|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Fermented soybean meal improves the growth performance, nutrient digestibility, and microbial flora in piglets显示文摘In order to increase nutritive values of soybean meal(SBM), 3 species of microbes were used to ferment SBM. Through a 3 x 3 orthogonal design and parameter measurements of soybean peptide and antinutritional factor contents in the fermented soybean meal(FSBM), it was estimated that the best microbial proportion of Bacillus subtilis, Hansenula anomala and Lactobacillus casei was 2:1:2 for SBM fermentation(P < 0.05). The further piglet feeding experiment showed that 10% FSBM substitute for SBM had no significant effect on growth performance of suckling piglets(d 7-28)(P> 0.05). However, newlyweaned piglets(d 28-38) fed 10% FSBM and different levels of plasma protein obtained higher average daily gain(ADG) and feed conversion ratio(FCR), compared with those without FSBM but with 6% plasma protein(P < 0.05). Piglets(d 38-68) fed diets supplemented with FSBM and soybean protein concentrate(SBPC) at 3.75% and 7.5% respectively increased nutrient digestibility,fecal enzyme activity and lactic acid bacteria counts, and decreased fecal Escherichia coli counts(P < 0.05), compared with the control. These data indicated that FSBM had positive effects on nutrient digestibility and fecal microflora for piglets. | Lin Yuan Juan Chang Qingqiang Yin Min Lu Yuanran Di Ping Wang Zhixiang Wang Erzhu Wang Fushan Lu | 2017 | Animal Nutrition2017，，1： | 31 |
| 2 | Hypoxia induces PGC-la expression and mitochondrial biogenesis in the myocardium of TOF patients显示文摘 | Qiang Wang Lin Zhang Zhixiang Fang Fang Zhao Zhiyuan Lv Zuguang Gu Junfeng Zhang Jin Wang Ke Zen Yang Xiang Dongjin Wang Chen-Yu Zhang | 2010 | Cell Research2010，20，6： | 13 |
| 3 | Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells显示文摘Background: The mitogen-activated extracellular signal-regulated kinase 1/2(MEK1/2) inhibitor trametinib has shown promising therapeutic effects on melanoma, but its efficacy on colorectal cancer(CRC) is limited. Synthetic lethality arises with a combination of two or more separate gene mutations that causes cell death, whereas individual mutations keep cells alive. This study aimed to identify the genes responsible for resistance to trametinib in CRC cells,using a synthetic lethal short hairpin RNA(shRNA) screening approach.Methods: We infected HT29 cells with a pooled lentiviral shRNA library and applied next-generation sequencing to identify shRNAs with reduced abundance after 8-day treatment of 20 nmol/L trametinib. HCT116 and HT29 cells were used in validation studies. Stable ring finger protein 183(RNF183)-overexpressing cell lines were generated by pcDNA4-myc/his-RNF183 transfection. Stable RNF 183-knockdown cell lines were generated by infection of lentiviruses that express RNF183 shRNA, and small interference RNA(siRNA) was used to knock down RNF183 transiently.Quantitative real-time PCR was used to determine the mRNA expression. Western blotting, immunohistochemical analysis, and enzyme-linked immunosorbent assay(ELISA) were used to evaluate the protein abundance. MTT assay,colony formation assay, and subcutaneous xenograft tumor growth model were used to evaluate cell proliferation.Results: In the primary screening, we found that the abundance of RNF183 shRNA was markedly reduced after treatment with trametinib. Trametinib induced the expression of RNF183, which conferred resistance to drug-induced cell growth repression and apoptotic and non-apoptotic cell deaths. Moreover, interleukin-8(IL-8) was a downstream gene of RNF183 and was required for the function of RNF183 in facilitating cell growth. Additionally, elevated RNF183 expression partly reduced the inhibitory effect of trametinib on IL-8 expression. Finally, xenograft tumor model showed the synergism of RNF183 knockdown and trametinib in repressing the growth of CRC cells in vivo.Conclusion: The RNF183-IL-8 axis is responsible for the resistance of CRC cells to the MEK1/2 inhibitor trametinib and may serve as a candidate target for combined therapy for CRC. | Rong Geng Xin Tan Zhixiang Zuo Jiangxue Wu Zhizhong Pan Wei Shi Ranyi Liu Chen Yao Gaoyuan Wang Jiaxin Lin Lin Qiu Wenlin Huang Shuai Chen | 2017 | Chinese Journal of Cancer2017，36，12： | 2 |
| 4 | Practical Experiences of Delivering Multidrug-Resistant Tuberculosis Comprehensive Supportive Care Services in China显示文摘Summary What is already known about this topic?The World Health Organization consolidated guidelines on recommend care for tuberculosis(TB)and support for multidrug-resistant TB(MDR-TB)patients.But guidelines have not provided detailed guidance or tools for health services providers to implement comprehensive patient care. | Yunzhou Ruan Ling Li Lin Xu Yanlin Zhao Li Zhong Zhixiang Xu Kai Wang Wei Su Renzhong Li | 2021 | China CDC weekly2021，3，26： | 2 |
| 5 | Surgical Management and Prognostic Factors of Hilar Cholangiocarcinoma: Experience with 115 Cases in China显示文摘 | Liu Yubin PhD Fang Chihua PhD Jian Zhixiang MM Ou Jinrui BA Liu Zixian BA Zheng Jianghua BA Lin Ye MD Jin Haosheng MD Lu Chaomin PhD | 2008 | Annals of Surgical Oncology2008，，8： | 2 |
| 6 | Dysregulated adaptive immune response contributes to severe COVID-19显示文摘Dear Editor,The outbreak of the new coronavirus 5ARS-CoV-2 has resulted in a global pandemic.Due to the lack of a specific drug against this virus,the current clinical management of this disease mainly depends on supportive care to reduce inflammatory responses and to keep the lung functioning1. | Kuai Yu Jingjing He Yongjian Wu Baosong Xie Xuefei Liu Bo Wei Haibo Zhou Bingliang Lin Zhixiang Zuo Wen Wen Wenxiong Xu Bin Zou Lai Wei Xi Huang Penghui Zhou | 2020 | Cell Research2020，30，9： | 1 |
| 7 | Simultaneous inference of phenotype-associated genes and relevant tissues from GWAS data via Bayesian integration of multiple tissue-specific gene networks显示文摘尽管染色体宽的协会研究( GWAS )成功地识别了几千 genomic , loci 在过去的十年与几百个复杂特点联系了,关于象失踪的可遗传性和弱 interpretability 的如此的问题的争论一直在呼吁让有效计算方法便于存在的广阔体积的先进分析并且期望基因数据。向这个目标,有与显型联系的基因趋于在生物基因集合或基因网络被充实的假设的基因级的综合 GWAS 分析最近吸引了许多注意,由于象越过研究的直接解释,不太多重的测试负担,和坚韧性的如此的优点。然而,存在在这个范畴的方法通常利用 non-tissue-specific 基因网络并且因此缺乏能力利用增进知识的织物特定的特征。克服这限制,我们建议一条贝叶斯的途径叫了图章(同时基因和纸巾的推理) 为联系显型的基因和相关纸巾的同时的推理集成 GWAS 数据和多重织物特定的基因网络。通过广泛的模拟研究,我们在为显型发现联系基因和相关纸巾显示出我们的方法的有效性。在到 14 复杂显型的真实 GWAS 数据的应用,我们在两个都译解表明了我们的方法的力量基因基础和显型的发现生物卓见。与这理解,我们期望为综合 GWAS 分析把图章看作一个珍贵工具,从而增加人的预防,诊断,和治疗继承了疾病和最后便于的精确药。 | Mengmeng Wu Zhixiang Lin Shining Ma Ting Chen Rui Jiang Wing Hung Wong | 2017 | Journal of Molecular Cell Biology2017，9，6： | 1 |
| 8 | Conducting polymer nanostructures and their application in biosensors显示文摘 | Xia Lin Wei Zhixiang Wan Meixiang | 2010 | J Colloid Interf Sci2010，341，1： | 1 |
| 9 | Deuterium and oxygen-18 and tritium contents of meteoric water in Beijing area 显示文摘 | Wei Keqin Lin Ruifen Wang Zhixiang | 1982 | Scientia Sinica (Series B)1982，，8： | 1 |
| 10 | Polyaniline nanotubes doped with sulfonated carbon nanotubes made via a self-assembly process 显示文摘 | Wei Zhixiang Wan Meixiang Lin Tong Dai Liming | 2003 | Adv Mater2003，15，： | 1 |
| 11 | Polyaniline nanotubes doped with sulfonated carbon nanotubes made via a self-assembly process 显示文摘 | Wei Zhixiang Wan Meixiang Lin Tong | 2003 | Adv Mater2003，15，2： | 1 |
| 12 | A Late Pleistocene-Holocene lacustrine record from Lake Manas, Zunggar (northern Xinjiang, western China)显示文摘 | Thomas E. Rhodes Fran?oise Gasse Ruifen Lin Jean-Charles Fontes Keqin Wei Philippe Bertrand Elisabeth Gibert Frédéric Mélières Piotr Tucholka Zhixiang Wang Zhi-Yuan Cheng | 1996 | Palaeogeography Palaeoclimatology Palaeoecology1996，，1： | 1 |
| 13 | Fabrication and Characterization of 3D Graded PDMS Scaffolds Using Vacuum-Assisted Resin Transfer Moulding显示文摘Graded porous scaffold can be applied to study the interactions between cells and scaffold with different pore sizes. Polydimethylsiloxane(PDMS) scaffold with an axial pore size grade was successfully manufactured via vacuum-assisted resin transfer moulding(VARTM) and particle leaching technologies. The properties of graded PDMS scaffolds, including porosity, water absorption, interconnectivity, compression modulus, as well as compression strength were investigated. The results showed that the smaller the size of the NaCl particles is, the higher the porosity and water absorption of graded PDMS scaffolds would be. The graded PDMS scaffold fabricated had a compressive modulus and a compressive strength of 19.69±1.42 kPa and 4.76±0.22 kPa, respectively. Moreover, the graded chitosan(CS)-coated PDMS scaffolds were prepared by using dip-coating technique under low vacuum and their hydrophilicity was examined. It is found that the water contact angle(WCA) will decrease with an increase in the CS solution concentration and the coating time, which indicates that CS-coated PDMS scaffolds exhibit noticeable hydrophilicity compared with graded PDMS scaffold. | 司军辉 LIN Jiahe ZHENG Zifeng CUI Zhixiang WANG Qianting | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，5： | 1 |
| 14 | Experimental determination of laminar burning velocities and Markstein lengths for 75% hydrous-ethanol, hydrogen and air gaseous mixtures显示文摘 | Zunhua Zhang Gesheng Li Lin Ouyang Zhixiang Pan Fubing You Xiaohong Gao | 2011 | International Journal of Hydrogen Energy2011，，20： | 1 |
| 15 | 显示文摘 | Wei Zhixiang Wan Meixiang Lin Tong | 2003 | Adv Mater2003，15，： | 1 |
| 16 | Conducting polymer nanostructures and their application in biosensors显示文摘 | Xia Lin Zhixiang Wei Wan Meixiang | 2010 | J Colloid Interface Sci2010，341，1： | 1 |
| 17 | Impact of genetic patterns on sorafenib efficacy in patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation: a multi-center, cohort study显示文摘Sorafenib therapy improves overall survival(OS)in patients with FLT3 internal tandem duplication(ITD)acute myeloid leukemia(AML)undergoing allogeneic hematopoietic stem cell transplantation.We explored the efficacy of sorafenib therapy in this population with different concomitant genetic patterns.In this multi-center,cohort study,we enrolled patients with FLT3-ITD AML undergoing allogenic hematopoietic cell transplantation.Patients with sorafenib maintenance post-transplantation for at least four weeks were allocated to the sorafenib group,and otherwise to the control group. | Ruoyang Shao Yu Zhang Jinping He Fen Huang Zhiping Fan Kaibo Yang Yajing Xu Na Xu Yi Luo Lan Deng Xi Zhang Jia Chen Mingzhe Han Xudong Li Sijian Yu Hui Liu Xinquan Liang Xiaodan Luo Pengcheng Shi Zhixiang Wang Ling Jiang Xuan Zhou Ren Lin Yan Chen Sanfang Tu Jing Sun Yu Wang Qifa Liu Li Xuan | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 18 | Orbital and Millennial-Scale Climate Variability over the Past 76 ka in the Western Tarim Basin, Northwest China显示文摘Paleoclimate changes during the last glacial in the arid central Asia are not as well understood as the monsoon-dominated areas of Asia. Here we report a 75-m-long sediment core over past 120 kyr based on astronomical tuning combined with the optically stimulated luminescence(OSL) dating in the Kashi depression of the western Tarim Basin, Northwest China. Analysis of grain size and highresolution gamma ray(GR) logs from the KT11 borehole across the last glacial period yields a climate history for the Tarim Basin which reflects the variations of its temperature and the hydrological cycles. Comparison of these records with north hemisphere summer insolation, the Greenland ice core temperature, stalagmites and the loess from the nearby region indicates that the deposits in the fluvio-lacustrine system of the Kashi depression responded to climate change at the Younger Dryas(YD), six Heinrich cooling events and the Dansgaard-Oeschger cycles. Our work indicates that the alternations between warm-humid and cold-dry climates were prevalent in the western Tarim Basin during the last glacial period, showing an in-phase pattern with the climate variations of the East Asian Monsoon, controlled ultimately by precession and North Atlantic Ocean climate variability on orbital-millennial time scales. | Rui Zhang Qiuzhen Yin Weihua Nai Zhixiang Wang Hao Lu Chunju Huang Yansheng Gu Lin Li Yusong Wang Linjing Liu | 2023 | Journal of Earth Science2023，34，1： | 0 |
| 19 | Mathematical modeling for of arctigenin from acidultrasonic-assisted extractionhydrolyzed FructusArctii显示文摘A mathematical model based on Fick' s first law wasestablished to describe the process of ultrasonic-assistedextraction of arctigenin from acid hydrolyzed FructusArctii.Acid hydrolization with hydrochloric acid promotes theconversion of arctiin to arctigenin in the arctiin-rich activepharmaceutical ingredient, and the hydrolyzed products werefurther examined to investigate the process setup. Byconsidering the mechanism of the extraction process andexperimental data, the effects of parameters including solventto solid ratio, particle size of hydrolyzed samples, ethanolvolume fraction, ultrasound power, extraction temperature andextraction time on concentration of arctigenin were analyzed indetail. The model was suitable for simulating the process ofultrasonic-assisted extraction of arctigenin. The simulationresults of the model agree well with experimental data with thedeviation below 13%, indicating that the mathematical modelcan provide valuable guidance for the extraction of arctigeninfrom acid hydrolyzed FructusArctii. | Dai Lin Zhang Yong Hu Chi Qian Hongliang Wang Zhixiang | 2017 | Journal of Southeast University(English Edition)2017，33，3： | 0 |
| 20 | Aromatic compounds-mediated synthesis of anatase-free hierarchical TS-1 zeolite:Exploring design strategies via machine learning and enhanced catalytic performance显示文摘Simultaneous achievement of constructing mesopores and eliminating anatase is a long-term pursuit for enhancing the catalytic performance of TS-1.Here,we developed an aromatic compounds-mediated synthesis method to prepare anatase-free and hierarchical TS-1 for olefin epoxidation.A series of hierarchical TS-1 zeolites were prepared by introducing aromatic compounds containing different functional groups via the crystallization process.The formation of intercrystalline mesopores and insertion of titanium into framework were facilitated at different extent.The synergistic coordination of carboxyl and hydroxyl in aromatic compounds with Ti(OH)4 realizes the uniform distribution of titanium species and eliminates the generation of anatase.Noteworthily,eight machine learning models were trained to reveal the mechanism of additive functional groups and preparation conditions on anatase formation and microstructure optimization.The prediction accuracy of most models can reach more than 80%.Benefiting from the larger mesopore volumes(0.37 cm3⋅g−1)and higher content of framework Ti species,TS-DHBDC-48h samples exhibit a higher catalytic performance than other zeolites,giving 1-hexene conversion of 49.3%and 1,2-epoxyhenane selectivity of 99.9%.The paper provides a facile aromatic compounds-mediated synthesis strategy and promotes the application of machine learning toward the design and optimization of new zeolites. | Chang’an Wang Guoqing An Jing Lin Xiaowei Zhang Zhiyuan Liu Yibin Luo Siqi Liu Zhixiang Cheng Tingting Guo Hongyi Gao Ge Wang Xingtian Shu | 2023 | Aggregate2023，4，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员