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| 1 | Herbal decoctosome is a novel form of medicine显示文摘Traditionally, herbal medicine is consumed by drinking decoctions produced by boiling herbs with water. The functional components of the decoction are heat stable. Small RNAs(sRNAs) were reported as a new class of functional components in decoctions. However, the mechanisms by which sRNAs survive heat treatment of the decoction and enter cells are unclear.Previous studies showed that plant-derived exosome-like nanoparticles(ELNs), which we call botanosomes, could deliver therapeutic reagents in vivo. Here, we report that heat-stable decoctosomes(ELNs) from decoctions have more therapeutic effects than the decoctions in vitro and demonstrate therapeutic efficacy in vivo. Furthermore, sRNAs, such as HJT-sRNA-m7 and PGY-sRNA-6, in the decoctosome exhibit potent anti-fibrosis and anti-inflammatory effects, respectively. Decoctosome is comprised of lipids, chemical compounds, proteins, and s RNAs. A medical decoctosome mimic is called bencaosome. A single lipid sphinganine(d22:0) identified in the decoctosome was mixed and heated with the synthesized sRNAs to form the simplest bencaosome. This simple bencaosome structure was identified by critical micelle concentration(cmc) assay that sRNAs coassembled with sphinganine(d22:0) to form the lipid layers of vesicles. The heating process facilitates co-assembly of sRNAs and sphinganine(d22:0) until a steady state is reached. The artificially produced sphinganine-HJT-sRNA-m7 and sphinganinePGY-sRNA-6 bencaosomes could ameliorate bleomycin-induced lung fibrosis and poly(I:C)-induced lung inflammation, respectively, following oral administration in mice. Our study not only demonstrates that the herbal decoctosome may represent a combinatory remedy in precision medicine but also provides an effective oral delivery route for nucleic acid therapy. | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao DANDan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 26 |
| 2 | Plant-derived phosphocholine facilitates cellular uptake of anti-pulmonary fibrotic HJT-sRNA-m7显示文摘Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-sRNA-m7, from a Chinese herbal medicine Hong Jing Tian(HJT, RHODIOHAE CRENULATAE RADIX ET RHIZOMA, Rhodiola crenulata) can effectively reduce the expressions of fibrotic hallmark genes and proteins both in alveolar in vitro and in mouse lung tissues in vivo. We also discovered over one hundred oil-soluble chemicals from HJT decoctions, most of which are found in lipid extracts from other Chinese herbals decoctions, including Pu Gong Ying(PGY, TARAXACI HERBA, Taraxacum mongolicum), Chuan Xin Lian(CXL, changed to 'ANDROGRAPHIS HERBA, Andrographis paniculata'), and Jin Yin Hua(JYH, lonicera japonica or Honeysuckle). We identified the active component in these decoctions as two forms of phosphocholines, PC(18:0/18:2) and PC(16:0/18:2). These PCs potentially could form liposomes with small RNAs to enter human alveolar and gastric cells. Our experimental results suggest an unprecendent lipid complex route through which botanic small RNA can enter human bodies.Our results provide an innovative treatment strategy for oral delivery of siRNAs as therapeutic medication. | Jianchao Du Zhu Liang Jiantao Xu Yan Zhao Xiaoyun Li Yanli Zhang DANDan Zhao Ruxuan Chen Yang Liu Trupti Joshi Jiahui Chang Zhiqing Wang Yanxu Zhang Jindong Zhu Qiang Liu Dong Xu Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 21 |
| 3 | Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis显示文摘The effective drug treatment of rheumatoid arthritis (RA) is hindered by poordelivery efficiency to the diseased site and the serious side effects caused bywide-spread drug distribution. Traditional drug-targeting strategies, such asligand modification, are complex, laborious, and inefficient. Inspired by theintrinsic relationship between platelets and RA, platelet-mimetic nanoparticles(PNPs) were developed for targeted drug delivery in RA. Through plateletreceptor-mediated adhesion, an intact platelet membrane was coated onto poly(lactic-co-glycolic add) nanopartides, endowing the resulting PNPs with variousfunctional receptors. By coating with platelet membranes, the nanoparticleswere stabilized and had a better circulation profile, providing a benefit forpassive targeting. In vitro binding of PNPs to inflamed endothelium, and in vivoaccumulation in joints of a collagen-induced arthritis (CIA) mouse model of RAwere significantly improved via P-selectin and GVPI recognition, indicating thatthe PNPs could effectively target to RA tissues through multiple mechanisms,similar to natural platelets. Moreover, FK506, a model drug, was loaded into thePNPs and used to treat RA. Pharmacodynamic studies demonstrated that theFK506-PNPs had a notable anti-arthritic effect in CIA mice. This study provides anew biomimetic targeting strategy with great potential for the treatment of RA. | Yuwei He Ruixiang Li Jianming Liang Ying Zhu Shuya Zhang Zicong Zheng Jing Qin Zhiqing Pang Jianxin Wang | 2018 | Nano Research2018，11，11： | 9 |
| 4 | Tauroursodeoxycholic acid(TUDCA) inhibits influenza A viral infection by disrupting viral proton channel M2显示文摘Influenza is a persistent threat to human health and there is a continuing requirement for updating antiinfluenza strategies. Initiated by observations of different endoplasmic reticulum(ER) responses of host to seasonal H1N1 and highly pathogenic avian influenza(HPAI) A H5N1 infections, we identified an alternative antiviral role of tauroursodeoxycholic acid(TUDCA), a clinically available ER stress inhibitor, both in vitro and in vivo. Rather than modulating ER stress in host cells, TUDCA abolished the proton conductivity of viral M2 by disrupting its oligomeric states, which induces inefficient viral infection. We also showed that M2 penetrated cells, whose intracellular uptake depended on its proton channel activity,an effect observed in both TUDCA and M2 inhibitor amantadine. The identification and application of TUDCA as an inhibitor of M2 proton channel will expand our understanding of IAV biology and complement current anti-IAV arsenals. | Ning Li Yanxu Zhang Shuangxiu Wu Ruodan Xu Zhiqing Li Jindong Zhu Hongliang Wang Xiao Li Mingyao Tian Huijun Lu Ningyi Jin Chengyu Jiang | 2019 | Science Bulletin2019，64，3： | 6 |
| 5 | Research advances on drought resistance mechanism of plant species in arid zones of China显示文摘Drought and shortage of water resources, which restrict the economy, society development and environmental protection, are key factors in arid zones of China. In the arid zones of Western China, researching plant drought resistance mechanism, selecting plant species with higher drought resistance, and developing water-saving techniques, are important for environmental improvement and economic development. This paper reviews research advances on drought resistance mechanism of plant species, based on research of morphological, physiological, and ecological adaptation mechanism of plant species under drought stress, such as anatomical structure of root systems and leaves, photosynthesis, antioxidant enzyme system, malondialdehyde (MDA), osmotic adjustment, endogenous hormone, drought-induced proteins and δ 13 C. Finally, this paper points out the key field of future research. | YaJuan Zhu Lei Li ZhiQing Jia | 2011 | Research in Cold and Arid Regions2011，3，5： | 5 |
| 6 | Recent insights for the emerging COVID-19:Drug discovery,therapeutic options and vaccine development显示文摘SARS-CoV-2 has been marked as a highly pathogenic coronavirus of COVID-19 disease into the human population,causing over 5.5 million confirmed cases worldwide.As COVID-19 has posed a global threat with significant human casualties and severe economic losses,there is a pressing demand to further understand the current situation and develop rational strategies to contain the drastic spread of the virus.Although there are no specific antiviral therapies that have proven effective in randomized clinical trials,currently,the rapid detection technology along with several promising therapeutics for COVID-19 have mitigated its drastic transmission.Besides,global institutions and corporations have commenced to parse out effective vaccines for the prevention of COVID-19.Herein,the present review will give exhaustive details of extensive researches concerning the drug discovery and therapeutic options for COVID-19 as well as some insightful discussions of the status of COVID-19. | Yuefei Zhu Jia Li Zhiqing Pang | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，1： | 4 |
| 7 | Strong interface contact between NaYF_(4):Yb,Er and CdS promoting photocatalytic hydrogen evolution of NaYF_(4):Yb,Er/CdS composites显示文摘To acquire efficient photocatalysts,it is necessary to make effective use of visible light/Near Infrared(NIR)light,which takes up a large percentage of sunlight.Integrating upconversion materials with visible light active photocatalysts has attracted much attention in this regard.The interface contact between upcon-version material and photocatalyst has potential influence on the properties and thus the performance of the system.In this work,NaYF_(4):Yb,Er/CdS composites of the upconversion material NaYF_(4):Yb,Er nanorods and CdS nanoparticles were synthesized by ion adsorption/precipitation process and were then annealed in an argon atmosphere at different temperatures to modulate the microstructures.The annealing pro-cess endows the crystal transformation of cubic CdS with low crystallinity to hexagonal CdS with high crystallinity and,importantly,good interface contact between NaYF_(4):Yb,Er and CdS.Consequently,the hy-drogen evolution activity greatly increases from 171 to 2539μmol h^(−1) g^(−1) under the light irradiation ofλ>400 nm,and from 0 to 19μmol h^(−1) g^(−1) under the light irradiation ofλ>600 nm.This work might provide a useful reference for the rational design of promising photocatalyst involving upconversion ma-terials. | Huaze Zhu Yongqiang Yang Yuyang Kang Ping Niu Xiangdong Kang Zhiqing Yang Hengqiang Ye Gang Liu | 2022 | Journal of Materials Science & Technology2022，，7： | 3 |
| 8 | Cloning and characterization of vernalization-related gene (ver203F) cDNA 3'end显示文摘Based on the cDNA fragment sequence of vernalization-related gene verc203 cloned by differential screening in our lab, the 5′primer has been designed. The cDNA 3′end of ver203 gene (1 197 bp) has been cloned by the RACE method. And it is identified by Northern blotting that its expression is special in vernalization treatment. After comparing the sequence in the nucleotide sequence databases of Genbank, EMBL and DDBJ, the gene has homology with Hordeum vulgare jesmonate-induced protein gene. It is suggested that this gene might be related to the signal transduction mediated by jamonate. | YONG Weidong, CHONG Kang , LIANG Tiebing, XU Zhihong , TAN Kehui and ZHU Zhiqing Research Center for Molecular and Developmental Biology, Institute of Botany, Chinese Academy of Sciences , Beijing 100093, China Shanghai Institute of Plant Physiology , Chinese Academy of Sciences , Shanghai 200032, China Corresponding authors | 1999 | Chinese Science Bulletin1999，44，14： | 3 |
| 9 | Identifying the Static and Dynamic Relationships Between Rural Population and Settlements in Jiangsu Province, China显示文摘Rapid urbanization has triggered large rural population floating into cities, which in turn affects rural human-land relationships. The actual human-land relationship involves the coupling level of a time point and dynamic change of a time interval. However, few studies have identified the rural human-land relationship from these two perspectives. This study combined static coupling analysis with a dynamic decoupling model to analyze the relationships between rural population and settlements from 2009 to 2018 in Jiangsu Province, China. Although the static coupling degree in Jiangsu Province was relatively high, the decoupling analysis found that the rural human-land relationship in most counties was uncoordinated. There were 11 combination types based on the coupling and decoupling relationships. The most common two types(accounting for 76.74%) were recession decoupling with high-level coupling and strong decoupling with high-level coupling. Although the majority of counties had a high-level coupling degree, an uncoordinated change in rural population and rural settlements was observed in these counties. Counties with relatively reasonable human-land relationships accounted for only 12.79% of the total. The combination features for each type were identified and differential policies were proposed for optimizing human-land relationship in rural areas. This study would contribute to our understanding of the multiple relationships between rural population and settlements involved in different patterns and processes, and expect to provide theoretical and methodological support for promoting rural revitalization and sustainable development in practice. | ZHU Zhiqing KONG Xuesong LI Yajing | 2020 | Chinese Geographical Science2020，30，5： | 3 |
| 10 | Erratum to:Herbal decoctosome is a novel form of medicine显示文摘Following the published article,we noticed an error duplication in Figure 5G“control”and“PGY-6”that was introduced during the revised process,with an attempt to replace it with higher-resolution images.Here we provide the original data in the first submitted manuscript(Figure 5G). | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao Dandan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2020 | Science China(Life Sciences)2020，63，9： | 2 |
| 11 | Large-area surface-enhanced Raman scattering-active substrates fabricated by femtosecond laser ablation显示文摘A rapid and simple approach to fabricate large-area surface-enhanced Raman scattering-active(SERS-active) substrates is reported.The substrates are fabricated by using femtosecond laser(fs-laser) direct writing on Silicon wafers,followed by thin-film coating of metal such as gold.The substrates are demonstrated to exhibit signal homogeneity and good enhancement ability for SERS.The maximum enhancement factor(EF) up to 3×10 7 of such SERS substrates for rhodamine 6G(R6G) at 785 nm excitation wavelength was measured.This technique could demonstrate a functional microchip with SERS capability of signal homogeneity,high sensitivity and chemical stability. | ZHU ZhiQing YAN ZhenDong ZHAN Peng WANG ZhenLin | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，9： | 2 |
| 12 | Characterization of Bimetallic Ru-Sn Supported Catalysts and Hydrogenation of 1,4-Cyclohexanedicarboxylic Acid 显示文摘 | Zhu Zhiqing Lu Zihong Li Bin | 2006 | Appl Catal A2006，302，2： | 1 |
| 13 | Changes in DNA base sequences in the mutant of Arabidopsis thaliana induced by low-energy N+ implantation显示文摘 | Fengqi Chang Xuanming Liu Yinxin Li Gengxiang Jia Jingjing Ma Gongshe Liu Zhiqing Zhu | 2003 | Science in China Series C: Life Sciences2003，，5： | 1 |
| 14 | Establishment of Caenorhabditis elegans SID-1-Dependent DNA Delivery System in Cultured Silkworm Cells显示文摘 | Jian Xu Kaito Yoshimura Hiroaki Mon Zhiqing Li Li Zhu Kazuhiro Iiyama Takahiro Kusakabe Jae Man Lee | 2014 | Molecular Biotechnology2014，，3： | 1 |
| 15 | Soaking RNAi-mediated modification of Sf9 cells for baculovirus expression system by ectopic expression of Caenorhabditis elegans SID-1显示文摘 | Jian Xu Yudai Nagata Hiroaki Mon Zhiqing Li Li Zhu Kazuhiro Iiyama Takahiro Kusakabe Jae Man Lee | 2013 | Applied Microbiology and Biotechnology2013，，13： | 1 |
| 16 | Characterization of Bimetallic Ru-Sn Supported Catalysts and Hydrogenation of 1,4-Cyclohexanedicarboxylic Acid显示文摘 | Zhu Zhiqing Lu Zihong Li Bin | 2006 | Appl Catal A2006，302，2： | 1 |
| 17 | A facile preparation of carbon-supported Pd nanoparticles for electrocatalytic oxidation of formic acid 显示文摘 | Yu Zhu Yongyin Kang Zhiqing Zou | 2008 | Electrochem Commun2008，10，5： | 1 |
| 18 | Detetion of p3^7ing1 inmice reveals a p53-independent role for ing1 in the suppression of cell proliferation,apoptosis,and tumorigenesis显示文摘 | Coles AH Liang Huiling Zhu Zhiqing | 2007 | Cancer Res2007，67，5： | 1 |
| 19 | Broad-spectrum and powerful neutralization of bacterial toxins by erythroliposomes with the help of macrophage uptake and degradation显示文摘Anti virulence strategy has been considered as one of the most promising approaches to combat drug-rcesistant bacterial infections.Porc-forming toxins(PFTs)are the largest class of bacterial toxins,inficting their virulence ffect through creating pores on the cell membrane.However,curent solutions for eliminating PFTs are mostly designed based on their molecular structure,requiring customized design for different interactions.In the present study,we employed erythroliposome(denoted as RM-PL),a biomimetic platform constructed by artificial lipid membranes and natural erythrocyle membranes,to necutralize different hemolytic PFTs regardless of their molecular structure.When tested with model PFTs,including a-hemolysin,listeriolysin O,and streptolysin O,RM-PL could completely inhibit toxin-induced hemolysis in a concentration-dependent manner.In vivo studies further confirmed that RM-PL.could eficiently neuralize various toxins and save animals'lives without causing damage to 0rgans or tissues.In addition,we explored the underlying mechanisms of this efficient detoxification ability and found that it was mainly macrophages in the spleen and the liver that took up RM-PL-absorbed toxins through a variety of endocytosis pathways and digested them in lysosomes.In summary,the biomimetic RM-PL presented a promising system for broad-spectrum and powerful toxin neutralization with a mech-anism of lysosome-mediaed loxin degradation. | Chunying Liu Shuangrong Ruan Ying He Xuejing Li Yuefei Zhu Honglan Wang Hanwei Huang Zhiqing Pang | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 1 |
| 20 | Porous Li-Na-K niobate bone-substitute ceramics;microstructure and piezoelectric properties 显示文摘 | Wang Qi Chen Xinmin Zhu Jianguo Darvell B W Chen Zhiqing | 2008 | Materials Letters2008，62，20： | 1 |
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