，21，9： | 7 |
| 9 | Decreased nitrous oxide emissions associated with functional microbial genes under bio-organic fertilizer application in vegetable fields显示文摘Bio-organic fertilizers enriched with plant growth-promoting microbes(PGPMs)have been widely used in crop fields to promote plant growth and maintain soil microbiome functions.However,their potential effects on N_(2)O emissions are of increasing concern.In this study,an in situ measurement experiment was conducted to investigate the effect of organic fertilizer containing Trichoderma guizhouense(a plant growth-promoting fungus)on soil N_(2)O emissions from a greenhouse vegetable field.The following four treatments were used:no fertilizer(control),chemical fertilizer(NPK),organic fertilizer derived from cattle manure(O),and organic fertilizer containing T.guizhouense(O+T,referring to bio-organic fertilizer).The abundances of soil N cycling-related functional genes(amoA)from ammonium-oxidizing bacteria(AOB)and archaea(AOA),as well as nirS,nirK,and nosZ,were simultaneously determined using quantitative PCR(qPCR).Compared to the NPK plot,seasonal total N_(2)O emissions decreased by 11.7%and 18.7%in the O and O+T plots,respectively,which was attributed to lower NH_(4)^(+)-N content and AOB amoA abundance in the O and O+T plots.The nosZ abundance was significantly greater in the O+T plot,whilst the AOB amoA abundance was significantly lower in the O+T plot than in the O plot.Relative to the organic fertilizer,bio-organic fertilizer application tended to decrease N_(2)O emissions by 7.9%and enhanced vegetable yield,resulting in a significant decrease in yield-scaled N_(2)O emissions.Overall,the results of this study suggested that,compared to organic and chemical fertilizers,bio-organic fertilizers containing PGPMs could benefit crop yield and mitigate N_(2)O emissions in vegetable fields. | Yajun GENG Yiming YUAN Yingcheng MIAO Junzhang ZHI Mengyuan HUANG Yihe ZHANG Hong WANG Qirong SHEN Jianwen ZOU Shuqing LI | 2021 | Pedosphere2021，31，2： | 7 |
| 10 | Geological characteristics and ‘‘sweet area'' evaluation for tight oil显示文摘紧密的油在世界上在异乎寻常的油的探索和开发成为了焦点,特别在北美洲和中国。在北美洲,为在水兵的紧密的油有集中的探索。在中国,为在大陆人沉积的紧密的油的商业探索现在是稳定地在进行之中的。与瓷器的发现在 Ordos 盆的第一个紧密的油 fieldXinanbian 油矿,紧密的油正式集成于为储备评估的范畴。地质上,紧密的油被分发在盆的消沉和斜坡描绘,广泛、成熟、高质量的来源岩石,大规模水库空间与微 -- 并且在靠近的接触并且与连续分发的 nanopore 喉咙系统,来源岩石和水库,和本地香甜的区域。紧密的油糖果区域的分发的评估应该集中于在六个特征之间的关系。这些是来源性质,岩性学,物理性质,易碎物,烃潜力,和压力 anisotropy。在北美洲,在自然破裂经常是现在的地方,紧密的油前景在薄片状的页岩或泥土被散布,与 TOC >4% ,孔 >7% ,易碎的矿物质内容 >50% , 50%80% 的油浸透, API > 35 湡 ? 畔灲湡 ? 浡 ? 慢楳獮漠 ? 散瑮慲? 敷瑳牥 ? 桃湩吗? | Cai-Neng Zou Zhi Yang Lian-Hua Hou Ru-Kai Zhu Jing-Wei Cui Song-Tao Wu Sen-Hu Lin Qiu-Lin Guo She-Jiao Wang Deng-Hua Li | 2015 | Petroleum Science2015，12，4： | 7 |
| 11 | Preparation and Characterization of Microencapsulated Hexadecane Used for Thermal Energy Storage显示文摘Polyurea microcapsules about 2.5μm in diameter containing phase change material for thermal energy storage application were synthesized and characterized by interfacial polycondensation method with toluene-2,4-diisocyanate and ethylenediamine as monomers in an emulsion system. Hexadecane was used as a phase change material and OP, which is nonionic surfactant, and used as an emulsifier. The chemical structure and thermal behavior of the microcapsules were investigated by FTIR and thermal analysis respectively. The results show encapsulated hexadecane has a good potential as a solar energy storage material. | Guang Long ZOU Zhi Cheng TAN Xiao Zheng LAN Li Xian SUN Tao ZHANG | 2004 | Chinese Chemical Letters2004，15，6： | 7 |
| 12 | Effects of nano TiN addition on the microstructure and mechanical properties of TiC based steel bonded carbides显示文摘TiC based steel bonded carbides with the addition of nano TiN were prepared by vacuum sintering techniques.The microstructure was investigated using scanning electron microscopy(SEM) and transmission electron microscopy(TEM),and the mechanical properties,such as bending strength,impact toughness,hardness,and density,were measured.The results indicate that the grain size becomes small and there is uniformity in the steel bonded carbide with nano addition;several smaller carbide particles are also found to be inlaid in the rim of the larger carbide grains and prevent the coalescence of TiC grains.The smaller and larger carbide grains joint firmly,and then the reduction of the average size of the grains leads to the increase in the mechanical properties of the steel bonded carbides with nano addition.But the mechanical properties do not increase monotonously with an increase in nano addition.When the nano TiN addition accounts for 6-8 wt.% of the amount of steel bonded carbides,the mechanical properties reach the maximum values and then decrease with further increase in nano TiN addition. | WANG Zhi' an DAI Haiyang ZOU Yu | 2008 | Rare Metals2008，27，1： | 7 |
| 13 | Biocatalyzed cross-coupling of sinomenine and 1,2-dihydroxybenzene by Coriolus unicolor显示文摘Sinomenine 是为风湿性关节炎(RA ) 的处理的临床上可得到的药。在与更好的 bioactivity 瞄准 sinomenine derivates 的发现的连续研究, sinomenine 和 1,2-dihydroxybenzene 的跨 coupling 反应由真菌 Coriolus 催化单色负担得起唯一的 CC 跨 coupled 混合物 2,和(S)-disinomenine 和(R)-disinomenine。2 的结构被 MS 和 NMR 光谱学阐明。化合物 2 是为在 SW982 房间的 IL-6 生产过剩上的禁止的活动的进一步的 assayed 并且(S)-disinomenine 和 sinomenine 与那些相比在 IL-6 (96% 抑制) 上展出了一项更多有势力活动(17% 和 12% 抑制,分别地) 。 | Zhang Shuang Deng Dan Zhao Yi Hu Jian Xin Li Kun Zou Jun Zhi Wang | 2012 | Chinese Chemical Letters2012，23，3： | 6 |
| 14 | “Exploring petroleum inside source kitchen”: Shale oil and gas in Sichuan Basin显示文摘The Sichuan Basin is rich in shale oil and gas resources,with favorable geological conditions that the other shale reservoirs in China cannot match.Thus,the basin is an ideal option for fully'exploring petroleum inside source kitchen'with respect to onshore shale oil and gas in China.This paper analyzes the characteristics of shale oil and gas resources in the United States and China,and points out that maturity plays an important role in controlling shale oil and gas composition.US shale oil and gas exhibit high proportions of light hydrocarbon and wet gas,whereas Chinese marine and transitional shale gas is mainly dry gas and continental shale oil is generally heavy.A comprehensive geological study of shale oil and gas in the Sichuan Basin reveals findings with respect to the following three aspects.First,there are multiple sets of organic-rich shale reservoirs of three types in the basin,such as the Cambrian Qiongzhusi Formation and Ordovician Wufeng Formation-Silurian Longmaxi Formation marine shale,Permian Longtan Formation transitional shale,Triassic Xujiahe Formation lake-swamp shale,and Jurassic lacustrine shale.Marine shale gas enrichment is mainly controlled by four elements:Deep-water shelf facies,moderate thermal evolution,calcium-rich and silicon-rich rock association,and closed roof/floor.Second,the'sweet section'is generally characterized by high total organic carbon,high gas content,large porosity,high brittle minerals content,high formation pressure,and the presence of lamellation/bedding and natural microfractures.Moreover,the'sweet area'is generally characterized by very thick organic-rich shale,moderate thermal evolution,good preservation conditions,and shallow burial depth,which are exemplified by the shale oil and gas in the Wufeng-Longmaxi Formation,Longtan Formation,and Daanzhai Member of the Ziliujing Formation.Third,the marine,transitional,and continental shale oil and gas resources in the Sichuan Basin account for 50%,25%,and 30%of the respective types of shale oil and gas geological resources in China,with great potential to become the cradle of the shale oil and gas industrial revolution in China.Following the'Conventional Daqing-Oil'(i.e.,the Daqing oilfield in the Songliao Basin)and the'Western Daqing-Oil&Gas'(i.e.,the Changqing oilfield in the Ordos Basin),the Southwest oil and gas field in the Sichuan Basin is expected to be built into a'Sichuan-Chongqing Daqing-Gas'in China. | Caineng ZOU Zhi YANG Shasha SUN Qun ZHAO Wenhua BAI Honglin LIU Songqi PAN Songtao WU Yilin YUAN | 2020 | Science China Earth Sciences2020，63，7： | 6 |
| 15 | Melanin nanoparticles alleviate sepsis-induced myocardial injury by suppressing ferroptosis and inflammation显示文摘Myocardial injury as one of the severe complications leads to the increasing morbidity and mortality in patients with sepsis.Recent studies reported that reactive oxygen species(ROS)-mediated ferroptosis plays a critical role in the development of heart diseases.Therefore,we hypothesized that anti-ferroptosis agent might be a novel potential therapeutic strategy for sepsis-induced cardiac injury.Herein,we demonstrated that a small biocompatible and MRI-visible melanin nanoparticles(MMPP)improves myocardial function by inhibiting ROS-related ferroptosis signaling pathway.In LPS-induced murine sepsis model,after a single dose intravenously injection of MMPP treatment,MMPP markedly alleviated the myocardial injury including cardiac function and heart structure disorder through suppressing iron-accumulation induced ferroptosis.In vitro,MMPP inhibited cardiomyocyte death by attenuating oxidative stress,inflammation and maintaining mitochondrial homeostasis.Collectively,our findings demonstrated that MMPP protected heart against sepsis-induced myocardial injury via inhibiting ferroptosis and inflammation,which might be a novel therapeutic approach in future. | Chang Liu Quan Zou Huixin Tang Jia Liu Shiqi Zhang Caihong Fan Junwei Zhang Ruiqing Liu Yashan Liu Ruiyan Liu Yan Zhao Qiang Wu Zhi Qi Yanna Shen | 2023 | Bioactive Materials2023，，6： | 5 |
| 16 | Clinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia(2021 Edition)显示文摘Benign prostatic hyperplasia (BPH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, and has become an important global burden of disease. Transurethral plasmakinetic resection of prostate (TUPKP) is one of the foremost surgical procedures for the treatment of BPH. It has become well established in clinical practice with good efficacy and safety. In 2018, we issued the guideline “2018 Standard Edition”. However much new direct evidence has now emerged and this may change some of previous recommendations. The time is ripe to develop new evidence-based guidelines, so we formed a working group of clinical experts and methodologists. The steering group members posed 31 questions relevant to the management of TUPKP for BPH covering the following areas: questions relevant to the perioperative period (preoperative, intraoperative, and postoperative) of TUPKP in the treatment of BPH, postoperative complications and the level of surgeons’ surgical skill. We searched the literature for direct evidence on the management of TUPKP for BPH, and assessed its certainty generated recommendations using the grade criteria by the European Association of Urology. Recommendations were either strong or weak, or in the form of an ungraded consensus-based statement. Finally, we issued 36 statements. Among them, 23 carried strong recommendations, and 13 carried weak recommendations for the stated procedure. They covered questions relevant to the aforementioned three areas. The preoperative period for TUPKP in the treatment of BPH included indications and contraindications for TUPKP, precautions for preoperative preparation in patients with renal impairment and urinary tract infection due to urinary retention, and preoperative prophylactic use of antibiotics. Questions relevant to the intraoperative period incorporated surgical operation techniques and prevention and management of bladder explosion. The application to different populations incorporating the efficacy and safety of TUPKP in the treatment of normal volume (< 80 ml) and large-volume (≥ 80 ml) BPH compared with transurethral urethral resection prostate, transurethral plasmakinetic enucleation of prostate and open prostatectomy;the efficacy and safety of TUPKP in high-risk populations and among people taking anticoagulant (antithrombotic) drugs. Questions relevant to the postoperative period incorporated the time and speed of flushing, the time indwelling catheters are needed, principles of postoperative therapeutic use of antibiotics, follow-up time and follow-up content. Questions related to complications incorporated types of complications and their incidence, postoperative leukocyturia, the treatment measures for the perforation and extravasation of the capsule, transurethral resection syndrome, postoperative bleeding, urinary catheter blockage, bladder spasm, overactive bladder, urinary incontinence, urethral stricture, rectal injury during surgery, postoperative erectile dysfunction and retrograde ejaculation. Final questions were related to surgeons’ skills when performing TUPKP for the treatment of BPH. We hope these recommendations can help support healthcare workers caring for patients having TUPKP for the treatment of BPH. | Xian-Tao Zeng Ying-Hui Jin Tong-Zu Liu Fang-Ming Chen De-Gang Ding Meng Fu Xin-Quan Gu Bang-Min Han Xing Huang Zhi Hou Wan-Li Hu Xin-Li Kang Gong-Hui Li Jian-Xing Li Pei-Jun Li Chao-Zhao Liang Xiu-Heng Liu Zhi-Yu Liu Chun-Xiao Liu Jiu-Min Liu Guang-Heng Luo Yi Luo Wei-Jun Qin Jian-Hong Qiu Jian-Xin Qiu Xue-Jun Shang Ben-Kang Shi Fa Sun Guo-Xiang Tian Ye Tian Feng Wang Feng Wang Yin-Huai Wang Yu-Jie Wang Zhi-Ping Wang Zhong Wang Qiang Wei Min-Hui Xiao Wan-Hai Xu Fa-Xian Yi Chao-Yang Zhu Qian-Yuan Zhuang Li-Qun Zhou Xiao-Feng Zou Nian-Zeng Xing Da-Lin He Xing-Huan Wang 无 | 2022 | Military Medical Research2022，9，5： | 4 |
| 17 | Theory, technology and prospects of conventional and unconventional natural gas显示文摘The development of natural gas in China has entered a golden and leap-forward stage, which is a necessary bridge to clean energy. This in-depth study on the status quo, theory, technology and prospect of natural gas development shows:(1) The global remaining proven recoverable reserves of natural gas are 186×1012 m3, and the reserves-production ratio is 52.4, indicating a solid resource base for long-term and rapid development.(2) Ten formation and distribution laws of conventional and unconventional natural gas reservoirs have been proposed. In terms of exploration geology, the theory of conventional 'monolithic' giant gas fields with different gas sources, and an unconventional gas accumulation theory with continuous distribution of 'sweet areas' in different lithologic reservoirs have been established; in terms of development geology, a development theory of conventional structural gas reservoirs is oriented to 'controlling water intrusion', while a development theory of unconventional gas is concentrated on man-made gas reservoirs.(3) With the geological resources(excluding hydrates) of 210×1012 m3 and the total proven rate of the resources less than 2% at present, the natural gas in China will see a constant increase in reserve and production; by 2030, the proven geological reserves of natural gas are expected to reach about(6 000-7 000)×108 m3, the production of conventional and unconventional natural gas each will reach about 1 000×108 m3, and the gas consumption will reach 5 500×108 m3. The dependence on imported natural gas may be 64% by 2030, and 70% by 2050.(4) Ten measures for future development of natural gas have been proposed, including strengthening exploration in large-scale resource areas, increasing the development benefits of unconventional gas, and enhancing the peak adjusting capacity of gas storage and scale construction of liquified natural gas. | ZOU Caineng YANG Zhi HE Dongbo WEI Yunsheng LI Jian JIA Ailin CHEN Jianjun ZHAO Qun LI Yilong LI Jun YANG Shen | 2018 | Petroleum Exploration and Development2018，45，4： | 4 |
| 18 | MicroRNA-142-3p is frequently upregulated in colorectal cancer and may be involved in the regulation of cell proliferation显示文摘MicroRNAs are small single-stranded RNA molecules consisting of approximately 22 nucleotides (nt), and have post-transcriptional regulatory functions. By gene chip screening, we previously showed that miR-142-3p was significantly upregulated in colorectal cancer tissue and was associated with clinicopathological features, compared with matched non-tumor tissue. In this study, we confirmed significant upregulation of miR-142-3p in 60 colorectal cancer samples and three colorectal cancer cell lines by quantitative real-time PCR (qRT-PCR). Using software and network resources, we predicted TCF7 as a target of miR-142-3p, which we confirmed with dual-luciferase assays. By RT-PCR and Western blot analysis, we found miR-142-3p negatively regulates TCF7 expression post-transcriptionally. CCK8 assays and growth curves indicated that overexpression of miR-142-3p in SW480 colorectal cancer cells potently inhibited cell proliferation in vitro. The expression of TCF7 mRNA and protein was upregulated in both colorectal cancer tissues and colorectal cancer cell lines, closely correlating with its function as an oncogene in promoting tumor cell proliferation and inhibiting apoptosis. With TCF7 as a direct target, our results suggested that miR-142-3p may be involved in the regulation of cell proliferation in colorectal cancer. | ZHOU JiaLiang JIANG Zhi WANG ZhengWu ZOU ShiTao ZHANG YunXia CAI Wei WANG MingZhi XU Min SHI DongTao CHEN WeiChang | 2013 | Chinese Science Bulletin2013，58，23： | 4 |
| 19 | Vortex-Induced Vibrations of A Long Flexible Cylinder in Linear and Exponential Shear Flows显示文摘A numerical study based on a wake oscillator model was conducted to determine the response performance of vortex-induced vibration(VIV) on a long flexible cylinder with pinned-pinned boundary conditions subjected to linear and exponential shear flows. The coupling equations of a structural vibration model and wake oscillator model were solved using a standard central finite difference method of the second order. The VIV response characteristics including the structural displacement, structural frequency, structural wavenumber, standing wave behavior,travelling wave behavior, structural velocity, lift force coefficient and transferred energy from the fluid to the structure with different flow profiles were compared. The numerical results show that the VIV displacement is a combination of standing waves and travelling waves. For linear shear flow, standing waves and travelling waves dominate the VIV response within the low-velocity and high-velocity zones, respectively. The negative values of the transferred energy only occur within the low-velocity zone. However, for exponential shear flow, travelling waves dominate the VIV response and the negative energy occurs along the entire length of the cylinder. | GAO Yun YANG Bin ZOU Li ZONG Zhi ZHANG Zhuang-zhuang | 2019 | China Ocean Engineering2019，33，1： | 3 |
| 20 | Furostanol saponins with inhibitory action against COX-2 production from Tupistra chinensis rhizomes显示文摘二 furostanol saponins 从 Tupistra chinensis 根茎从甲醇摘录的 n-butanol 部分被获得,湖北的申农吉亚·福雷斯特区域的民间药省。他们的结构是被决定( 25S )-26-O-(β-d-glucopyranosyl)-furost-1β, 3 β, 22 ,26-tetrol-3-O-β-d-glucopyranosyl-( 1 → 4 ) -β-d-glucopyranosyl-(1 → 2 ) -β-d-glucopyranoside ( 1 )并且( 25R )-26-O-(β-d-glucopyranosyl)-furost-1β, 3 β 22 , 26-tetrol 3-O-β-d-glucopyranosyl-( 1 → 4 ) -β-d-glucopyranosyl-(1 → 2 ) -β-d-glucopyranoside ( 2 ),在化学、分光镜的证据的基础上。向在老鼠腹部的巨噬细胞的 COX-2 生产的 1 和 2 个显示的显著禁止的行动在 20 μ g /mL 由 LPS 导致了。 | Kun Zou Jun Zhi Wang Jun Wu Yuan Zhou Chuang Liu Fei Jun Dan Ya Xiong Zhang Jin Yang | 2007 | Chinese Chemical Letters2007，18，10： | 3 |
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