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| 1 | A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity显示文摘由调整 transcriptional 激活剂 Yorkie (Yki ) 的活动的河马(Hpo ) 小径控制织物生长和机关尺寸,它在原子核与抄写因素 Scalloped (Sd ) 联系下游地支持指向基因表示。这里,我们识别新奇蛋白质 Sd-Binding-Protein (SdBP )/Tgi,它直接通过它的 TDU 域为绑定与 Yki 竞争到 Sd 并且禁止 Sd-Yki transcriptional 活动。我们也发现 SdBP 经由它的 PPXY 主题与 Yki WW 领域通过协会在原子核保留 Yki。一起,我们作为 Hpo 小径的一个新奇部件识别 SdBP,否定地调整 Sd-Yki 的 transcriptional 活动限制织物生长。 | Tong Guo Yi Lu Peixue Li Meng-Xin Yin Dekang Lv Wenjing Zhang Huizhen Wang Zhaocai Zhou Hongbin Ji Yun Zhao Lei Zhang | 2013 | Cell Research2013，23，10： | 13 |
| 2 | Potentiating CD8^(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling显示文摘Metabolic regulation has been proven to play a critical role in T cell antitumor immunity.However,cholesterol metabolism as a key component of this regulation remains largely unexplored.Herein,we found that the low-density lipoprotein receptor(LDLR),which has been previously identified as a transporter for cholesterol,plays a pivotal role in regulating CD8+T cell antitumor activity.Besides the involvement of cholesterol uptake which is mediated by LDLR in T cell priming and clonal expansion,we also found a non-canonical function of LDLR in CD8+T cells:LDLR interacts with the T-cell receptor(TCR)complex and regulates TCR recycling and signaling,thus facilitating the effector function of cytotoxic T-lymphocytes(CTLs).Furthermore,we found that the tumor microenvironment(TME)downregulates CD8+T cell LDLR level and TCR signaling via tumor cell-derived proprotein convertase subtilisin/kexin type 9(PCSK9)which binds to LDLR and prevents the recycling of LDLR and TCR to the plasma membrane thus inhibits the effector function of CTLs.Moreover,genetic deletion or pharmacological inhibition of PCSK9 in tumor cells can enhance the antitumor activity of CD8+T cells by alleviating the suppressive effect on CD8+T cells and consequently inhibit tumor progression.While previously established as a hypercholesterolemia target,this study highlights PCSK9/LDLR as a potential target for cancer immunotherapy as well. | Juanjuan Yuan Ting Cai Xiaojun Zheng Yangzi Ren Jingwen Qi Xiaofei Lu Huihui Chen Huizhen Lin Zijie Chen Mengnan Liu Shangwen He Qijun Chen Siyang Feng Yingjun Wu Zhenhai Zhang Yanqing Ding Wei Yang | 2021 | Protein & Cell2021，12，4： | 12 |
| 3 | A series of naphthalimide azoles: Design, synthesis and bioactive evaluation as potential antimicrobial agents显示文摘A series of naphthalimide azoles as potential antibacterial and antifungal agents were conveniently and efficiently synthesized starting from commercially available 6-bromobenzo[de]isochromene-1,3-dione. All the new compounds were characterized by NMR, IR, MS and HRMS spectra. Their antimicrobial activities were evaluated against four Gram-positive bacteria, four Gram-negative bacteria and two fungi using two-fold serial dilution technique. The biological assay indicated that most of the prepared compounds exhibited inhibition to the tested strains. In particular, the triazolium derivatives not only gave higher efficacy than their corresponding precursory azoles, but also demonstrated comparable or even better potency than the reference drugs Chloromycin, Orbifloxacin and Fluconazole. Some factors including structural fragments, pH and ClogP values of the target molecules were also preliminarily discussed. | DAMU Guri L. V. WANG QingPeng ZHANG HuiZhen ZHANG YiYi LV JingSong ZHOU ChengHe | 2013 | Science China Chemistry2013，56，7： | 8 |
| 4 | Triglycerides and ratio of triglycerides to high-density lipoprotein cholesterol are better than liver enzymes to identify insulin resistance in urban middle-aged and older non-obese Chinese without diabetes显示文摘 | Sun Yu Li Wenjuan Hou Xinguo Wang Chuan Li Chengqiao Zhang Xiuping Yang Weifang Ma Zeqiang Wang Weiqing Ning Guang Zheng Huizhen Ma Aixia Song Jun Lin Peng Liang Kai Liu Fuqiang Gong Lei Wang Meijian Xiao Juan Yan Fei Yang Junpeng Wang Lingshu Tian Meng Liu Jidong Zhao Ruxing Zhu Ping Chen Li | 2014 | Chinese Medical Journal2014，，10： | 7 |
| 5 | Synthesis and biological activities of thio-triazole derivatives as novel potential antibacterial and antifungal agents显示文摘A series of novel thio-triazole derivatives including thiols, thioethers and thiones as well as some corresponding triazolium compounds were conveniently and efficiently synthesized from commercially available halobenzyl halides and thiosemicarbazide. All the new compounds were characterized by 1 H NMR, 13 C NMR, FTIR, MS and HRMS spectra. Their antibacterial and antifungal activities in vitro were evaluated against four Gram-positive bacteria, four Gram-negative bacteria and two fungi by two-fold serial dilution technique. The preliminary bioassay indicated that some prepared triazoles exhibited effective antibacterial and antifungal activities. Especially, 3,4-dichlorobenzyl triazolethione and its triazolium derivatives displayed the most potent activities against all the tested strains. | WANG QingPeng ZHANG JingQing DAMU Guri L.V. WAN Kun ZHANG HuiZhen ZHOU ChengHe | 2012 | Science China Chemistry2012，55，10： | 7 |
| 6 | An indicator-guided photo-controlled drug delivery system based on mesoporous silica/gold nanocomposites显示文摘mesoporous 硅石 / 黄金(MSN/Au ) nanocomposite 为明确地目标为肿瘤房间的控制相片的药交货被设计。MSN/Au nanocomposite 由基于 MSN 的药搬运人组成,金 nanoparticle (AuNP ) 基于指示物。当基于 MSN 的药搬运人是 mesoporous 硅石时, nanoparticle 与相片可切换的偶氮苯使不能调动(偶氮) 一半,基于 AuNP 的指示物是与矩阵 metalloproteinase (MMP ) 修改的熄灭荧光的 AuNP 底层并且 poly (乙烯乙二醇) 。二种 nanoparticles 被连接由一, cyclodextrin (, CD ) 更暗淡的桥牌。在 vitro,研究证明 nanocomposite 明确地与肿瘤地点 overexpressing MMP-2 交往了,为释放的随后的紫外轻照耀的启用的指导它骗诱药。通过基于 AuNP 的指示物和基于 MSN 的药搬运人的集成, MSN/Au nanocomposite 能精确本地化释放的药到肿瘤地点,显著地从而改进治疗学的功效。 | Guofeng Luo Weihai Chen Huizhen Jia Yunxia Sun Han Cheng Renxi Zhuo Xianzheng Zhang | 2015 | Nano Research2015，8，6： | 6 |
| 7 | Design,synthesis,and biological evaluation of novel benzimidazole derivatives and their interaction with calf thymus DNA and synergistic effects with clinical drugs显示文摘A series of new benzimidazole derivatives was synthesized and characterized by IR,1H NMR,13C NMR,MS,and HRMS spectra.All the new compounds were screened for their antimicrobial activities in vitro by a twofold serial dilution technique.The bioactive evaluation showed that 3,5-bis(trifluoromethyl)phenyl benzimidazoles were comparably or even more strongly antibacterial and antifungal than the reference drugs Chloromycin,Norfloxacin,and Fluconazole.The combination of2,4-difluorobenzyl benzimidazole derivative 5l and its hydrochloride 7 respectively with the antibacterials Chloromycin,Norfloxacin,and the antifungal Fluconazole was more sensitive to methicillin-resistant MRSA and Fluconazole-insensitive A.flavus.In addition,the interaction of compound 5l with calf thymus DNA demonstrated that this compound could effectively intercalate into DNA to form a compound 5l-DNA complex that might block DNA replication and thereby exert good antimicrobial activity. | ZHANG HuiZhen LIN JianMei RASHEED Syed ZHOU ChengHe | 2014 | Science China Chemistry2014，57，6： | 5 |
| 8 | Crystalline behaviors and phase transition during the manufacture of fine denier PA6 fibers显示文摘Recently we have successfully produced fine denier PA6 fibers by using additives containing lanthanide compounds.Meanwhile,crystallization and phase transition of PA6 fibers during spinning and drawing processes were investigated.During the spinning process,β phase crystal could be obtained in as-spun PA6 fibers which were produced with relatively high melt draw ratio,while γ phase crystal predominated when the melt draw ratio was relatively low.β phase crystal,whose behaviors are similar with those of γ phase by FT-IR and XRD characterization,could be transformed to α form easily when PA6 fibers are immersed in boiling water.However,γ phase crystal of PA6 remains unchanged in boiling water.Thus,β and γ phase crystals of PA6 can be differentiated by the crystalline behaviors of PA6 fibers after treatment in boiling water.Further experiments demonstrate that the β phase can also be produced during a drawing process where a phase transformation from γ to α occurs.In other words,β phase may act as an intermediate state during the phase transformation. | ZHANG ChengFeng LIU YuHai LIU ShaoXuan LI HuiZhen HUANG Kun PAN QingHua HUA XiaoHui HAO ChaoWei MA QingFang LV ChangYou LI WeiHong YANG ZhanLan ZHAO Ying WANG DuJin LAI GuoQiao JIANG JianXiong XU YiZhuang WU JinGuang | 2009 | Science China Chemistry2009，52，11： | 4 |
| 9 | Unbiased subgenome evolution following a recent whole-genome duplication in pear(Pyrus bretschneideri Rehd.)显示文摘Genome fractionation(also known as diploidization)frequently occurs following paleopolyploidization events.Biased fractionation between subgenomes has been found in some paleo-allopolyploids,while this phenomenon is absent in paleo-autopolyploids.Pear(Pyrus bretschneideri Rehd.)experienced a recent whole-genome duplication(WGD,~30 million years ago);however,the evolutionary fate of the two subgenomes derived from this WGD event is not clear.In this study,we identified the two paleo-subgenomes in pear using peach(Prunus persica)as an outgroup and investigated differences in the gene loss rate,evolutionary rate,gene expression level,and DNA methylation level between these two subgenomes.Fractionation bias was not found between the two pear subgenomes,which evolved at similar evolutionary rates.The DNA methylation level of the two subgenomes showed little bias,and we found no expression dominance between the subgenomes.However,we found that singleton genes and homeologous genes within each subgenome showed divergent evolutionary patterns of selective constraints,expression and epigenetic modification.These results provide insights into subgenome evolution following paleopolyploidization in pear. | Qionghou Li Xin Qiao Hao Yin Yuhang Zhou Huizhen Dong Kaijie Qi Leiting Li Shaoling Zhang | 2019 | Horticulture Research2019，6，1： | 4 |
| 10 | Recent advances in the coupling of CO2 and epoxides into cyclic carbonates under halogen-free condition显示文摘The chemical transformation of CO2 and epoxides into cyclic carbonates has been receiving much attention and is one of the successful examples for CO2 utilization as carbon resource.Many catalysts containing halide anions have been explored and exhibit excellent catalytic activity.However,halogen salt is generally toxic and corrosive to reactors.From a green chemistry perspective,it is more attractive to develop a halogen-free catalyst with excellent performance.Herein,a review of recent research progress of halogen-free catalysts in the cycloaddition of CO2 and epoxide is presented.According to previous experimental and theoretical works,two possible strategies for achieving the halogen-free process were summarized.The relationship between catalytic activity and catalyst structure,the mechanism of CO2 activation should be both studied deeply combined with experimental results and DFT calculation,which can guide the design of new catalysts and realize halogen-free process under mild reaction conditions. | Feng Zhang Yanyan Wang Xiaochun Zhang Xiangping Zhang Huizhen Liu Buxing Han | 2020 | Green Chemical Engineering2020，1，2： | 4 |
| 11 | Integrated Modelling of Microstructure Evolution and Mechanical Properties Prediction for Q&P Hot Stamping Process of Ultra‑High Strength Steel显示文摘High strength steel products with good ductility can be produced via Q&P hot stamping process,while the phase transformation of the process is more complicated than common hot stamping since two-step quenching and one-step carbon partitioning processes are involved.In this study,an integrated model of microstructure evolution relating to Q&P hot stamping was presented with a persuasively predicted results of mechanical properties.The transformation of diffusional phase and non-diffusional phase,including original austenite grain size individually,were considered,as well as the carbon partitioning process which affects the secondary martensite transformation temperature and the subsequent phase transformations.Afterwards,the mechanical properties including hardness,strength,and elongation were calculated through a series of theoretical and empirical models in accordance with phase contents.Especially,a modified elongation prediction model was generated ultimately with higher accuracy than the existed Mileiko’s model.In the end,the unified model was applied to simulate the Q&P hot stamping process of a U-cup part based on the finite element software LS-DYNA,where the calculated outputs were coincident with the measured consequences. | Yang Chen Huizhen Zhang Johnston Jackie Tang Xianhong Han Zhenshan Cui | 2020 | Chinese Journal of Mechanical Engineering2020，33，3： | 3 |
| 12 | Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence显示文摘Lipotoxicity, caused by intracellular lipid accumulation, accelerates the degenerative process of cellular senescence, which has implications in cancer development and therapy. Previously, carnitine palmitoyltransferase 1C(CPT1C), a mitochondrial enzyme that catalyzes carnitinylation of fatty acids, was found to be a critical regulator of cancer cell senescence. However, whether loss of CPT1C could induce senescence as a result of lipotoxicity remains unknown. An LC/MS-based lipidomic analysis of PANC-1,MDA-MB-231, HCT-116 and A549 cancer cells was conducted after siRNA depletion of CPT1C. Cellular lipotoxicity was further confirmed by lipotoxicity assays. Significant changes were found in the lipidome of CPT1C-depleted cells, including major alterations in fatty acid, diacylglycerol, triacylglycerol, oxidative lipids, cardiolipin, phosphatidylglycerol, phosphatidylcholine/phosphatidylethanolamine ratio and sphingomyelin. This was coincident with changes in expressions of mRNAs involved in lipogenesis.Histological and biochemical analyses revealed higher lipid accumulation and increased malondialdehyde and reactive oxygen species, signatures of lipid peroxidation and oxidative stress. Reduction of ATP synthesis, loss of mitochondrial transmembrane potential and down-regulation of expression of mitochondriogenesis gene m RNAs indicated mitochondrial dysfunction induced by lipotoxicity, which could further result in cellular senescence. Taken together, this study demonstrated CPT1C plays a critical role in the regulation of cancer cell lipotoxicity and cell senescence, suggesting that inhibition of CPT1C may serve as a new therapeutic strategy through induction of tumor lipotoxicity and senescence. | Huizhen Zhang Yongtao Wang Lihuan Guan Yixin Chen Panpan Chen Jiahong Sun Frank J.Gonzalez Min Huang Huichang Bi | 2021 | Journal of Pharmaceutical Analysis2021，11，3： | 3 |
| 13 | Clear cell renal cell carcinoma: Contrast-enhanced ultrasound features relation to tumor size显示文摘 | Jun Jiang Yaqing Chen Yongchang Zhou Huizhen Zhang | 2008 | European Journal of Radiology2008，，1： | 3 |
| 14 | Quantum-inspired ant algorithm for knapsack problems显示文摘The knapsack problem is a well-known combinatorial optimization problem which has been proved to be NP-hard.This paper proposes a new algorithm called quantum-inspired ant algorithm(QAA) to solve the knapsack problem.QAA takes the advantage of the principles in quantum computing,such as qubit,quantum gate, and quantum superposition of states,to get more probabilistic-based status with small colonies.By updating the pheromone in the ant algorithm and rotating the quantum gate,the algorithm can finally reach the optimal solution. The detailed steps to use QAA are presented,and by solving series of test cases of classical knapsack problems,the effectiveness and generality of the new algorithm are validated. | Wang Honggang Ma Liang Zhang Huizhen Li Gaoya | 2009 | Journal of Systems Engineering and Electronics2009，20，5： | 3 |
| 15 | Co-Administration of Multiple Childhood Vaccines--Guangdong Province,2019显示文摘What is already known about this topic?The Co-Administration of Multiple Vaccines were implemented in many countries and have been shown to significantly reduce many times of visiting the vaccination clinic.What is added by this report?It is the first time to calculate the cost of visiting vaccination clinic from transportation and workabsence for children’s families in Guangdong.What are the implications for public health practice?We demonstrated the importance of Co-Administration of Multiple Vaccines that reduce the vaccination cost of children’s families.The policy should be promoted as soon as possible. | Hai Li Yanqiu Tan Haiying Zeng Fengmei Zeng Xing Xu Yu Liao Qi Zhu Meng Zhang Xuguang Chen Min Kang Fujie Xu Huizhen Zheng | 2020 | China CDC weekly2020，2，1： | 3 |
| 16 | The Fibrillin-1/VEGFR2/STAT2 signaling axis promotes chemoresistance via modulating glycolysis and angiogenesis in ovarian cancer organoids and cells显示文摘Background:Chemotherapy resistance is a primary reason of ovarian cancer therapy failure;hence it is important to investigate the underlying mechanisms of chemotherapy resistance and develop novel potential therapeutic targets.Methods:RNA sequencing of cisplatin-resistant and sensitive(chemoresis-tant and chemosensitive,respectively)ovarian cancer organoids was performed,followed by detection of the expression level of fibrillin-1(FBN1)in organoids and clinical specimens of ovarian cancer.Subsequently,glucose metabolism,angiogenesis,and chemosensitivity were analyzed in structural glycoprotein FBNl-knockout cisplatin-resistant ovarian cancer organoids and cell lines.To gain insights into the specific functions and mechanisms of action of FBN1 in ovarian cancer,immunoprecipitation,silver nitrate staining,mass spectrometry,immunofluorescence,Western blotting,and Forister resonance energy transfer-fluorescence lifetime imaging analyses were performed,followed by in vivo assays using vertebrate model systems of nude mice and zebrafish.Results:FBN1 expression was significantly enhanced in cisplatin-resistant ovar-ian cancer organoids and tissues,indicating that FBNI might be a key factor in chemoresistance of ovarian cancer.We also discovered that FBN1 sustained the energy stress and induced angiogenesis in vitro and in vivo,which promoted the cisplatin-resistance of ovarian cancer.Knockout of FBN1 combined with treat-ment of the antiangiogenic drug apatinib improved the cisplatin-sensitivity of ovarian cancer cells.Mechanistically,FBN1 mediated the phosphorylation of vascular endothelial growth factor receptor 2(VEGFR2)at the Tyrl054 residue,which activated its downstream focal adhesion kinase(FAK)/protein kinase B(PKB or AKT)pathway,induced the phosphorylation of signal transducer and activator of transcription 2(STAT2)at the tyrosine residue 690(Tyr690),pro-moted the nuclear translocation of STAT2,and ultimately altered the expression of genes associated with STAT2-mediated angiogenesis and glycolysis.Conclusions:The FBN1/VEGFR2/STAT2 signaling axis may induce chemore-sistance of ovarian cancer cells by participating in the process of glycolysis and angiogenesis.The present study suggested a novel FBNl-targeted therapy and/or combination of FBN1 inhibition and antiangiogenic drug for treating ovarian cancer. | Ziliang Wang Wei Chen Ling Zuo Midie Xu Yong Wu Jiami Huang Xu Zhang Yongheng Li Jing Wang Jing Chen Husheng Wang Huizhen Sun | 2022 | Cancer Communications2022，42，3： | 3 |
| 17 | Highly efficient catalytic performances of nitro compounds via hierarchical PdNPs-loaded MXene/polymer nanocomposites synthesized through electrospinning strategy for wastewater treatment显示文摘The problem of water pollution has become increasingly serious,and it has already threatened the survival of mankind and has become an obstacle to the healthy development of human health.Here,we prepared a novel polyvinyl alcohol(PVA)/polyacrylic acid(PAA)/MXene fiber membrane by electrospinning.After heat treatment of film and subsequent modification with Pd nanoparticles,PVA/PAA/MXene@PdNPs composite nanofiber membrane with high specific surface area and excellent catalytic performance was finally prepared.The uniform distribution of MXene sheets in the composite fiber membrane not only solves the problem that the MXene sheet is not easy to be monolayerized,but also can grow the self-reduced Pd nanoparticles on the MXene sheets.In addition,the composite nanofiber membrane exhibits excellent catalytic ability and cycle stability for 4-nitrophenol(4-NP)and 2-nitrophenol(2-NA),providing new strategy for the study of catalytic composite materials related to degradation of wastewater. | Juanjuan Yin Fangke Zhan Tifeng Jiao Huizhen Deng Guodong Zou Zhenhua Bai Qingrui Zhang Qiuming Peng | 2020 | Chinese Chemical Letters2020，31，4： | 3 |
| 18 | Spatial distribution characteristics of bacterial community structure and gene abundance in sediments of the Bohai Sea显示文摘This study investigated differences in the community structure and environmental responses of the bacterial community in sediments of the Bohai Sea.Illumina high-throughput sequencing technology and real-time PCR were used to assay the bacterial 16S rRNA genes in the surface sediments of 13 sampling stations in the Bohai Sea.The results showed that sediments at the majority of the 13 sampling stations were contaminated by heavy metal mercury.The main phyla of bacteria recorded included Proteobacteria(52.92%),Bacteroidetes(11.76%),Planctomycetes(7.39%),Acidobacteria(6.53%)and Chloroflexi(4.97%).The genus with the highest relative abundance was Desulfobulbus(4.99%),which was the dominant genus at most sampling stations,followed by Lutimonas and Halioglobus.The main factors influencing bacterial community structure were total organic carbon,followed by depth and total phosphorus.The content of lead,cadmium,chromium,copper and zinc had a consistent effect on community structure.Arsenic showed a negative correlation with bacterial community structure in most samples,while the impact of mercury on community structure was not significant.The bacterial community in sediment samples from the Bohai Sea was rich in diversity and displayed an increase in diversity from high to low latitudes.The data indicated that the Bohai Sea had abundant microbial resources and was rich in bacteria with the potential to metabolize many types of pollutants. | Quanrui Chen Jingfeng Fan Jie Su Hongxia Ming Zhihao Sun Mengfei Li Xiaohui Zhao Yantao Wang Yingxue Zhang Huizhen Zhang Yuan Jin Xiaowan Ma Bin Wang | 2020 | Acta Oceanologica Sinica2020，39，2： | 2 |
| 19 | CD44 clustering is involved in monocyte differentiation显示文摘进巨噬细胞的单核白血球的区别是在生理、病理学的条件下面的一个重要过程,位于单核白血球区别的机制下面的 butthe 不是完全清楚的。一些粘附分子被报导了 toplay 在房间区别的一个重要角色。CD44 是调停的一个重要粘附分子 cellcell 和 cellmatrixinteraction,并且参予许多细胞的功能。当 CD44 被报导了显示出在单核白血球和巨噬细胞之间的不同 activatedstates,我们建议 CD44 可以涉及单核白血球区别。在这研究,我们在单核白血球区别探索了 CD44 的角色并且进一步学习了被包含在里面的机制。THP-1 房间(人的 monocytic 白血病房间线) 与 phorbol 12 十四酸盐 13 醋酸盐(PMA ) 被导致在 vitro 建立 monocytedifferentiation 的模型。它被发现那个 CD44 表达式,到玻尿的酸的有约束力的能力显著地被增加,并且 distributionof CD44 在区别期间被变换成簇。聚类的导致 PMA 的 CD44 和由堵住 CD44 的 CD44 高表示 weresuppressed,它导致了 CD14 表示的抑制。ERK1/2 signalwas 的导致 PMA 的 phosphorylation 也由堵住 CD44 压制了。我们的结果建议 CD44 涉及单核白血球区别。mechanismsof 单核白血球区别追随者 CD44 激活可以包括 CD44 高表示并且聚类哪个接着带 ERK1/2 的 tophosphorylation。 | Guoliang Zhang Huizhen Zhang Yiwen Liu Yiqing He Wenjuan Wang Yan Du Cuixia Yang Feng Gao | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 2 |
| 20 | Can other host species of cotton bollworm be non-Bt refuges to prolong the effectiveness of Bt-cotton?显示文摘The potential ecological risks of Bacillus thurigiensis (Bt) insecticides and Bt-crops have caused increasing concern since their commercial release in the field, among which pests’ resistance to Bt-crops is the major ecological risk. Refuge tactic, which can produce sensitive populations, has proved to be a key and sound resistance management strategy in USA and Australia; however, no tactics have been performed in China where Bt-cotton is mostly planted with other host crops of cotton bollworm. Genetic variation and gene flow among different host populations of the cotton bollworm Helicoverpa armigera were analyzed using PCR fingerprinting method. The results show that maize and castor-oil plant, as well as cotton can take effect as refuges to prevent resistance of cotton bollworm to Bt-cotton, while peanut and sesame are not as suitable for planting with Bt-cotton as refuges in the field as low gene flow was detected among populations on peanut, sesame and Bt cotton. | TAN Shengjiang CHEN Xiaofeng LI Dianmo ZHANG Huizhen | 2001 | Chinese Science Bulletin2001，46，21： | 2 |
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