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| 1 | Behaviors and kinetics of toluene adsorption-desorption on activated carbons with varying pore structure显示文摘This work was undertaken to investigate the behaviors and kinetics of toluene adsorption and desorption on activated carbons with varying pore structure. Five kinds of activated carbon from different raw materials were selected. Adsorption isotherms and breakthrough curves for toluene were measured. Langmuir and Freundlich equations were fitted to the equilibrium data, and the Freundlich equation was more suitable for simulating toluene adsorption. The process consisted of monolayer, multilayer and partial active site adsorption types. The effect of the pore structure of the activated carbons on toluene adsorption capacity was investigated. The quasi-first-order model was more suitable for describing the process than the quasi-second-order model. The adsorption data was also modeled by the internal particle diffusion model and it was found that the adsorption process could be divided into three stages. In the external surface adsorption process, the rate depended on the specific surface area. During the particle diffusion stage, pore structure and volume were the main factors affecting adsorption rate. In the final equilibrium stage, the rate was determined by the ratio of meso-and macro-pores to total pore volume. The rate over the whole adsorption process was dominated by the toluene concentration. The desorption behavior of toluene on activated carbons was investigated,and the process was divided into heat and mass transfer parts corresponding to emission and diffusion mechanisms, respectively. Physical adsorption played the main role during the adsorption process. | Xi Yang Honghong Yi Xiaolong Tang Shunzheng Zhao Zhongyu Yang Yueqiang Ma Tiecheng Feng Xiaoxu Cui | 2018 | Journal of Environmental Sciences2018，30，5： | 28 |
| 2 | Middle Triassic post-orogenic extension on Hainan Island: Chronology and geochemistry constraints of bimodal intrusive rocks显示文摘This work studies new petrological and geochemical data and zircon U-Pb ages for bimodal intrusive rocks from Xinglong region, Hainan Island. Zircon U-Pb dating yields mean 238 U/ 206 Pb ages of 238 ± 2 Ma and 234 ± 2 Ma for diabasic and granitic phases, respectively, representing the Middle Triassic emplacement. The diabase and granite bodies were formed from discrete mafic and acidic magma sources that experienced local mechanical mixing at their mutual contacts. Although SiO 2 content of intrusions is bimodal, trace element ratios indicate that both were formed in a post-orogenic extensional setting. Sr-Nd isotopic composition reflects a shared EMII type enriched mantle source component, possibly influenced by subduction-fluid metasomatism. | TANG LiMei CHEN HanLin DONG ChuanWan YANG ShuFeng SHEN ZhongYue CHENG XiaoGan FU LuLu | 2013 | Science China Earth Sciences2013，56，5： | 12 |
| 3 | Recombinant vaccine containing an RBD-Fc fusion induced protection against SARS-CoV-2 in nonhuman primates and mice显示文摘The novel coronavirus SARS-CoV-2 has infected more than 104 million individuals and resulted in more than 2.2 million deaths worldwide as of February 7,2021(http://gffzze7c39cdc9e894ca6su55uk6cqubwc6f9u.ffgz.tsg.suse.edu.cn).The COVID-19 pandemic highlights the need for safe and effective vaccines against SARS-CoV-2 infection. | Shihui Sun Lei He Zhongpeng Zhao Hongjing Gu Xin Fang Tiecheng Wang Xiaolan Yang Shaolong Chen Yongqiang Deng Jiangfan Li Jian Zhao Liang Li Xinwang Li Peng He Ge Li Hao Li Yuee Zhao Chunrun Gao Xiaoling Lang Xin Wang Guoqiang Fei Yan Li Shusheng Geng Yuwei Gao Wenjin Wei Zhongyu Hu Gencheng Han Yansong Sun | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 4 | Therapeutic mechanisms of integrated traditional Chinese and conventional medicine underlying its treatment of precancerous lesions of gastric cancer显示文摘China has a high incidence of gastric cancer. Secondary prevention of gastric cancer is a major public health problem that must be solved urgently. Modern medicine focuses on the pathogenesis of precancerous lesions of gastric cancer(PLGC), and it has been found that there are a variety of abnormal gene expression patterns in PLGC. This study summarizes recent advances in our understanding of the therapeutic mechanisms of PLGC from various clinical studies;this will provide a reference for studying the therapeutic mechanisms of Traditional Chinese Medicine in the treatment of PLGC from the combined points of view of Traditional Chinese and Conventional medicine. | XU Qing WANG Yang LI Zhongyu YAN Jiaxing ZHAO Yingpan WANG Ping WEN Yandong | 2022 | Journal of Traditional Chinese Medicine2022，42，6： | 4 |
| 5 | Structural basis of Zika virus helicase in recognizing its substrates显示文摘Zika 的最近的爆炸爆发病毒(ZIKV ) 感染在南方和中美洲和加勒比海被报导了。与 ZIKV 感染联系的新生的头小畸型已经引起了国际担心的一种公共健康紧急情况。没有特定的疫苗或药当前是可得到的治疗 ZIKV 感染。ZIKV helicase,在病毒的 RNA 复制起一个枢轴的作用,是为治疗的一个吸引人的目标。我们决定了 ZIKV helicase-ATP-Mn 2+ 和 ZIKV helicase-RNA 的水晶结构。这是到 ATP 的任何 flavivirus helicase 界限的第一结构。有相关 flavivirus helicases 的比较证明了尽管在活跃地点的批评 P 环在不同种类之中有可变符合构造,认出 ATP/Mn 2+ 采用一个相同模式。ZIKV helicase-RNA 的结构表明了在 RNA 绑定之上,马达领域的旋转能引起重要 conformational 变化。惊人地,尽管 ZIKV 和登革热病毒(DENV ) apo-helicases 份额为 RNA 绑定保存了残余,他们在为 RNA 识别的不同单个模式的马达域旋转结果的不同礼貌。它建议 flavivirus helicases 能发展了一台保存引擎为 RNA 放松,而是不同马达领域旋转从 nucleoside triphosphate 把化学能变换成机械精力在可变 RNA 识别的结果适应单个病毒的复制的模式。 | Hongliang Tian Xiaoyun Ji Xiaoyun Yang Zhongxin Zhang zuoku Lu Kailin Yang Cheng Chen Qi Zhao Heng Chi Zhongyu Mu Wei Xie Zefang Wang Huiqiang Lou Haitao Yang Zihe Rao | 2016 | Protein & Cell2016，7，8： | 3 |
| 6 | Microstructure and Tribological Properties of Plasma-sprayed Nanostructured Sulfide Coating显示文摘磨擦并且穿喷洒血浆的 nanostructured FeS 的性质涂层在 MHK-500 磨擦上被调查并且在油润滑油和干燥磨擦下面穿测试者状况。微观结构,穿的表面形态学和涂层的阶段作文被扫描电子显微镜学(SEM ) 和 X 光检查衍射(XRD ) 描绘。涂层主要由 FeS 组成,这被发现, Fe_(1-x ) S 和氧化物的小数量也被发现。涂层被 50-100 nm 的小粒子在尺寸形成。涂层的厚度是约 150 亩 m。plasma-sprayednanostructured FeS 涂层的磨擦减小和穿抵抗性质比 GCrl5 钢底层的优异。特别在油润滑油状况下面, nanostructured FeS 涂层的磨擦系数是中的 50% 个 GCrl5 钢,涂层的 wear 疤宽度是,这也在高负担下面归结为 GG15 钢的中的将近 50% 个。涂层的失败主要在油润滑油和干燥磨擦状况下面被归因于塑料变丑。 | Yang XU Yaohui GUAN Zhongyu ZHENG Xiaohui TONG | 2006 | Journal of Materials Science & Technology2006，22，5： | 3 |
| 7 | Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction显示文摘 | Jing Ai Rong Zhang Yue Li Jielin Pu Yanjie Lu Jundong Jiao Kang Li Bo Yu Zhuqin Li Rongrong Wang Lihong Wang Qiang Li Ning Wang Hongli Shan Zhongyu Li Baofeng Yang | 2009 | Biochemical and Biophysical Research Communications2009，，： | 2 |
| 8 | 转录组-代谢组联合分析揭示低温下采后雷竹笋木质化分子调控机制显示文摘雷竹(Phyllostachys violascens)笋是中国传统的山珍之一,是一种天然绿色食品。但其采后易消耗大量水分和营养而快速老化,在一般条件下难以贮藏。文中首次通过“转录组—代谢组”联合分析揭示了低温贮藏条件下雷竹笋木质化的调控机制,研究表明:与常温贮藏相比,低温可显著抑制采后竹笋中PAL、POD酶活性,降低失水率和总木质素含量,从而将竹笋保鲜时间至少延长20 d。通过“转录组—代谢组”联合分析表明,低温下竹笋木质素前体物质、茉莉酸含量呈上升趋势,并在后期显著富集,说明低温可诱导茉莉酸积累、抑制木质素合成。对低温响应、茉莉酸合成和木质素合成通路关键基因进行筛选,并通过共表达分析发现,低温信号可能通过“低温—木质化”和“低温—茉莉酸—木质化”2种通路共同抑制采后竹笋中木质素合成,延缓其保鲜时间。上述结果可为揭示采后竹笋木质化分子调控通路研究提供了一定依据。 | 侯丹(翻译) 林新春(翻译) Haiwen Lu Zhongyu Zhao Jialong Pei Huqing Yang Aimin Wu Xuejun Yu | 2021 | 世界竹藤通讯2021，19，5： | 2 |
| 9 | Tumor Cell Detection Device Based on Surface Plasmon Resonance Imaging and Image Processing显示文摘 | YANG Mengchao JIN Xinyu YUAN Maokai LIU Fan LANG Yicong WU Zhongyu XIANG Liancheng ZHOU Chao OUYANG Bo JIN Wei MU Ying | 2014 | Chemical Research in Chinese Universities2014，30，2： | 2 |
| 10 | Magma flow inferred from magnetic fabrics in Wanning gabbro pluton and diabase dykes, Hainan显示文摘Measurements of anisotropy of magnetic susceptibility (AMS) were performed on a gabbro pluton and 7 diabase dykes in the Wanning area, southeast Hainan Island. Rock magnetism showed that pseudo-single domain (PSD) to multidomain (MD) Ti-poor magnetite carries the magnetic fabric in the gabbro pluton whereas MD Ti-poor magnetite carries the magnetic fabric in the diabase dykes. The corrected anisotropy degree (Pj ) in most specimens was found to be less than 1.2 which is indicative of a possible flow-related magnetic fabric. The AMS eigenvectors within each site are generally well grouped. The maximum susceptibility axes (K1 ) of the gabbro pluton are inclined towards the north at low angles (< 30°). K1 axes of the diabase dykes are inclined towards the NNW and SSE with dip angles of ≤ 30°. From this study, it appears that the emplacement mode of the gabbro pluton was characterized by intrusion from the north to the south at a low angle whereas the diabase dykes were emplaced from the NNW to the SSE at low to moderate angles. This was verified by comparison of the rock fabric to the magnetic fabric. All of this evidence leads to the conclusion that the Wanning gabbro pluton and diabase dykes were the products of pulsative intrusion from the same magma chamber in the area far to the north of Wanning, which suggests that basic rocks may exist beneath the Indosin- ian granite in the area to the north of Wanning. | PAN XiaoQing SHEN ZhongYue DONG ChuanWan CHEN HanLin CHENG XiaoGan YANG ShuFeng ZHANG ZhiLiang | 2012 | Chinese Science Bulletin2012，57，16： | 2 |
| 11 | New insights into the mechanism of localised corrosion induced by TiN-containing inclusions in high strength low alloy steel显示文摘This work investigated the chemical and electrochemical mechanisms of localised corrosion triggered by CaS·xMgO·y Al_(2)O_(3)·TiN complex inclusions in high strength low alloy steel(HSLAS)under a simulated marine environment.Special focus was given to the role of the TiN portion of the inclusion on the initiation and growth of the corrosion pits.The thermodynamic process of pitting initiation was investigated by Gibbs free energy,Pourbaix diagram and first principle calculation.Localised corrosion is mainly induced by inclusions and triggered by dissolution of adjacent distorted matrix.Chemical dissolution of CaS portion in CaS·xMgO·y Al_(2)O_(3)·TiN complex inclusion creates an acidic aggressive environment that accelerates the further dissolution of inclusion and matrix.Galvanic coupling effect between TiN inclusion and matrix is directly verified.TiN covered with a TiOfilm acts as the cathodic phase in galvanic corrosion,although it has a lower Volta potential than the matrix.This is an unusual correlation with the scanning Kelvin probe force microscopy result,which has been explained for this special system. | Chao Liu Reynier I.Revilla Xuan Li Zaihao Jiang Shufeng Yang Zhongyu Cui Dawei Zhang Herman Terryn Xiaogang Li | 2022 | Journal of Materials Science & Technology2022，，29： | 2 |
| 12 | 无人机遥感在植物生态学中的应用与挑战显示文摘无人机为获取高时空分辨率的遥感数据提供了经济灵活的工具,为植物生态学家开展从个体到区域尺度的生态学研究提供了新的机遇和手段。但作为一种新兴的技术手段,当前无人机遥感在植物生态学中的应用仍充满了挑战,植物生态学的科研需求与无人机遥感的生态应用需要更为深入的融合。本文综述了无人机遥感技术在植物生态学中的应用,展望了无人机在植物生态学研究中的应用前景。在所综述的400篇文献中,59%的文章发表于非植物生态学领域的遥感类期刊,遥感学者与生态学者的关注点存在较大差异。当前的研究集中在无人机遥感的技术层面,如数据处理和遥感反演方法等,对生态学问题本身的关注较少。综述的文献中,61%的研究案例集中在群落尺度,可见光(RGB)相机和多光谱相机是最常用的传感器类型(75%)。无人机遥感数据中蕴藏着诸多待挖掘的、有重要意义的生态参数,这些参数有助于我们识别林窗的几何特征,构建林冠的化学组合,更好地了解林冠表面的不规则性和群落的异质性。无人机遥感技术在植物生态学研究中的深入应用,需要集植物生态学家和遥感专家之合力共同推进。 | Zhongyu Sun Xiaonian Wang Zhihui Wang Long Yang Yichun Xie Yuhui Huang | 2021 | Journal of Plant Ecology2021，14，6： | 1 |
| 13 | A large human domain antibody library combining heavy and light chain CDR3 diversity显示文摘 | Weizao Chen Zhongyu Zhu Yang Feng Dimiter S. Dimitrov | 2010 | Molecular Immunology2010，，4： | 1 |
| 14 | Conformational selection and adaptation to ligand binding in T4 lysozyme cavity mutants显示文摘 | Carlos J. López Zhongyu Yang Christian Altenbach Wayne L. Hubbell | 2013 | Proceedings of the National Academy of Sciences2013，，46： | 1 |
| 15 | The antigenicity of SARS-CoV-2 Delta variants aggregated 10 high-frequency mutations in RBD has not changed sufficiently to replace the current vaccine strain显示文摘Emerging SARS-CoV-2 variants are the most serious problem for COVID-19 prophylaxis and treatment.To determine whether the SARS-CoV-2 vaccine strain should be updated following variant emergence like seasonal flu vaccine,the changed degree on antigenicity of SARS-CoV-2 variants and H3N2 flu vaccine strains was compared.The neutralization activities of Alpha,Beta and Gamma variants’spike protein-immunized sera were analysed against the eight current epidemic variants and 20 possible variants combining the top 10 prevalent RBD mutations based on the Delta variant,which were constructed using pseudotyped viruses.Meanwhile,the neutralization activities of convalescent sera and current inactivated and recombinant protein vaccine-elicited sera were also examined against all possible Delta variants.Eight HA protein-expressing DNAs elicited-animal sera were also tested against eight pseudotyped viruses of H3N2 flu vaccine strains from 2011–2019.Our results indicate that the antigenicity changes of possible Delta variants were mostly within four folds,whereas the antigenicity changes among different H3N2 vaccine strains were approximately 10–100-fold.Structural analysis of the antigenic characterization of the SARS-CoV-2 and H3N2 mutations supports the neutralization results.This study indicates that the antigenicity changes of the current SARS-CoV-2 may not be sufficient to require replacement of the current vaccine strain. | Jiajing Wu Jianhui Nie Li Zhang Hao Song Yimeng An Ziteng Liang Jing Yang Ruxia Ding Shuo Liu Qianqian Li Tao Li Zhimin Cui Mengyi Zhang Peng He Youchun Wang Xiaowang Qu Zhongyu Hu Qihui Wang Weijin Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 1 |
| 16 | Antitumor activity of bee pollen polysaccharides from Rosa rugosa显示文摘 | Bo Wang Qiyu Diao Zhongyu Zhang Yang Liu Qipin Gao Yifa Zhou Shanshan Li | 2013 | Molecular Medicine Reports2013，，5： | 1 |
| 17 | Water-based iso?tropically conductive adhesives: Towards green and low-cost flexible electronics 显示文摘 | Yang Cheng Lin Wei Li Zhongyu | 2011 | Adv Funct Mater2011，21，23： | 1 |
| 18 | Apoptosis of human trabecular meshwork cells induced by transforming growth factor-β2 in vitro in vitro显示文摘 | Cao Yang Wei Houren Pfaffl Michael Da Banghong Li Zhongyu | 2004 | Journal of Huazhong University of Science and Technology2004，，1： | 1 |
| 19 | Dedifferentiated human umbilical cord mesenchymal stem cell reprogramming of endogenous hSDF-1a expression participates in neural restoration in hypoxic-ischemic brain damagerats显示文摘The transplantation of human umbilical cord mesenchymal stem cells(hUC-MSCs)can promote hypoxic-ischemic brain damage(HIBD)nerve repair,but finding suitable seed cells to optimize transplantation and improve treatment efficiency is an urgent problem to be solved.In this study,we induced hUC-MSCs into dedifferentiated hUC-MSCs(De-hUC-MSCs),and the morphology,stem cell surface markers,proliferation and tri-directional differentiation ability of the De-hUC-MSCs and hUC-MSCs were detected.A whole-gene chip was utilized for genome cluster,gene ontology and KEGG pathway analyses of differentially expressed genes.De-hUC-MSCs were transplanted into HIBD rats,and behavioral experiments and immunofluorescence assays were used to assess the therapeutic effect.A lentivirus vector for human stromal cell-derived factor-1(hSDF-1a)was constructed,and the role of hSDF-1a in the neuroprotective effect and mechanism of De-hUC-MSCs was verified.De-hUC-MSCs displayed similar cell morphology,stem cell surface marker expression,cell proliferation and even three-dimensional differentiation ability as hUC-MSCs but exhibited greater treatment potential in vivo.The reprogramming mechanism of hSDF-1a participated in the dedifferentiation process.By successfully constructing a stable hSDF-1a cell line,we found that De-hUC-MSCs might participate in nerve repair through the hSDF-1a/CXCR4/PI3K/Akt pathway.De-hUC-MSCs reprogramming of endogenous hSDF-1a expression may mediate the hSDF-1a/CXCR4/PI3K/Akt pathway involved in nerve repair in HIBD rats. | Zhou Xiaoqin Liu Jia Dai Mengjie Gu Jialu Bi Yang Wang Yuting Hu Huajian Liu Bo Zhang Xiaojun Li Zhongyue Chen Jie Li Tingyu Zhan Xue | 2021 | Genes & Diseases2021，8，3： | 1 |
| 20 | Genotype analysis of rotaviruses isolated from children during a phase III clinical trial with the hexavalent rotavirus vaccine in China显示文摘The oral hexavalent live human-bovine reassortant rotavirus vaccine(RV6)developed by Wuhan Institute of Biological Products Co.,Ltd(WIBP)has finished a randomized,placebo-controlled phase III clinical trial in four provinces of China in 2021.The trail demonstrated that RV6 has a high vaccine efficacy against the prevalent strains and is safe for use in infants.During the phase III clinical trial(2019–2021),200 rotavirus-positive fecal samples from children with RV gastroenteritis(RVGE)were further studied.Using reverse transcription-polymerase chain reaction and high-throughput sequencing,VP7 and VP4 sequences were obtained and their genetic characteristics,as well as the differences in antigenic epitopes of VP7,were analyzed in detail.Seven rotavirus genotypes were identified.The predominant rotavirus genotype was G9P[8](77.0%),followed by prevalent strains G8P[8](8.0%),G3P[8](3.5%),G3P[9](1.5%),G1P[8](1.0%),G2P[4](1.0%),and G4P[6](1.0%).The amino acid sequence identities of G1,G2,G3,G4,G8,and G9 genotypes of isolates compared to the vaccine strains were 98.8%,98.2%–99.7%,88.4%–99.4%,98.2%,94.2%–100%,and 93.9%–100%,respectively.Notably,the vaccine strains exhibited high similarity in amino acid sequence,with only minor differences in antigenic epitopes compared to the Chinese endemic strains.This supports the potential application of the vaccine in preventing diseases caused by rotaviruses. | Wenqi Zou Qingchuan Yu Yan Liu Qingliang Li Hong Chen Jiamei Gao Chen Shi Ying Wang Wei Chen Xuan Bai Biao Yang Jiuwei Zhang Ben Dong Bo Ruan Liuyifan Zhou Gelin Xu Zhongyu Hu Xiaoming Yang | 2023 | Virologica Sinica2023，38，6： | 0 |
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