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| 1 | Chinese consensus guidelines for diagnosis and management of gastrointestinal stromal tumor显示文摘In order to further promote the standardization of diagnosis and treatment of gastrointestinal stromal tumor(GIST) in China, the members of Chinese Society of Clinical Oncology(CSCO) Expert Committee on GIST thoroughly discussed the key contents of the consensus guidelines, and voted on the controversial issue. In final, the Chinese consensus guidelines for the diagnosis and management of GIST(2017 edition) was formed on the basis of 2013 edition consensus guidelines, which is hereby announced. The consensus included the pathological diagnosis,recurrence risk classification evaluation, targeted agent therapy, surgery and principles of surveillance of GIST. | jian li yingjiang ye jian wang bo zhang shukui qin yingqiang shi yulong he xiaobo liang xiufeng liu ye zhou xin wu xinhua zhang ming wang zhidong gao tianlong lin hui cao lin shen | 2017 | Chinese Journal of Cancer Research2017，29，4： | 104 |
| 2 | Identification of coastal wetlands of international importance for waterbirds:a review of China Coastal Waterbird Surveys 2005–2013显示文摘Background:China's coastal wetlands belong to some of the most threatened ecosystems worldwide.The loss and degradation of these wetlands seriously threaten waterbirds that depend on wetlands.Methods:The China Coastal Waterbird Census was organized by volunteer birdwatchers in China's coastal region.Waterbirds were surveyed synchronously once every month at 14 sites,as well as irregularly at a further 18 sites,between September 2005 and December 2013.Results:A total of 75 species of waterbirds met the 1 % population level Ramsar listing criterion at least once at one site.The number of birds of the following species accounted for over 20 % of the total flyway populations at a single site:Mute Swan(Cygnus olor),Siberia Crane(Grus leucogeranus),Far Eastern Oystercatcher(Haematopus osculans),Bar-tailed Godwit(Limosa lapponica),Spotted Greenshank(Tringa guttifer),Great Knot(Calidris tenuirostris),Spoon-billed Sandpiper(Calidris pygmeus),Saunders' s Gull(Larus saundersi),Relict Gull(Larus relictus),Great Cormorant(Phalacrocorax carbo),Eurasian Spoonbill(Platalea leucorodia),Black-faced Spoonbill(Platalea minor) and Dalmatian Pelican(Pelecanus crispus).A total of 26 sites supported at least one species of which their number met the1 % criterion.Forty-two species met the 1 % criterion in the Yellow River Delta,Shandong;29 at the Cangzhou coast,Hebei and 26 species at the Lianyungang coast,Jiangsu.Conclusions:The results highlight the international importance of China's coastal wetlands for waterbirds.This study also demonstrates that participation of local birdwatchers in waterbird surveys results in data that are invaluable not only for understanding the current status of waterbirds in China's coastal regions but also for waterbird conservation and management. | Qingquan Bai Jianzhong Chen Zhihong Chen Guotai Dong Jiangtian Dong Wenxiao Dong Vivian Wing Kan Fu Yongxiang Han Gang Lu Jing Li Yang Liu Zhi Lin Derong Meng Jonathan Martinez Guanghui Ni Kai Shan Renjie Sun Suixing Tian Fengqin Wang Zhiwei Xu Yat-tung Yu Jin Yang Zhidong Yang Lin Zhang Ming Zhang Xiangwu Zeng | 2015 | Chinese Birds2015，，3： | 20 |
| 3 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 4 | A single TiO_(2)-coated side-glowing optical fiber for photocatalytic wastewater treatment显示文摘By means of TiO2-layer-on-SiO2-layer, anatase TiO2 was deposited on novel side- glowing optical fibers, which can provide side UV radiation along the whole fiber length. FE-SEM images show that the double layers adhered well to the side-glowing optical fiber, and the TiO2 coating was homogeneous and smooth. The decomposition reaction of reactive brilliant red dye X-3B on a single TiO2-coated side-glowing optical fiber indicated that the side-scattering UV light intensity was strong enough for photocatalytic oxi-dation reaction. Therefore, TiO2-coated side-glowing optical fibers open up a new way to use the optical fiber reactor in photocatalytic wastewater treatment. | HU Yan XU Jingjing YUAN Chunwei LIN Jian YIN Zhidong | 2005 | Chinese Science Bulletin2005，50，18： | 7 |
| 5 | Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS显示文摘The activity and stability of the adapter protein MAVS (also known as VISA, Cardif and IPS-1), which critically mediates cellular antiviral responses, are extensively regulated by ubiquitination. However, the process whereby MAVS is deubiquitinated is unclear. Here, we report that the ovarian tumor family deubiquitinase 4 (OTUD4) targets MAVS for deubiquitination. Viral infection leads to the IRF3/7-dependent upregulation of OTUD4 which interacts with MAVS to remove K48-linked polyubiquitin chains, thereby maintaining MAVS stability and promoting innate antiviral signaling. Knockout or knockdown of OTUD4 impairs RNA virus-triggered activation of IRF3 and NF-κB, expression of their downstream target genes, and potentiates VSV replication in vitro and in vivo. Consistently, Cre-ER Otud4fl/fl or Lyz2-Cre Otud4fl/fl mice produce decreased levels of type I interferons and proinflammatory cytokines and exhibit increased sensitivity to VSV infection compared to their control littermates. In addition, reconstitution of MAVS into OTUD4-deficient cells restores virus-induced expression of downstream genes and cellular antiviral responses. Together, our findings uncover an essential role of OTUD4 in virus-triggered signaling and contribute to the understanding of deubiquitination-mediated regulation of innate antiviral responses. | Tianzi Liuyu Keying Yu Liya Ye Zhidong Zhang Man Zhang Yujie Ren Zeng Cai Qiyun Zhu Dandan Lin Bo Zhong | 2019 | Cell Research2019，29，1： | 7 |
| 6 | Existence and stability of periodic solution of a Lotka–Volterra predator–prey model with state dependent impulsive effects显示文摘 | Linfei Nie Jigen Peng Zhidong Teng Lin Hu | 2008 | Journal of Computational and Applied Mathematics2008，，2： | 1 |
| 7 | Existence and stability of periodic solution of a predator–prey model with state-dependent impulsive effects显示文摘 | Linfei Nie Zhidong Teng Lin Hu Jigen Peng | 2008 | Mathematics and Computers in Simulation2008，，7： | 1 |
| 8 | Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines显示文摘 | Yu-Chlng Lin Liang You Zhidong Xu | 2006 | Biochem Biophys Res Commun2006，41，2： | 1 |
| 9 | Ethephon chemical harvest of black currant (Ribes nigrum)显示文摘 | Zhang Zhidong Li Yadong Wu Lin and An Wei | 2002 | Acta Horticulturae2002，585，： | 1 |
| 10 | Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines显示文摘 | Yu-Ching Lin Liang You Zhidong Xu | 2006 | Biochem Biophys Res Commun2006，41，2： | 1 |
| 11 | Optimization of Ultrasonic Extraction Process of Oenanthe benghalensis Polysaccharide by Orthogonal Test显示文摘[Objectives] The research aimed to explore extraction method of Oenanthe benghalensis polysaccharide,and determine the optimal process of its ultrasonic extraction by orthogonal test. [Methods] Phenol-sulfuric acid method was used to determine polysaccharide's content. Based on single-factor experiment and orthogonal test,the influences of solid-liquid ratio( A),ultrasonic extraction temperature( B),ultrasonic power( C) and ultrasonic time( D) on extraction rate of O. benghalensis polysaccharide were studied,and the optimal process of ultrasonic extraction was selected. [Results] The influence order of solid-liquid ratio( A),ultrasonic extraction temperature( B),ultrasonic power( C) and ultrasonic time( D) on extraction rate of O. benghalensis polysaccharide was A > D > B > C. Via the orthogonal test,it was determined that the optimal extraction condition of O. benghalensis polysaccharide was as below: solid-liquid ratio 1∶ 25( g/mL),extraction temperature 60℃,extraction power 80 W,extraction time 40 min. Under the condition,extraction rate of O. benghalensis polysaccharide was9. 80%. [Conclusions] The process could provide the reference basis for extracting and producing O. benghalensis polysaccharides. | Liufu LU Aiyue LUO Bingyang LIN Zhenlian XIE Guangyu GAN Xiuzhen HUANG Zhidong LEI Shimei CHEN Suoyi HUANG | 2018 | Medicinal Plant2018，9，5： | 1 |
| 12 | The Dynamics of a Lotka-Volterrs Predator-prey Model with State Dependent Impulsive Harvest for Predator显示文摘 | Nie Linfei Teng Zhidong Hu Lin | 2009 | BioSystems2009，98，： | 1 |
| 13 | 查看详情显示文摘 | Sun Lin Shao Rong Chen Zhidong | | 0，，14： | 1 |
| 14 | Structural design for birefringent holey fiber with a beat length insensitive to wavelength显示文摘 | Lin Jianqiang Shi Zhidong Li Mingiia | 2009 | ApplOpt2009，48，25： | 1 |
| 15 | effects of precur-sors on preparation of pd/r - alumina catalyst for synthesisof dimethyl oxalate 显示文摘 | Lin Qian Ji Yang Jiang Zhidong | 2007 | Ind Eng Chem Res2007，46，： | 1 |
| 16 | Generation of gene-target dogs using CRISPR/Cas9 system显示文摘Dear Editor,Dogs(Canis familiaris)serve as human companions and are raised to herd livestock,aid hunters,guard homes,perform police and rescue work,and guide the blind.Dogs exhibit close similarities to humans in terms of metabolic,physiological,and anatomical characteristics,and thus are ideal genetic and clinical models to study human diseases(Tsai et al.,2007).Gene target technology is a powerful tool to create new strains of animals with favorable traits.However,thus far,gene-target dogs have not been developed due to their unique species-specific reproductive characteristics,which limits the applications of dogs especially in the field of biomedical research.Recently,clustered regularly interspaced short palindromic repeats(CRISPRs)/CRISPR-associated(Cas)9 system was applied to edit specific genes with a high efficiency(Cong et al.,2013;Mali et al.,2013).Here we attempt to explore the feasibility of producing gene knockout(KO)dogs by using this technology.Beagle dog,the most widely used breed in biomedical research,was used as our animal model.Myostatin(MSTN)was chosen as the first gene of interest. | Qingjian Zou Xiaomin Wang Yunzhong Liu Zhen Ouyang Haibin Long Shu Wei Jige Xin Bentian Zhao Sisi Lai Jun Shen Qingchun Ni Huaqiang Yang Huilin Zhong Li Li Minhua Hu Quanjun Zhang Zhidong Zhou Jiaxin He Quanmei Yan Nana Fan Yu Zhao Zhaoming Liu Lin Guo Jiao Huang Guanguan Zhang Jun Ying Liangxue Lai Xiang Gao | 2015 | Journal of Molecular Cell Biology2015，7，6： | 1 |
| 17 | Permanence andstability in non- autonomous predator-prey Lotka-Volterrasystems with feedback controls显示文摘 | NIE Linfei TENG Zhidong HU Lin | 2009 | Computers and Mathemat-ics with Applications2009，58，3： | 1 |
| 18 | Existence and stability of periodic solution of a LotkaVolterra predator-prey model with state-dependent impulsive effects显示文摘 | NIE Linfei PENG Jigen TENG Zhidong HU Lin | | 0，，： | 1 |
| 19 | Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma显示文摘 | Sonny Batra Yihui Shi Kristopher M. Kuchenbecker Biao He Noemi Reguart Iwao Mikami Liang You Zhidong Xu Yu-Ching Lin Geneviève Clément David M. Jablons | 2006 | Biochemical and Biophysical Research Communications2006，，4： | 1 |
| 20 | Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines显示文摘 | Yu-Ching Lin Liang You Zhidong Xu Biao He Iwao Mikami Elaine Thung Josephine Chou Kristopher Kuchenbecker Jae Kim Dan Raz Cheng-Ta Yang Jan-Kan Chen David M. Jablons | 2006 | Biochemical and Biophysical Research Communications2006，，2： | 1 |
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