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| 1 | Advances and prospects in biomimetic multilayered scaffolds for articular cartilage regeneration显示文摘Due to the sophisticated hierarchical structure and limited reparability of articular cartilage(AC),the ideal regeneration of AC defects has been a major challenge in the field of regenerative medicine.As defects progress,they often extend from the cartilage layer to the subchondral bone and ultimately lead to osteoarthritis.Tissue engineering techniques bring new hope for AC regeneration.To meet the regenerative requirements of the heterogeneous and layered structure of native AC tissue,a substantial number of multilayered biomimetic scaffolds have been studied.Ideal multilayered scaffolds should generate zone-specific functional tissue similar to native AC tissue.This review focuses on the current status of multilayered scaffolds developed for AC defect repair,including design strategies based on the degree of defect severity and the zone-specific characteristics of AC tissue,the selection and composition of biomaterials,and techniques for design and manufacturing.The challenges and future perspectives of biomimetic multilayered scaffold strategies for AC regeneration are also discussed. | Liwei Fu Zhen Yang Cangjian Gao Hao Li Zhiguo Yuan Fuxin Wang Xiang Sui Shuyun Liu Quanyi Guo | 2020 | Regenerative Biomaterials2020，7，6： | 7 |
| 2 | Estimation of the three-dimensional in situ stress field around a large deep underground cavern group near a valley显示文摘Understanding three-dimensional(3D)in situ stress field is of key importance for estimating the stability of large deep underground cavern groups near valleys.However,the complete 3D in situ stress fields around large deep underground cavern groups are difficult to determine based on in situ stress data from a limited number of measuring points due to the insufficient representativeness and unreliability of such measurements.In this study,an integrated approach for estimating the 3D in situ stress field around a large deep underground cavern group near a valley is developed based on incomplete in situ stress measurements and the stress-induced failures of tunnels excavated prior to the step excavation of the cavern group.This integrated approach is implemented via four interrelated and progressive basic steps,i.e.inference of the regional tectonic stress field direction,analyses of in situ stress characteristics and measurement reliability,regression-based in situ stress field analysis and reliability assessment,and modified in situ stress field analysis and reliability verification.The orientations and magnitudes of the 3D in situ stress field can be analyzed and obtained at a strategic level following these four basic steps.First,the tectonic stress field direction around the cavern group is deduced in accordance with the regional tectonic framework and verified using a regional crustal deformation velocity map.Second,the reliability of the in situ stress measurements is verified based on the locations and depths of stressinduced brittle failures in small tunnels(such as exploratory tunnels and pilot tunnels)within the excavation range of the cavern group.Third,considering the influences of the valley topography and major geological structures,the 3D in situ stress field is regressed using numerical simulation and multiple linear regression techniques based on the in situ stress measurements.Finally,the regressed in situ stress field is further modified and reverified based on the stress-induced brittle failures of small tunnels and the initial excavation of the cavern group.A case study of the Shuangjiangkou underground cavern group demonstrates that the proposed approach is reliable for estimating the 3D in situ stress fields of large deep underground cavern groups near valleys,thus contributing to the optimization of practical excavation and design of mitigating the instability of the surrounding rock masses during step excavations. | Dingping Xu Xiang Huang Quan Jiang Shaojun Li Hong Zheng Shili Qiu Huaisheng Xu Yonghong Li Zhiguo Li Xingdong Ma | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，3： | 6 |
| 3 | Production of aneuhaploid and euhaploid sporocytes by meiotic restitution in fertile hybrids between durum wheat Langdon chromosome substitution lines and Aegilops tauschii显示文摘Fertile F1 hybrids were obtained between durum wheat (Triticum durum Desf.) Langdon (LDN) and its 10 disomic substitution (LDN DS) lines with Aegilops tauschii accession AS60 without embryo rescue. Selfed seedset rates for hybrids of LDN with AS60 were 36.87% and 49.45% in 2005 and 2006, respectively. Similar or higher selfed seedset rates were observed in the hybrids of 1D (1A), 1D (1B), 3D (3A), 4D (4B), 7D (7A), and 2D (2B) with AS60, while lower in hybrids of 3D (3B) + 3BL, 5D (5A) + 5AL, 5D (5B) + 5B and 6D (6B) + 6BS with AS60 compared with the hybrids of LDN with AS60. Observation of male gametogenesis showed that meiotic restitution, both first-division restitution (FDR) and single-division meiosis (SDM) resulted in the formation of functional unreduced gametes, which in turn produced seeds. Both euhaploid and aneuhaploid gametes were produced in F1 hybrids. This suggested a strategy to simultane-ously transfer and locate major genes from the ancestral species T. turgidum or Ae. tauschii. Moreover, there was no significant difference in the aneuhaploid rates between the F1 hybrids of LDN and LDN DS lines with AS60, suggesting that meiotic pairing between the two D chromosomes in the hybrids of LDN DS lines with AS60 did not promote the formation of aneuhaploid gametes. | Lianquan Zhang Qijiao Chen Zhongwei Yuan Zhiguo Xiang Youliang Zheng Dengcai Liu | 2008 | Journal of Genetics and Genomics2008，35，10： | 5 |
| 4 | Incidence, risk factors for amputation among patients with diabetic foot ulcer in a Chinese tertiary hospital显示文摘 | Xiang Li Ting Xiao Yuzhen Wang Hongbin Gu Zhiguo Liu Yufeng Jiang Yanjun Liu Zuqian Lu Xiaopin Yang Yin Lan Zhangrong Xu | 2011 | Diabetes Research and Clinical Practice2011，，1： | 2 |
| 5 | Rate compatible reconciliation for continuous-variable quantum key distribution using Raptor-like LDPC codes显示文摘In the practical continuous-variable quantum key distribution(CV-QKD)system,the postprocessing process,particularly the error correction part,significantly impacts the system performance.Multi-edge type low-density parity-check(MET-LDPC)codes are suitable for CV-QKD systems because of their Shannon-limit-approaching performance at a low signal-to-noise ratio(SNR).However,the process of designing a low-rate MET-LDPC code with good performance is extremely complicated.Thus,we introduce Raptor-like LDPC(RL-LDPC)codes into the CV-QKD system,exhibiting both the rate compatible property of the Raptor code and capacity-approaching performance of MET-LDPC codes.Moreover,this technique can significantly reduce the cost of constructing a new matrix.We design the RL-LDPC matrix with a code rate of 0.02 and easily and effectively adjust this rate from 0.016 to 0.034.Simulation results show that we can achieve more than 98%reconciliation efficiency in a range of code rate variation using only one RL-LDPC code that can support high-speed decoding with an SNR less than-16.45 d B.This code allows the system to maintain a high key extraction rate under various SNRs,paving the way for practical applications of CV-QKD systems with different transmission distances. | Chao Zhou Xiang Yu Wang ZhiGuo Zhang Song Yu ZiYang Chen Hong Guo | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，6： | 2 |
| 6 | Exponential p-stability of impulsive stochastic differential equa tions with delays显示文摘 | Yang Zhiguo Xu Daoyi Xiang Li | 2006 | Physics Letters A2006，，2： | 1 |
| 7 | Hierarchical macro-microporous WPU-ECM scaffolds combined with Microfracture Promote in Situ Articular Cartilage Regeneration in Rabbits显示文摘Tissue engineering provides a promising avenue for treating cartilage defects.However,great challenges remain in the development of structurally and functionally optimized scaffolds for cartilage repair and regeneration.In this study,decellularized cartilage extracellular matrix(ECM)and waterborne polyurethane(WPU)were employed to construct WPU and WPU-ECM scaffolds by water-based 3D printing using low-temperature deposition manufacturing(LDM)system,which combines rapid deposition manufacturing with phase separation techniques.The scaffolds successfully achieved hierarchical macro-microporous structures.After adding ECM,WPU scaffolds were markedly optimized in terms of porosity,hydrophilia and bioactive components.Moreover,the optimized WPU-ECM scaffolds were found to be more suitable for cell distribution,adhesion,and proliferation than the WPU scaffolds.Most importantly,the WPU-ECM scaffold could facilitate the production of glycosaminoglycan(GAG)and collagen and the upregulation of cartilage-specific genes.These results indicated that the WPU-ECM scaffold with hierarchical macro-microporous structures could recreate a favorable microenvironment for cell adhesion,proliferation,differentiation,and ECM production.In vivo studies further revealed that the hierarchical macro-microporous WPU-ECM scaffold combined with the microfracture procedure successfully regenerated hyaline cartilage in a rabbit model.Six months after implantation,the repaired cartilage showed a similar histological structure and mechanical performance to that of normal cartilage.In conclusion,the hierarchical macro-microporous WPU-ECM scaffold may be a promising candidate for cartilage tissue engineering applications in the future. | Mingxue Chen YangYang Li Shuyun Liu Zhaoxuan Feng Hao Wang Dejin Yang Weimin Guo Zhiguo Yuan Shuang Gao Yu Zhang Kangkang Zha Bo Huang Fu Wei Xinyu Sang Qinyu Tian Xuan Yang Xiang sui Yixin Zhou Yufeng Zheng Quanyi Guo | 2021 | Bioactive Materials2021，6，7： | 1 |
| 8 | 3D-printed cell-free PCL-MECM scaffold with biomimetic micro-structure and micro-environment to enhance in situ meniscus regeneration显示文摘Despite intensive effort was made to regenerate injured meniscus by cell-free strategies through recruiting endogenous stem/progenitor cells,meniscus regeneration remains a great challenge in clinic.In this study,we found decellularized meniscal extracellular matrix(MECM)preserved native meniscal collagen and glycosaminoglycans which could be a good endogenous regeneration guider for stem cells.Moreover,MECM significantly promoted meniscal fibrochondrocytes viability and proliferation,increased the expression of type II collagen and proteoglycans in vitro.Meanwhile,we designed 3D-printed polycaprolactone(PCL)scaffolds which mimic the circumferential and radial collagen orientation in native meniscus.Taken these two advantages together,a micro-structure and micro-environment dually biomimetic cell-free scaffold was manipulated.This cell-free PCL-MECM scaffold displayed superior biocompatibility and yielded favorable biomechanical capacities closely to native meniscus.Strikingly,neo-menisci were regenerated within PCL-MECM scaffolds which were transplanted into knee joints underwent medial meniscectomy in rabbits and sheep models.Histological staining confirmed neo-menisci showed meniscus-like heterogeneous staining.Mankin scores showed PCL-MECM scaffold could protect articular cartilage well,and knee X-ray examination revealed same results.Knee magnetic resonance imaging(MRI)scanning also showed some neo-menisci in PCL-MECM scaffold group.In conclusion,PCL-MECM scaffold appears to optimize meniscus regeneration.This could represent a promising approach worthy of further investigation in preclinical applications. | Weimin Guo Mingxue Chen Zhenyong Wang Yue Tian Jinxuan Zheng Shuang Gao Yangyang Li Yufeng Zheng Xu Li Jingxiang Huang Wei Niu Shuangpeng Jiang Chunxiang Hao Zhiguo Yuan Yu Zhang Mingjie Wang Zehao Wang Jiang Peng Aiyuan Wang Yu Wang Xiang Sui Wenjing Xu Libo Hao Xifu Zheng Shuyun Liu Quanyi Guo | 2021 | Bioactive Materials2021，6，10： | 1 |
| 9 | Synthesis of polycyclic spiro-fused indolines via IBX-mediated cascade cyclization显示文摘We report a 2-iodoxybenzoic acid(IBX)-mediated intarmolecular oxidative spiro-fused tandem cyclization reaction of tryptophan analogs bearing an N-arylamides side-chain to rapidly afford polycyclic spiroindolines featuring multiple stereocenters including a quaternary stereocenters under mild reaction conditions.Among them,a novelty azaphosphol idine-containing spiroindoline compound is synthesized for the first time.It may open the door to azaphos pholidine-containing spiroindoline compound of potential interest in synthetic and medicinal chemistry.A plausible mechanism is proposed. | Zhiguo Zhang Xiaoqing Song Guofeng Li Xiang Li Dan Zheng Xuna Zhao Huanran Miao Guisheng Zhang Lantao Liu | 2021 | Chinese Chemical Letters2021，32，4： | 1 |
| 10 | A specific probe for two-photon fluorescence lysosomal imaging显示文摘 | Zhiguo Wu Mingliang Tang Tian Tian Jianguo Wu Yuanlin Deng Xiaohu Dong Zheng Tan Xiaocheng Weng Zhihong Liu Chunjiang Wang Xiang Zhou | 2011 | Talanta2011，，： | 1 |
| 11 | Public health implications of Yersinia enterocolitica investigation:an ecological modeling and molecular epidemiology study显示文摘Background Yersinia enterocolitica has been sporadically recovered from animals,foods,and human clinical samples in various regions of Ningxia,China.However,the ecological and molecular characteristics of Y.enterocolitica,as well as public health concerns about infection in the Ningxia Hui Autonomous Region,remain unclear.This study aims to analyze the ecological and molecular epidemiological characteristics of Y.enterocolitis in order to inform the public health intervention strategies for the contains of related diseases.Methods A total of 270 samples were collected for isolation[animals(n=208),food(n=49),and patients(n=13)],then suspect colonies were isolated and identified by the API20E biochemical identification system,serological tests,biotyping tests,and 16S rRNA-PCR.Then,we used an ecological epidemiological approach combined with machine learning algorithms(general linear model,random forest model,and eXtreme Gradient Boosting)to explore the associations between ecological factors and the pathogenicity of Y.enterocolitis.Furthermore,average nucleotide identity(ANI)estimation,single nucleotide polymorphism(SNP),and core gene multilocus sequence typing(cgMLST)were applied to characterize the molecular profile of isolates based on whole genome sequencing.The statistical test used single-factor analysis,Chi-square tests,t-tests/ANOVA-tests,Wilcoxon rank-sum tests,and Kruskal–Wallis tests.Results A total of 270 isolates of Yersinia were identified from poultry and livestock(n=191),food(n=49),diarrhoea patients(n=13),rats(n=15),and hamsters(n=2).The detection rates of samples from different hosts were statistically different(χ^(2)=22.636,P<0.001).According to the relatedness clustering results,270 isolates were divided into 12 species,and Y.enterocolitica(n=187)is a predominated species.Pathogenic isolates made up 52.4%(98/187),while non-pathogenic isolates made up 47.6%(89/187).Temperature and precipitation were strongly associated with the pathogenicity of the isolates(P<0.001).The random forest(RF)prediction model showed the best performance.The prediction result shows a high risk of pathogenicity Y.enterocolitica was located in the northern,northwestern,and southern of the Ningxia Hui Autonomous Region.The Y.enterocolitica isolates were classified into 54 sequence types(STs)and 125 cgMLST types(CTs),with 4/O:3 being the dominant bioserotype in Ningxia.The dominant STs and dominant CTs of pathogenic isolates in Ningxia were ST429 and HC100_2571,respectively.Conclusions The data indicated geographical variations in the distribution of STs and CTs of Y.enterocolitica isolates in Ningxia.Our work offered the first evidence that the pathogenicity of isolates was directly related to fluctuations in temperature and precipitation of the environment.CgMLST typing strategies showed that the isolates were transmitted to the population via pigs and food.Therefore,strengthening health surveillance on pig farms in high-risk areas and focusing on testing food of pig origin are optional strategies to prevent disease outbreaks. | Yuan Yue Jinxin Zheng Mei Sheng Xiang Liu Qiong Hao Shunxian Zhang Shuai Xu Zhiguo Liu Xuexin Hou Huaiqi Jing Yang Liu Xuezhang Zhou Zhenjun Li | 2023 | Infectious Diseases of Poverty2023，12，2： | 1 |
| 12 | Anchoring Pt nanoparticles and Ti_(3)C_(2)T_(x)MXene nanosheets on CdS nanospheres as efficient synergistic photocatalysts for hydrogen evolution显示文摘The development of a new-fashioned functional nanomaterial with an outstanding photocatalytic hydrogen evolution reaction(HER)activity under visible-light irradiation is a sustainable and promising strategy to cope with the increasingly serious global energy crisis.Herein,an advanced ternary photocatalytic HER catalyst,in which the Pt nanoparticles and Ti_(3)C_(2)T_(x)nanosheets are synchronously anchored on the surface of CdS nanospheres(Ti_(3)C_(2)T_(x)/Pt@CdS),is elaborately constructed via acid etching,sel-freduction,and solvothermal treatment.Therein,the synergistic promoting effect between Ti_(3)C_(2)T_(x)and Pt on the charge transfer of CdS effectively hinders the backtransfer of electrons to recombine with holes,resulting in a high-effective utilization of photoexcited charges.The obtained Ti_(3)C_(2)T_(x)/Pt@CdS possesses a superior photocatalytic HER activity compared to that of single active component catalyst.This work demonstrates the great potential of MXene materials in constructing high performance photocatalysts. | JIANG JiZhou XIONG ZhiGuo WANG HaiTao XIANG Kun WU PingXiu ZOU Jing | 2022 | Science China(Technological Sciences)2022，65，12： | 1 |
| 13 | Multiple Access Techniques for 5G显示文摘Over the past few decades,wireless communications have advanced tremendously and have becomean indispensable part of our lives.Wireless networks have become more and more pervasive in orderto guarantee global digital connectivity.Wireless devices have quickly evolved into multimediasmartphones running applications that demand high-speed and high-quality data connections. | YUAN Jinhong DING Zhiguo XIANG Jiying YUAN Zhifeng | 2016 | ZTE Communications2016，14，4： | 0 |
| 14 | Analysis of Chinese Citizens’Perception and Its Differences of City Spirit:A Case Study of Hefei City显示文摘City spirit is the soul of the city.The spread of city spirit not only could establish a civilized specimen for citizens,but also create a good cultural atmosphere for the city.Hefei residents’perception of city spirit is extensive,and most of Hefei citizens consider the expression words of city spirit are very appropriate,which is enlightened,open-minded,actual and innovate.Great majority of Hefei citizens willing to support the propaganda and promotion of the city spirit,and they think the promotion of the city spirit plays a key role in the way of city’s development.In addition,significant differences in the perception of urban spirituality emerge among residents with different economic and social characteristics.There are four aspects about how to enhance the public perception of city spirit,which including increasing dissemination channels and means,strengthening guidance according to the difference of residents,encouraging participation of community residents,and building good atmosphere depending on the city’s advantages. | Zhiguo Yao Fei Liu Min Xiang | 2022 | Journal of Geographical Research2022，5，3： | 0 |
| 15 | Corrigendum to“Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment”[Bioact.Mater.18C(2022)1-14]显示文摘 | Lei Zhang Zhiguo Qin Han Sun Xiang Chen Jian Dong Siyu Shen Liming Zheng Ning Gu Qing Jiang | 2023 | Bioactive Materials2023，，1： | 0 |
| 16 | Improvement for LEACH Algorithm in Wireless Sensor Network显示文摘According to the energy bottleneck of the wireless sensor network, the LEACH algorithm is improved in this paper, in the LEACH algorithm, it maybe that the cluster head nodes are far from the base station, and cluster head node has non-uniform distribution, in this case, nodes soon died after consuming energy, so the focus from three aspects of the optimal number of the cluster head and uniform distribution and many jump communication to improve, the improved algorithm through the simulation tests show that network node energy has been obviously saved, at the same time the lifecycle of the system is also effectively extension. In the application of the wireless sensor, we should always hold the principle of energy-first, therefore the LEACH which is a hierarchical routing protocol can save energy has played a crucial role, but the optimal number of the cluster head and uniform distribution can’t be archived because of the change of the location of the cluster head nodes. In addition, when the cluster head far away from center sink node communicate with center sink node, the cluster head will exhaust energy quickly to die, that may affect lifecycle of whole of monitoring network and lead to worse expansibility. For some problems of the LEACH algorithm, the LEACH algorithm is improved in this paper from three aspects of the optimal number of the cluster head and uniform distribution and many jump communication, the improved algorithm through the simulation tests show that network node energy has been obviously saved. | Shiying Xia Minsheng Tan Zhiguo Zhao Ting Xiang | 2016 | 国际计算机前沿大会会议论文集2016，，1： | 0 |
| 17 | Multilayered PdTe_(2)/thin Si heterostructures as self-powered flexible photodetectors with heart rate monitoring ability显示文摘Two-dimensional layered material/semiconductor heterostructures have emerged as a category of fascinating architectures for developing highly efficient and low-cost photodetection devices.Herein,we present the construction of a highly efficient flexible light detector operating in the visible-near infrared wavelength regime by integrating a PdTe2 multilayer on a thin Si film.A representative device achieves a good photoresponse performance at zero bias including a sizeable current on/off ratio exceeding 105,a decent responsivity of~343 mA/W,a respectable specific detectivity of~2.56×10^(12)Jones,and a rapid response time of 4.5/379μs,under 730 nm light irradiation.The detector also displays an outstanding long-term air stability and operational durability.In addition,thanks to the excellent flexibility,the device can retain its prominent photodetection performance at various bending radii of curvature and upon hundreds of bending tests.Furthermore,the large responsivity and rapid response speed endow the photodetector with the ability to accurately probe heart rate,suggesting a possible application in the area of flexible and wearable health monitoring. | Chengyun Dong Xiang An Zhicheng Wu Zhiguo Zhu Chao Xie Jian-An Huang Linbao Luo | 2023 | Journal of Semiconductors2023，44，11： | 0 |
| 18 | Unraveling the reaction mechanism of low dose Mn dopant in Ni(OH)_(2) supercapacitor electrode显示文摘Mn doping is deemed as a promising strategy to improve the electrochemical performance of the a-Ni(OH)_(2)battery-type supercapacitor electrode.However,the internal structure evolution,the pathways and the dynamics of the proton/intercalated anion migration,as well as the functioning mechanism of Mn dopant to stabilize the layered structure during cycles remain unclear.Here,we unveil that irreversible oxidization of Mn^(3+)at the initial CV cycles,which will remain as Mn^(4+)in the NiO_(2)slabs after the first oxidization to effectively suppress the phase transformation fromα-Ni(OH)_(2)/γ-NiOOH toβ-Ni(OH)_(2)/β-NiOOH and further maintain the structural integrity of electrode.With a synergistic combination of theoretical calculations and various structural probes including XRD and^(2)H MAS solid state NMR,we decode the structure evolution and dynamics in the initial CV(cyclic voltammetry)cycles,including the absorption/desorption of hydrogen containing species,migration of intercalated anions/water molecules and the change of interlayer space.This present work elucidates a close relationship between doping chemistry and structural reliability,paving a novel way of reengineering supercapacitor electrode materials. | Zhiguo Zhang Hua Huo Zhenjiang Yu Lizhi Xiang Bingxing Xie Chunyu Du Jiajun Wang Geping Yin | 2021 | Journal of Energy Chemistry2021，30，10： | 0 |
| 19 | Achievable secrecy rate of bit-interleaved coded modulation schemes显示文摘We study the impact of various modulation mapping strategies and signal constellation shapes on the secrecy rates achievable with bit-interleaved coded modulation (BICM) schemes. Transmission over an ergodic Rayleigh fading channel is assumed throughout this work. Various constellations and mapping techniques are considered in this work to maximize the capacity difference between the main channel and the eavesdropper channel, rather than to optimize the capacity of both channels. We show that in terms of achievable secrecy rate, Gray and Quasi-Gray mappings only perform well at low SNR but outperformed by other mapping techniques when SNR increases. The proper design of signal mapping can significantly enhance the achievable secrecy rate in BICM schemes. It is indicated that the key parameter to the secrecy rate of a BICM system is the distance spectrum of Euclidean distances for mappings. | Weichen XIANG Stéphane Le Goff Zhiguo DING | 2012 | Journal of Modern Transportation2012，20，4： | 0 |
| 20 | Combination therapy with saxagliptin and vitamin D for the preservation ofβ-cell function in adult-onset type 1 diabetes:a multi-center,randomized,controlled trial显示文摘Disease modifying therapies aiming to preserveβ-cell function in patients with adult-onset autoimmune type 1 diabetes are lacking.Here,we conducted a multi-centre,randomized,controlled trial to assess theβ-cell preservation effects of saxagliptin alone and saxagliptin combined with vitamin D as adjunctive therapies in adult-onset autoimmune type 1 diabetes.In this 3-arm trial,301 participants were randomly assigned to a 24-month course of the conventional therapy(metformin with or without insulin)or adjunctive saxagliptin or adjunctive saxagliptin plus vitamin D to the conventional therapy.The primary endpoint was the change from baseline to 24 months in the fasting C-peptide.The secondary endpoints included the area under the concentration-time curve(AUC)for C-peptide level in a 2-h mixed-meal tolerance test,glycemic control,total daily insulin use and safety,respectively.The primary endpoint was not achieved in saxagliptin plus vitamin D group(P=0.18)and saxagliptin group(P=0.26).However,compared with the conventional therapy,2-h C-peptide AUC from 24 months to baseline decreased less with saxagliptin plus vitamin D(-276 pmol/L vs.-419 pmol/L;P=0.01),and not to the same degree with saxagliptin alone(-314 pmol/L;P=0.14).Notably,for participants with higher glutamic acid decarboxylase antibody(GADA)levels,the decline ofβ-cell function was much lower in saxagliptin plus vitamin D group than in the conventional therapy group(P=0.001).Insulin dose was significantly reduced in both active treatment groups than in the conventional therapy group despite all groups having similar glycemic control.In conclusion,the combination of saxagliptin and vitamin D preserves pancreaticβ-cell function in adult-onset autoimmune type 1 diabetes,an effect especially efficacious in individuals with higher GADA levels.Our results provide evidence for a novel adjunct to insulin and metformin as potential initial treatment for adult-onset type 1 diabetes.(ClinicalTrials.gov identifier:NCT02407899). | Xiang Yan Xia Li Bingwen Liu Jiaqi Huang Yufei Xiang Yuhang Hu Xiaohan Tang Ziwei Zhang Gan Huang Zhiguo Xie Houde Zhou Zhenqi Liu Xiangbing Wang Richard David Leslie Zhiguang Zhou | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 0 |
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