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| 1 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 2 | NOVEL SYNTHESIS OF ULTRAFINE HOURGLASS-SHAPED ALUMINUM HYDROXIDE PARTICLES显示文摘In a novel method for synthesizing ultrafine aluminum hydroxide particles presented in this paper, the morphology and crystal structure of the particles were investigated by TEM, XRD, etc. The process consisted of two steps: chemical precipitation by acid and carbonation. The product has an hourglass or half-hourglass morphology with a narrow size distribution of 150-200 nm. Major endothermal peak of decomposition was found at 270°C by differential thermal analysis. X-ray diffraction identified the product as bayerite. Those properties were compared with those of alu- minum hydroxide prepared by carbonization only. | Qiuling Zhou Ling Zhang Chunzhong Li Wei Shao | 2006 | China Particuology2006，4，5： | 2 |
| 3 | An essential role for PNLDC1 in piRNA 3' end trimming and male fertility in mice显示文摘 | Yue Zhang Rui Guo Yiqiang Cui Zhiping Zhu Yingwen Zhang Hao Wu Bo Zheng Qiuling Yue Shun Bai Wentao Zeng Xuejiang Guo Zuomin Zhou Bin Shen Ke Zheng Mingxi Liu Lan Ye Jiahao Sha | 2017 | Cell Research2017，27，11： | 2 |
| 4 | Aluminum Hydroxide Filled Ethylene Vinyl Acetate (EVA) Composites: Effect of the Interfacial Compatibilizer and the Particle Size显示文摘 | Zhang Ling Li Chunzhong Zhou Qiuling | 2007 | Mater Sci2007，42，12： | 1 |
| 5 | Geochronology and geochemis-try of the Late Triassic Longtan pluton in South China: terminationof the crustal melting and Indosinian orogenesis 显示文摘 | QiuL Yan D P Zhou M F | 2014 | InternationalJournal of Earth Sciences2014，103，3： | 1 |
| 6 | Flame synthesis of carbon nanotubes with high density on stainless steel mesh 显示文摘 | Zhou Qiuling Li Chunzhong Gu Feng | 2007 | Journal of Alloys and Compounds2007，16，： | 1 |
| 7 | Controllable synthesis of carbon nanotubes with ultrafine inner diameters in ethanol flame 显示文摘 | Wang Lanjuan Li Chunzhong Zhou Qiuling | 2007 | Phisica B2007，398，： | 1 |
| 8 | Controllable synthesis of carbon nanotubes with ultrafine inner diameters in ethanol flame显示文摘 | Wang Lanjuan Li Chunzhong Zhou Qiuling etal | 2007 | Physica B2007，398，1： | 1 |
| 9 | Estrogen improved metabolic syndrome through down-regulation of VEGF and HIF-1α to inhibit hypoxia of periaortic and intra-abdominal fat in ovariectomized female rats显示文摘 | JinWen Xu QiuLing Xiang GuiPing Lin XiaoDong Fu KeWen Zhou Ping Jiang ShuHui Zheng TingHuai Wang | 2012 | Molecular Biology Reports2012，，8： | 1 |
| 10 | Analy- sis of deformation localization and the complete s~ess-strain re- lation for brittle rock subjected to dynamic compressive loads显示文摘 | ZHOU Xiaoping HA Qiuling ZHANG Yongxing | 2004 | International Journal of Rock Mechanics and Mining Sciences2004，41，2： | 1 |
| 11 | Aluminumhydroxide filled ethylene vinyl acetate(EVA)composites:Effect of the interfacial compatibilizer and the particle size显示文摘 | Zhang Ling Li Chunzhong Zhou Qiuling | 2007 | Journal of Materials Science2007，42，： | 1 |
| 12 | A novel Physarum polycephalum SR protein kinase specifically phosphorylates the RS domain of the human SR protein, ASF/SF2显示文摘象蛋白质一样的充满丝氨酸的蛋白质 kinase (SRPK ) 的 A 1591-bp cDNA 在 Physarum polycephalum 被识别了(GenBank 同意没有。DQ140379 ) 。cDNA 在 bp 包含二个重复序列 1153 并且 bp 395547。编码顺序是 56% 对人的 SRPK1 相应并且被称为 Physarum SRPK (PSRPK ) 。与另外的 SRPK 一致, PSRPK 的一致主题在二保存的域(CD ) 以内。然而,在 N 终端和 CD 之间的分叉的主题比另外的 SRPK 的相应序列短得多。学习这蛋白质的结构和功能,我们在 Escherichia coli 并且在 vitro phosphorylation 试金执行了合作表示实验在人的 SR 蛋白质上调查 recombinant PSRPK 的 phosphorylation 效果, ASF/SF2。西方的污点分析显示出那 PSRPK 能在 E 的 phosphorylate ASF/SF2。coli 房间。Autoradiographic 检查显示出那 recombinant PSRPK 和有在 N 终点的 28-aa 删除的 PSRPK 的一种截断的形式能 phosphorylate ASF/SF2 和包含 RS 领域的 ASF/SF2 的一种截断的形式。然而,这二 PSRPK 形成不能 phosphorylate 缺乏 RS 领域的截断的形式 ASF/SF2。也 CD 缺乏的 PSRPK 的一种截断的形式不举办任何 phosphorylation 活动。这些结果显示在 PSRPK 的 phosphorylation 地点象另外的 SRPK 一样,位于 SR 蛋白质的 RS 领域以内并且它的 phosphorylation 活动仔细与二 CD 被联系。PSRPK 的结构和功能上的这研究证明它是 SRPK 家庭的一个新成员。 | Shide Liu Kang Kang Jianhua Zhang Qiuling Ouyang Zhuolong Zhou Shengli Tian Miao Xing | 2009 | Acta Biochimica et Biophysica Sinica2009，41，8： | 1 |
| 13 | Aluminum hydroxide filled ethylene vinyl acetate (EVA) composites: effect of the interfacial compatibilizer and the particle size显示文摘 | Ling Zhang Chun Zhong Li Qiuling Zhou Wei Shao | 2007 | Journal of Materials Science2007，，12： | 1 |
| 14 | Experimental investigations of thermal and flow characteristics of curved trapezoidal wing- let type vortex generators 显示文摘 | Zhou Guobing Ye Qiuling | 2012 | Applied Thermal Engineer- ing2012，37，： | 1 |
| 15 | Aluminum hydroxide filled ethylene vinyl acetate (EVA) composites: effect of the interfacial compatibilizer and the particle size显示文摘 | Ling Zhang Chun Zhong Li Qiuling Zhou Wei Shao | 2007 | Journal of Materials Science2007，，12： | 1 |
| 16 | Stimuli-responsive gel-micelles with flexible modulation of drug release for maximized antitumor efficacy显示文摘设计的刺激应答的药交货设备由于他们的最大化的治疗学的功效为疾病处理在生物应用保持广阔诺言。在这研究,一篇小说,稳定地, cross-linked ,和pH敏感的可被细菌破坏的 gel-micelle 与 amphiphilic 被构造 trimethylene dipiperidine甲基丙烯结合酐玻尿的 acid-stearylamine ( TMDP-MA-HA-SA , TMHS )改善与 paclitaxel ( PTX )的灵活细胞内部的交货指向肿瘤 .The cross-linked methacrylate 契约显著地改进了 TMHS gel-micelle 的 biostability (~ 200 nm )在上在生理的条件下面交叉结合得非,当玻尿的酸玩时cross-linked 的渐渐的降级玻尿的酸壳被集中的玻尿酸酵素触发。同时,在酸的条件下面(pH < 6.5 ) , pH 敏感的 TMDP 一半的第三级的胺是 protonated 并且从而 solubilized gel-micellar 核心部分。结果的被触发 pH 的内部核心的空格很快面对主要降级了的多重 cytosolic 酶推动了 PTX 版本仍然保持恐水病 stearylamine 核心。在期间在里面 vitro cytotoxicity 试金,装载 PTX 的 TMHS 胶化微粒(CLTMHSPTX ) 与 1.42 g/mL (PTX 集中) 的 IC 50 对人的 hepatocellular 癌 HepG2 房间揭示了 anticancer 功效,比另外的组显著地低。在平行,在里面 CL TMHS 对 BALB/c 异种皮移植肿瘤动物模型的 PTX 胶化微粒表明了 72.06% 的更大的肿瘤生长抑制能力,与在安全集中的另外的处理组相比。因而, cross-linked 和刺激应答的 CL TMHS PTX 胶化微粒抓住为有最大化的 antitumor 功效的恐水病的 anticancer 药的细胞内部的交货的灵活调整的一个大潜力。 | Djamila Aouameur Hao Cheng Yaw Opoku-Damoah Bo Sun Qiuling Dong Yue Han Jianping Zhou Yang Ding | 2018 | Nano Research2018，11，8： | 1 |
| 17 | The haplotype-resolved T2T genome of teinturier cultivar Yan73 reveals the genetic basis of anthocyanin biosynthesis in grapes显示文摘Teinturier grapes are characterized by the typical accumulation of anthocyanins in grape skin,flesh,and vegetative tissues,endowing them with high utility value in red wine blending and nutrient-enriched foods developing.However,due to the lack of genome information,the mechanism involved in regulating teinturier grape coloring has not yet been elucidated and their genetic utilization research is still insufficient.Here,the cultivar‘Yan73’was used for assembling the telomere-to-telomere(T2T)genome of teinturier grapes by combining the High Fidelity(HiFi),Hi-C and ultralong Oxford Nanopore Technologies(ONT)reads.Two haplotype genomes were assembled,at the sizes of 501.68 Mb and 493.38 Mb,respectively.In the haplotype 1 genome,the transposable elements(TEs)contained 32.77%of long terminal repeats(LTRs),while in the haplotype 2 genome,31.53%of LTRs were detected in TEs.Furthermore,obvious inversions were identified in chromosome 18 between the two haplotypes.Transcriptome profiling suggested that the gene expression patterns in‘Cabernet Sauvignon’and‘Yan73’were diverse depending on tissues,developmental stages,and varieties.The transcription program of genes in the anthocyanins biosynthesis pathway between the two cultivars exhibited high similarity in different tissues and developmental stages,whereas the expression levels of numerous genes showed significant differences.Compared with other genes,the expression levels of VvMYBA1 and VvUFGT4 in all samples,VvCHS2 except in young shoots and VvPAL9 except in the E-L23 stage of‘Yan73’were higher than those of‘Cabernet Sauvignon’.Further sequence alignments revealed potential variant gene loci and structure variations of anthocyanins biosynthesis related genes and a 816 bp sequence insertion was found in the promoter of VvMYBA1 of‘Yan73’haplotype 2 genome.The‘Yan73’T2T genome assembly and comparative analysis provided valuable foundations for further revealing the coloring mechanism of teinturier grapes and the genetic improvement of grape coloring traits. | Kekun Zhang Mengrui Du Hongyan Zhang Xiaoqian Zhang Shuo Cao Xu Wang Wenrui Wang Xueqiang Guan Penghui Zhou Jin Li Wenguang Jiang Meiling Tang Qiuling Zheng Muming Cao Yongfeng Zhou Keqin Chen Zhongjie Liu Yulin Fang | 2023 | Horticulture Research2023，10，11： | 0 |
| 18 | An Olefinic 1,2-α-Boryl Migration Enables 1,2-Bis(boronic esters)via Radical-Polar Crossover Reaction显示文摘A radical-induced 1,2-α-boryl migration through radical polar crossover reactions has been described.In this work,in situ formed vinyldiboron“ate”complexes from alkenyl Grignard reagent and diborylalkanes react with commercial radical precursors under light initiation.This three-component process enables diborylation of alkene.This protocol features high atom economy,a broad substrate scope as well as good functional group toleration with mild conditions. | Feng Zhang Shangteng Liao Lu Zhou Kai Yang Chenglan Wang Yixian Lou Cece Wang Qiuling Song | 2022 | Chinese Journal of Chemistry2022，40，5： | 0 |
| 19 | Photoinduced NaI-Promoted Radical Borylation of Alkyl Halides and Pseudohalides显示文摘Main observation and conclusion A method for photoinduced NaI-promoted radical borylation of aliphatic halides and pseudohalides with bis(catecholato)diboron(B_(2)cat_(2))as the boron source is introduced.The borylation reaction is operationally simple and shows high functional group tolerance and broad substrate scope.Preliminary mechanistic studies suggest that the reaction proceeds through S_(N)2-based radical-generation strategy. | Chenglan Wang Lu Zhou Kai Yang Feng Zhang Qiuling Song | 2021 | Chinese Journal of Chemistry2021，39，7： | 0 |
| 20 | Atom Recombination of Difluorocarbene Enables 3-Fluorinated Oxindoles from 2-Aminoarylketones显示文摘Contrary to the traditional implementation as a difluoromethyl group and recently disclosed role of C1 synthons in synthetic organic chemistry,difluorocarbene(:CF_(2))is reported herein to proceed in unprecedented atom recombination as both a C1 synthon and F1 reagent simultaneously to render valuable 3-fluorinated oxindoles from 2-aminoarylketones.The reaction does not require catalyst and features a broad range of substrates with good functional group compatibility and ease of execution.This transformation could be employed to the quick-constructions of certain bioactive molecule derivatives.The mechanistic experiments and density functional theory(DFT)calculations indicate that this atom recombination reaction of:CF_(2) for the synthesis of 3-fluorinated oxindoles may involve a rearrangement process of epoxide intermediates. | Guan Zhang Qianqian Shi Mengyuan Hou Kai Yang Shihui Wang Shuai Wang Wangyang Li Chaokun Li Jian Qiu Hetao Xu Lu Zhou Cece Wang Shi-Jun Li Yu Lan Qiuling Song | 2022 | CCS Chemistry2022，4，5： | 0 |
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